MMP2 (matrix metallopeptidase 2) - Rat Genome Database

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Gene: MMP2 (matrix metallopeptidase 2) Homo sapiens
Symbol: MMP2
Name: matrix metallopeptidase 2
RGD ID: 730821
Description: Enables metallopeptidase activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to UV-A; endodermal cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Biomarker of several diseases, including artery disease (multiple); carcinoma (multiple); cardiomyopathy (multiple); cholesteatoma (multiple); and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 72 kDa gelatinase; 72 kDa type IV collagenase; CLG4; CLG4A; collagenase type IV-A; gelatinase A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; MMP-2; MMP-II; MONA; neutrophil gelatinase; TBE-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1655,389,700 - 55,506,691 (+)EnsemblGRCh38hg38GRCh38
GRCh381655,478,830 - 55,506,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371655,512,742 - 55,540,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,070,589 - 54,098,104 (+)NCBINCBI36hg18NCBI36
Build 341654,070,603 - 54,097,652NCBI
Celera1640,027,315 - 40,054,814 (+)NCBI
Cytogenetic Map16q12.2NCBI
HuRef1641,400,533 - 41,427,983 (+)NCBIHuRef
CHM1_11656,920,344 - 56,947,845 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IAGP,IEP,ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute Otitis Media  (ISO)
adrenoleukodystrophy  (IEP)
alcohol use disorder  (ISO)
alcoholic liver cirrhosis  (EXP)
Alzheimer's disease  (IEP)
amyotrophic lateral sclerosis  (IEP,ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (IEP)
aortic disease  (EXP)
Aortic Rupture  (EXP)
aortic valve disease 2  (IEP)
arteriosclerosis  (IDA)
Arteriovenous Fistula  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (IEP)
Behcet's disease  (IEP)
bone disease  (EXP)
Bone Neoplasms  (EXP)
brain ischemia  (ISO)
Breast Neoplasms  (EXP,IAGP,IEP)
calcinosis  (EXP)
Cardiomegaly  (ISO)
cardiomyopathy  (IEP)
carotid artery disease  (IDA)
Carotid Artery Injuries  (ISO)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (EXP)
cerebral infarction  (EXP)
cervix uteri carcinoma in situ  (IEP)
Chemical and Drug Induced Liver Injury  (EXP)
Chlamydophila Infections  (IDA)
cholangiocarcinoma  (IEP,ISO)
cholestasis  (ISO)
cholesteatoma  (IEP)
cholesteatoma of middle ear  (IEP)
Choroidal Neovascularization  (ISO)
Chronic Periodontitis  (IEP,ISO)
Colorectal Neoplasms  (EXP,ISO)
congestive heart failure  (IEP,ISO)
conjunctivitis  (ISO)
Craniofacial Abnormalities  (EXP)
cutaneous leishmaniasis  (EXP,IEP)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (EXP)
diabetic retinopathy  (IDA,IEP)
dilated cardiomyopathy  (IEP,ISO)
Disease Progression  (EXP)
ductal carcinoma in situ  (IEP)
Embolism  (IDA)
end stage renal disease  (IEP)
Endometrial Neoplasms  (IEP)
endometriosis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (EXP)
Experimental Liver Cirrhosis  (EXP)
Experimental Liver Neoplasms  (EXP,ISO)
extrahepatic cholestasis  (EXP)
Fetal Growth Retardation  (EXP,IAGP)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gallbladder Neoplasms  (IEP)
gastric ulcer  (ISO)
glioblastoma  (EXP,IEP)
Gouty Arthritis  (IEP)
Graft Occlusion, Vascular  (ISO)
head and neck squamous cell carcinoma  (IAGP)
heart valve disease  (IEP)
hemangioma  (IEP)
hepatocellular carcinoma  (EXP)
Herpes Simplex Encephalitis  (ISO)
high grade glioma  (ISO)
Hydatidiform Mole  (IEP)
Hyperoxia  (ISO)
Hyperplasia  (ISO)
hypertension  (EXP,IDA,ISO)
