Glb1 (galactosidase, beta 1) - Rat Genome Database

Name: Glb1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Glb1 (galactosidase, beta 1) Rattus norvegicus

Analyze

Symbol:

Glb1

Name:

galactosidase, beta 1

RGD ID:

1597145

Description:

Exhibits beta-galactosidase activity and galactoside binding activity. Involved in galactose catabolic process; response to Thyroglobulin triiodothyronine; and response to cortisone. Localizes to lysosome. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to human GLB1 (galactosidase beta 1); PARTICIPATES IN Fabry disease pathway; galactose metabolic pathway; galactosemia pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; aldehydo-D-glucose.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

beta-galactosidase; galactosidase, beta 1 (mapped); Glb1_mapped

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GLB1 (galactosidase beta 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Glb1 (galactosidase, beta 1)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Glb1 (galactosidase beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GLB1 (galactosidase beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GLB1 (galactosidase beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Glb1 (galactosidase beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GLB1 (galactosidase beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	GLB1 (galactosidase beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Glb1 (galactosidase beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Glb1 (galactosidase, beta 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	GLB1 (galactosidase beta 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	glb1 (galactosidase, beta 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	bgal-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Ect3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Gal	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	bgal-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	114,085,508 - 114,158,127 (+)	NCBI
Rnor_6.0 Ensembl	8	122,439,328 - 122,511,939 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	122,439,328 - 122,511,939 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	121,752,146 - 121,824,793 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	118,791,550 - 118,864,281 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	8	113,332,049 - 113,404,466 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atopic dermatitis (ISO)

bone development disease (ISO)

contact dermatitis (ISO)

Corneal Opacity (ISO)

genetic disease (ISO)

GM1 gangliosidosis (ISO)

GM1 gangliosidosis type 1 (ISO)

GM1 gangliosidosis type 2 (ISO)

GM1 gangliosidosis type 3 (ISO)

high grade glioma (ISO)

intellectual disability (ISO)

mucopolysaccharidosis IV (ISO)

mucopolysaccharidosis type IVB (ISO)

osteochondrodysplasia (ISO)

osteogenesis imperfecta type 7 (ISO)

Otitis Media with Effusion (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

aldehydo-D-glucose (EXP,ISO)

all-trans-retinoic acid (ISO)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

arsenic acid (ISO)

arsenous acid (EXP,ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

butan-1-ol (ISO)

butanal (ISO)

carbon nanotube (ISO)

chloroquine (ISO)

choline (ISO)

cis-caffeic acid (EXP)

clofibrate (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

coumarin (EXP)

cyclosporin A (ISO)

D-glucose (EXP,ISO)

dextran sulfate (ISO)

diarsenic trioxide (EXP,ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (ISO)

doxorubicin (ISO)

endosulfan (EXP)

flavokawain B (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

genistein (ISO)

glafenine (EXP)

glucose (EXP,ISO)

hydrogen peroxide (ISO)

isoprenaline (EXP)

L-methionine (ISO)

methotrexate (ISO)

myrtenal (EXP)

N-acetyl-L-cysteine (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

NAD zwitterion (EXP)

NAD(+) (EXP)

nickel atom (ISO)

nicotinamide (EXP)

nitric oxide (ISO)

NMN zwitterion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (EXP,ISO)

pirinixic acid (ISO)

pravastatin (ISO)

resveratrol (EXP,ISO)

ritonavir (ISO)

SB 203580 (ISO)

silicon dioxide (ISO)

simvastatin (ISO)

sirolimus (EXP)

sodium arsenate (EXP)

sodium arsenite (EXP,ISO)

sodium fluoride (ISO)

Soman (EXP)

streptozocin (ISO)

tamoxifen (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

trans-caffeic acid (EXP)

tremolite asbestos (ISO)

valproic acid (ISO)

wogonin (ISO)

Yessotoxin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular carbohydrate metabolic process (ISO)

galactose catabolic process (IDA)

response to cortisone (IEP)

response to Thyroglobulin triiodothyronine (IEP)

Cellular Component

cytoplasm (ISO)

extracellular space (ISO)

Golgi apparatus (IEA,ISO)

intracellular membrane-bounded organelle (ISO)

lysosome (IDA,ISO)

vacuole (IBA)

Molecular Function

beta-galactosidase activity (IBA,IDA,IMP,ISO)

galactoside binding (IDA)

hydrolase activity (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Fabry disease pathway (ISO)

galactose metabolic pathway (IEA,ISO)

galactosemia pathway (ISO)

ganglioside metabolic pathway (IEA)

Gaucher's disease pathway (ISO)

glycosaminoglycan degradation pathway (IEA)

Krabbe disease pathway (ISO)

metachromatic leukodystrophy pathway (ISO)

sphingolipid metabolic pathway (IEA,ISO)

References

References - curated


1.	Douglas TC, etal., Genetics. 1982 Mar;100(3):455-73.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Jumawan J, etal., Biol Neonate. 1977;32(3-4):211-7.
4.	Leeper LL and Henning SJ, Biol Neonate. 1983;44(1):28-35.
5.	Majumder GC and Turkington RW, Biochemistry. 1974 Jul 2;13(14):2857-64.
6.	Mayer FQ, etal., Mol Genet Metab. 2009 Mar;96(3):148. doi: 10.1016/j.ymgme.2008.11.159. Epub 2008 Dec 16.
7.	Morrone A, etal., Hum Mutat. 2000;15(4):354-66.
8.	OMIM Disease Annotation Pipeline
9.	Paschke E, etal., Hum Genet. 2001 Aug;109(2):159-66.
10.	Pipeline to import KEGG annotations from KEGG into RGD
11.	Pipeline to import SMPDB annotations from SMPDB into RGD
12.	Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1996 Jan 26;154(2):165-70.
13.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	RGD automated import pipeline for gene-chemical interactions
15.	Santamaria R, etal., Clin Genet. 2007 Mar;71(3):273-9.
16.	Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
17.	Weismann CM, etal., Hum Mol Genet. 2015 Aug 1;24(15):4353-64. doi: 10.1093/hmg/ddv168. Epub 2015 May 10.

Additional References at PubMed

PMID:1914521	PMID:4830244	PMID:7203014	PMID:11927518	PMID:19056867	PMID:19710420	PMID:20849834	PMID:22128166	PMID:23376485	PMID:23533145	PMID:24737316	PMID:25936995
PMID:29514215	PMID:32423114

Genomics

Comparative Map Data

Glb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	114,085,508 - 114,158,127 (+)	NCBI
Rnor_6.0 Ensembl	8	122,439,328 - 122,511,939 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	122,439,328 - 122,511,939 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	121,752,146 - 121,824,793 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	118,791,550 - 118,864,281 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	8	113,332,049 - 113,404,466 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

GLB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	3	32,996,609 - 33,097,202 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	3	32,996,617 - 33,097,146 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	3	33,038,109 - 33,138,638 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	3	33,038,100 - 33,138,694 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	33,013,104 - 33,113,698 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	3	33,013,234 - 33,113,632	NCBI
Celera	3	32,980,743 - 33,081,754 (-)	NCBI
Cytogenetic Map	3	p22.3	NCBI
HuRef	3	32,977,821 - 33,078,667 (-)	NCBI		HuRef
CHM1_1	3	32,988,097 - 33,088,772 (-)	NCBI		CHM1_1

Glb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	114,230,146 - 114,303,447 (+)	NCBI	GRCm39		mm39
GRCm38	9	114,401,078 - 114,474,379 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	114,401,076 - 114,474,898 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	114,310,237 - 114,383,495 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	114,249,817 - 114,323,075 (+)	NCBI			mm8
Celera	9	114,872,858 - 114,948,660 (+)	NCBI		Celera
Cytogenetic Map	9	F3	NCBI
cM Map	9	64.4	NCBI

Glb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	231,076 - 312,500 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955421	230,957 - 311,504 (-)	NCBI	ChiLan1.0	ChiLan1.0

GLB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	33,231,208 - 33,336,804 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	33,231,209 - 33,336,804 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	32,892,039 - 33,031,959 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

GLB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	23	3,732,040 - 3,814,191 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	23	3,721,768 - 3,814,209 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Glb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936473	23,348,431 - 23,440,271 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GLB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	18,878,612 - 18,953,146 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	18,878,407 - 18,978,999 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GLB1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	77,480,895 - 77,592,130 (-)	NCBI
ChlSab1.1 Ensembl	15	77,480,598 - 77,592,120 (-)	Ensembl

Glb1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624788	10,970,657 - 11,110,839 (-)	NCBI

Position Markers

RH130801

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	122,511,123 - 122,511,342	NCBI	Rnor6.0
Rnor_5.0	8	121,823,977 - 121,824,196	UniSTS	Rnor5.0
RGSC_v3.4	8	118,863,465 - 118,863,684	UniSTS	RGSC3.4
Celera	8	113,403,642 - 113,403,861	UniSTS
RH 3.4 Map	8	1203.8	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH134983

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	122,449,487 - 122,449,684	NCBI	Rnor6.0
Rnor_5.0	8	121,762,341 - 121,762,538	UniSTS	Rnor5.0
RGSC_v3.4	8	118,801,709 - 118,801,906	UniSTS	RGSC3.4
Celera	8	113,342,195 - 113,342,392	UniSTS
RH 3.4 Map	8	1202.0	UniSTS
Cytogenetic Map	8	q32	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	50529480	128036471	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	65717449	128033050	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	76103982	127182642	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	78805083	123805083	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	78805083	123805083	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	78805083	123805083	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	78805083	123805083	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	80697934	125697934	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	83894304	128894304	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	89058229	132243842	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	100873811	133307652	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	100873811	133307652	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102051964	133307652	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	104682575	133307652	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	104682575	133307652	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	107769005	129956433	Rat
1599689	Iddm24	Insulin dependent diabetes mellitus QTL 24	4.72	0.001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	8	120870965	127609447	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	105
Count of miRNA genes:	81
Interacting mature miRNAs:	94
Transcripts:	ENSRNOT00000013632
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	29	51	35	19	35	1	1	62	35	36	11	1
Low		14	6	6		6	7	10	12		5		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000013632 ⟹ ENSRNOP00000013632

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	122,439,328 - 122,511,939 (+)	Ensembl

RefSeq Acc Id:

NM_001108192 ⟹ NP_001101662

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	114,085,508 - 114,158,127 (+)	NCBI
Rnor_6.0	8	122,439,328 - 122,511,939 (+)	NCBI
Rnor_5.0	8	121,752,146 - 121,824,793 (+)	NCBI
RGSC_v3.4	8	118,791,550 - 118,864,281 (+)	RGD
Celera	8	113,332,049 - 113,404,466 (+)	RGD

Sequence:

