Gene: Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) Rattus norvegicus
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Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding (ortholog); kinase activity (ortholog); INVOLVED IN negative regulation of gene expression; phosphatidylinositol phosphorylation; positive regulation of smooth muscle cell proliferation; PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH autosomal recessive polycystic kidney disease; adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); FOUND IN phosphatidylinositol 3-kinase complex; lamellipodium (ortholog); phosphatidylinositol 3-kinase complex, class IA (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; all-trans-retinoic acid; ammonium chloride
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC116320; p110alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA
Orthologs:
Homo sapiens (human) : PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)  HGNC  Alliance
Mus musculus (house mouse) : Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Canis lupus familiaris (dog) : PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Sus scrofa (pig) : PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02118,831,350 - 118,861,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02138,491,967 - 138,521,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,640,277 - 118,672,440 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12118,603,330 - 118,613,969 (+)NCBI
Celera2110,329,861 - 110,360,075 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
  
More on Pik3ca
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620916
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE



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