Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Mmp9 (matrix metallopeptidase 9) Rattus norvegicus
Analyze
Symbol: Mmp9
Name: matrix metallopeptidase 9
Description: Exhibits fibronectin binding activity and metallopeptidase activity. Involved in several processes, including aging; cellular response to cell-matrix adhesion; and cellular response to cytokine stimulus. Localizes to the extracellular space and protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); kidney disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); autoimmune hypersensitivity disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9); PARTICIPATES IN fibroblast growth factor signaling pathway; syndecan signaling pathway; urinary bladder cancer pathway; INTERACTS WITH (+)-Tetrandrine; (R)-carnitine; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 92 kDa gelatinase; 92 kDa type IV collagenase; 92-kDa type IV collagenase; gelatinase B; GELB; matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase); matrix metalloproteinase-9; MMP-9
Orthologs:
Homo sapiens (human) : MMP9 (matrix metallopeptidase 9)  HGNC  Alliance
Mus musculus (house mouse) : Mmp9 (matrix metallopeptidase 9)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mmp9 (matrix metallopeptidase 9)
Pan paniscus (bonobo/pygmy chimpanzee) : MMP9 (matrix metallopeptidase 9)
Canis lupus familiaris (dog) : MMP9 (matrix metallopeptidase 9)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp9 (matrix metallopeptidase 9)
Sus scrofa (pig) : MMP9 (matrix metallopeptidase 9)
more info ...
Allele / Splice: Mmp9em6Mcwi   Mmp9em4Mcwi  
Genetic Models: SS-Mmp9em4Mcwi SS-Mmp9em6Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03161,413,410 - 161,421,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03167,578,904 - 167,605,890 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,985,473 - 155,993,433 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13155,891,508 - 155,899,467 (+)NCBI
Celera3152,289,466 - 152,297,426 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations