Mmp2 (matrix metallopeptidase 2) - Rat Genome Database

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Gene: Mmp2 (matrix metallopeptidase 2) Rattus norvegicus
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Symbol: Mmp2
Name: matrix metallopeptidase 2
RGD ID: 621316
Description: Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in extracellular space. Used to study artery disease (multiple); conjunctivitis; proteinuria; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2); PARTICIPATES IN syndecan signaling pathway; gonadotropin-releasing hormone signaling pathway; urinary bladder cancer pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 72 kDa gelatinase; 72 KDa type IV collagenase; gelatinase A; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase-2; MMP-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Mmp2em2Mcwi  
Genetic Models: SS-Mmp2em1Mcwi-/- SS-Mmp2em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,327,643 - 30,355,856 (-)NCBIGRCr8
mRatBN7.21914,154,657 - 14,182,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,850,377 - 15,877,927 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01921,045,167 - 21,072,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,990,811 - 24,019,370 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,542,771 - 15,570,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,629,728 - 26,658,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,246,036 - 15,275,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1914,077,766 - 14,105,839 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IDA,IEP,ISO)
Acute Lung Injury  (IEP)
acute necrotizing pancreatitis  (IEP)
Acute Otitis Media  (ISO)
adrenoleukodystrophy  (ISO)
alcohol use disorder  (IEP)
alcoholic liver cirrhosis  (ISO)
Alveolar Bone Loss  (IEP)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aortic disease  (ISO)
aortic dissection  (ISO)
Aortic Rupture  (ISO)
aortic valve disease 2  (ISO)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IEP,ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
bone disease  (ISO)
Bone Neoplasms  (ISO)
brain ischemia  (IEP)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IEP)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chlamydophila Infections  (ISO)
cholangiocarcinoma  (IEP,ISO)
cholestasis  (IEP)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IDA,ISO)
Chronic Periodontitis  (IDA,ISO)
colon adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (IEP,ISO)
congestive heart failure  (IEP,ISO)
conjunctivitis  (IDA)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous leishmaniasis  (ISO)
Diabetic Nephropathies  (IEP,IMP)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Embolism  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (IEP)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (IEP,ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
extrahepatic cholestasis  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (IEP)
focal segmental glomerulosclerosis  (IEP)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (IEP)
genetic disease  (ISO)
glioblastoma  (ISO)
Gouty Arthritis  (ISO)
Graft Occlusion, Vascular  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
high grade glioma  (IEP)
Hydatidiform Mole  (ISO)
Hyperoxia  (IEP)
Hyperplasia  (IEP)
hypertension  (IEP,ISO)
Hypertensive Nephropathy  (IMP)
hypertrophic cardiomyopathy  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (IEP,ISO)
ischemia  (ISO)
Joubert syndrome 1  (ISO)
keratoconus  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (IDA)
leiomyoma  (ISO)
liver cirrhosis  (IEP,ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
Malignant Pleural Effusions  (ISO)
Mandibular Diseases  (ISO)
Marfan syndrome  (ISO)
Maxillary Diseases  (ISO)
Metabolic Bone Diseases  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocarditis  (ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neointima  (IEP,ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IEP,ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
Nose Neoplasms  (ISO)
ocular hypertension  (IEP)
Oral Lichen Planus  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteolysis  (ISO)
Osteolysis Hereditary Multicentric  (ISO)
osteonecrosis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (IEP)
Pneumococcal Meningitis  (IMP)
polycystic ovary syndrome  (IEP)
Polypoidal Choroidal Vasculopathy  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (IEP)
prostate cancer  (ISO)
proteinuria  (IMP)
pseudoxanthoma elasticum  (ISO)
pterygium  (ISO)
pulmonary embolism  (IDA)
pulmonary emphysema  (IEP,ISO)
pulmonary fibrosis  (ISO)
Puromycin Aminonucleoside Nephrosis  (IEP)
pyoderma gangrenosum  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (IDA)
respiratory syncytial virus infectious disease  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (IEP)
Sepsis  (IMP)
skin melanoma  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
stomach carcinoma  (IEP)
Stroke  (IEP,ISO)
Sturge-Weber syndrome  (ISO)
Subarachnoid Hemorrhage  (IDA)
Sweet syndrome  (ISO)
temporal arteritis  (ISO)
Testicular Germ Cell Tumor  (ISO)
thoracic aortic aneurysm  (IEP,ISO)
transient cerebral ischemia  (IDA,IEP)
transitional cell carcinoma  (ISO)
traumatic brain injury  (IEP)
tropical spastic paraparesis  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (IEP,ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (IEP)
Venous Thrombosis  (IDA,IEP)
Weight Gain  (ISO)
Winchester syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-hydroxy-1-norresistomycin  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3-hydroxypicolinic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP,ISO)
9,10-phenanthroquinone  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
ageladine A  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allyl isothiocyanate  (ISO)
alpha-D-galactose  (EXP)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
aluminium atom  (EXP)
aluminium oxide  (ISO)
aluminium(0)  (EXP)
AM-251  (ISO)
ambroxol  (EXP)
amitrole  (ISO)
ammonium chloride  (EXP)
anagliptin  (ISO)
andrographolide  (ISO)
anethole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arecoline  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
astemizole  (EXP)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
Bacoside a  (EXP)
baicalein  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
beta-aminopropionitrile  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP)
betulin  (EXP)
betulinic acid  (EXP,ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
brazilein  (ISO)
brucine  (ISO)
bucladesine  (ISO)
bufalin  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium dichloride  (EXP,ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capecitabine  (ISO)
capsaicin  (EXP,ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carvedilol  (EXP,ISO)
carvone  (ISO)
casticin  (ISO)
celastrol  (EXP)
celecoxib  (EXP,ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
Chebulagic acid  (EXP)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chitosan  (EXP)
chlordecone  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciprofloxacin  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (EXP)
columbamine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin B  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (EXP)
deguelin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP,ISO)
Dictamnine  (ISO)
dieckol  (ISO)
diethyl maleate  (EXP)
dihydroartemisinin  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (ISO)
diosgenin  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP,ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
embelin  (ISO)
emetine  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP,ISO)
excitatory amino acid agonist  (ISO)
farrerol  (EXP)
fenbendazole  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferrichrome  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (ISO)
flavonol  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
fosinopril  (ISO)
fructose  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galactose  (EXP)
gallic acid  (EXP,ISO)
Garcinol  (ISO)
gatifloxacin  (EXP)
Genipin  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
Geraniin  (ISO)
geraniol  (EXP)
gingerol  (ISO)
Ginkgoic acid  (ISO)
ginsenoside Rg1  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Gly-His-Lys  (EXP)
glycidol  (EXP)
glycyrrhizinic acid  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
harmaline  (ISO)
heparin  (ISO)
hesperidin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hinokiflavone  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (EXP)
ICI 118551  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irigenin  (ISO)
irinotecan  (ISO)
iron trichloride  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
JTE-013  (ISO)
juglone  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
lasofoxifene  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (EXP)
letrozole  (ISO)
leuprolide  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (EXP)
lithocholic acid  (ISO)
loliolide  (ISO)
lomefloxacin  (EXP)
losartan  (EXP,ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mannuronic acid  (EXP)
marimastat  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
Methanandamide  (ISO)
methotrexate  (EXP)
methyl caffeate  (ISO)
methylcobalamin  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoprolol  (EXP,ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP,ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
morin  (EXP)
morusin  (ISO)
moxifloxacin  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naproxen  (EXP)
naringin  (ISO)
Neferine  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitroglycerin  (ISO)
Nonylphenol  (ISO)
NORCANTHARIDIN  (ISO)
norfloxacin  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
oridonin  (ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-cresol  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (EXP,ISO)
phenanthrolines  (EXP)
phenethyl caffeate  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phosphatidylcholine  (EXP)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirfenidone  (EXP)
piroxicam  (ISO)
platycodin D  (EXP)
plumbagin  (ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prazosin  (EXP)
prednisolone  (EXP)
prinomastat  (ISO)
probucol  (ISO)
progesterone  (ISO)
propanal  (ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ramipril  (EXP)
