RGD Reference Report - Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population. - Rat Genome Database

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Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population.

Authors: Lee, SY  Kim, MJ  Kang, HG  Yoo, SS  Choi, YY  Lee, WK  Cha, SI  Kim, CH  Jung, TH  Park, JY 
Citation: Lee SY, etal., Respiration. 2010;80(2):133-8. Epub 2010 Feb 16.
RGD ID: 5129494
Pubmed: PMID:20160424   (View Abstract at PubMed)
DOI: DOI:10.1159/000284926   (Journal Full-text)

BACKGROUND: Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase (MMP) genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent. OBJECTIVES: To investigate the association of 3 polymorphisms of MMP genes (MMP-1 -1607G-->GG, MMP-9 -1562C-->T and MMP-12 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population. METHODS: The genotypes of the 3 polymorphisms were determined in 301 patients with COPD and 333 healthy controls. RESULTS: Of the 3 polymorphisms studied, only the distribution of the MMP-9 -1562C-->T genotypes was significantly different between the cases and controls (p = 0.01), with the frequency of the variant T allele being significantly lower in the cases than in the controls (10.4 vs. 15.7%; p = 0.006). Individuals with at least 1 variant T allele were at a significantly decreased risk of COPD when compared with those with homozygous wild-type alleles (adjusted odds ratio = 0.69; 95% CI = 0.45-0.98; p = 0.04). CONCLUSIONS: These findings suggest that the MMP-9 -1562C-->T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chronic obstructive pulmonary disease susceptibilityIAGP 5129494DNA:polymorphism: :-1562C-->T (human)RGD 
chronic obstructive pulmonary disease susceptibilityISOMMP9 (Homo sapiens)5129494; 5129494DNA:polymorphism: :-1562C-->T (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP9  (matrix metallopeptidase 9)


Additional Information