Mmp9 (matrix metallopeptidase 9) - Rat Genome Database

Name: Mmp9
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Mmp9 (matrix metallopeptidase 9) Rattus norvegicus

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Symbol:

Mmp9

Name:

matrix metallopeptidase 9

RGD ID:

621320

Description:

Exhibits fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Localizes to extracellular space and protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9); PARTICIPATES IN fibroblast growth factor signaling pathway; syndecan signaling pathway; urinary bladder cancer pathway; INTERACTS WITH (+)-Tetrandrine; (R)-carnitine; (R)-noradrenaline.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

92 kDa gelatinase; 92 kDa type IV collagenase; 92-kDa type IV collagenase; gelatinase B; GELB; matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase); matrix metalloproteinase-9; MMP-9

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MMP9 (matrix metallopeptidase 9)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Mmp9 (matrix metallopeptidase 9)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Mmp9 (matrix metallopeptidase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MMP9 (matrix metallopeptidase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MMP9 (matrix metallopeptidase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mmp9 (matrix metallopeptidase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MMP9 (matrix metallopeptidase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MMP9 (matrix metallopeptidase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mmp9 (matrix metallopeptidase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Mmp9 (matrix metallopeptidase 9)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	MMP9 (matrix metallopeptidase 9)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	mmp9 (matrix metallopeptidase 9)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	zmp-6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Allele / Splice:

Mmp9^em6Mcwi Mmp9^em4Mcwi

Genetic Models:

SS-Mmp9^em4Mcwi SS-Mmp9^em6Mcwi

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	153,684,158 - 153,692,118 (+)	NCBI
Rnor_6.0 Ensembl	3	161,413,298 - 161,421,520 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	161,413,410 - 161,421,473 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	167,578,904 - 167,605,890 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	155,985,473 - 155,993,433 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	155,891,508 - 155,899,467 (+)	NCBI
Celera	3	152,289,466 - 152,297,426 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

abdominal aortic aneurysm (IDA,ISO)

Acute Coronary Syndrome (ISO)

Acute Lung Injury (IEP)

adrenoleukodystrophy (ISO)

adult respiratory distress syndrome (ISO)

Albuminuria (ISO)

alcohol use disorder (IEP)

Alcoholic Liver Diseases (IEP)

allergic contact dermatitis (IEP,ISO)

Alzheimer's disease (ISO)

amyotrophic lateral sclerosis (ISO)

Angina, Stable (ISO)

angle-closure glaucoma (ISO)

Animal Disease Models (ISO)

Animal Mammary Neoplasms (ISO)

anodontia (ISO)

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ISO)

aortic aneurysm (ISO)

aortic disease (ISO)

Aortic Rupture (ISO)

Arterial Injury (IDA)

arteriosclerosis (IDA,ISO)

Arteriovenous Fistula (IEP,ISO)

arteriovenous malformation (ISO)

asthma (IEP,ISO)

atopic dermatitis (ISO)

atrial fibrillation (ISO)

attention deficit hyperactivity disorder (ISO)

autism spectrum disorder (ISO)

autoimmune lymphoproliferative syndrome (ISO)

autosomal dominant polycystic kidney disease (ISO)

bacterial meningitis (ISO)

bacterial pneumonia (ISO)

Behcet's disease (ISO)

Bone Neoplasms (ISO)

brain edema (IEP,ISO)

brain infarction (ISO)

Brain Injuries (IDA,IMP,ISO)

Brain Injuries, Traumatic (ISO)

brain ischemia (IDA,ISO)

Breast Neopla

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)