Exhibits enzyme binding activity. Predicted to be involved in positive regulation of oxidoreductase activity and removal of superoxide radicals. Predicted to localize to cytoplasm; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human CCS (copper chaperone for superoxide dismutase); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA], Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein]
[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CCS mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CCS mRNA
[Clofibrate co-treated with Acetaminophen] affects the expression of CCS mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CCS mRNA]
CCS protein promotes the reaction [[Copper results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein], CCS protein promotes the reaction [Copper results in increased activity of HIF1A protein]
CCS protein promotes the reaction [[Copper results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein], CCS protein promotes the reaction [Copper results in increased activity of HIF1A protein]
lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein], lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]
Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA], Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin