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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccs
Name: copper chaperone for superoxide dismutase
Acc ID: CHEBI:26355
Term: heme b
Definition: A metalloprotoporphyrin in which the four pyrrole nitrogens of the protoporphyrin moiety are coordinated to iron. It is the most abundant of the heme compounds.
Chemical ID: MESH:D006418
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccsmultiple interactionsISOCcs (Mus musculus)6480464CTD[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]PMID:19039664
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