MMP9 (matrix metallopeptidase 9) - Rat Genome Database
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Gene: MMP9 (matrix metallopeptidase 9) Pan paniscus
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Symbol: MMP9
Name: matrix metallopeptidase 9
RGD ID: 12008550
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); fibronectin binding (ortholog); identical protein binding (ortholog); INVOLVED IN aging (ortholog); cellular response to cadmium ion (ortholog); cellular response to cell-matrix adhesion (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; syndecan signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Coronary Syndrome (ortholog); Acute Lung Injury (ortholog); FOUND IN extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase-9
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12043,432,389 - 43,440,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,432,389 - 43,440,129 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02042,346,305 - 42,354,018 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
Acute Lung Injury  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
alcohol use disorder  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Angina, Stable  (ISO)
angle-closure glaucoma  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
anodontia  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aortic aneurysm  (ISO)
aortic disease  (ISO)
Aortic Rupture  (ISO)
Arterial Injury  (ISO)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (ISO)
arteriovenous malformation  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
bacterial meningitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Bone Neoplasms  (ISO)
brain edema  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
bronchiolitis obliterans  (ISO)
Bronchopulmonary Dysplasia  (ISO)
bullous pemphigoid  (ISO)
Burns  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
childhood absence epilepsy  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Choroidal Neovascularization  (ISO)
chronic inflammatory demyelinating polyradiculoneuropathy  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Periodontitis  (ISO)
chronic ulcer of skin  (ISO)
Cicatrix  (ISO)
cognitive disorder  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
conjunctivochalasis  (ISO)
coronary artery disease  (ISO)
crescentic glomerulonephritis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Down syndrome  (ISO)
Duchenne muscular dystrophy  (ISO)
ductal carcinoma in situ  (ISO)
Embolism  (ISO)
Emphysema  (ISO)
endometrial carcinoma  (ISO)
endometriosis  (ISO)
epidermolysis bullosa simplex  (ISO)
epilepsy  (ISO)
esophagus adenocarcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
facial paralysis  (ISO)
familial hyperlipidemia  (ISO)
Febrile Seizures  (ISO)
Fibrosis  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
focal epilepsy  (ISO)
focal segmental glomerulosclerosis  (ISO)
fragile X syndrome  (ISO)
gastric ulcer  (ISO)
glaucoma  (ISO)
glioblastoma  (ISO)
glomerulosclerosis  (ISO)
Gouty Arthritis  (ISO)
heart valve disease  (ISO)
hepatic veno-occlusive disease  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
Hyperoxia  (ISO)
Hyperoxic Lung Injury  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
ileus  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
intracranial aneurysm  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
Laryngeal Neoplasms  (ISO)
Lead Poisoning  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lupus nephritis  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
malignant astrocytoma  (ISO)
Malignant Pleural Effusions  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Mandibuloacral Dysplasia with Type A Lipodystrophy  (ISO)
Marfan syndrome  (ISO)
membranous glomerulonephritis  (ISO)
meningococcal meningitis  (ISO)
Metaphyseal Anadysplasia  (ISO)
Metaphyseal Anadysplasia 2  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
Mycoplasma Infections  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
neuromyelitis optica  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
ocular hypertension  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
paracoccidioidomycosis  (ISO)
Parkinsonism  (ISO)
Pathologic Constriction  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
pre-eclampsia  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
primary progressive multiple sclerosis  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
pterygium  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
pyoderma gangrenosum  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respirovirus Infections  (ISO)
retinal disease  (ISO)
retinal ischemia  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (ISO)
rosacea  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
Sjogren's syndrome  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
stomach carcinoma  (ISO)
Stroke  (ISO)
Sturge-Weber syndrome  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sunburn  (ISO)
Sweet syndrome  (ISO)
systemic scleroderma  (ISO)
Tachycardia, Atrioventricular Nodal Reentry  (ISO)
Takayasu's arteritis  (ISO)
temporal arteritis  (ISO)
temporal lobe epilepsy  (ISO)
thoracic aortic aneurysm  (ISO)
thrombosis  (ISO)
transient cerebral ischemia  (ISO)
tuberous sclerosis  (ISO)
tularemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
varicose veins  (ISO)
Venous Thrombosis  (ISO)
ventricular septal defect  (ISO)
viral encephalitis  (ISO)
visual epilepsy  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cell-matrix adhesion  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to iron(III) ion  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to UV-A  (ISO)
collagen catabolic process  (ISO)
