Mmp9 (matrix metallopeptidase 9) - Rat Genome Database

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Gene: Mmp9 (matrix metallopeptidase 9) Rattus norvegicus
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Symbol: Mmp9
Name: matrix metallopeptidase 9
RGD ID: 621320
Description: Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; extracellular matrix of synaptic cleft; and postsynaptic density, intracellular component. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9); PARTICIPATES IN fibroblast growth factor signaling pathway; syndecan signaling pathway; urinary bladder cancer pathway; INTERACTS WITH (+)-Tetrandrine; (R)-carnitine; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 92 kDa gelatinase; 92 kDa type IV collagenase; 92-kDa type IV collagenase; gelatinase B; GELB; matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase); matrix metalloproteinase-9; MMP-9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mmp9em6Mcwi   Mmp9em4Mcwi  
Genetic Models: SS-Mmp9em4Mcwi SS-Mmp9em6Mcwi
Candidate Gene For: Eau4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83174,103,474 - 174,111,434 (+)NCBIGRCr8
mRatBN7.23153,684,158 - 153,692,118 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,683,858 - 153,692,120 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,492,813 - 157,500,796 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,991,783 - 165,999,766 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,735,564 - 163,743,543 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,413,410 - 161,421,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,413,298 - 161,421,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,578,904 - 167,605,890 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,985,473 - 155,993,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,891,508 - 155,899,467 (+)NCBI
Celera3152,289,466 - 152,297,426 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Mmp9Ratabdominal aortic aneurysm  ISOMMP9 (Homo sapiens)1582641 RGD 
Mmp9Ratabdominal aortic aneurysm severityISOMMP9 (Homo sapiens)9068941 RGDPMID:16432074 and REF_RGD_ID:1582641
Mmp9Ratabdominal aortic aneurysm treatmentIDA 13207313 RGD 
Mmp9RatAcute Lung Injury  IEP 13207316 RGD 
Mmp9RatAcute Otitis Media  ISOMmp9 (Mus musculus)127284853mRNA:increased expression:middle ear (mouse)RGD 
Mmp9Ratadrenoleukodystrophy  ISOMMP9 (Homo sapiens)13204814protein:increased expression:cerebrospinal fluidRGD 
Mmp9Ratadult respiratory distress syndrome  ISOMMP9 (Homo sapiens)5129208protein:increased expression:lungRGD 
Mmp9RatAlbuminuria onsetISOMMP9 (Homo sapiens)7207214associated with Diabetes Mellitus more ...RGD 
Mmp9Ratalcohol use disorder  IEP 13207311 RGD 
Mmp9RatAlcoholic Liver Diseases  IEP 1642042protein:increased expression:liverRGD 
Mmp9Ratallergic contact dermatitis  IEP 2325935mRNA:increased expression:skin and lymph nodeRGD 
Mmp9Ratallergic contact dermatitis  ISOMmp9 (Mus musculus)8693317 RGD 
Mmp9Ratallergic contact dermatitis  ISOMmp9 (Mus musculus)8547869 RGD 
Mmp9RatAlveolar Bone Loss treatmentIEP 329956421associated with periodontal diseaseRGD 
Mmp9RatAlzheimer's disease  ISOMMP9 (Homo sapiens)7207052protein:increased expression:plasma (human)RGD 
Mmp9Ratamyotrophic lateral sclerosis  ISOMmp9 (Mus musculus)13204793protein:increased expression:skin of body and spinal cordRGD 
Mmp9Ratamyotrophic lateral sclerosis severityISOMMP9 (Homo sapiens)7207054protein:increased expression:serum and cerebrospinal fluid (human)RGD 
Mmp9Ratangle-closure glaucoma no_associationISOMMP9 (Homo sapiens)8549724DNA:SNP:promoter:-1562C>T (human)RGD 
Mmp9Ratangle-closure glaucoma  ISOMMP9 (Homo sapiens)8547830DNA:SNPs: :rs17576 and rs3918249 (human)RGD 
Mmp9Ratangle-closure glaucoma  ISOMMP9 (Homo sapiens)8547816DNA:SNP: :rs2664538 (human)RGD 
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Mmp9Ratadenosine deaminase deficiency  ISOMMP9 (Homo sapiens)8554872ClinVar Annotator: match by term: Severe combined immunodeficiency more ...ClinVarPMID:26255240 more ...