show sequence

CTCAGTAACCCCCGGAGGTGGAGCGGCTGGCCAGAGCGCCCACTGCAGAGTGGAGCGGTCCCAT
CGCGGCGCCGTCATGTTCCGGGTCCCCCTGTGTATGCTGCTCCCGCTCCTGGCGCTCCTGCAGT
TGCTGGGCGCTGCGCACAGTTTCTATAATGTCTCCCAGAGGACATTTGAGCTGGACTACAAACG
GGACCGCTTCCTCAAGGATGGGCAGCCATTCCGCTACATCTCGGGAAGCATTCACTACTTCCGG
ATACCCCGATTCTACTGGGAGGACCGGCTGCTAAAGATGAAGATGGCTGGGCTGGATGCAATCC
AGACGTACGTGCCCTGGAACTTCCATGAACCCCAGCCAGGACAATATGACTTTTCTGGGGACCG
TGATGTGGAACATTTCATTCAGCTGGCTCACCAGCTGGGACTCCTGGTGATCCTGAGGCCTGGG
CCCTACATCTGTGCAGAGTGGGACATGGGGGGCTTACCCGCTTGGTTACTAGAGAAAGAATCGA
TCGTTCTCCGGTCTTCCGACCCAGATTACCTTGCAGCTGTGGATAAATGGCTGGCAGTCCTTCT
GCCCAAGATGAAGCGTCTGCTCTACCAGAACGGAGGGCCCATCATAACCGTGCAGGTTGAGAAT
GAGTACGGGTCCTACTTCGCCTGCGATTATAACTACCTGCGTTTCCTGGAGCACCGCTTCCGCT
ACCATTTGGGTAACGACATCATTCTCTTCACCACTGACGGAGCAGCTGAAAAATTACTCAAGTG
TGGGACCCTGCAGGACCTCTACGCCACAGTGGATTTTGGAACAACCGGCAATATCACACGAGCT
TTCCTGATCCAGAGGAATTTTGAACCCAAAGGACCTTTGATCAATTCTGAGTTCTATACTGGCT
GGTTAGACCACTGGGGTCAACCCCATTCCAAAGTGAATACTAAGAAGTTGGTGGCCTCCCTCTA
TAACCTGCTTGCCTACGGGGCCAGCGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCC
TATTGGAATGGTGCCAACATGCCCTATGCCCCACAGCCAACCAGCTATGACTATGACGCCCCAC
TGAGCGAGGCAGGAGACCTCACTGAGAAGTACTTCGCAGTACGAGATGTCATTCGGAAGTTTAA
AGAAGTCCCAGAAGGCCCTATCCCTCCATCTACACCCAAGTTCGCATATGGAAAAGTTGCTCTG
AGAAAGTTCAAGACGGTGACGGAAGCTCTGGGTATACTGTGTCCCAACGGGCCCGTGAAAAGCC
TCTACCCCTTGACGTTCACTCAGGTAAAACAGTATTTTGGGTATGTGCTATACCGAACGACACT
TCCTCAAGATTGCAGTAACCCGAAACCCATTTTCTCTTCACCCATAAATGGTGTCCGTGATCGG
GCCTACGTCTCTGTGGACGGGGTCCCCCAAGGAATCCTTGATCGAAACCGTATGAACGTTCTGA
ACATTCGGGGGAAGGCCGGAGCCACGCTAGACATTCTGGTGGAGAACATGGGGCGTGTGAACTA
TGGCAACTCCATCAAAGACTTTAAGGGTTTGATTTCCAACATGACCCTCAACTTCACTGTCCTC
ACCAACTGGACAATGTTCCCACTGGACACTGAGGCCCTGGCACGCAGCCATCTTGGGAACTGGG
AGGCCGCTGATGAGGGTCACCTCGATGGACACTCGACCTTACGTTCTTCAAATTTCACACTCCC
CACCTTTTACGTGGGCAACTTCTCCATCCCCTCGGGCATCCCAGACCTGCCGCAGGACACCTTC
ATCCAGTTTCCCGGATGGGCCAAGGGCCAAGTATGGATCAATGGCTTTAACCTCGGGCGATACT
GGCCCACAAAGGGCCCACAAATGACCTTGTTTGTGCCAAGGAACATCCTGACCACTTCAGCCCC
AAACAACATCACAGTGCTAGAACTGGAGTCGTCACCCTGCAGTAATGGGACCCTAGAGCTATGT
ACAGTAGAGTTTGTTGACACTCCGGTTATTGGCTGACCTCAGTGGCCATTTTCCAGGCCAGTCT
GGTCAAGACTCAGGGCTGACCCGCCTGCGACGACTGATCCTCTGGGCACACAACCCTACTCTTG
CTACGTGGACCACCCTTATGGTACAGAATTGTGGAATGTGTGTATCCTGCTGGTGACTGCAGCC
CTGCCTTGCCTGACCACCCACCCTCGTGGCCACCAGGAAGGCTGAAGAGAGTGGATACCATAGG
AATACACAGCTGGTGTGCCGAGTTGGAACAAAACTTGAATAATGTCCCTTATTCTGACTTGAAA
TAATCATGTCTTTCTGATGAATAAAATTTGAATGCAAGCTGTGGTCTTCCTGTCATTAGTGTAT
CAGGCAGGTATTAAACTCTGAGGTCTGACTTAAATCTCAACTAGACTTGAGTGGGCTGGGTGAA
GCCACTTCACTAGCTTGAGATTCAAAGTGGGTAGGAGAGAGTGCTGGTTTAGGCTAGCAGAGGG
CTTCGTTTTTGATCCCGGTTTGACTGTTTCTGAATCTCTGTGATATCTACGAGGTGAGACATCT
CCAGTTACAAACCACCTAAGAGATTAACAGTTGCTCAAAGTAGGTGCTGCGGTCTCTCTTTACA
GTTAAGTAGAAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTT
CATGTATGTATGGAGATGCATGTGTATTTACATGTATTTGTGCAGGTCAAAGGCCCATCTTTGG
CCCATTTCTCAGGACTGCCTTAGTGTCTAGGAACATACGGAATGTATAAAATGTAATTCTGCTT
ATGTTTGAGACGCTGTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101662	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76992	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001101662 ⟸ NM_001108192
- Peptide Label:	precursor
- UniProtKB:	D3ZUM4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFRVPLCMLLPLLALLQLLGAAHSFYNVSQRTFELDYKRDRFLKDGQPFRYISGSIHYFRIPRF YWEDRLLKMKMAGLDAIQTYVPWNFHEPQPGQYDFSGDRDVEHFIQLAHQLGLLVILRPGPYIC AEWDMGGLPAWLLEKESIVLRSSDPDYLAAVDKWLAVLLPKMKRLLYQNGGPIITVQVENEYGS YFACDYNYLRFLEHRFRYHLGNDIILFTTDGAAEKLLKCGTLQDLYATVDFGTTGNITRAFLIQ RNFEPKGPLINSEFYTGWLDHWGQPHSKVNTKKLVASLYNLLAYGASVNLYMFIGGTNFAYWNG ANMPYAPQPTSYDYDAPLSEAGDLTEKYFAVRDVIRKFKEVPEGPIPPSTPKFAYGKVALRKFK TVTEALGILCPNGPVKSLYPLTFTQVKQYFGYVLYRTTLPQDCSNPKPIFSSPINGVRDRAYVS VDGVPQGILDRNRMNVLNIRGKAGATLDILVENMGRVNYGNSIKDFKGLISNMTLNFTVLTNWT MFPLDTEALARSHLGNWEAADEGHLDGHSTLRSSNFTLPTFYVGNFSIPSGIPDLPQDTFIQFP GWAKGQVWINGFNLGRYWPTKGPQMTLFVPRNILTTSAPNNITVLELESSPCSNGTLELCTVEF VDTPVIG hide sequence

