Mrpl41 (mitochondrial ribosomal protein L41) - Rat Genome Database

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Gene: Mrpl41 (mitochondrial ribosomal protein L41) Rattus norvegicus
Analyze
Symbol: Mrpl41
Name: mitochondrial ribosomal protein L41
RGD ID: 1310241
Description: Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL41 (mitochondrial ribosomal protein L41); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 39S ribosomal protein L41, mitochondrial; L41mt; large ribosomal subunit protein mL41; LOC296551; MGC109209; MRP-L41
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,178,837 - 28,179,755 (-)NCBIGRCr8
mRatBN7.237,780,658 - 7,781,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,779,143 - 7,782,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,885,417 - 10,886,335 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,471,647 - 19,472,565 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,661,491 - 17,662,409 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,181,044 - 2,181,962 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,181,045 - 2,181,962 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,162,292 - 2,163,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,120,299 - 5,121,217 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,120,299 - 5,121,217 (-)NCBI
Celera32,609,889 - 2,610,807 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
translation  (IBA,ISO,ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9857009   PMID:15489334   PMID:16024796   PMID:18614015   PMID:22658674   PMID:22681889   PMID:25278503   PMID:28892042  


Genomics

Comparative Map Data
Mrpl41
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,178,837 - 28,179,755 (-)NCBIGRCr8
mRatBN7.237,780,658 - 7,781,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,779,143 - 7,782,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,885,417 - 10,886,335 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,471,647 - 19,472,565 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,661,491 - 17,662,409 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,181,044 - 2,181,962 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,181,045 - 2,181,962 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,162,292 - 2,163,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,120,299 - 5,121,217 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,120,299 - 5,121,217 (-)NCBI
Celera32,609,889 - 2,610,807 (-)NCBICelera
Cytogenetic Map3p13NCBI
MRPL41
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,551,879 - 137,552,555 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,551,879 - 137,552,555 (+)EnsemblGRCh38hg38GRCh38
GRCh379140,446,331 - 140,447,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,566,165 - 139,566,827 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,722,180 - 137,722,843NCBI
Celera9110,970,573 - 110,971,271 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,910,437 - 109,911,135 (+)NCBIHuRef
CHM1_19140,595,192 - 140,595,890 (+)NCBICHM1_1
T2T-CHM13v2.09149,805,033 - 149,805,709 (+)NCBIT2T-CHM13v2.0
Mrpl41
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,862,482 - 24,865,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,864,129 - 24,865,110 (-)EnsemblGRCm39 Ensembl
GRCm38224,972,470 - 24,975,098 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,974,117 - 24,975,098 (-)EnsemblGRCm38mm10GRCm38
MGSCv37224,827,990 - 24,830,618 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,794,479 - 24,797,107 (-)NCBIMGSCv36mm8
Celera224,696,392 - 24,699,026 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.88NCBI
Mrpl41
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,436,174 - 5,437,016 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,436,174 - 5,437,016 (+)NCBIChiLan1.0ChiLan1.0
MRPL41
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2111,825,993 - 1,826,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan191,828,326 - 1,829,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,631,543 - 108,632,733 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,594,974 - 137,595,619 (+)NCBIpanpan1.1PanPan1.1panPan2
MRPL41
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,220,805 - 48,221,656 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,221,159 - 48,221,566 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,408,039 - 47,408,882 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,082,913 - 49,083,757 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,083,267 - 49,083,674 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,859,305 - 47,860,149 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,158,286 - 48,159,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,204,755 - 48,205,599 (-)NCBIUU_Cfam_GSD_1.0
Mrpl41
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,840,534 - 202,841,646 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669533,111 - 535,184 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669533,593 - 534,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPL41
(Sus scrofa - pig)		 No map positions available.
MRPL41
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112654,233 - 654,942 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12654,321 - 654,734 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,695,504 - 4,696,270 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrpl41
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760517,200 - 518,884 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760517,200 - 518,805 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrpl41
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:90
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000044802
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat

Markers in Region
RH128428  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.237,780,818 - 7,781,002 (+)MAPPERmRatBN7.2
mRatBN7.2885,195,269 - 85,195,453 (+)MAPPERmRatBN7.2
Rnor_6.0891,820,974 - 91,821,157NCBIRnor6.0
Rnor_6.032,181,205 - 2,181,388NCBIRnor6.0
Rnor_5.0891,338,627 - 91,338,810UniSTSRnor5.0
Rnor_5.032,162,453 - 2,162,636UniSTSRnor5.0
RGSC_v3.435,120,460 - 5,120,643UniSTSRGSC3.4
RGSC_v3.4889,362,373 - 89,362,556UniSTSRGSC3.4
Celera884,840,039 - 84,840,222UniSTS
Celera32,610,050 - 2,610,233UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3p13UniSTS
UniSTS:234343  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2885,195,048 - 85,195,172 (+)MAPPERmRatBN7.2
Rnor_6.0891,820,753 - 91,820,876NCBIRnor6.0
Rnor_5.0891,338,406 - 91,338,529UniSTSRnor5.0
RGSC_v3.4889,362,152 - 89,362,275UniSTSRGSC3.4
Celera884,839,818 - 84,839,941UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044802   ⟹   ENSRNOP00000042070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl32,181,045 - 2,181,962 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110175   ⟹   ENSRNOP00000095947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,779,143 - 7,782,818 (-)Ensembl
RefSeq Acc Id: NM_001013426   ⟹   NP_001013444
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,178,837 - 28,179,755 (-)NCBI
mRatBN7.237,780,658 - 7,781,576 (-)NCBI
Rnor_6.032,181,044 - 2,181,962 (-)NCBI
Rnor_5.032,162,292 - 2,163,210 (-)NCBI
RGSC_v3.435,120,299 - 5,121,217 (-)RGD
Celera32,609,889 - 2,610,807 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013444 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91293 (Get FASTA)   NCBI Sequence Viewer  
  EDL93648 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095947
  ENSRNOP00000095947.1
  ENSRNOP00055000634
  ENSRNOP00060035294
  ENSRNOP00065033851
GenBank Protein Q5BJX1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001013444   ⟸   NM_001013426
- Peptide Label: precursor
- UniProtKB: Q5BJX1 (UniProtKB/Swiss-Prot),   A6JSZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042070   ⟸   ENSRNOT00000044802
RefSeq Acc Id: ENSRNOP00000095947   ⟸   ENSRNOT00000110175

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJX1-F1-model_v2 AlphaFold Q5BJX1 1-134 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691855
Promoter ID:EPDNEW_R2380
Type:initiation region
Name:Mrpl41_1
Description:mitochondrial ribosomal protein L41
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,181,965 - 2,182,025EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310241 AgrOrtholog
BioCyc Gene G2FUF-50491 BioCyc
Ensembl Genes ENSRNOG00000029875 Ensembl
  ENSRNOG00000063489 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055000479 UniProtKB/Swiss-Prot
  ENSRNOG00060024636 UniProtKB/Swiss-Prot
  ENSRNOG00065024174 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000110175 ENTREZGENE
  ENSRNOT00000110175.1 UniProtKB/Swiss-Prot
  ENSRNOT00055000820 UniProtKB/Swiss-Prot
  ENSRNOT00060042610 UniProtKB/Swiss-Prot
  ENSRNOT00065041440 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7307323 IMAGE-MGC_LOAD
InterPro Ribosomal_L27/L41_mit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:296551 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109209 IMAGE-MGC_LOAD
NCBI Gene 296551 ENTREZGENE
PANTHER 39S RIBOSOMAL PROTEIN L41, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOCHONDRIAL RIBOSOMAL PROTEIN L41 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam MRP-L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrpl41 PhenoGen
RatGTEx ENSRNOG00000029875 RatGTEx
  ENSRNOG00000063489 RatGTEx
  ENSRNOG00055000479 RatGTEx
  ENSRNOG00060024636 RatGTEx
  ENSRNOG00065024174 RatGTEx
UniProt A6JSZ9 ENTREZGENE, UniProtKB/TrEMBL
  Q5BJX1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Mrpl41  mitochondrial ribosomal protein L41  Mrpl41_predicted  mitochondrial ribosomal protein L41 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mrpl41_predicted  mitochondrial ribosomal protein L41 (predicted)      Symbol and Name status set to approved 70820 APPROVED