Exhibits enzyme binding activity. Predicted to be involved in positive regulation of oxidoreductase activity and removal of superoxide radicals. Predicted to localize to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human CCS (copper chaperone for superoxide dismutase); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,2,2-tetramine.
Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA], Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein]
[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CCS mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CCS mRNA
[Clofibrate co-treated with Acetaminophen] affects the expression of CCS mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CCS mRNA]
CCS protein promotes the reaction [[Copper results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein], CCS protein promotes the reaction [Copper results in increased activity of HIF1A protein]
CCS protein promotes the reaction [[Copper results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein], CCS protein promotes the reaction [Copper results in increased activity of HIF1A protein]
lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein], lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]
Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA], Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Gene-Chemical Interaction Annotations
