MMP9 (matrix metallopeptidase 9) - Rat Genome Database
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Gene: MMP9 (matrix metallopeptidase 9) Homo sapiens
Symbol: MMP9
Name: matrix metallopeptidase 9
RGD ID: 1348437
Description: Exhibits identical protein binding activity; metalloendopeptidase activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to UV-A; positive regulation of keratinocyte migration; and regulation of apoptotic signaling pathway. Localizes to extracellular space. Implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); brain disease (multiple); carcinoma (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 92 kDa gelatinase; 92 kDa type IV collagenase; CLG4B; GELB; macrophage gelatinase; MANDP2; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase-9; MMP-9; type V collagenase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2046,008,908 - 46,016,561 (+)EnsemblGRCh38hg38GRCh38
GRCh382046,008,908 - 46,016,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372044,637,547 - 44,645,200 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,070,954 - 44,078,607 (+)NCBINCBI36hg18NCBI36
Build 342044,070,953 - 44,078,606NCBI
Celera2041,348,998 - 41,356,660 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2041,378,970 - 41,386,505 (+)NCBIHuRef
CHM1_12044,540,180 - 44,547,844 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (EXP,IEP,ISO)
Acute Coronary Syndrome  (EXP)
Acute Lung Injury  (ISO)
adrenoleukodystrophy  (IEP)
adult respiratory distress syndrome  (IEP)
Albuminuria  (IEP)
alcohol use disorder  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (IEP)
amyotrophic lateral sclerosis  (IEP,ISO)
Angina, Stable  (EXP)
angle-closure glaucoma  (IAGP)
Animal Disease Models  (EXP)
Animal Mammary Neoplasms  (ISO)
anodontia  (IAGP)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (IEP)
aortic aneurysm  (EXP)
aortic disease  (EXP)
Aortic Rupture  (EXP)
Arterial Injury  (ISO)
arteriosclerosis  (IAGP,ISO)
Arteriovenous Fistula  (ISO)
arteriovenous malformation  (IEP)
astrocytoma  (EXP)
atopic dermatitis  (ISO)
atrial fibrillation  (IEP)
attention deficit hyperactivity disorder  (IEP)
autism spectrum disorder  (IMP,ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autosomal dominant polycystic kidney disease  (IEP)
bacterial meningitis  (IDA)
bacterial pneumonia  (IEP,ISO)
Behcet's disease  (IEP)
Bone Neoplasms  (EXP)
brain edema  (EXP,ISO)
brain infarction  (IEP)
Brain Injuries  (EXP,ISO)
Brain Injuries, Traumatic  (EXP)
brain ischemia  (EXP,ISO)
Breast Neoplasms  (EXP,IAGP,IEP,IMP)
Bronchial Hyperreactivity  (IMP)
bronchiectasis  (IEP)
bronchiolitis obliterans  (IEP)
Bronchopulmonary Dysplasia  (ISO)
bullous pemphigoid  (ISO)
Burns  (ISO)
calcinosis  (EXP)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (IEP,ISO)
carotid artery disease  (IDA)
Carotid Artery Injuries  (ISO)
Cerebral Hemorrhage  (EXP,ISO)
cerebral infarction  (EXP)
Chemical and Drug Induced Liver Injury  (EXP)
childhood absence epilepsy  (ISO)
cholangiocarcinoma  (IEP,ISO)
cholesteatoma  (IEP)
cholesteatoma of middle ear  (IEP)
chorioamnionitis  (IEP)
Choroidal Neovascularization  (IEP,ISO)
chronic inflammatory demyelinating polyradiculoneuropathy  (IEP)
chronic obstructive pulmonary disease  (EXP,IAGP,IEP,ISO)
Chronic Periodontitis  (ISO)
chronic ulcer of skin  (IAGP)
Cicatrix  (ISO)
cognitive disorder  (ISO)
Colonic Neoplasms  (EXP,ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (IEP,ISO)
conjunctivochalasis  (IEP)
coronary artery disease  (IAGP,ISO)
crescentic glomerulonephritis  (ISO)
cystic fibrosis  (IEP)
dermatomyositis  (IEP)
Diabetic Foot  (IEP)
Diabetic Nephropathies  (IAGP,ISO)
diabetic neuropathy  (EXP)
diabetic retinopathy  (IDA,IEP,ISO)
Down syndrome  (IDA)
Duchenne muscular dystrophy  (ISO)
ductal carcinoma in situ  (IEP)
Embolism  (IEP)
Emphysema  (ISO)
endometrial carcinoma  (IEP)
endometriosis  (ISO)
epidermolysis bullosa simplex  (IEP)
epilepsy  (IEP)
esophagus adenocarcinoma  (IEP)
exfoliation syndrome  (IAGP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (EXP)
facial paralysis  (ISO)
familial hyperlipidemia  (IEP)
Febrile Seizures  (IEP)
Fibrosis  (ISO)
Focal Cortical Dysplasia of Taylor  (IEP)
focal epilepsy  (ISO)
focal segmental glomerulosclerosis  (ISO)
fragile X syndrome  (IEP,ISO)
gastric ulcer  (EXP,ISO)
glaucoma  (IEP)
glioblastoma  (EXP,IEP,IMP)
glomerulosclerosis  (ISO)
Gouty Arthritis  (IEP)
heart valve disease  (IEP)
hepatic veno-occlusive disease  (ISO)
hepatocellular carcinoma  (EXP,ISO)
Herpes Simplex Encephalitis  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperlipoproteinemia Type II  (IEP)
Hyperoxia  (ISO)
Hyperoxic Lung Injury  (ISO)
Hyperplasia  (EXP)
hypertension  (EXP,IAGP,IDA,IEP,ISO)
hypertrophic cardiomyopathy  (IEP)
ileus  (ISO)
Inflammation  (EXP,ISO)
interstitial lung disease  (IDA,IEP)
intracranial aneurysm  (IAGP,IEP,ISO)
ischemia  (ISO)
Kawasaki disease  (IEP,ISO)
kidney disease  (ISO)
Laryngeal Neoplasms  (IEP)
Lead Poisoning  (EXP)
liver disease  (EXP)
Liver Injury  (ISO)