razoxane  (EXP)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rhodotorulic acid  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
S-adenosyl-L-homocysteine  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (EXP)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
sanguinarine  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
scoparone  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silibinin  (EXP,ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium silicate  (EXP)
solasodine  (ISO)
Sophoricoside  (ISO)
sorafenib  (ISO)
sparfloxacin  (EXP)
sphingosine 1-phosphate  (ISO)
squalene  (EXP)
streptozocin  (EXP,ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
taurocholic acid  (ISO)
tebuconazole  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
terazosin  (EXP)
terbinafine  (ISO)
testosterone  (EXP)
tetracaine  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
thyroxine  (EXP)
titanium atom  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
tomatidine  (ISO)
Tomentosin  (ISO)
topotecan  (EXP)
trans-anethole  (ISO)
trans-cinnamic acid  (ISO)
trans-rhaponticin  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triciribine  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropisetron  (EXP)
tyrphostin AG 1478  (ISO)
ubiquinone-0  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (EXP,ISO)
Ursonic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
varespladib methyl  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEP)
blood vessel maturation  (IEA,ISO)
bone trabecula formation  (IEA,ISO)
cell migration  (IMP)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to cytokine stimulus  (IEP)
cellular response to estradiol stimulus  (IMP)
cellular response to fluid shear stress  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to reactive oxygen species  (IEA,ISO)
cellular response to UV-A  (IEA,ISO,ISS)
collagen catabolic process  (IBA,IDA,IEA,ISO)
embryo implantation  (IEA,ISO)
endodermal cell differentiation  (IEA,ISO)
extracellular matrix organization  (IBA,IEA)
face morphogenesis  (IEA,ISO)
female pregnancy  (IEP)
heart development  (IDA)
intramembranous ossification  (IEA,ISO)
luteinization  (IEP)
macrophage chemotaxis  (IDA)
negative regulation of cell adhesion  (IDA)
negative regulation of vasoconstriction  (IDA)
ovarian follicle development  (IDA)
ovulation from ovarian follicle  (IEP)
parturition  (IEP)
peripheral nervous system axon regeneration  (IDA)
positive regulation of apoptotic process  (IDA)
positive regulation of cell migration  (IMP)
positive regulation of innate immune response  (ISO)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IMP)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
prostate gland epithelium morphogenesis  (IMP)
protein catabolic process  (IDA)
proteolysis  (IDA,IEA,ISO)
response to activity  (IEP)
response to amyloid-beta  (IEA,ISO)
response to cytokine  (IEP)
response to electrical stimulus  (IEP)
response to estrogen  (IDA)
response to hydrogen peroxide  (IDA)
response to hyperoxia  (IEP)
response to hypoxia  (IBA,IDA,IEA,ISO)
response to mechanical stimulus  (IDA)
response to nicotine  (IEP)
response to oxidative stress  (IDA)
response to retinoic acid  (IEP)
response to xenobiotic stimulus  (IDA,IEP)
skeletal system morphogenesis  (ISO)
tissue remodeling  (IBA,IDA,IEA)

Cellular Component
cytoplasm  (ISO)
extracellular matrix  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)
mitochondrion  (ISO)
nucleus  (IEA)
plasma membrane  (IEA,ISO)
sarcomere  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration. Abdul-Muneer PM, etal., Brain Behav Immun. 2017 Jan;59:190-199. doi: 10.1016/j.bbi.2016.09.002. Epub 2016 Sep 7.
2. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
3. Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
4. Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Alfonso-Jaume MA, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1838-46. Epub 2006 May 12.
5. Downregulation of remodelling enzymatic activity induced by an angiotensin-converting enzyme inhibitor (perindopril) reduces the degeneration of experimental abdominal aortic aneurysms in a rat model. Alsac JM, etal., Eur J Vasc Endovasc Surg. 2011 Apr;41(4):474-80. doi: 10.1016/j.ejvs.2010.12.007. Epub 2011 Jan 20.
6. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
7. Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
8. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
9. Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats. Barichello T, etal., Exp Biol Med (Maywood). 2014 Feb;239(2):225-31. doi: 10.1177/1535370213508354. Epub 2014 Jan 13.
10. Delayed cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-alpha activation in rat hearts subjected to global ischaemia-reperfusion. Barlaka E, etal., Can J Physiol Pharmacol. 2013 Aug;91(8):608-16. doi: 10.1139/cjpp-2012-0412. Epub 2013 Mar 3.
11. The involvement of oxidants and NF-kappaB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. Ben-David D, etal., Inflamm Res. 2012 Jul;61(7):673-88. doi: 10.1007/s00011-012-0461-7. Epub 2012 Mar 13.
12. Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy. Beranek M, etal., Mol Vis. 2008 Jun 14;14:1114-21.
13. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Bergman MR, etal., Biochem J 2003 Feb 1;369(Pt 3):485-96.
14. Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. Bhattacharyya SS, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Jul;8(7):645-54.
15. Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium. Bogusiewicz M, etal., Gynecol Endocrinol. 2007 Sep;23(9):541-6.
16. Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are prognostic factors in cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV) or virus persistence after treatment of CIN. Branca M, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1543-56.
17. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
18. MMP-2 regulates rat ventral prostate development in vitro. Bruni-Cardoso A, etal., Dev Dyn. 2010 Mar;239(3):737-46.
19. Stromal remodelling is required for progressive involution of the rat ventral prostate after castration: Identification of a matrix metalloproteinase-dependent apoptotic wave. Bruni-Cardoso A, etal., Int J Androl. 2009 Nov 10.
20. Vascular extracellular matrix remodeling in cerebral aneurysms. Bruno G, etal., J Neurosurg. 1998 Sep;89(3):431-40.
21. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
22. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
23. Remodeling of experimental arteriovenous fistula with increased matrix metalloproteinase expression in rats. Chan CY, etal., J Vasc Surg. 2007 Apr;45(4):804-11.
24. Effects of hypoxia, hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 in hepatic stellate cells. Chen PS, etal., World J Gastroenterol 2001 Oct;7(5):647-51.
25. Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. Chen Y, etal., Eur Respir J. 2010 Apr;35(4):904-12. Epub 2009 Nov 6.
26. Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Cheng S, etal., Biochem J 2002 Sep 15;366(Pt 3):807-16.
27. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis. Cheung C, etal., Cardiovasc Pathol. 2006 Mar-Apr;15(2):63-74.
28. Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion. Cho KO, etal., J Neurosci Res. 2006 Feb 1;83(2):285-91.
29. Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis. Choi EY, etal., Exp Mol Med. 2002 Dec 31;34(6):391-400.
30. Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma. Christopoulos TA, etal., Oncol Rep. 2007 Oct;18(4):855-60.
31. The clinical significance of gelatinase B in gouty arthritis of the knee. Chu SC, etal., Clin Chim Acta. 2004 Jan;339(1-2):77-83.
32. Regulation of collagen degradation in the rat myocardium after infarction. Cleutjens JP, etal., J Mol Cell Cardiol. 1995 Jun;27(6):1281-92.
33. Thrombus versus Wall Biological Activities in Experimental Aortic Aneurysms. Coutard M, etal., J Vasc Res. 2009 Dec 16;47(4):355-366.
34. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Covington MD, etal., Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51. Epub 2005 Aug 2.
35. Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. Dahi S, etal., J Vasc Surg. 2005 Sep;42(3):539-45.
36. Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood-brain barrier dysfunction in an animal model of severe sepsis. Dal-Pizzol F, etal., Mol Neurobiol. 2013 Aug;48(1):62-70. doi: 10.1007/s12035-013-8433-7. Epub 2013 Mar 12.
37. Calcaneal tendon regions exhibit different MMP-2 activation after vertical jumping and treadmill running. De Mello Malheiro OC, etal., Anat Rec (Hoboken). 2009 Oct;292(10):1656-62.
38. Matrix metalloproteinase-2 promoter polymorphism is associated with breast cancer in a Mexican population. Delgado-Enciso I, etal., Gynecol Obstet Invest. 2008;65(1):68-72. Epub 2007 Sep 13.
39. Characterisation of matrix metalloproteinases and the effects of a broad-spectrum inhibitor (BB-1101) in peripheral nerve regeneration. Demestre M, etal., Neuroscience. 2004;124(4):767-79.
40. Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in diabetic and healthy subjects. Derosa G, etal., Diabetes Metab. 2007 Apr;33(2):129-34. Epub 2007 Feb 22.
41. Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension. Derosa G, etal., Endothelium. 2006 May-Jun;13(3):227-31.
42. Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions. Di Carlo A, etal., Oncol Rep. 2007 Aug;18(2):425-31.
43. Nonstenotic bicuspid aortic valve is associated with elevated plasma asymmetric dimethylarginine. Drapisz S, etal., J Cardiovasc Med (Hagerstown). 2013 Jun;14(6):446-52. doi: 10.2459/JCM.0b013e3283588dfa.