hypertrophic cardiomyopathy  (IEP)
immunoglobulin light chain amyloidosis  (IEP)
Inflammation  (EXP)
intracranial aneurysm  (IAGP,IEP,ISO)
ischemia  (ISO)
keratoconus  (IEP)
laryngeal squamous cell carcinoma  (IEP)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (IEP)
liver cirrhosis  (EXP,ISO)
lung non-small cell carcinoma  (IEP)
lupus nephritis  (EXP)
Lymphatic Metastasis  (IEP)
macular degeneration  (IAGP)
Malignant Pleural Effusions  (IEP)
Mammary Neoplasms, Experimental  (EXP,ISO)
Mandibular Diseases  (EXP)
Marfan syndrome  (EXP,IEP,ISO)
Maxillary Diseases  (EXP)
Metabolic Bone Diseases  (EXP)
Multiple Organ Failure  (ISO)
myocardial infarction  (EXP,ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
myopia  (IAGP)
Nasal Polyps  (IEP)
Nasopharyngeal Neoplasms  (EXP)
Neointima  (EXP,ISO)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (EXP,IEP,ISO)
Nephrogenic Fibrosing Dermopathy  (IEP)
Nose Neoplasms  (EXP)
ocular hypertension  (ISO)
Oral Lichen Planus  (IEP)
oral submucous fibrosis  (EXP)
osteoarthritis  (IEP)
Osteolysis  (IAGP)
Osteolysis Hereditary Multicentric  (EXP,IAGP)
osteonecrosis  (EXP)
osteosarcoma  (EXP)
Ovarian Neoplasms  (IAGP)
pancreatic cancer  (EXP,IEP)
pancreatic ductal carcinoma  (IEP)
papilloma  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (IEP)
periodontitis  (ISO)
Pneumococcal Meningitis  (ISO)
polycystic ovary syndrome  (ISO)
Polypoidal Choroidal Vasculopathy  (IEP)
pre-eclampsia  (IEP)
primary biliary cholangitis  (ISO)
prostate cancer  (IEP)
pseudoxanthoma elasticum  (IAGP)
pterygium  (IDA)
pulmonary embolism  (ISO)
pulmonary emphysema  (EXP,ISO)
pulmonary fibrosis  (EXP)
Puromycin Aminonucleoside Nephrosis  (ISO)
pyoderma gangrenosum  (IEP)
renal cell carcinoma  (IEP)
renal hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
retinal vein occlusion  (IAGP)
rheumatoid arthritis  (EXP)
Right Ventricular Hypertrophy  (ISO)
Sepsis  (ISO)
skin melanoma  (IEP)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (IEP)
stomach carcinoma  (ISO)
Stroke  (IEP,ISO)
Sturge-Weber syndrome  (IEP)
Subarachnoid Hemorrhage  (ISO)
Sweet syndrome  (IEP)
temporal arteritis  (IDA)
Testicular Germ Cell Tumor  (EXP)
thoracic aortic aneurysm  (EXP,ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (IEP)
tropical spastic paraparesis  (IEP)
type 2 diabetes mellitus  (IEP)
Ulcer  (IEP)
urinary bladder cancer  (EXP,IEP)
Uterine Cervical Neoplasms  (IEP)
vascular dementia  (ISO)
Venous Thrombosis  (ISO)
Weight Gain  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dihydroxybenzoic acid  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (EXP)
3-hydroxypicolinic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-Nerolidylcatechol  (EXP)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7-ketocholesterol  (EXP,ISO)
9,10-phenanthroquinone  (EXP)
acetaldehyde  (EXP,ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (EXP)
ageladine A  (EXP)
AICA ribonucleotide  (EXP)
alachlor  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (ISO)
alpha-mangostin  (EXP)
alpha-naphthoflavone  (ISO)
aluminium atom  (ISO)
aluminium oxide  (EXP)
aluminium(0)  (ISO)
AM-251  (EXP)
ambroxol  (ISO)
amitrole  (EXP)
ammonium chloride  (ISO)
anagliptin  (EXP)
andrographolide  (ISO)
anethole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
apigenin  (EXP)
arachidonic acid  (EXP)
arecoline  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
astemizole  (ISO)
atorvastatin calcium  (ISO)
azoxystrobin  (EXP)
baicalein  (EXP,ISO)
beclomethasone  (EXP)