Mmp9Ratfocal epilepsy  ISOMMP9 (Homo sapiens)8554872ClinVar Annotator: match by term: Focal-onset seizureClinVarPMID:32581362
Mmp9Ratgalactosialidosis  ISOMMP9 (Homo sapiens)8554872ClinVar Annotator: match by term: Combined deficiency of sialidase AND beta galactosidaseClinVarPMID:15110321 more ...
Mmp9RatMetaphyseal Anadysplasia 2  ISOMMP9 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16631427 more ...
Mmp9RatT-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations  ISOMMP9 (Homo sapiens)8554872ClinVar Annotator: match by term: T-cell immunodeficiency more ...ClinVarPMID:22174160 and PMID:28492532
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Mmp9Ratabdominal aortic aneurysm  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17196988
Mmp9RatAcute Coronary Syndrome  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20981132
Mmp9RatAnimal Disease Models  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21051829
Mmp9Rataortic aneurysm  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10231640
Mmp9Rataortic disease  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15545515
Mmp9RatAortic Rupture  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18178469
Mmp9Ratasthma  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11742282 and PMID:15131573
Mmp9RatBone Neoplasms  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16475674
Mmp9Ratbrain edema  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15529013
Mmp9RatBrain Injuries  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19631748
Mmp9Ratbrain ischemia  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15060315
Mmp9RatBreast Neoplasms  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19617202
Mmp9Ratcalcinosis  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15545515 and PMID:21193197
Mmp9RatCerebral Hemorrhage  ISOMMP9 (Homo sapiens)11554173CTD more ...CTDPMID:14630814 more ...
Mmp9Ratcerebral infarction  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16846501
Mmp9RatChemical and Drug Induced Liver Injury  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22507835
Mmp9Ratchronic obstructive pulmonary disease  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19299917
Mmp9RatColonic Neoplasms  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15725655
Mmp9Ratdiabetic neuropathy  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20213226
Mmp9RatDisease Progression  ISOMMP9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34626302
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Mmp9RatMetaphyseal Anadysplasia 2  ISOMMP9 (Homo sapiens)7240710 OMIM 

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Mmp9Rat(+)-pilocarpine increases activityISOMmp9 (Mus musculus)6480464Pilocarpine results in increased activity of MMP9 proteinCTDPMID:19631748
Mmp9Rat(+)-pilocarpine increases expressionISOMmp9 (Mus musculus)6480464Pilocarpine results in increased expression of MMP9 proteinCTDPMID:19631748
Mmp9Rat(+)-Pimaric acid multiple interactionsISOMMP9 (Homo sapiens)6480464pimaric acid inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein] and pimaric acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]CTDPMID:22705379
Mmp9Rat(+)-Tetrandrine multiple interactionsEXP 6480464tetrandrine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP9 protein]CTDPMID:22001142
Mmp9Rat(+)-Tetrandrine decreases expressionISOMMP9 (Homo sapiens)6480464tetrandrine results in decreased expression of MMP9 proteinCTDPMID:30549224
Mmp9Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMmp9 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [Toluene 2 more ...CTDPMID:16516891
Mmp9Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMMP9 (Homo sapiens)6480464epigallocatechin gallate affects the reaction [Doxorubicin affects the activity of MMP9 protein] and epigallocatechin gallate inhibits the reaction [Particulate Matter results in increased expression of MMP9 protein]CTDPMID:31252129 and PMID:35218280
Mmp9Rat(-)-epigallocatechin 3-gallate decreases activityISOMmp9 (Mus musculus)6480464epigallocatechin gallate results in decreased activity of MMP9 proteinCTDPMID:11746506
Mmp9Rat(24S)-24-hydroxycholesterol increases expressionISOMMP9 (Homo sapiens)648046424-hydroxycholesterol results in increased expression of MMP9 mRNACTDPMID:24802026
