Mmp2 (matrix metallopeptidase 2) - Rat Genome Database

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Gene: Mmp2 (matrix metallopeptidase 2) Rattus norvegicus
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Symbol: Mmp2
Name: matrix metallopeptidase 2
RGD ID: 621316
Description: Exhibits fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Localizes to cytoplasm and extracellular space. Used to study artery disease (multiple); conjunctivitis; and transient cerebral ischemia. Biomarker of several diseases, including alcohol use disorder; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2); PARTICIPATES IN syndecan signaling pathway; gonadotropin-releasing hormone signaling pathway; urinary bladder cancer pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 72 kDa gelatinase; 72 KDa type IV collagenase; gelatinase A; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase-2; MMP-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Mmp2em2Mcwi  
Genetic Models: SS-Mmp2em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21914,154,657 - 14,182,870 (-)NCBI
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01915,542,771 - 15,570,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01926,629,728 - 26,658,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,246,036 - 15,275,061 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1914,077,766 - 14,105,839 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IDA,IEP,ISO)
Acute Lung Injury  (IEP)
Acute Necrotizing Pancreatitis  (IEP)
adrenoleukodystrophy  (ISO)
alcohol use disorder  (IEP)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aortic disease  (ISO)
Aortic Rupture  (ISO)
aortic valve disease 2  (ISO)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IEP,ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
bone disease  (ISO)
Bone Neoplasms  (ISO)
brain ischemia  (IEP)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IEP)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chlamydophila Infections  (ISO)
cholangiocarcinoma  (IEP,ISO)
cholestasis  (IEP)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IDA,ISO)
Chronic Periodontitis  (IDA,ISO)
Colorectal Neoplasms  (IEP,ISO)
congestive heart failure  (IEP,ISO)
conjunctivitis  (IDA)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous leishmaniasis  (ISO)
Diabetic Nephropathies  (IEP)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Embolism  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (IEP)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (IEP,ISO)
extrahepatic cholestasis  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (IEP)
focal segmental glomerulosclerosis  (IEP)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (IEP)
glioblastoma  (ISO)
Gouty Arthritis  (ISO)
Graft Occlusion, Vascular  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
high grade glioma  (IEP)
Hydatidiform Mole  (ISO)
Hyperoxia  (IEP)
Hyperplasia  (IEP)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (ISO)
Immunoglobulin Light-chain Amyloidosis  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (IEP,ISO)
ischemia  (ISO)
keratoconus  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (IDA)
leiomyoma  (ISO)
liver cirrhosis  (IEP,ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
Malignant Pleural Effusions  (ISO)
Mammary Neoplasms, Experimental  (IEP,ISO)
Mandibular Diseases  (ISO)
Marfan syndrome  (ISO)
Maxillary Diseases  (ISO)
Metabolic Bone Diseases  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocarditis  (ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neointima  (IEP,ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IEP,ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
Nose Neoplasms  (ISO)
ocular hypertension  (IEP)
Oral Lichen Planus  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteolysis  (ISO)
Osteolysis Hereditary Multicentric  (ISO)
osteonecrosis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (IEP)
Pneumococcal Meningitis  (IMP)
polycystic ovary syndrome  (IEP)
Polypoidal Choroidal Vasculopathy  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (IEP)
prostate cancer  (ISO)
pseudoxanthoma elasticum  (ISO)
pterygium  (ISO)
pulmonary embolism  (IDA)
pulmonary emphysema  (IEP,ISO)
pulmonary fibrosis  (ISO)
Puromycin Aminonucleoside Nephrosis  (IEP)
pyoderma gangrenosum  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (IDA)
respiratory syncytial virus infectious disease  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (IEP)
Sepsis  (IMP)
skin melanoma  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
stomach carcinoma  (IEP)
Stroke  (IEP,ISO)
Sturge-Weber syndrome  (ISO)
Subarachnoid Hemorrhage  (IDA)
Sweet syndrome  (ISO)
temporal arteritis  (ISO)
Testicular Germ Cell Tumor  (ISO)
thoracic aortic aneurysm  (IEP,ISO)
transient cerebral ischemia  (IDA,IEP)
transitional cell carcinoma  (ISO)
tropical spastic paraparesis  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (IEP,ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (IEP)
Venous Thrombosis  (IDA,IEP)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,3'-diindolylmethane  (ISO)
3-hydroxypicolinic acid  (ISO)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (EXP,ISO)
9,10-phenanthroquinone  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
ageladine A  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (EXP)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP)
aluminium atom  (EXP)
aluminium oxide  (ISO)
aluminium(0)  (EXP)
AM-251  (ISO)
ambroxol  (EXP)
amitrole  (ISO)
ammonium chloride  (EXP)
Anacardic acid  (ISO)
anagliptin  (ISO)
andrographolide  (ISO)
anethole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
astemizole  (EXP)
atorvastatin calcium  (EXP,ISO)
baicalein  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP)
betulin  (EXP)
betulinic acid  (EXP,ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
brazilein  (ISO)
brucine  (ISO)
bucladesine  (ISO)
bufalin  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium dichloride  (EXP,ISO)
