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Gene: Tirap (TIR domain containing adaptor protein) Rattus norvegicus
Symbol: Tirap
Name: TIR domain containing adaptor protein
RGD ID: 1595496
Description: Predicted to have several functions, including Toll-like receptor binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and response to bacterium. Predicted to localize to endocytic vesicle and ruffle membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein); PARTICIPATES IN Toll-like receptor signaling pathway; tuberculosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC680127; similar to Toll-interleukin 1 receptor domain-containing adaptor protein; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; toll/interleukin-1 receptor domain-containing adapter protein
Homo sapiens (human) : TIRAP (TIR domain containing adaptor protein)  HGNC  Alliance
Mus musculus (house mouse) : Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tirap (TIR domain containing adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TIRAP (TIR domain containing adaptor protein)
Canis lupus familiaris (dog) : TIRAP (TIR domain containing adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tirap (TIR domain containing adaptor protein)
Sus scrofa (pig) : TIRAP (TIR domain containing adaptor protein)
Chlorocebus sabaeus (African green monkey) : TIRAP (TIR domain containing adaptor protein)
Heterocephalus glaber (naked mole-rat) : Tirap (TIR domain containing adaptor protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0836,382,029 - 36,399,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl836,385,353 - 36,388,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0836,400,673 - 36,406,908 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4834,966,856 - 34,969,727 (-)NCBIRGSC3.4rn4RGSC3.4
Celera834,950,692 - 34,968,852 (-)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tirap
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1595496
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.