C7 (complement C7) - Rat Genome Database

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Gene: C7 (complement C7) Rattus norvegicus
Analyze
Symbol: C7
Name: complement C7
RGD ID: 620318
Description: Involved in intracellular sodium ion homeostasis. Predicted to be part of membrane attack complex. Used to study visual epilepsy. Biomarker of membranous glomerulonephritis and myocardial infarction. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7); PARTICIPATES IN coagulation cascade pathway; complement system pathway; prion disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 1-nitropropane; 17beta-estradiol.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: MODEL
Previously known as: complement component 7; complement component C7; complement component C7-like; LOC103694886; LOC310126
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8255,815,687 - 55,892,605 (-)NCBIGRCr8
mRatBN7.2254,088,116 - 54,165,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,088,116 - 54,158,535 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0254,707,621 - 54,781,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,709,138 - 54,777,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,735,309 - 73,806,693 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,147,136 - 54,250,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1254,080,702 - 54,129,568 (-)NCBI
Celera249,739,049 - 49,813,376 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
diazinon  (EXP)
dichloroacetic acid  (ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
diuron  (EXP)
folic acid  (ISO)
furan  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
irinotecan  (EXP)
L-ethionine  (EXP)
Mecamylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP)
silicon dioxide  (EXP,ISO)
sotorasib  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
trametinib  (ISO)
triclosan  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
tubocurarine  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Detection of terminal complement components in experimental immune glomerular injury. Adler S, etal., Kidney Int. 1984 Dec;26(6):830-7.
2. The membrane attack complex of complement induces caspase activation and apoptosis. Nauta AJ, etal., Eur J Immunol 2002 Mar;32(3):783-92.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Sublytic complement attack increases intracellular sodium in rat skeletal muscle. Okamoto K, etal., J Surg Res. 2000 May 15;90(2):174-82.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. Soane L, etal., J Immunol. 2001 Aug 15;167(4):2305-11.
11. Time course studies on the initiation of complement activation in acute myocardial infarction induced by coronary artery ligation in rats. Sumitra M, etal., Mol Cell Biochem. 2005 Jan;268(1-2):149-58.
12. Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. Xiong ZQ, etal., J Neurosci. 2003 Feb 1;23(3):955-60.
Additional References at PubMed
PMID:9688553   PMID:18178252   PMID:22832194   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
C7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8255,815,687 - 55,892,605 (-)NCBIGRCr8
mRatBN7.2254,088,116 - 54,165,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,088,116 - 54,158,535 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0254,707,621 - 54,781,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,709,138 - 54,777,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,735,309 - 73,806,693 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,147,136 - 54,250,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1254,080,702 - 54,129,568 (-)NCBI
Celera249,739,049 - 49,813,376 (-)NCBICelera
Cytogenetic Map2q16NCBI
C7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38540,909,497 - 40,984,643 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl540,909,492 - 41,020,216 (+)EnsemblGRCh38hg38GRCh38
GRCh37540,909,599 - 40,984,745 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,945,356 - 41,018,798 (+)NCBINCBI36Build 36hg18NCBI36
Build 34540,945,355 - 41,018,796NCBI
Celera540,798,197 - 40,871,625 (+)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef540,861,350 - 40,935,010 (+)NCBIHuRef
CHM1_1540,911,673 - 40,985,046 (+)NCBICHM1_1
T2T-CHM13v2.0541,165,912 - 41,241,067 (+)NCBIT2T-CHM13v2.0
C7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,017,232 - 5,093,230 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,018,244 - 5,093,222 (-)EnsemblGRCm39 Ensembl
GRCm38154,987,750 - 5,063,773 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl154,988,762 - 5,063,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37154,938,822 - 5,013,662 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36154,936,037 - 5,010,877 (-)NCBIMGSCv36mm8
Celera154,838,417 - 4,913,553 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.98NCBI
C7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542625,173,463 - 25,230,897 (+)NCBIChiLan1.0ChiLan1.0
C7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2469,354,717 - 69,429,838 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1567,510,052 - 67,583,432 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0569,405,041 - 69,478,445 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1574,447,559 - 74,520,730 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,447,559 - 74,520,649 (-)Ensemblpanpan1.1panPan2
C7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,450,660 - 68,502,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,451,578 - 68,513,386 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,133,714 - 68,185,839 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0468,962,923 - 69,015,455 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl468,962,925 - 69,015,307 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1468,722,997 - 68,775,078 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0468,835,383 - 68,888,145 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0469,374,269 - 69,426,946 (-)NCBIUU_Cfam_GSD_1.0
C7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,634,993 - 229,684,377 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365181,689,328 - 1,731,770 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365181,687,482 - 1,736,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,846,860 - 25,903,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,846,860 - 25,902,707 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21627,055,926 - 27,111,985 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,671,625 - 39,752,336 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl439,671,551 - 39,753,626 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607130,096,885 - 30,178,561 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475913,992,681 - 14,114,411 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475913,991,104 - 14,114,271 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C7
804 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:538
Count of miRNA genes:260
Interacting mature miRNAs:321
Transcripts:ENSRNOT00000060343
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat

Markers in Region
D2Got406  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2254,095,032 - 54,095,332 (+)MAPPERmRatBN7.2
Rnor_6.0254,713,408 - 54,713,707NCBIRnor6.0
Rnor_5.0273,741,096 - 73,741,395UniSTSRnor5.0
RGSC_v3.4254,151,124 - 54,151,423UniSTSRGSC3.4
Celera249,744,841 - 49,745,140UniSTS
Cytogenetic Map2q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 23 7 19 7 8 9 5 25 25 11 8
Low 8 20 20 20 2 57 10 16
Below cutoff 6 14 14 14 10

Sequence


RefSeq Acc Id: ENSRNOT00000082548   ⟹   ENSRNOP00000074387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl254,088,116 - 54,158,535 (-)Ensembl
Rnor_6.0 Ensembl254,709,138 - 54,777,729 (-)Ensembl
RefSeq Acc Id: XM_063282844   ⟹   XP_063138914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8255,815,687 - 55,892,605 (-)NCBI
RefSeq Acc Id: XM_063282845   ⟹   XP_063138915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8255,815,687 - 55,892,594 (-)NCBI
Protein Sequences
Protein RefSeqs XP_063138914 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138915 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG32053 (Get FASTA)   NCBI Sequence Viewer  
  EDL75730 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: ENSRNOP00000074387   ⟸   ENSRNOT00000082548
RefSeq Acc Id: XP_063138914   ⟸   XM_063282844
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063138915   ⟸   XM_063282845
- Peptide Label: isoform X2
Protein Domains
MACPF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K7X7-F1-model_v2 AlphaFold A0A0G2K7X7 1-846 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620318 AgrOrtholog
BioCyc Gene G2FUF-54182 BioCyc
Ensembl Genes ENSRNOG00000061379 Ensembl
Gene3D-CATH Low-density Lipoprotein Receptor UniProtKB/TrEMBL
  Thrombospondin type-1 (TSP1) repeat UniProtKB/TrEMBL
InterPro LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  MAC_perforin UniProtKB/TrEMBL
  MACPF UniProtKB/TrEMBL
  MACPF_CS UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene 117517 ENTREZGENE
PANTHER COMPLEMENT COMPONENT C6 UniProtKB/TrEMBL
  COMPLEMENT COMPONENT C7 UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/TrEMBL
  MACPF UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen C7 PhenoGen
PRINTS COMPLEMENTC9 UniProtKB/TrEMBL
  TSP1REPEAT UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  MACPF_1 UniProtKB/TrEMBL
  MACPF_2 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061379 RatGTEx
SMART LDLa UniProtKB/TrEMBL
  MACPF UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP LDL receptor-like module UniProtKB/TrEMBL
  TSP-1 type 1 repeat UniProtKB/TrEMBL
UniProt A6KGD5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 C7  complement C7  LOC103694886  complement component C7-like  Data merged from RGD:9123610 737654 PROVISIONAL
2016-08-18 C7  complement C7  C7  complement component 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694886  complement component C7-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-04-27 C7  complement component 7  C7_predicted  complement component 7 (predicted)  Data merged from RGD:1307923 737654 APPROVED
2005-01-20 C7  complement component 7      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 C7_predicted  complement component 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 C7  complement component 7      Symbol and Name status set to provisional 70820 PROVISIONAL