embryo implantation  (ISO)
endodermal cell differentiation  (ISO)
extracellular matrix organization  (ISO)
heart development  (ISO)
kidney development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cation channel activity  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
negative regulation of epithelial cell differentiation involved in kidney development  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
ossification  (ISO)
parturition  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of keratinocyte migration  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
proteolysis  (ISO)
response to amyloid-beta  (ISO)
response to drug  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to high light intensity  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to oxidative stress  (ISO)
response to radiation  (ISO)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to vitamin A  (ISO)
skeletal system development  (ISO)
tissue remodeling  (ISO)
transformation of host cell by virus  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
MMP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12043,432,389 - 43,440,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,432,389 - 43,440,129 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02042,346,305 - 42,354,018 (+)NCBIMhudiblu_PPA_v0panPan3
MMP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2046,008,908 - 46,016,561 (+)EnsemblGRCh38hg38GRCh38
GRCh382046,008,908 - 46,016,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372044,637,547 - 44,645,200 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,070,954 - 44,078,607 (+)NCBINCBI36hg18NCBI36
Build 342044,070,953 - 44,078,606NCBI
Celera2041,348,998 - 41,356,660 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2041,378,970 - 41,386,505 (+)NCBIHuRef
CHM1_12044,540,180 - 44,547,844 (+)NCBICHM1_1
Mmp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,782,246 - 164,797,770 (+)NCBIGRCm39mm39
GRCm382164,940,326 - 164,955,850 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,940,780 - 164,955,850 (+)EnsemblGRCm38mm10GRCm38
MGSCv372164,773,751 - 164,781,346 (+)NCBIGRCm37mm9NCBIm37
MGSCv362164,639,456 - 164,647,051 (+)NCBImm8
Celera2170,885,579 - 170,893,176 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.27NCBI
Mmp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23153,684,158 - 153,692,118 (+)NCBI
Rnor_6.0 Ensembl3161,413,298 - 161,421,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03161,413,410 - 161,421,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03167,578,904 - 167,605,890 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,985,473 - 155,993,433 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13155,891,508 - 155,899,467 (+)NCBI
Celera3152,289,466 - 152,297,426 (+)NCBICelera
Cytogenetic Map3q42NCBI
Mmp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544511,295,448 - 11,303,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,295,500 - 11,303,322 (-)NCBIChiLan1.0ChiLan1.0
MMP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2433,274,268 - 33,281,293 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12433,274,260 - 33,281,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mmp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365147,038,240 - 7,045,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,175,056 - 48,188,264 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,179,690 - 48,186,782 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,819,971 - 53,827,064 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MMP9
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1217,867,267 - 17,874,757 (-)NCBI
ChlSab1.1 Ensembl217,867,177 - 17,874,712 (-)Ensembl
Mmp9
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247908,584,399 - 8,591,763 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008951382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000054070   ⟹   ENSPPAP00000031206
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2043,432,389 - 43,440,129 (+)Ensembl
RefSeq Acc Id: XM_008951382   ⟹   XP_008949630
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.12043,432,389 - 43,440,129 (+)NCBI
Mhudiblu_PPA_v02042,346,305 - 42,354,018 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008949630 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008949630   ⟸   XM_008951382
- Sequence:
RefSeq Acc Id: ENSPPAP00000031206   ⟸   ENSPPAT00000054070
Protein Domains
Fibronectin type-II


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038539 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000031206 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000054070 UniProtKB/TrEMBL
Gene3D-CATH 1.10.101.10 UniProtKB/TrEMBL
  2.10.10.10 UniProtKB/TrEMBL
  2.110.10.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro FN_type2_dom UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/TrEMBL
  Hemopexin-like_dom UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  M10A_MMP UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  MMP9 UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/TrEMBL
  Pept_M10A UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/TrEMBL
  PGBDSf UniProtKB/TrEMBL
NCBI Gene MMP9 ENTREZGENE
PANTHER PTHR10201:SF30 UniProtKB/TrEMBL
Pfam fn2 UniProtKB/TrEMBL
  Hemopexin UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/TrEMBL
PIRSF Peptidase_M10A_matrix UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/TrEMBL
  FN2_1 UniProtKB/TrEMBL
  FN2_2 UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/TrEMBL
SMART FN2 UniProtKB/TrEMBL
  SM00120 UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP SSF47090 UniProtKB/TrEMBL
  SSF50923 UniProtKB/TrEMBL
  SSF57440 UniProtKB/TrEMBL
UniProt A0A2R9BNH8_PANPA UniProtKB/TrEMBL