RGD Reference Report - [Expression of matrix metalloproteinase-2,9 in cholesteatoma from different positions]. - Rat Genome Database

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[Expression of matrix metalloproteinase-2,9 in cholesteatoma from different positions].

Authors: Wang, J  Yu, LS 
Citation: Wang J and Yu LS, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;44(1):44-8.
RGD ID: 8657059
Pubmed: PMID:19484988   (View Abstract at PubMed)

OBJECTIVE: To study various expressions and roles of MMP-2,9 in cholesteatoma from different positions. METHODS: MMP-2 and MMP-9 were detected with immunohistochemical methods using antibody in 18 attic cholesteatoma, 16 tympanic sinus cholesteatoma, 10 auditory meatal skin in cholesteatoma (CAMS) and 10 normal auditory meatal skin (NAMS). RESULTS: The stain in cholesteatoma was stronger than that in CAMS and NAMS (P < 0.05). Expression of MMP-2,9 was seen in all layers of the epithelium in cholesteatoma and the stain was strongest in basement membrane. Expression of MMP-2,9 in tympanic sinus cholesteatoma was stronger than that in attic cholesteatoma. The expression of MMP-2 and MMP-9 were closely related in cholesteatoma (r = 0.974, P < 0.01). The expression of MMP-2,9 in cholesteatoma was related with destruction of ossicular chain (r = 0.789, P < 0.01; r = 0.803, P < 0.01). CONCLUSIONS: MMPs play a very important role in bone destruction in cholesteatoma. The destruction of bone in tympanic sinus cholesteatoma is more severe than that in attic cholesteatoma. Tympanic sinus cholesteatomas are more invasive in destruction surround bone matrix.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MMP2Humancholesteatoma  IEP  RGD 
MMP9Humancholesteatoma  IEP  RGD 
Mmp2Ratcholesteatoma  ISOMMP2 (Homo sapiens) RGD 
Mmp2Mousecholesteatoma  ISOMMP2 (Homo sapiens) RGD 
Mmp9Ratcholesteatoma  ISOMMP9 (Homo sapiens) RGD 
Mmp9Mousecholesteatoma  ISOMMP9 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp2  (matrix metallopeptidase 2)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp2  (matrix metallopeptidase 2)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP2  (matrix metallopeptidase 2)
MMP9  (matrix metallopeptidase 9)


Additional Information