Mmp9Rat(24S)-24-hydroxycholesterol multiple interactionsISOMMP9 (Homo sapiens)6480464Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of MMP9 mRNA]CTDPMID:24802026
Mmp9Rat(25R)-cholest-5-ene-3beta,26-diol increases expressionISOMMP9 (Homo sapiens)648046427-hydroxycholesterol results in increased expression of MMP9 mRNACTDPMID:24802026
Mmp9Rat(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISOMMP9 (Homo sapiens)6480464Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of MMP9 mRNA]CTDPMID:24802026
Mmp9Rat(R)-carnitine multiple interactionsEXP 6480464Carnitine inhibits the reaction [sunitinib results in decreased expression of MMP9 mRNA]CTDPMID:26581635
Mmp9Rat(R)-noradrenaline increases expressionISOMMP9 (Homo sapiens)6480464Norepinephrine results in increased expression of MMP9 mRNACTDPMID:24929186
Mmp9Rat(R)-noradrenaline increases expressionEXP 6480464Norepinephrine results in increased expression of MMP9 mRNACTDPMID:16864425
Mmp9Rat(R)-noradrenaline increases activityEXP 6480464Norepinephrine results in increased activity of MMP9 proteinCTDPMID:16864425
Mmp9Rat(R)-noradrenaline multiple interactionsEXP 6480464trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]CTDPMID:16864425
Mmp9Rat(R)-noradrenaline increases activityISOMMP9 (Homo sapiens)6480464Norepinephrine results in increased activity of MMP9 proteinCTDPMID:24929186
Mmp9Rat(R)-noradrenaline multiple interactionsISOMMP9 (Homo sapiens)6480464N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA] more ...CTDPMID:24929186
Mmp9Rat(S)-colchicine decreases expressionISOMMP9 (Homo sapiens)6480464Colchicine results in decreased expression of MMP9 mRNACTDPMID:33684465

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Biological Process
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Mmp9Ratapoptotic process acts_upstream_ofISOMmp9 (Mus musculus)1624291MGI:1932294 PMID:15800063RGDPMID:15800063
Mmp9Ratapoptotic process acts_upstream_ofIEAUniProtKB:P41245 and ensembl:ENSMUSP000000178811600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratcell migration involved_inISOMMP9 (Homo sapiens)1624291RNAcentral:URS000029D9F1_9606 PMID:28280358RGDPMID:28280358
Mmp9Ratcell migration involved_inIEAUniProtKB:P14780 and ensembl:ENSP000003614051600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratcellular response to cell-matrix adhesion  IEP 2325787 RGD 
Mmp9Ratcellular response to cell-matrix adhesion  IMP 2325968 RGD 
Mmp9Ratcellular response to cytokine stimulus  IEP 2325816 RGD 
Mmp9Ratcellular response to interleukin-1  IEP 2325789 RGD 
Mmp9Ratcellular response to interleukin-1  IEP 2313720Il-1betaRGD 
Mmp9Ratcellular response to iron(III) ion  IEP 7207286 RGD 
Mmp9Ratcellular response to lipopolysaccharide  IEP 7207286 RGD 
Mmp9Ratcellular response to low-density lipoprotein particle stimulus  IEP 2325827 RGD 
Mmp9Ratcellular response to tumor necrosis factor  IEP 7207278 RGD 
Mmp9Ratcellular response to UV-A involved_inISOMMP9 (Homo sapiens)1624291 PMID:31380578RGDPMID:31380578
Mmp9Ratcellular response to UV-A involved_inIEAUniProtKB:P14780 and ensembl:ENSP000003614051600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratcollagen catabolic process  IDA 7207278 RGD 
Mmp9Ratcollagen catabolic process involved_inIBAMGI:101900 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mmp9Ratcollagen catabolic process acts_upstream_of_or_withinIEAUniProtKB:P41245 and ensembl:ENSMUSP000000178811600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratcollagen catabolic process acts_upstream_of_or_withinISOMmp9 (Mus musculus)1624291 PMID:9291580RGDPMID:9291580
Mmp9Ratcollagen catabolic process involved_inIEAUniProtKB-KW:KW-01771600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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Mmp9Ratextracellular matrix located_inIEAInterPro:IPR001818 and InterPro:IPR0211581600115GO_REF:0000002InterProGO_REF:0000002
Mmp9Ratextracellular matrix of synaptic cleft is_active_inIDA 405650358PMID:18332222SynGO 
Mmp9Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Mmp9Ratextracellular space located_inIEAUniProtKB:P14780 and ensembl:ENSP000003614051600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratextracellular space  IDA 1642033 RGD 
Mmp9Ratextracellular space is_active_inIBAPANTHER:PTN002565758 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mmp9Ratextracellular space located_inISOMMP9 (Homo sapiens)1624291 PMID:24236012 more ...RGDPMID:24236012 more ...
Mmp9Ratextracellular space located_inISSUniProtKB:P147801600115GO_REF:0000024UniProtGO_REF:0000024
Mmp9Ratglutamatergic synapse is_active_inIDA 2325331PMID:19420267SynGO 
Mmp9Ratglutamatergic synapse is_active_inIDA 405650358PMID:18332222SynGO 
Mmp9Ratpostsynaptic density, intracellular component is_active_inIDA 405650358PMID:18332222SynGO 
Mmp9Ratprotein-containing complex  IDA 2325938 RGD 
Mmp9RatSchaffer collateral - CA1 synapse is_active_inEXP 405650393PMID:19047646SynGO 
Mmp9RatSchaffer collateral - CA1 synapse is_active_inIDA 405650393PMID:19047646SynGO 
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Molecular Function
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Mmp9Ratendopeptidase activity enablesISOMMP9 (Homo sapiens)1624291 PMID:12062105 more ...RGDPMID:12062105 more ...
Mmp9Ratendopeptidase activity enablesIEAUniProtKB:P14780 and ensembl:ENSP000003614051600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratfibronectin binding  IPIFn1 (Rattus norvegicus)2296060 RGD 
Mmp9Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Mmp9Ratidentical protein binding enablesIEAUniProtKB:P14780 and ensembl:ENSP000003614051600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratidentical protein binding enablesISOMMP9 (Homo sapiens)1624291UniProtKB:P14780 more ...RGDPMID:17937912 more ...
Mmp9Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Mmp9Ratmetalloendopeptidase activity enablesISSUniProtKB:P412451600115GO_REF:0000024UniProtGO_REF:0000024
Mmp9Ratmetalloendopeptidase activity  TAS 628551 RGD 
Mmp9Ratmetalloendopeptidase activity enablesIEAUniProtKB:P41245 and ensembl:ENSMUSP000000178811600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratmetalloendopeptidase activity enablesISOMmp9 (Mus musculus)1624291 PMID:12419962 more ...RGDPMID:12419962 more ...
Mmp9Ratmetalloendopeptidase activity enablesIBAFB:FBgn0033438 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mmp9Ratmetalloendopeptidase activity enablesIEAInterPro:IPR001818 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mmp9Ratmetalloendopeptidase activity enablesIEAUniProtKB:P14780 and ensembl:ENSP000003614051600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratmetalloendopeptidase activity enablesIEAEC:3.4.24.351600115GO_REF:0000003UniProtGO_REF:0000003
Mmp9Ratmetalloendopeptidase activity enablesISSUniProtKB:P147801600115GO_REF:0000024UniProtGO_REF:0000024
Mmp9Ratmetalloendopeptidase activity enablesISOMMP9 (Homo sapiens)1624291 PMID:16192646 more ...RGDPMID:16192646 more ...
Mmp9Ratmetallopeptidase activity  IDA 70539 RGD 
Mmp9Ratmetallopeptidase activity enablesIEAUniProtKB:P14780 and ensembl:ENSP000003614051600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp9Ratmetallopeptidase activity enablesIEAUniProtKB-KW:KW-04821600115GO_REF:0000043UniProtGO_REF:0000043
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Imported Annotations - KEGG (archival)

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Mmp9Raturinary bladder cancer pathway  IEA 6907045 KEGGrno:05219

Imported Annotations - PID (archival)

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Mmp9Ratfibroblast growth factor signaling pathway  ISOMMP9 (Homo sapiens)6484113 PIDPID:200220
Mmp9Ratsyndecan signaling pathway  ISOMMP9 (Homo sapiens)6484113 PIDPID:200156
Mmp9Ratsyndecan signaling pathway  ISOMMP9 (Homo sapiens)6484113 PIDPID:200134
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Mmp9Ratdecreased circulating creatinine level inducesIMPcontrolled sodium chloride content diet597805897compared to wild type littermateRGD 
Mmp9Ratdecreased urine albumin level inducesIMPcontrolled sodium chloride content diet597805897compared to wild type littermateRGD 
Mmp9Ratsalt-sensitive hypertension amelioratesIMP 597805897 RGD 

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Reference Title
Reference Citation
1. Neutrophil adsorption by polymyxin B-immobilized fiber column for acute exacerbation in patients with interstitial pneumonia: a pilot study. Abe S, etal., Blood Purif. 2010;29(4):321-6. Epub 2010 Feb 24.
2. Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Afonso AA, etal., Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2506-12.
3. Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury. Albaiceta GM, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L535-43. Epub 2008 Jan 25.
4. Downregulation of remodelling enzymatic activity induced by an angiotensin-converting enzyme inhibitor (perindopril) reduces the degeneration of experimental abdominal aortic aneurysms in a rat model. Alsac JM, etal., Eur J Vasc Endovasc Surg. 2011 Apr;41(4):474-80. doi: 10.1016/j.ejvs.2010.12.007. Epub 2011 Jan 20.
5. Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification. Alvarez J, etal., J Bone Miner Res. 2005 Jun;20(6):1011-21. Epub 2005 Feb 7.
6. The role of AdipoR1 and AdipoR2 in liver fibrosis. Alzahrani B, etal., Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):700-708. doi: 10.1016/j.bbadis.2017.12.012. Epub 2017 Dec 10.
7. Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis. Andersen GN, etal., Respir Med. 2007 Oct;101(10):2199-206. Epub 2007 Jul 20.
8. Genetic variations in MMP9 and MMP13 contribute to tooth agenesis in a Brazilian population. Antunes LS, etal., J Oral Sci. 2013;55(4):281-6.
9. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
10. Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. Aoki T, etal., Stroke. 2007 Jan;38(1):162-9. Epub 2006 Nov 22.
11. Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC. Arnold S, etal., Exp Biol Med (Maywood). 2008 Jul;233(7):860-73. Epub 2008 Apr 29.
12. Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
13. Matrix metalloproteinase-9 genetic variation and primary angle closure glaucoma in a Caucasian population. Awadalla MS, etal., Mol Vis. 2011;17:1420-4. Epub 2011 May 27.
14. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
15. Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-¿B, MMP-9 and up-regulated claudin-5 expression. Bai X, etal., Neurochem Res. 2014 Aug;39(8):1405-15. doi: 10.1007/s11064-014-1326-y. Epub 2014 May 20.
16. Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats. Barichello T, etal., Exp Biol Med (Maywood). 2014 Feb;239(2):225-31. doi: 10.1177/1535370213508354. Epub 2014 Jan 13.
17. Angiostatin and matrix metalloprotease expression following ischemic acute renal failure. Basile DP, etal., Am J Physiol Renal Physiol 2004 May;286(5):F893-902. Epub 2004 Jan 6.
18. Effects of two conventional preoperative radiation schedules on anastomotic healing in the rat colon. Bedirli A, etal., Eur Surg Res. 2007;39(3):141-7. Epub 2007 Mar 2.
19. MMP9 polymorphisms and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study. Beeghly-Fadiel A, etal., Breast Cancer Res Treat. 2011 Apr;126(2):507-13. doi: 10.1007/s10549-010-1119-1. Epub 2010 Aug 20.
20. Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo. Beliveau A, etal., Genes Dev. 2010 Dec 15;24(24):2800-11. doi: 10.1101/gad.1990410.
