RGD Reference Report - Stromal remodelling is required for progressive involution of the rat ventral prostate after castration: Identification of a matrix metalloproteinase-dependent apoptotic wave. - Rat Genome Database

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Stromal remodelling is required for progressive involution of the rat ventral prostate after castration: Identification of a matrix metalloproteinase-dependent apoptotic wave.

Authors: Bruni-Cardoso, A  Augusto, TM  Pravatta, H  Damas-Souza, DM  Carvalho, HF 
Citation: Bruni-Cardoso A, etal., Int J Androl. 2009 Nov 10.
RGD ID: 2325820
Pubmed: PMID:19906188   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2605.2009.01004.x   (Journal Full-text)

Prostate epithelial-cell apoptosis occurs in response to androgen deprivation. We have hypothesized that continued regression would require stromal changes. Studying apoptosis kinetics up to the 14th day after castration, we identified successive waves of apoptosis, with a prominent peak on day 11. This peak was associated with caspase-3 activity, nuclear translocation of apoptosis-inducing factor and clusterin expression. The apoptosis peak on day 11 was preceded by increased MMP-2 and MMP-7 activation, and MMP-9 expression on days 9 and 10. Treatment with the matrix metalloproteinases inhibitors doxycyclin, hydrocortisone, or GM6001 caused significant reduction in the apoptosis rate on day 11. The present data demonstrate that prostatic epithelial-cell deletion at the 11th day after castration was induced by focal degradation of the extracellular matrix associated with stromal remodelling.

Objects referenced in this article
Gene Mmp2 matrix metallopeptidase 2 Rattus norvegicus
Gene Mmp9 matrix metallopeptidase 9 Rattus norvegicus

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