44. Effect of a specific endothelin receptor A antagonist and an angiotensin-converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis. Ebihara I, etal., Nephrol Dial Transplant. 1997 May;12(5):1001-6.
45. Noninvasive diagnosis of bladder cancer by detection of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitor (TIMP-2) in urine. Eissa S, etal., Eur Urol. 2007 Nov;52(5):1388-96. Epub 2007 Apr 10.
46. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
47. Changes in the expression of MMP2, MMP9, and ColIV in stromal cells in oral squamous tongue cell carcinoma: relationships and prognostic implications. Fan HX, etal., J Exp Clin Cancer Res. 2012 Oct 29;31:90. doi: 10.1186/1756-9966-31-90.
48. Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells. Fan WH and Karnovsky MJ, J Biol Chem 2002 Mar 22;277(12):9800-5.
49. MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS. Fang L, etal., J Neurol Sci. 2010 Jul 15;294(1-2):51-6. doi: 10.1016/j.jns.2010.04.005. Epub 2010 May 4.
50. The study of ISO induced heart failure rat model. Feng W and Li W, Exp Mol Pathol. 2010 Apr;88(2):299-304. Epub 2009 Nov 10.
51. Azithromycin reduces inflammation in a rat model of acute conjunctivitis. Fernandez-Robredo P, etal., Mol Vis. 2013;19:153-65. Epub 2013 Jan 28.
52. MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. Filippov S, etal., J Exp Med. 2005 Sep 5;202(5):663-71.
53. The role of matrix metalloproteinases 2 and 9 during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Fracalossi AC, etal., J Mol Histol. 2010 Feb;41(1):19-25. Epub 2010 Mar 6.
54. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
55. Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease. Friese RS, etal., Clin Exp Hypertens. 2009 Oct;31(7):521-33. doi: 10.3109/10641960802668730.
56. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Ganguly K, etal., Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30.
57. Dynamic changes of matrix metalloproteinases in rat liver during the development of diethylnitrosamine-induced hepatocarcinoma. Gao Y, etal., Di Yi Jun Yi Da Xue Xue Bao 2002 Oct;22(10):865-8.
58. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
59. Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26.
60. Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of metalloproteinase-1 predicts outcome in patients with congestive heart failure. George J, etal., Am Heart J. 2005 Sep;150(3):484-7.
61. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
62. Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions. Graesslin O, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1911-7.
63. Fetal MMP2/MMP9 polymorphisms and intrauterine growth restriction risk. Gremlich S, etal., J Reprod Immunol. 2007 Jun;74(1-2):143-51. Epub 2007 Mar 23.
64. Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. Gress TM, etal., Int J Cancer. 1995 Aug 9;62(4):407-13.
65. Chinese yellow wine and red wine inhibit matrix metalloproteinase-2 and improve atherosclerotic plaque in LDL receptor knockout mice. Guo H, etal., Cardiovasc Ther. 2010 Jun;28(3):161-8. doi: 10.1111/j.1755-5922.2009.00132.x. Epub 2010 Mar 31.
66. Tissue-specific enhancer-promoter interactions regulate high level constitutive expression of matrix metalloproteinase 2 by glomerular mesangial cells. Harendza S, etal., J Biol Chem 1995 Aug 11;270(32):18786-96.
67. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. He H, etal., Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
68. Induction of Matrix Metalloproteinase-2 Enhances Systemic Vasoconstriction after Hypoxia. He JZ, etal., Am J Physiol Heart Circ Physiol. 2006 Sep 15;.
69. Interstitial fibrosis in the heart: differences in extracellular matrix proteins and matrix metalloproteinases in end-stage dilated, ischaemic and valvular cardiomyopathy. Herpel E, etal., Histopathology. 2006 May;48(6):736-47.
70. Matrix metalloproteinase 2 polymorphisms in a caucasian population with abdominal aortic aneurysm. Hinterseher I, etal., J Surg Res. 2006 Jun 15;133(2):121-8. Epub 2006 Feb 3.
71. Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and Diabetes-Induced Nephropathy. Hirata T, etal., J Cardiovasc Pharmacol. 2023 Aug 25. doi: 10.1097/FJC.0000000000001473.
72. Matrix metalloproteinase-2 and epidermal growth factor are decreased in platelets of Alzheimer patients. Hochstrasser T, etal., Curr Alzheimer Res. 2012 Oct;9(8):982-9.
73. Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization. Hosford GE, etal., Pediatr Res. 2004 Jul;56(1):26-34. Epub 2004 May 5.
74. Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Hosomi N, etal., Neuroscience. 2005;134(1):225-31.
75. Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis. Hsu CC and Lai SC, Int J Exp Pathol. 2007 Dec;88(6):437-43.
76. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
77. Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms. Ikonomidis JS, etal., Circulation. 2005 Aug 30;112(9 Suppl):I242-8.
78. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
79. Interleukin-1beta enhanced action of kinins on extracellular matrix of spontaneous hypertensive rat cardiac fibroblasts. Imai C, etal., Clin Exp Hypertens 2005 Jan;27(1):59-69.
80. Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Iniesta P, etal., Oncol Rep. 2007 Jan;17(1):217-23.
81. Evidence for the involvement of matrix metalloproteinases in the cardiovascular effects produced by nicotine. Jacob-Ferreira AL, etal., Eur J Pharmacol. 2010 Feb 10;627(1-3):216-22. Epub 2009 Oct 30.
82. Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma. Jan YY, etal., Ann Surg. 2004 Jul;240(1):89-94.
83. Membrane type 1-matrix metalloproteinase (MMP)-associated MMP-2 activation increases in the rat ovary in response to an ovulatory dose of human chorionic gonadotropin. Jo M, etal., Biol Reprod. 2004 Apr;70(4):1024-32. Epub 2003 Dec 10.
84. Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. Johanns M, etal., Sci Rep. 2017 Jun 28;7(1):4328. doi: 10.1038/s41598-017-04648-y.
85. Matrix metalloproteinases are down-regulated in rat lenses exposed to oxidative stress. John M, etal., Exp Eye Res. 2004 Dec;79(6):839-46.
86. Magnetic brain stimulation upregulates adhesion and prevents Eae: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target. Jovanova-Nesic K, etal., Int J Neurosci. 2009;119(9):1399-418.
87. Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer. Juuti A, etal., Oncology. 2006;71(1-2):61-8. Epub 2007 Mar 21.
88. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
89. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Kassiri Z, etal., Circ Res. 2005 Aug 19;97(4):380-90. Epub 2005 Jul 21.
90. Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. Kawata N, etal., Urology. 2007 Jun;69(6):1049-53.
91. Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
92. Aortic adaptation to pregnancy: elevated expression of matrix metalloproteinases-2 and -3 in rat gestation. Kelly BA, etal., Mol Hum Reprod. 2004 May;10(5):331-7. Epub 2004 Mar 25.
93. The imbalanced expression of matrix metalloproteinases in nephrogenic systemic fibrosis. Kelly BC, etal., J Am Acad Dermatol. 2010 Sep;63(3):483-9. doi: 10.1016/j.jaad.2009.09.006.
94. Role of TGF-beta1, extracellular matrix, and matrix metalloproteinase in the healing process of the pancreas after induction of acute necrotizing pancreatitis using arginine in rats. Kihara Y, etal., Pancreas. 2001 Oct;23(3):288-95.
95. PAF enhances MMP-2 production in rat aortic VSMCs via a beta-arrestin2-dependent ERK signaling pathway. Kim YH, etal., J Lipid Res. 2013 Oct;54(10):2678-86. doi: 10.1194/jlr.M037176. Epub 2013 Aug 2.
96. Immunohistochemical changes in matrix metalloproteinase-2 and 9 during small bowel allograft rejection in rats. Kimizuka K, etal., Transplant Proc 2002 May;34(3):1047-8.
97. Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy. Kizaki K, etal., Biol Pharm Bull. 2005 Dec;28(12):2331-4.
98. Low serum level of pro-matrix metalloproteinase 2 correlates with aggressive behavior in breast carcinoma. Kuvaja P, etal., Hum Pathol. 2006 Oct;37(10):1316-23. Epub 2006 Jul 26.
99. Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) inhibits experimental choroidal neovascularization in vivo and VEGF-induced cell migration and tube formation in vitro. Lai K, etal., Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5702-12. doi: 10.1167/iovs.10-6370.
100. Preconditioning decreases ischemia/reperfusion-induced release and activation of matrix metalloproteinase-2. Lalu MM, etal., Biochem Biophys Res Commun 2002 Aug 30;296(4):937-41.