RefSeq Acc Id:

ENSRNOP00000013632 ⟸ ENSRNOT00000013632

Protein Domains

BetaGal_dom4_5 Glyco_hydro_35

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696354

Promoter ID:

EPDNEW_R6879

Type:

initiation region

Name:

Glb1_1

Description:

galactosidase, beta 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	122,439,360 - 122,439,420	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1597145	AgrOrtholog
Ensembl Genes	ENSRNOG00000010196	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000013632	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013632	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.260	UniProtKB/TrEMBL
InterPro	B-gal_1-like	UniProtKB/TrEMBL
	BetaGal_jelly_roll_dom	UniProtKB/TrEMBL
	Galactose-bd-like	UniProtKB/TrEMBL
	Gly_Hdrlase_35_cat	UniProtKB/TrEMBL
	Glyco_hydro_35_CS	UniProtKB/TrEMBL
	Glyco_hydro_catalytic_core	UniProtKB/TrEMBL
	Glycoside_Hdrlase_35	UniProtKB/TrEMBL
KEGG Report	rno:316033	UniProtKB/TrEMBL
NCBI Gene	316033	ENTREZGENE
PANTHER	Glyco_hydro_35	UniProtKB/TrEMBL
Pfam	BetaGal_dom4_5	UniProtKB/TrEMBL
	Glyco_hydro_35	UniProtKB/TrEMBL
PhenoGen	Glb1	PhenoGen
PIRSF	B-gal	UniProtKB/TrEMBL
PRINTS	GLHYDRLASE35	UniProtKB/TrEMBL
PROSITE	GLYCOSYL_HYDROL_F35	UniProtKB/TrEMBL
Superfamily-SCOP	Gal_bind_like	UniProtKB/TrEMBL
	Glyco_hydro_cat	UniProtKB/TrEMBL
UniProt	D3ZUM4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Glb1	galactosidase, beta 1	Glb1_predicted	galactosidase, beta 1 (predicted)	'predicted' is removed	2292626	APPROVED
2007-04-11	Glb1_predicted	galactosidase, beta 1 (predicted)	Glb1_mapped	galactosidase, beta 1 (mapped)	Data Merged	737654	APPROVED
2007-01-09	Glb1_predicted	galactosidase, beta 1 (predicted)	Glb1	galactosidase, beta 1	Gene type set to predicted; nomenclature changed appropriately	1299863	APPROVED
2007-01-09		galactosidase, beta 1	Glb1	galactosidase, beta 1 (mapped)	Name updated	1299863	APPROVED
2006-11-20	Glb1	galactosidase, beta 1 (mapped)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-11-17	Glb1_mapped	galactosidase, beta 1 (mapped)			Symbol and Name updated	1556543	APPROVED
2002-06-10	Glb1	Galactosidase, beta 1			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)