cantharidin  (ISO)
capecitabine  (ISO)
capsaicin  (EXP,ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carvedilol  (EXP,ISO)
casticin  (ISO)
celastrol  (EXP)
celecoxib  (EXP,ISO)
CGS-21680  (ISO)
Chebulagic acid  (EXP)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chlordecone  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (EXP)
columbamine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin B  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
DDT  (EXP)
Deguelin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
diethyl maleate  (EXP)
dihydroartemisinin  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (ISO)
diosgenin  (EXP)
dioxygen  (EXP,ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP,ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
embelin  (ISO)
emetine  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP,ISO)
excitatory amino acid agonist  (ISO)
farrerol  (EXP)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferrichrome  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (ISO)
flavonol  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
fosinopril  (ISO)
fructose  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galactose  (EXP)
gallic acid  (EXP,ISO)
Genipin  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
Geraniin  (ISO)
gingerol  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
Gly-His-Lys  (EXP)
glycidol  (EXP)
glycyrrhizinic acid  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
heparin  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hinokiflavone  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
ibuprofen  (EXP)
ICI 118551  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (EXP)
indometacin  (EXP,ISO)
iron trichloride  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
juglone  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
lasofoxifene  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP)
letrozole  (ISO)
leuprolide  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (EXP)
lithocholic acid  (ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mannuronic acid  (EXP)
marimastat  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
Methanandamide  (ISO)
methotrexate  (EXP)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoprolol  (EXP,ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
morin  (EXP)
morusin  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naproxen  (EXP)
naringin  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (EXP,ISO)
nitroglycerin  (ISO)
Nonylphenol  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
oridonin  (ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
phenanthrolines  (EXP)
phenethyl caffeate  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phosphatidylcholine  (EXP)
piperine  (ISO)
pipoxolan  (ISO)
pirfenidone  (EXP)
piroxicam  (ISO)
platycodin D  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prazosin  (EXP)
prednisolone  (EXP)
prinomastat  (ISO)
Pristimerin  (EXP)
probucol  (ISO)
progesterone  (ISO)
propanal  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
raloxifene  (EXP)
ramipril  (EXP)
razoxane  (EXP)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Rhaponticin  (EXP)
rhodotorulic acid  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
S-adenosyl-L-homocysteine  (EXP,ISO)
S-allylcysteine  (EXP)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
sanguinarine  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
serpentine asbestos  (ISO)
silibinin  (EXP,ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
solasodine  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
taurocholic acid  (ISO)
tebuconazole  (ISO)
telmisartan  (EXP)
terbinafine  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
tomatidine  (ISO)
Tomentosin  (ISO)
topotecan  (EXP)
trans-anethole  (ISO)
trans-cinnamic acid  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triciribine  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropisetron  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IDA,IEP)
angiogenesis  (IEP)
blood vessel maturation  (IEA,ISO)
bone trabecula formation  (IEA,ISO)
cell migration  (IMP)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to cytokine stimulus  (IEP)
cellular response to estradiol stimulus  (IMP)
cellular response to fluid shear stress  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to reactive oxygen species  (IEA,ISO)
cellular response to UV-A  (IEA,ISO,ISS)
collagen catabolic process  (IBA,IDA,IEA,ISO)
embryo implantation  (IEA,ISO)
endodermal cell differentiation  (IEA,ISO)
extracellular matrix organization  (IBA)
face morphogenesis  (IEA,ISO)
female pregnancy  (IEP)
heart development  (IDA)
intramembranous ossification  (IEA,ISO)
luteinization  (IEP)
negative regulation of cell adhesion  (IDA)
negative regulation of vasoconstriction  (IDA)
ovarian follicle development  (IDA)
ovulation from ovarian follicle  (IEP)
parturition  (IEP)
peripheral nervous system axon regeneration  (IDA)
positive regulation of apoptotic process  (IDA)
positive regulation of cell migration  (IMP)
positive regulation of innate immune response  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
prostate gland epithelium morphogenesis  (IMP)
proteolysis  (IDA,IEA,ISO)
response to activity  (IEP)
response to amyloid-beta  (IEA,ISO)
response to cytokine  (IEP)
response to drug  (IDA,IEP)
response to electrical stimulus  (IEP)
response to estrogen  (IDA)
response to hydrogen peroxide  (IDA)
response to hyperoxia  (IEP)
response to hypoxia  (IBA,IDA,IEA,ISO)
response to mechanical stimulus  (IDA)
response to nicotine  (IEP)
response to oxidative stress  (IDA)
response to radiation  (IEP)
response to retinoic acid  (IEP)
skeletal system morphogenesis  (ISO)
tissue remodeling  (IBA,IDA)

Cellular Component
cytoplasm  (IDA,ISO)
extracellular matrix  (IEA)
extracellular space  (IDA,IEA,ISO)
mitochondrion  (ISO)
nucleus  (IEA)
plasma membrane  (IEA,ISO)
sarcomere  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
3. Alfonso-Jaume MA, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1838-46. Epub 2006 May 12.
4. Alsac JM, etal., Eur J Vasc Endovasc Surg. 2011 Apr;41(4):474-80. doi: 10.1016/j.ejvs.2010.12.007. Epub 2011 Jan 20.
5. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
6. Barichello T, etal., Exp Biol Med (Maywood). 2014 Feb;239(2):225-31. doi: 10.1177/1535370213508354. Epub 2014 Jan 13.
7. Barlaka E, etal., Can J Physiol Pharmacol. 2013 Aug;91(8):608-16. doi: 10.1139/cjpp-2012-0412. Epub 2013 Mar 3.
8. Ben-David D, etal., Inflamm Res. 2012 Jul;61(7):673-88. doi: 10.1007/s00011-012-0461-7. Epub 2012 Mar 13.
9. Beranek M, etal., Mol Vis. 2008 Jun 14;14:1114-21.
10. Bergman MR, etal., Biochem J 2003 Feb 1;369(Pt 3):485-96.
11. Bhattacharyya SS, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Jul;8(7):645-54.
12. Bogusiewicz M, etal., Gynecol Endocrinol. 2007 Sep;23(9):541-6.
13. Branca M, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1543-56.
14. Bruni-Cardoso A, etal., Dev Dyn. 2010 Mar;239(3):737-46.
15. Bruni-Cardoso A, etal., Int J Androl. 2009 Nov 10.
16. Bruno G, etal., J Neurosurg. 1998 Sep;89(3):431-40.
17. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
18. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
19. Chan CY, etal., J Vasc Surg. 2007 Apr;45(4):804-11.
20. Chen PS, etal., World J Gastroenterol 2001 Oct;7(5):647-51.
21. Chen Y, etal., Eur Respir J. 2010 Apr;35(4):904-12. Epub 2009 Nov 6.
22. Cheng S, etal., Biochem J 2002 Sep 15;366(Pt 3):807-16.
23. Cheung C, etal., Cardiovasc Pathol. 2006 Mar-Apr;15(2):63-74.
24. Cho KO, etal., J Neurosci Res. 2006 Feb 1;83(2):285-91.
25. Choi EY, etal., Exp Mol Med. 2002 Dec 31;34(6):391-400.
26. Christopoulos TA, etal., Oncol Rep. 2007 Oct;18(4):855-60.
27. Chu SC, etal., Clin Chim Acta. 2004 Jan;339(1-2):77-83.
28. Cleutjens JP, etal., J Mol Cell Cardiol. 1995 Jun;27(6):1281-92.
29. Coutard M, etal., J Vasc Res. 2009 Dec 16;47(4):355-366.
30. Covington MD, etal., Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51. Epub 2005 Aug 2.
31. Dahi S, etal., J Vasc Surg. 2005 Sep;42(3):539-45.
32. Dal-Pizzol F, etal., Mol Neurobiol. 2013 Aug;48(1):62-70. doi: 10.1007/s12035-013-8433-7. Epub 2013 Mar 12.
33. De Mello Malheiro OC, etal., Anat Rec (Hoboken). 2009 Oct;292(10):1656-62.
34. Delgado-Enciso I, etal., Gynecol Obstet Invest. 2008;65(1):68-72. Epub 2007 Sep 13.
35. Demestre M, etal., Neuroscience. 2004;124(4):767-79.
36. Derosa G, etal., Diabetes Metab. 2007 Apr;33(2):129-34. Epub 2007 Feb 22.
37. Derosa G, etal., Endothelium. 2006 May-Jun;13(3):227-31.
38. Di Carlo A, etal., Oncol Rep. 2007 Aug;18(2):425-31.
39. Drapisz S, etal., J Cardiovasc Med (Hagerstown). 2013 Jun;14(6):446-52. doi: 10.2459/JCM.0b013e3283588dfa.
40. Ebihara I, etal., Nephrol Dial Transplant. 1997 May;12(5):1001-6.
41. Eissa S, etal., Eur Urol. 2007 Nov;52(5):1388-96. Epub 2007 Apr 10.
42. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
43. Fan HX, etal., J Exp Clin Cancer Res. 2012 Oct 29;31:90. doi: 10.1186/1756-9966-31-90.
44. Fan WH and Karnovsky MJ, J Biol Chem 2002 Mar 22;277(12):9800-5.
45. Fang L, etal., J Neurol Sci. 2010 Jul 15;294(1-2):51-6. doi: 10.1016/j.jns.2010.04.005. Epub 2010 May 4.
46. Feng W and Li W, Exp Mol Pathol. 2010 Apr;88(2):299-304. Epub 2009 Nov 10.
47. Fernandez-Robredo P, etal., Mol Vis. 2013;19:153-65. Epub 2013 Jan 28.
48. Filippov S, etal., J Exp Med. 2005 Sep 5;202(5):663-71.
49. Fracalossi AC, etal., J Mol Histol. 2010 Feb;41(1):19-25. Epub 2010 Mar 6.
50. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
51. Friese RS, etal., Clin Exp Hypertens. 2009 Oct;31(7):521-33. doi: 10.3109/10641960802668730.
52. Ganguly K, etal., Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30.
53. Gao Y, etal., Di Yi Jun Yi Da Xue Xue Bao 2002 Oct;22(10):865-8.
54. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
55. Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26.
56. George J, etal., Am Heart J. 2005 Sep;150(3):484-7.
57. GOA data from the GO Consortium
58. Graesslin O, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1911-7.
59. Gremlich S, etal., J Reprod Immunol. 2007 Jun;74(1-2):143-51. Epub 2007 Mar 23.
60. Gress TM, etal., Int J Cancer. 1995 Aug 9;62(4):407-13.
61. Guo H, etal., Cardiovasc Ther. 2010 Jun;28(3):161-8. doi: 10.1111/j.1755-5922.2009.00132.x. Epub 2010 Mar 31.
62. Harendza S, etal., J Biol Chem 1995 Aug 11;270(32):18786-96.
63. He H, etal., Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
64. He JZ, etal., Am J Physiol Heart Circ Physiol. 2006 Sep 15;.
65. Herpel E, etal., Histopathology. 2006 May;48(6):736-47.
66. Hinterseher I, etal., J Surg Res. 2006 Jun 15;133(2):121-8. Epub 2006 Feb 3.
67. Hochstrasser T, etal., Curr Alzheimer Res. 2012 Oct;9(8):982-9.
68. Hosford GE, etal., Pediatr Res. 2004 Jul;56(1):26-34. Epub 2004 May 5.
69. Hosomi N, etal., Neuroscience. 2005;134(1):225-31.
70. Hsu CC and Lai SC, Int J Exp Pathol. 2007 Dec;88(6):437-43.
71. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
72. Ikonomidis JS, etal., Circulation. 2005 Aug 30;112(9 Suppl):I242-8.
73. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
74. Imai C, etal., Clin Exp Hypertens 2005 Jan;27(1):59-69.
75. Iniesta P, etal., Oncol Rep. 2007 Jan;17(1):217-23.
76. Jacob-Ferreira AL, etal., Eur J Pharmacol. 2010 Feb 10;627(1-3):216-22. Epub 2009 Oct 30.
77. Jan YY, etal., Ann Surg. 2004 Jul;240(1):89-94.
78. Jo M, etal., Biol Reprod. 2004 Apr;70(4):1024-32. Epub 2003 Dec 10.
79. Johanns M, etal., Sci Rep. 2017 Jun 28;7(1):4328. doi: 10.1038/s41598-017-04648-y.
80. John M, etal., Exp Eye Res. 2004 Dec;79(6):839-46.
81. Jovanova-Nesic K, etal., Int J Neurosci. 2009;119(9):1399-418.
82. Juuti A, etal., Oncology. 2006;71(1-2):61-8. Epub 2007 Mar 21.
83. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
84. Kassiri Z, etal., Circ Res. 2005 Aug 19;97(4):380-90. Epub 2005 Jul 21.
85. Kawata N, etal., Urology. 2007 Jun;69(6):1049-53.
86. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
87. Kelly BA, etal., Mol Hum Reprod. 2004 May;10(5):331-7. Epub 2004 Mar 25.
88. Kelly BC, etal., J Am Acad Dermatol. 2010 Sep;63(3):483-9. doi: 10.1016/j.jaad.2009.09.006.
89. Kihara Y, etal., Pancreas. 2001 Oct;23(3):288-95.
90. Kim YH, etal., J Lipid Res. 2013 Oct;54(10):2678-86. doi: 10.1194/jlr.M037176. Epub 2013 Aug 2.
91. Kimizuka K, etal., Transplant Proc 2002 May;34(3):1047-8.
92. Kizaki K, etal., Biol Pharm Bull. 2005 Dec;28(12):2331-4.
93. Kuvaja P, etal., Hum Pathol. 2006 Oct;37(10):1316-23. Epub 2006 Jul 26.
94. Lai K, etal., Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5702-12. doi: 10.1167/iovs.10-6370.
95. Lalu MM, etal., Biochem Biophys Res Commun 2002 Aug 30;296(4):937-41.
96. Lee EK, etal., PLoS One. 2014 Oct 14;9(10):e110109. doi: 10.1371/journal.pone.0110109. eCollection 2014.
97. Lee MF, etal., Food Chem. 2013 Jun 1;138(2-3):802-7. doi: 10.1016/j.foodchem.2012.11.094. Epub 2012 Dec 1.
98. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
99. Li H, etal., Zhonghua Nei Ke Za Zhi 2002 Jun;41(6):393-8.
100. Li HC, etal., Breast Cancer Res Treat. 2004 Nov;88(1):75-85.
101. Li W and Shen HH, Chin Med J (Engl). 2007 Jan 5;120(1):5-11.
102. Li WB, etal., Zhonghua Er Ke Za Zhi. 2008 May;46(5):347-53.
103. Li X, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Oct;24(10):608-11.
104. Li XL, etal., Yi Chuan. 2008 Apr;30(4):455-62.
105. Lin NN, etal., J Surg Res. 2013 Jan;179(1):e41-8. doi: 10.1016/j.jss.2012.02.008. Epub 2012 Mar 28.
106. Liu K, etal., Endocrinology. 1999 Nov;140(11):5330-8.
107. Liu Y, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2014 Mar;49(3):155-60.
108. Longin J and Le Magueresse-Battistoni B, Mol Cell Endocrinol 2002 Mar 28;189(1-2):25-35.
109. Lu LS, etal., Eur Rev Med Pharmacol Sci. 2012 Dec;16(15):2037-43.
110. Machado LS, etal., BMC Neurosci. 2006 Jul 17;7:56.
111. Mahmoodzadeh S, etal., Cardiovasc Res. 2010 Mar 1;85(4):719-28. Epub 2009 Oct 27.
112. Malinsky RR, etal., Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1345-8. doi: 10.1007/s00405-012-2219-9. Epub 2012 Oct 12.
113. Manase K, etal., Reprod Biol Endocrinol. 2006 Jun 2;4:32.
114. Manikandan P, etal., Life Sci. 2010 Apr 29.
115. Mao JW, etal., World J Gastroenterol. 2012 Dec 21;18(47):7063-9. doi: 10.3748/wjg.v18.i47.7063.
116. Maretti-Mira AC, etal., Clin Exp Immunol. 2011 Feb;163(2):207-14. doi: 10.1111/j.1365-2249.2010.04285.x. Epub 2010 Nov 22.
117. Marti HP, etal., Biochem J 1993 Apr 15;291 ( Pt 2):441-6.
118. Martinez-Torres FJ, etal., Neurosci Lett. 2004 Sep 30;368(3):274-8.
119. Marzano AV, etal., Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2):451-60.
120. Matsuyama Y, etal., J Surg Oncol. 2002 Jun;80(2):105-10.
121. Mazaud S, etal., Dev Biol. 2005 Jan 15;277(2):403-16.
122. Medina C, etal., Am J Physiol Gastrointest Liver Physiol 2003 Jan;284(1):G116-22.
123. Mendes O, etal., Clin Exp Metastasis. 2005;22(3):237-46.
124. Mertens PR, etal., J Biol Chem 2002 Jul 12;277(28):24875-82.
125. MGD data from the GO Consortium
126. Misra S, etal., J Vasc Interv Radiol. 2010 Aug;21(8):1255-61. doi: 10.1016/j.jvir.2010.02.043. Epub 2010 Jul 3.
127. Mitropoulos D, etal., Eur Urol. 2007 Feb;51(2):447-56; discussion 456. Epub 2006 Jul 5.
128. Miyake JA, etal., Lipids Health Dis. 2009 Mar 17;8:8. doi: 10.1186/1476-511X-8-8.
129. Muhs BE, etal., J Surg Res. 2003 May 1;111(1):8-15.
130. Murugan RS, etal., Anticancer Res. 2009 Jun;29(6):2301-5.
131. Naito T, etal., Nephrol Dial Transplant. 2005 Nov;20(11):2333-48. Epub 2005 Jul 26.
132. Nakano A, etal., J Neurosurg. 1995 Aug;83(2):298-307.
133. NCBI rat LocusLink and RefSeq merged data July 26, 2002
134. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
135. Niebroj-Dobosz I, etal., Eur J Neurol. 2010 Feb;17(2):226-31. doi: 10.1111/j.1468-1331.2009.02775.x. Epub 2009 Oct 1.
136. Nishikaku AS, etal., Int J Exp Pathol. 2009 Oct;90(5):527-37. doi: 10.1111/j.1365-2613.2009.00663.x.
137. Noda K, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):2163-70.
138. Norgauer J, etal., Br J Dermatol. 2002 Dec;147(6):1180-6.
139. OMIM Disease Annotation Pipeline
140. Orimoto AM, etal., J Cutan Pathol. 2008 Mar;35(3):285-91. doi: 10.1111/j.1600-0560.2007.00810.x.
141. Orlandi A, etal., Am J Pathol. 2005 Jun;166(6):1619-28.
142. Ortak H, etal., Cornea. 2012 Sep;31(9):1048-51. doi: 10.1097/ICO.0b013e318254c028.
143. Ortak H, etal., Exp Eye Res. 2013 Aug;113:151-5. doi: 10.1016/j.exer.2013.06.009. Epub 2013 Jun 18.
144. Ortak H, etal., Ophthalmic Genet. 2013 Dec;34(4):217-22. doi: 10.3109/13816810.2013.781192. Epub 2013 Mar 28.
145. Pannu H, etal., J Neurosurg. 2006 Sep;105(3):418-23.
146. Park JJ, etal., Arch Pharm Res. 2011 Aug;34(8):1389-97. doi: 10.1007/s12272-011-0820-x. Epub 2011 Sep 11.
147. Pay S, etal., Clin Exp Rheumatol. 2007 Jul-Aug;25(4 Suppl 45):S70-5.
148. Peihong S and Perry F, Ethiop Med J. 2007 Jan;45(1):79-83.
149. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
150. Petignat P, etal., Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1679-84.
151. Peviani SM, etal., Neurol Res. 2009 Aug 5.
152. Pipeline to import KEGG annotations from KEGG into RGD
153. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
154. Planas AM, etal., Neurobiol Dis. 2001 Oct;8(5):834-46.
155. Podesser BK, etal., Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H984-91.
156. Polewicz D, etal., J Cell Mol Med. 2010 May 26.
157. Polyakova V, etal., J Cell Mol Med. 2008 Jan-Feb;12(1):189-208. doi: 10.1111/j.1582-4934.2008.00219.x. Epub 2008 Jan 10.
158. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
159. Qazi H, etal., PLoS One. 2011;6(5):e20348. doi: 10.1371/journal.pone.0020348. Epub 2011 May 26.
160. Qi Q, etal., Int J Clin Exp Pathol. 2014 Apr 15;7(5):1880-8. eCollection 2014.
161. Qin YH, etal., Pediatr Nephrol. 2009 Aug;24(8):1477-86. Epub 2009 Apr 9.
162. Raffetto JD, etal., J Surg Res. 2010 Apr;159(2):755-64. Epub 2008 Oct 24.
163. Randall LE and Hall RC, Connect Tissue Res 2002;43(2-3):205-11.
164. Ratajska A and Cleutjens JP, Basic Res Cardiol. 2002 May;97(3):189-97.
165. Rey MC, etal., Am J Dermatopathol. 2011 Jun;33(4):413-4. doi: 10.1097/DAD.0b013e3181e2e8d6.
166. RGD automated data pipeline
167. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
168. RGD automated import pipeline for gene-chemical interactions
169. Rivilis I, etal., Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1430-8.
170. Rizzi E, etal., Exp Mol Pathol. 2013 Feb;94(1):1-9. doi: 10.1016/j.yexmp.2012.10.010. Epub 2012 Oct 13.
171. Roldan V, etal., Am Heart J. 2008 Jul;156(1):85-91.
172. Rouzier C, etal., Clin Genet. 2006 Mar;69(3):271-6.
173. Rubaci AH, etal., J Oral Pathol Med. 2012 Oct;41(9):689-96. doi: 10.1111/j.1600-0714.2012.01160.x. Epub 2012 May 3.
174. Sanders JS, etal., Am J Physiol Renal Physiol. 2007 Dec;293(6):F1927-34. Epub 2007 Sep 26.
175. Segarra M, etal., Ann Rheum Dis. 2007 Nov;66(11):1429-35. Epub 2007 May 14.
176. Seitzman RL, etal., Am J Epidemiol. 2008 May 15;167(10):1217-25. doi: 10.1093/aje/kwn024. Epub 2008 Mar 20.
177. Shang T, etal., J Surg Res. 2014 May 1;188(1):316-25. doi: 10.1016/j.jss.2013.11.1105. Epub 2013 Dec 6.
178. Shen J, etal., Biochem Biophys Res Commun. 2006 Sep 8;347(4):1011-20. Epub 2006 Jul 12.
179. Sheng L, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Dec;33(12):1080-4.
180. Shin HW, etal., Otolaryngol Head Neck Surg. 2009 Oct;141(4):442-7.
181. Simonetti O, etal., Cancer. 2002 Nov 1;95(9):1963-70.
182. Sinha I, etal., Surgery. 2004 Aug;136(2):176-82.
183. Siu MK and Cheng CY, Biol Reprod. 2004 Apr;70(4):945-64. Epub 2003 Nov 26.
184. Sivaramakrishnan V and Niranjali Devaraj S, Chem Biol Interact. 2009 Aug 14;180(3):353-9. Epub 2009 Feb 21.
185. Slongo ML, etal., Biol Chem 2002 Jan;383(1):235-9.
186. Sluijter JP, etal., Stroke. 2006 Jan;37(1):235-9. Epub 2005 Dec 8.
187. Sotnikova NY, etal., Fertil Steril. 2010 May 15;93(8):2701-5. Epub 2010 Jan 8.
188. Souza-Costa DC, etal., Chest. 2005 Nov;128(5):3705-10.
189. Sreenivasan AK, etal., Vasc Med. 2013 Jun;18(3):122-8. doi: 10.1177/1358863X13486312.
190. Staack A, etal., BMC Urol. 2006 Aug 10;6:19.
191. Stewart JA Jr, etal., J Mol Cell Cardiol. 2006 Jul;41(1):97-107. Epub 2006 Jun 12.
192. Struckmann K, etal., Verh Dtsch Ges Pathol. 2005;89:178-83.
193. Sun H, etal., Diabetes Res Clin Pract. 2013 Apr;100(1):85-95. doi: 10.1016/j.diabres.2013.01.012. Epub 2013 Feb 4.
194. Szklarczyk A, etal., J Neurosci 2002 Feb 1;22(3):920-30.
195. Símová J, etal., Folia Biol (Praha). 2013;59(4):154-61.
196. Takahashi I, etal., J Mol Histol. 2005 Jun;36(5):355-66. Epub 2005 Oct 6.
197. Tchetverikov I, etal., Ann Rheum Dis. 2004 Jul;63(7):881-3.
198. Thibert KA, etal., PLoS One. 2012;7(11):e50430. doi: 10.1371/journal.pone.0050430. Epub 2012 Nov 21.
199. Tominaga M, etal., Clin Exp Rheumatol. 1999 Jul-Aug;17(4):463-6.
200. Trudel D, etal., Hum Pathol. 2008 Mar 7;.
201. Tummers AM, etal., J Surg Res. 2010 May 1;160(1):9-13. Epub 2009 May 13.
202. Umar S, etal., Pathol Res Pract. 2007;203(12):863-72. Epub 2007 Oct 29.
203. Urso L, etal., Biochem Pharmacol. 2010 Mar 15;79(6):810-6. Epub 2009 Oct 27.
204. Vaish V, etal., Cell Biochem Biophys. 2013 Jun;66(2):205-27. doi: 10.1007/s12013-012-9469-4.
205. Vinothini G, etal., Oncol Res. 2009;17(10):483-93.
206. Volman TJ, etal., J Pathol. 2004 Aug;203(4):968-75.
207. Vukasovic I, etal., Clin Chem Lab Med. 2006;44(4):428-34.
208. Wang H, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Oct;18(10):620-2.
209. Wang J and Yu LS, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;44(1):44-8.
210. Wang M and Lakatta EG, Hypertension 2002 Apr;39(4):865-73.
211. Wang TL, etal., J Mol Cell Cardiol. 2004 Sep;37(3):785-94.
212. Wang W, etal., Circulation 2002 Sep 17;106(12):1543-9.
213. Wang Z, etal., J Surg Res. 2010 Jan 5.
214. Webb KE, etal., Arterioscler Thromb Vasc Biol. 1997 Sep;17(9):1837-44.
215. Wojciechowski R, etal., Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4989-95. doi: 10.1167/iovs.10-5474. Epub 2010 May 19.
216. Wu M and Li YG, Mol Cell Biochem. 2006 Jan;282(1-2):141-6.
217. Wu S, etal., Pharmacology. 2013;91(3-4):123-30. doi: 10.1159/000346128. Epub 2013 Jan 23.
218. Wu W, etal., Med Oncol. 2009;26(2):117-23. Epub 2008 Jul 30.
219. Wu XQ, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Nov;32(11):1526-30.
220. Xiong W, etal., J Vasc Surg. 2008 Jan;47(1):166-72; discussion 172. doi: 10.1016/j.jvs.2007.09.016.
221. Xu H, etal., PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014.
222. Xu SL, etal., Zhonghua Yan Ke Za Zhi. 2009 Mar;45(3):260-5.
223. Xue AM, etal., Zhonghua Bing Li Xue Za Zhi. 2007 Jun;36(6):405-9.
224. Yamaguchi T, etal., Pancreas 2002 May;24(4):348-56.
225. Yang B, etal., Kidney Int. 2014 Feb;85(2):289-306. doi: 10.1038/ki.2013.290. Epub 2013 Aug 7.
226. Yang DC, etal., Cardiology. 2010;116(2):133-41. doi: 10.1159/000317245. Epub 2010 Jul 1.
227. Yang J, etal., Life Sci. 2013 Dec 18;93(25-26):1033-8.
228. Yang SF, etal., Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4588-96. doi: 10.1167/iovs.08-3147. Epub 2009 May 6.
229. Yang Y, etal., J Neurochem. 2010 Jan;112(1):134-49. Epub 2009 Oct 15.
230. Yigit O, etal., Laryngoscope. 2011 Mar;121(3):667-73. doi: 10.1002/lary.21462. Epub 2011 Feb 8.
231. Yin CY, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Nov;29(11):2205-7.
232. Yokoyama M, etal., Pancreas. 2002 May;24(4):344-7.
233. Yu TY, etal., BMC Musculoskelet Disord. 2013 Jan 2;14:2. doi: 10.1186/1471-2474-14-2.
234. Zarbock R, etal., Clin Chim Acta. 2010 Oct 9;411(19-20):1487-90. doi: 10.1016/j.cca.2010.06.006. Epub 2010 Jun 10.
235. Zeng R, etal., Mol Vis. 2013;19:729-36. Epub 2013 Mar 21.
236. Zhang C, etal., Pathol Oncol Res. 2010 Mar;16(1):47-53. Epub 2009 Jul 25.
237. Zhang H, etal., Zhonghua Fu Chan Ke Za Zhi. 2006 Aug;41(8):509-13.
238. Zhang Y, etal., Dig Dis Sci. 2010 Jan 28.
239. Zhang YB, etal., Chin J Traumatol. 2010 Jun 1;13(3):188-92.
240. Zhao XQ, etal., Hua Xi Kou Qiang Yi Xue Za Zhi. 2006 Jun;24(3):202-5.
241. Zhao YG, etal., Mol Reprod Dev 2002 Jun;62(2):149-58.
242. Zheng Y, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Apr;46(4):299-302.
243. Zhong S, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):614-9. doi: 10.1007/s11596-009-0516-3. Epub 2009 Oct 11.
Additional References at PubMed
PMID:11747814   PMID:11824471   PMID:11824476   PMID:12419962   PMID:12477932   PMID:12617792   PMID:12747454   PMID:12970340   PMID:14512418   PMID:15038770   PMID:15051632   PMID:15052653  
PMID:15075185   PMID:15212943   PMID:15255544   PMID:15269222   PMID:15300910   PMID:15480899   PMID:15509661   PMID:15522203   PMID:15609629   PMID:15615723   PMID:15621209   PMID:15637127  
PMID:15652546   PMID:15655118   PMID:15728709   PMID:15793858   PMID:15802562   PMID:15863497   PMID:15956706   PMID:16047157   PMID:16097048   PMID:16148033   PMID:16200464   PMID:16337314  
PMID:16377938   PMID:16484357   PMID:16575906   PMID:16680016   PMID:16680367   PMID:16690877   PMID:16707552   PMID:16707787   PMID:16738242   PMID:16815061   PMID:16816895   PMID:16854986  
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PMID:17428795   PMID:17440987   PMID:17496904   PMID:17505812   PMID:17561096   PMID:17607299   PMID:17644578   PMID:17684756   PMID:17854826   PMID:17903365   PMID:17960656   PMID:17986262  
PMID:17987394   PMID:18000599   PMID:18031717   PMID:18052689   PMID:18071296   PMID:18075836   PMID:18247145   PMID:18264108   PMID:18279587   PMID:18293392   PMID:18320202   PMID:18327702  
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PMID:20388014   PMID:20543091   PMID:20548288   PMID:20551380   PMID:20683769   PMID:20853596   PMID:20887714   PMID:20939987   PMID:20940000   PMID:21039990   PMID:21041693   PMID:21141515  
PMID:21165643   PMID:21171825   PMID:21176109   PMID:21186625   PMID:21212518   PMID:21220710   PMID:21308405   PMID:21354273   PMID:21355315   PMID:21376707   PMID:21385940   PMID:21414971  
PMID:21461559   PMID:21468558   PMID:21505995   PMID:21536992   PMID:21595847   PMID:21814480   PMID:21876619   PMID:21882490   PMID:21884701   PMID:21895415   PMID:21952436   PMID:22045122  
PMID:22045123   PMID:22071631   PMID:22083546   PMID:22092673   PMID:22094487   PMID:22095325   PMID:22098918   PMID:22105553   PMID:22110735   PMID:22135757   PMID:22197817   PMID:22199370  
PMID:22207560   PMID:22342460   PMID:22345572   PMID:22378877   PMID:22419075   PMID:22449415   PMID:22496348   PMID:22509276   PMID:22618526   PMID:22634718   PMID:22773570   PMID:22897943  
PMID:22914642   PMID:22974613   PMID:23006733   PMID:23088810   PMID:23154389   PMID:23179310   PMID:23383440   PMID:23399998   PMID:23404084   PMID:23481598   PMID:23500774   PMID:23621950  
PMID:23676944   PMID:23790633   PMID:23845380   PMID:23891690   PMID:23950935   PMID:23979707   PMID:23988659   PMID:24006456   PMID:24062440   PMID:24114974   PMID:24160412   PMID:24194850  
PMID:24236012   PMID:24375642   PMID:24380732   PMID:24440697   PMID:24560960   PMID:24685074   PMID:24704473   PMID:24722316   PMID:24769238   PMID:24784232   PMID:24792035   PMID:24907869  
PMID:24935409   PMID:24988912   PMID:25004875   PMID:25013773   PMID:25028660   PMID:25077715   PMID:25108165   PMID:25158309   PMID:25326689   PMID:25343559   PMID:25451385   PMID:25537973  
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Genomics

Comparative Map Data
Mmp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21914,154,657 - 14,182,870 (-)NCBI
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01915,542,771 - 15,570,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01926,629,728 - 26,658,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,246,036 - 15,275,061 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1914,077,766 - 14,105,839 (-)NCBICelera
Cytogenetic Map19p11NCBI
MMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1655,389,700 - 55,506,691 (+)EnsemblGRCh38hg38GRCh38
GRCh381655,478,830 - 55,506,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371655,512,742 - 55,540,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,070,589 - 54,098,104 (+)NCBINCBI36hg18NCBI36
Build 341654,070,603 - 54,097,652NCBI
Celera1640,027,315 - 40,054,814 (+)NCBI
Cytogenetic Map16q12.2NCBI
HuRef1641,400,533 - 41,427,983 (+)NCBIHuRef
CHM1_11656,920,005 - 56,947,862 (+)NCBICHM1_1
Mmp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,553,920 - 93,580,049 (+)NCBIGRCm39mm39
GRCm39 Ensembl893,553,919 - 93,580,048 (+)Ensembl
GRCm38892,827,290 - 92,853,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,827,291 - 92,853,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37895,351,227 - 95,377,319 (+)NCBIGRCm37mm9NCBIm37
MGSCv36895,716,456 - 95,742,548 (+)NCBImm8
Celera897,157,107 - 97,183,318 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.99NCBI
Mmp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543313,024,418 - 13,052,775 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543313,024,844 - 13,050,041 (+)NCBIChiLan1.0ChiLan1.0
MMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11654,817,228 - 54,844,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1654,812,694 - 54,844,279 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01635,711,866 - 35,738,881 (+)NCBIMhudiblu_PPA_v0panPan3
MMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,471,092 - 60,492,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,471,257 - 60,494,113 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,105,772 - 57,130,788 (-)NCBI
ROS_Cfam_1.0261,016,206 - 61,041,216 (-)NCBI
UMICH_Zoey_3.1257,844,808 - 57,869,825 (-)NCBI
UNSW_CanFamBas_1.0258,869,067 - 58,894,067 (-)NCBI
UU_Cfam_GSD_1.0259,747,357 - 59,772,363 (-)NCBI
Mmp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934951,763,246 - 51,787,737 (-)NCBI
SpeTri2.0NW_0049364757,801,356 - 7,825,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl630,058,594 - 30,086,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1630,059,247 - 30,087,031 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2627,526,396 - 27,553,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI
MMP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1541,264,382 - 41,291,657 (+)NCBI
ChlSab1.1 Ensembl541,264,354 - 41,291,004 (+)Ensembl
Mmp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247571,450,680 - 1,479,160 (-)NCBI

Position Markers
RH130872  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01915,542,878 - 15,543,065NCBIRnor6.0
Rnor_5.01926,629,835 - 26,630,022UniSTSRnor5.0
RGSC_v3.41915,246,143 - 15,246,330UniSTSRGSC3.4
Celera1914,077,873 - 14,078,060UniSTS
Cytogenetic Map19p11UniSTS
PMC18111P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01915,542,958 - 15,543,107NCBIRnor6.0
Rnor_5.01926,629,915 - 26,630,064UniSTSRnor5.0
RGSC_v3.41915,246,223 - 15,246,372UniSTSRGSC3.4
Celera1914,077,953 - 14,078,102UniSTS
Cytogenetic Map19p11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124933090Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127635288Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19129558305Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19129558305Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19132379055Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19138221845Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19138221845Rat
9590090Insglur8