1 to 20 of 409 rows
1 to 10 of 31 rows
PMID:2551898   PMID:7590350   PMID:8605986   PMID:9256427   PMID:9291580   PMID:9789069   PMID:11860503   PMID:12062105   PMID:12172377   PMID:12183632   PMID:12419962   PMID:12717622  
PMID:12832476   PMID:14523003   PMID:14575305   PMID:14643899   PMID:14663338   PMID:14707083   PMID:14732351   PMID:15051632   PMID:15111317   PMID:15146242   PMID:15211589   PMID:15240011  
PMID:15269222   PMID:15480897   PMID:15615723   PMID:15621209   PMID:15800063   PMID:15802562   PMID:15851690   PMID:15863497   PMID:15990452   PMID:16097048   PMID:16192646   PMID:16303771  
PMID:16478919   PMID:16481424   PMID:16488444   PMID:16721810   PMID:16738242   PMID:16762003   PMID:16877562   PMID:16919608   PMID:17053025   PMID:17116693   PMID:17143608   PMID:17188498  
PMID:17189680   PMID:17202418   PMID:17334234   PMID:17428795   PMID:17456343   PMID:17496904   PMID:17574586   PMID:17607299   PMID:17704059   PMID:17909100   PMID:17937912   PMID:17986262  
PMID:17987394   PMID:17996850   PMID:18000599   PMID:18031717   PMID:18052689   PMID:18073506   PMID:18077379   PMID:18247145   PMID:18264108   PMID:18292396   PMID:18320202   PMID:18352832  
PMID:18390195   PMID:18401426   PMID:18502312   PMID:18556655   PMID:18664349   PMID:18667463   PMID:18675881   PMID:18678246   PMID:18713734   PMID:18769934   PMID:18799129   PMID:18830828  
PMID:18935914   PMID:18940814   PMID:18974601   PMID:18976709   PMID:18993041   PMID:19022250   PMID:19037103   PMID:19052882   PMID:19085380   PMID:19085832   PMID:19132994   PMID:19148693  
PMID:19167969   PMID:19184368   PMID:19201691   PMID:19229995   PMID:19235898   PMID:19259351   PMID:19272421   PMID:19299917   PMID:19330523   PMID:19404732   PMID:19462901   PMID:19464272  
PMID:19478225   PMID:19497125   PMID:19524937   PMID:19537852   PMID:19551335   PMID:19570337   PMID:19607919   PMID:19685505   PMID:19703360   PMID:19734212   PMID:19838811   PMID:19847888  
1 to 10 of 31 rows



Mmp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83174,103,474 - 174,111,434 (+)NCBIGRCr8
mRatBN7.23153,684,158 - 153,692,118 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,683,858 - 153,692,120 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,492,813 - 157,500,796 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,991,783 - 165,999,766 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,735,564 - 163,743,543 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,413,410 - 161,421,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,413,298 - 161,421,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,578,904 - 167,605,890 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,985,473 - 155,993,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,891,508 - 155,899,467 (+)NCBI
Celera3152,289,466 - 152,297,426 (+)NCBICelera
Cytogenetic Map3q42NCBI
MMP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382046,008,908 - 46,016,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2046,008,908 - 46,016,561 (+)EnsemblGRCh38hg38GRCh38
GRCh372044,637,547 - 44,645,200 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,070,954 - 44,078,607 (+)NCBINCBI36Build 36hg18NCBI36
Build 342044,070,953 - 44,078,606NCBI
Celera2041,348,998 - 41,356,660 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2041,378,970 - 41,386,505 (+)NCBIHuRef
CHM1_12044,540,180 - 44,547,844 (+)NCBICHM1_1
T2T-CHM13v2.02047,744,921 - 47,752,589 (+)NCBIT2T-CHM13v2.0
Mmp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,782,246 - 164,797,770 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,782,700 - 164,797,770 (+)EnsemblGRCm39 Ensembl
GRCm382164,940,326 - 164,955,850 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,940,780 - 164,955,850 (+)EnsemblGRCm38mm10GRCm38
MGSCv372164,773,751 - 164,781,346 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,639,456 - 164,647,051 (+)NCBIMGSCv36mm8
Celera2170,885,579 - 170,893,176 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.27NCBI
Mmp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544511,295,448 - 11,303,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,295,500 - 11,303,322 (-)NCBIChiLan1.0ChiLan1.0
