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Gene: Tirap (TIR domain containing adaptor protein) Rattus norvegicus
Symbol: Tirap
Name: TIR domain containing adaptor protein
Description: Predicted to have several functions, including Toll-like receptor binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein dimerization activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of signal transduction; and response to bacterium. Predicted to localize to the endocytic vesicle and ruffle membrane. Human ortholog(s) of this gene implicated in malaria; primary immunodeficiency disease; and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein); PARTICIPATES IN Toll-like receptor signaling pathway; tuberculosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC680127; similar to Toll-interleukin 1 receptor domain-containing adaptor protein; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; toll/interleukin-1 receptor domain-containing adapter protein
Homo sapiens (human) : TIRAP (TIR domain containing adaptor protein)  HGNC  Alliance
Mus musculus (house mouse) : Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tirap (TIR domain containing adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TIRAP (TIR domain containing adaptor protein)
Canis lupus familiaris (dog) : TIRAP (TIR domain containing adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tirap (TIR domain containing adaptor protein)
Sus scrofa (pig) : TIRAP (TIR domain containing adaptor protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0836,382,029 - 36,399,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0836,400,673 - 36,406,908 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4834,966,856 - 34,969,727 (-)NCBIRGSC3.4rn4RGSC3.4
Celera834,950,692 - 34,968,852 (-)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Tirap
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1595496
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.