benazepril  (ISO)
benomyl  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (EXP,ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
betulinic acid  (EXP,ISO)
bicalutamide  (EXP)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
brazilein  (EXP)
brucine  (EXP,ISO)
bucladesine  (EXP)
bufalin  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
calcitriol  (EXP)
calcium dichloride  (EXP,ISO)
cantharidin  (EXP)
capecitabine  (EXP)
capsaicin  (EXP,ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carfilzomib  (ISO)
carvedilol  (EXP,ISO)
casticin  (EXP,ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
CGS-21680  (EXP)
Chebulagic acid  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chlordecone  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
coenzyme Q10  (ISO)
columbamine  (EXP)
conjugated linoleic acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
coumarin  (EXP)
crocidolite asbestos  (EXP,ISO)
cucurbitacin B  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
Deguelin  (EXP)
demethoxycurcumin  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
diethyl maleate  (ISO)
dihydroartemisinin  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (EXP)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (ISO)
disodium selenite  (ISO)
disulfiram  (EXP)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (EXP,ISO)
EC (phospholipase A2) inhibitor  (EXP)
EC (peptidyl-dipeptidase A) inhibitor  (EXP)
edaravone  (ISO)
elemental selenium  (EXP)
ellagic acid  (EXP)
embelin  (EXP)
emetine  (EXP)
entinostat  (EXP,ISO)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
eugenol  (EXP,ISO)
excitatory amino acid agonist  (ISO)
farrerol  (ISO)
fenofibrate  (EXP)
ferric oxide  (ISO)
ferrichrome  (EXP)
Fexofenadine hydrochloride  (EXP)
fisetin  (EXP,ISO)
flavonol  (EXP)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
fosinopril  (ISO)
fructose  (ISO)
fucoidan  (EXP)
fulvestrant  (EXP)
furan  (ISO)
galactose  (ISO)
gallic acid  (EXP,ISO)
Genipin  (EXP)
Geniposide pentaacetate  (ISO)
genistein  (EXP,ISO)
Geraniin  (EXP)
gingerol  (EXP)
Ginkgoic acid  (EXP)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
Gly-His-Lys  (ISO)
glycidol  (ISO)
glycyrrhizinic acid  (ISO)
graphene oxide  (ISO)
graphite  (ISO)
heparin  (EXP)
Hexachloro-1,3-butadiene  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP)
hinokiflavone  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
hydroxamic acid  (EXP)
ibuprofen  (ISO)
ICI 118551  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
indinavir  (ISO)
indometacin  (EXP,ISO)
iron trichloride  (EXP)
isoliquiritigenin  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
juglone  (EXP)
kaempferol  (EXP)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (EXP)
L-cysteine  (EXP)
L-methionine  (ISO)
lasofoxifene  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
leuprolide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithocholic acid  (EXP,ISO)
losartan  (ISO)
lovastatin  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mannuronic acid  (ISO)
marimastat  (EXP)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (EXP,ISO)
melittin  (EXP)
menadione  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
Methanandamide  (EXP)
methotrexate  (ISO)
methyl caffeate  (EXP)
methylcobalamin  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
metoprolol  (EXP,ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
minocycline  (EXP,ISO)
miquelianin  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
morin  (ISO)
morusin  (EXP)
N-acetyl-1,4-benzoquinone imine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
naringin  (EXP)
Neferine  (EXP)
nerolidol  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitroglycerin  (EXP)
Nonylphenol  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP)
oleic acid  (EXP)
omeprazole  (ISO)
oridonin  (EXP)
oroxylin A  (EXP)
osthole  (EXP)
ouabain  (EXP)
oxaliplatin  (ISO)
oxytocin  (ISO)
ozone  (ISO)
p-cresol  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
pentanal  (EXP)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (ISO)
phenanthrolines  (ISO)
phenethyl caffeate  (ISO)
phenylarsine oxide  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidic acid  (EXP)
phosphatidylcholine  (ISO)
picoxystrobin  (EXP)
picropodophyllotoxin  (EXP)
piperine  (EXP)
pipoxolan  (EXP)
pirfenidone  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
potassium bromate  (ISO)
potassium chromate  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
prazosin  (ISO)
prednisolone  (ISO)
prinomastat  (EXP)
probucol  (EXP)
progesterone  (EXP)
propanal  (EXP)
propranolol  (EXP)
prostaglandin E2  (EXP)
prostaglandin F2alpha  (EXP)
protein kinase inhibitor  (EXP)
protoporphyrin  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
radon atom  (EXP)
radon(0)  (EXP)
raloxifene  (ISO)
ramipril  (ISO)
razoxane  (ISO)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rhodotorulic acid  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rutin  (EXP,ISO)
S-adenosyl-L-homocysteine  (ISO)
S-allylcysteine  (ISO)
Salinomycin  (EXP)
Salvianolic acid A  (EXP)
sanguinarine  (EXP)
saxagliptin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
selenium atom  (EXP)
selumetinib  (EXP)
serpentine asbestos  (EXP,ISO)
silibinin  (EXP,ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
solasodine  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (EXP)
squalene  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP)
sumatriptan  (ISO)
sunitinib  (EXP)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP)
taurocholic acid  (EXP)
tebuconazole  (EXP)
telmisartan  (ISO)
temozolomide  (EXP)
terbinafine  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP)
tetrahydrocurcumin  (ISO)
tetraphene  (EXP)
thalidomide  (EXP)
thioacetamide  (ISO)
thymoquinone  (EXP)
titanium atom  (EXP)
titanium dioxide  (ISO)
tolfenamic acid  (EXP)
tomatidine  (EXP)
Tomentosin  (EXP)
topotecan  (ISO)
trans-anethole  (EXP)
trans-cinnamic acid  (ISO)
trans-rhaponticin  (ISO)
tributylstannane  (ISO)
trichostatin A  (EXP)
triciribine  (EXP)
triclosan  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropisetron  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP,ISO)
Ursonic acid  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (EXP)
withaferin A  (EXP)
wogonin  (EXP)
wortmannin  (EXP)
Y-27632  (EXP)
zafirlukast  (EXP)
zearalenone  (EXP)
zerumbone  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis  (IEA,ISO)
blood vessel maturation  (IEA,ISO)
bone trabecula formation  (IEA,ISO)
cell migration  (ISO)
cellular protein metabolic process  (TAS)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to reactive oxygen species  (IEA,ISO)
cellular response to UV-A  (IDA)
collagen catabolic process  (IBA,ISO,TAS)
embryo implantation  (IEA,ISO)
endodermal cell differentiation  (IEP)
ephrin receptor signaling pathway  (TAS)
extracellular matrix disassembly  (TAS)
extracellular matrix organization  (IBA)
face morphogenesis  (IEA,ISO)
female pregnancy  (ISO)
heart development  (ISO)
intramembranous ossification  (IEA,ISO)
luteinization  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of vasoconstriction  (ISO)
ovarian follicle development  (ISO)
ovulation from ovarian follicle  (ISO)
parturition  (ISO)
peripheral nervous system axon regeneration  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
prostate gland epithelium morphogenesis  (ISO)
proteolysis  (IDA,IEA,ISO)
response to activity  (ISO)
response to amyloid-beta  (ISS)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (IBA,ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to oxidative stress  (ISO)
response to radiation  (ISO)
response to retinoic acid  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal system morphogenesis  (ISO)
tissue remodeling  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal cutaneous elastic fiber morphology  (IAGP)
Abnormal facial shape  (IAGP)
Abnormal form of the vertebral bodies  (IAGP)
Abnormal fundus morphology  (IAGP)
Abnormal hand morphology  (IAGP)
Abnormality of the orbital region  (IAGP)
Ankle flexion contracture  (IAGP)
Ankylosis of feet small joints  (IAGP)
Antinuclear antibody positivity  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Arthropathy  (IAGP)
Atrial septal defect  (IAGP)
Atrioventricular block  (IAGP)
Autosomal recessive inheritance  (IAGP)
Bicuspid aortic valve  (IAGP)
Brachycephaly  (IAGP)
Broad clavicles  (IAGP)
Broad metacarpals  (IAGP)
Broad metatarsal  (IAGP)
Bulbous nose  (IAGP)
C1-C2 subluxation  (IAGP)
Camptodactyly of toe  (IAGP)
Carpal osteolysis  (IAGP)
Childhood onset  (IAGP)
Coarctation of aorta  (IAGP)
Coarse facial features  (IAGP)
Corneal opacity  (IAGP)
Delayed closure of the anterior fontanelle  (IAGP)
Delayed eruption of teeth  (IAGP)
Diabetes mellitus  (IAGP)
Distal tapering of metatarsals  (IAGP)
Double outlet right ventricle  (IAGP)
Finger swelling  (IAGP)
Frontal bossing  (IAGP)
Gait disturbance  (IAGP)
Gingival overgrowth  (IAGP)
Hip contracture  (IAGP)
Hirsutism  (IAGP)
Hypercholesterolemia  (IAGP)
Hypermelanotic macule  (IAGP)
Hypertelorism  (IAGP)
Hypertension  (IAGP)
Hypertriglyceridemia  (IAGP)
Hypoplasia of the maxilla  (IAGP)
Increased susceptibility to fractures  (IAGP)
Infantile onset  (IAGP)
Intellectual disability  (IAGP)
Interphalangeal joint contracture of finger  (IAGP)
Interphalangeal joint erosions  (IAGP)
Iris coloboma  (IAGP)
Juvenile onset  (IAGP)
Kyphoscoliosis  (IAGP)
Localized skin lesion  (IAGP)
Macular degeneration  (IAGP)
Metacarpal osteolysis  (IAGP)
Metaphyseal widening  (IAGP)
Metatarsal osteolysis  (IAGP)
Micrognathia  (IAGP)
Mitral valve prolapse  (IAGP)
Myopia  (IAGP)
Narrow nasal bridge  (IAGP)
Nodular goiter  (IAGP)
Omphalocele  (IAGP)
Osteolysis involving tarsal bones  (IAGP)
Osteopenia  (IAGP)
Osteoporosis  (IAGP)
Papilledema  (IAGP)
Peripheral opacification of the cornea  (IAGP)
Pes cavus  (IAGP)
Pes planus  (IAGP)
Polycystic ovaries  (IAGP)
Premature thelarche  (IAGP)
Proptosis  (IAGP)
Protrusio acetabuli  (IAGP)
Pterygium  (IAGP)
Retinal hemorrhage  (IAGP)
Sclerotic cranial sutures  (IAGP)
Short stature  (IAGP)
Split hand  (IAGP)
Subcutaneous nodule  (IAGP)
Thickened skin  (IAGP)
Thin metacarpal cortices  (IAGP)
Thin metatarsal cortices  (IAGP)
Type I diabetes mellitus  (IAGP)
Ventricular septal defect  (IAGP)
Vertebral compression fracture  (IAGP)
Wide cranial sutures  (IAGP)
Widened metacarpal shaft  (IAGP)
Wrist flexion contracture  (IAGP)

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