MMP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22151,748,843 - 51,757,462 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12051,741,951 - 51,749,613 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02042,346,305 - 42,354,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12043,432,389 - 43,440,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,432,389 - 43,440,129 (+)Ensemblpanpan1.1panPan2
MMP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12433,274,260 - 33,281,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2433,274,268 - 33,281,293 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,801,110 - 32,807,958 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,984,592 - 33,991,450 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,984,589 - 33,991,650 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12433,242,837 - 33,249,697 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02433,358,136 - 33,364,990 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,897,331 - 33,904,192 (+)NCBIUU_Cfam_GSD_1.0
Mmp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640191,584,597 - 191,592,230 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,037,639 - 7,045,793 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,038,240 - 7,045,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,179,671 - 48,186,788 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,179,690 - 48,186,782 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,819,971 - 53,827,064 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MMP9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1217,867,267 - 17,874,757 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl217,867,177 - 17,874,712 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605066,502,195 - 66,509,744 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247908,583,457 - 8,591,713 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247908,584,399 - 8,591,763 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Mmp9
19 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir125arno-miR-125a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir664-2rno-miR-664-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir132rno-miR-132-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:81
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000023965
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 39 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat

1 to 10 of 39 rows
D3Wox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23153,683,950 - 153,684,056 (+)MAPPERmRatBN7.2
Rnor_6.03161,413,203 - 161,413,308NCBIRnor6.0
Rnor_5.03167,597,610 - 167,597,715UniSTSRnor5.0
RGSC_v3.43155,985,266 - 155,985,371UniSTSRGSC3.4
Celera3152,289,259 - 152,289,364UniSTS
Cytogenetic Map3q42UniSTS
PMC162218P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23153,691,448 - 153,692,111 (+)MAPPERmRatBN7.2
Rnor_6.03161,420,804 - 161,421,466NCBIRnor6.0
Rnor_5.03167,605,211 - 167,605,873UniSTSRnor5.0
RGSC_v3.43155,992,764 - 155,993,426UniSTSRGSC3.4
Celera3152,296,757 - 152,297,419UniSTS
Cytogenetic Map3q42UniSTS
D17Mit102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23153,683,940 - 153,684,099 (+)MAPPERmRatBN7.2
Rnor_6.03161,413,193 - 161,413,351NCBIRnor6.0
Rnor_5.03167,597,600 - 167,597,758UniSTSRnor5.0
RGSC_v3.43155,985,256 - 155,985,414UniSTSRGSC3.4
Celera3152,289,249 - 152,289,407UniSTS
Cytogenetic Map3q42UniSTS
D2Dcr116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23153,683,938 - 153,684,073 (+)MAPPERmRatBN7.2
Rnor_6.03161,413,191 - 161,413,325NCBIRnor6.0
Rnor_5.03167,597,598 - 167,597,732UniSTSRnor5.0
RGSC_v3.43155,985,254 - 155,985,388UniSTSRGSC3.4
Celera3152,289,247 - 152,289,381UniSTS
Cytogenetic Map3q42UniSTS
Mmp9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23153,685,293 - 153,685,355 (+)MAPPERmRatBN7.2
Rnor_6.03161,414,546 - 161,414,607NCBIRnor6.0
Rnor_5.03167,598,953 - 167,599,014UniSTSRnor5.0
RGSC_v3.43155,986,609 - 155,986,670UniSTSRGSC3.4
Celera3152,290,602 - 152,290,663UniSTS
Cytogenetic Map3q42UniSTS


This gene Mmp9 is modified in the following models/strains:
SS-Mmp9em4Mcwi     SS-Mmp9em6Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 39 109 91 90 59 25 59 6 205 84 89 45 59 31



Ensembl Acc Id: ENSRNOT00000023965   ⟹   ENSRNOP00000023965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,683,858 - 153,692,120 (+)Ensembl
Rnor_6.0 Ensembl3161,413,298 - 161,421,520 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088776   ⟹   ENSRNOP00000069060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,683,858 - 153,692,120 (+)Ensembl
Rnor_6.0 Ensembl3161,413,410 - 161,420,812 (+)Ensembl
RefSeq Acc Id: NM_031055   ⟹   NP_112317
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83174,103,474 - 174,111,434 (+)NCBI
mRatBN7.23153,684,158 - 153,692,118 (+)NCBI
Rnor_6.03161,413,410 - 161,421,473 (+)NCBI
Rnor_5.03167,578,904 - 167,605,890 (+)NCBI
RGSC_v3.43155,985,473 - 155,993,433 (+)RGD
Celera3152,289,466 - 152,297,426 (+)RGD
Sequence:
Protein RefSeqs NP_112317 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA90911 (Get FASTA)   NCBI Sequence Viewer  
  AAB01721 (Get FASTA)   NCBI Sequence Viewer  
  CAD27893 (Get FASTA)   NCBI Sequence Viewer  
  EDL96479 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023965
GenBank Protein P50282 (Get FASTA)   NCBI Sequence Viewer  
  QST77665 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112317   ⟸   NM_031055
- Peptide Label: precursor
- UniProtKB: P50282 (UniProtKB/Swiss-Prot),   D3ZYK8 (UniProtKB/TrEMBL),   A6JXD0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023965   ⟸   ENSRNOT00000023965
Ensembl Acc Id: ENSRNOP00000069060   ⟸   ENSRNOT00000088776
Fibronectin type-II

Name Modeler Protein Id AA Range Protein Structure
AF-P50282-F1-model_v2 AlphaFold P50282 1-708 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692672
Promoter ID:EPDNEW_R3196
Type:single initiation site
Name:Mmp9_1
Description:matrix metallopeptidase 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03161,413,391 - 161,413,451EPDNEW


1 to 40 of 54 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-46817 BioCyc
Ensembl Genes ENSRNOG00000017539 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023965 ENTREZGENE
Gene3D-CATH 2.10.10.10 UniProtKB/Swiss-Prot
  2.110.10.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
InterPro FN_type2_dom UniProtKB/Swiss-Prot
  FN_type2_sf UniProtKB/Swiss-Prot
  Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  Hemopexin_CS UniProtKB/Swiss-Prot
  IPR006970 UniProtKB/Swiss-Prot
  Kringle-like UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
  PGBD-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:81687 UniProtKB/Swiss-Prot
NCBI Gene 81687 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
  PTHR10201:SF30 UniProtKB/Swiss-Prot
Pfam fn2 UniProtKB/Swiss-Prot
  Hemopexin UniProtKB/Swiss-Prot
  Peptidase_M10 UniProtKB/Swiss-Prot
  PF04886 UniProtKB/Swiss-Prot
PharmGKB MMP9 RGD
PhenoGen Mmp9 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS FNTYPEII UniProtKB/Swiss-Prot
  MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot
  FN2_1 UniProtKB/Swiss-Prot
  FN2_2 UniProtKB/Swiss-Prot
  HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
1 to 40 of 54 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Mmp9  matrix metallopeptidase 9    matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)  Name updated 1299863 APPROVED
2002-08-07 Mmp9  matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_disease increased expression is observed in rheumatoid arthiritis and periodontal disease, highly expressed in patients with ulcerative colitis 628551
gene_expression expressed in the colonic wall tissue of colotic and normal rats 628551
gene_function zinc and calcium-dependent endopeptidase, secreted as a zymogens 628551
gene_process involved in tissue destruction and remodelling 628551
gene_process degrades type IV collagen and gelatine 628551
gene_regulation expression induced by TNFalpha in testis 727488
gene_regulation oral administration of dextran sulphate sodium (DSS) induced upregulatin of pro-Mmp-9 activity, activity dependent on the extent of inflammed colonic tissue 628551
gene_regulation after exposure of cultured cardiac fibroblasts to IL-1 beta, expression was enhanced in cells of both SHR and WKY strains to equivalent levels as measured by both semiquantitative PCR and zymographic studies 1358958