101. Melissa officinalis extract inhibits laser-induced choroidal neovascularization in a rat model. Lee EK, etal., PLoS One. 2014 Oct 14;9(10):e110109. doi: 10.1371/journal.pone.0110109. eCollection 2014.
102. Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats. Lee MF, etal., Food Chem. 2013 Jun 1;138(2-3):802-7. doi: 10.1016/j.foodchem.2012.11.094. Epub 2012 Dec 1.
103. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
104. The role of matrix metalloproteinases in extracellular matrix remodelling in chronic obstructive pulmonary disease rat models Li H, etal., Zhonghua Nei Ke Za Zhi 2002 Jun;41(6):393-8.
105. Prognostic value of matrix metalloproteinases (MMP-2 and MMP-9) in patients with lymph node-negative breast carcinoma. Li HC, etal., Breast Cancer Res Treat. 2004 Nov;88(1):75-85.
106. Effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice. Li W and Shen HH, Chin Med J (Engl). 2007 Jan 5;120(1):5-11.
107. [Retinoic acid diminished the expression of lung tissue matrix metalloproteinase-2 and matrix metalloproteinase-9 in hyperoxia-exposed premature rats through regulating mitogen-activated protein kinases]. Li WB, etal., Zhonghua Er Ke Za Zhi. 2008 May;46(5):347-53.
108. [Effects of unfractionated heparin on expression of metalloproteinase-2 and -9 in acute lung injury rats]. Li X, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Oct;24(10):608-11.
109. [Association of SNPs in the promoter of MMP-2 and TIMP-2 genes with epithelial ovarian cancer.] Li XL, etal., Yi Chuan. 2008 Apr;30(4):455-62.
110. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
111. Early activation of myocardial matrix metalloproteinases and degradation of cardiac troponin I after experimental subarachnoid hemorrhage. Lin NN, etal., J Surg Res. 2013 Jan;179(1):e41-8. doi: 10.1016/j.jss.2012.02.008. Epub 2012 Mar 28.
112. Distinct expression of gelatinase A [matrix metalloproteinase (MMP)-2], collagenase-3 (MMP-13), membrane type MMP 1 (MMP-14), and tissue inhibitor of MMPs type 1 mediated by physiological signals during formation and regression of the rat corpus luteum. Liu K, etal., Endocrinology. 1999 Nov;140(11):5330-8.
113. [Influence of periodontal therapy on serum interleukin-6 and carotid metalloproteinases in animals with chronic periodontitis associated with atherosclerosis]. Liu Y, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2014 Mar;49(3):155-60.
114. Evidence that MMP-2 and TIMP-2 are at play in the FSH-induced changes in Sertoli cells. Longin J and Le Magueresse-Battistoni B, Mol Cell Endocrinol 2002 Mar 28;189(1-2):25-35.
115. Elevated expression of both MDR1 and MMP-2 genes in metastasized lymph node of invasive ductal breast cancer. Lu LS, etal., Eur Rev Med Pharmacol Sci. 2012 Dec;16(15):2037-43.
116. Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. Machado LS, etal., BMC Neurosci. 2006 Jul 17;7:56.
117. 17beta-Estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts. Mahmoodzadeh S, etal., Cardiovasc Res. 2010 Mar 1;85(4):719-28. Epub 2009 Oct 27.
118. Matrix metalloproteinases and their impact on sinusal extension in chronic rhinosinusitis with nasal polyps. Malinsky RR, etal., Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1345-8. doi: 10.1007/s00405-012-2219-9. Epub 2012 Oct 12.
119. Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Manase K, etal., Reprod Biol Endocrinol. 2006 Jun 2;4:32.
120. Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. Manikandan P, etal., Life Sci. 2010 Apr 29.
121. Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats. Mao JW, etal., World J Gastroenterol. 2012 Dec 21;18(47):7063-9. doi: 10.3748/wjg.v18.i47.7063.
122. Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression. Maretti-Mira AC, etal., Clin Exp Immunol. 2011 Feb;163(2):207-14. doi: 10.1111/j.1365-2249.2010.04285.x. Epub 2010 Nov 22.
123. Homology cloning of rat 72 kDa type IV collagenase: cytokine and second-messenger inducibility in glomerular mesangial cells. Marti HP, etal., Biochem J 1993 Apr 15;291 ( Pt 2):441-6.
124. Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis. Martinez-Torres FJ, etal., Neurosci Lett. 2004 Sep 30;368(3):274-8.
125. Inflammatory cells, cytokines and matrix metalloproteinases in amicrobial pustulosis of the folds and other neutrophilic dermatoses. Marzano AV, etal., Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2):451-60.
126. Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas. Matsuyama Y, etal., J Surg Oncol. 2002 Jun;80(2):105-10.
127. Basal membrane remodeling during follicle histogenesis in the rat ovary: contribution of proteinases of the MMP and PA families. Mazaud S, etal., Dev Biol. 2005 Jan 15;277(2):403-16.
128. Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis. Medina C, etal., Am J Physiol Gastrointest Liver Physiol 2003 Jan;284(1):G116-22.
129. Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Mendes O, etal., Clin Exp Metastasis. 2005;22(3):237-46.
130. Combinatorial interactions of p53, activating protein-2, and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells. Mertens PR, etal., J Biol Chem 2002 Jul 12;277(28):24875-82.
131. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
132. Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency. Misra S, etal., J Vasc Interv Radiol. 2010 Aug;21(8):1255-61. doi: 10.1016/j.jvir.2010.02.043. Epub 2010 Jul 3.
133. Terazosin modifies the content of glycosaminoglycans and the activity of matrix metalloproteinase 2 in the rat ventral prostate. Mitropoulos D, etal., Eur Urol. 2007 Feb;51(2):447-56; discussion 456. Epub 2006 Jul 5.
134. Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. Miyake JA, etal., Lipids Health Dis. 2009 Mar 17;8:8. doi: 10.1186/1476-511X-8-8.
135. Temporal expression and activation of matrix metalloproteinases-2, -9, and membrane type 1-matrix metalloproteinase following acute hindlimb ischemia. Muhs BE, etal., J Surg Res. 2003 May 1;111(1):8-15.
136. Black tea polyphenols target matrix metalloproteinases, RECK, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model. Murugan RS, etal., Anticancer Res. 2009 Jun;29(6):2301-5.
137. Expression of matrix metalloproteinase-9 associated with ets-1 proto-oncogene in rat tubulointerstitial cells. Naito T, etal., Nephrol Dial Transplant. 2005 Nov;20(11):2333-48. Epub 2005 Jul 26.
138. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. Nakano A, etal., J Neurosurg. 1995 Aug;83(2):298-307.
139. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
140. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
141. Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Niebroj-Dobosz I, etal., Eur J Neurol. 2010 Feb;17(2):226-31. doi: 10.1111/j.1468-1331.2009.02775.x. Epub 2009 Oct 1.
142. Matrix metalloproteinases with gelatinolytic activity induced by Paracoccidioides brasiliensis infection. Nishikaku AS, etal., Int J Exp Pathol. 2009 Oct;90(5):527-37. doi: 10.1111/j.1365-2613.2009.00663.x.
143. Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy. Noda K, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):2163-70.
144. Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers. Norgauer J, etal., Br J Dermatol. 2002 Dec;147(6):1180-6.
145. Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. O'Brien J, etal., Am J Pathol. 2010 Mar;176(3):1241-55. Epub 2010 Jan 28.
146. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
147. High numbers of human skin cancers express MMP2 and several integrin genes. Orimoto AM, etal., J Cutan Pathol. 2008 Mar;35(3):285-91. doi: 10.1111/j.1600-0560.2007.00810.x.
148. Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas. Orlandi A, etal., Am J Pathol. 2005 Jun;166(6):1619-28.
149. The relation between keratoconus and plasma levels of MMP-2, zinc, and SOD. Ortak H, etal., Cornea. 2012 Sep;31(9):1048-51. doi: 10.1097/ICO.0b013e318254c028.
150. Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion. Ortak H, etal., Exp Eye Res. 2013 Aug;113:151-5. doi: 10.1016/j.exer.2013.06.009. Epub 2013 Jun 18.
151. The role of MMP2 (-1306C>T) and TIMP2 (-418 G>C) promoter variants in age-related macular degeneration. Ortak H, etal., Ophthalmic Genet. 2013 Dec;34(4):217-22. doi: 10.3109/13816810.2013.781192. Epub 2013 Mar 28.
152. The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. Pannu H, etal., J Neurosurg. 2006 Sep;105(3):418-23.
153. Induction of secretory leukocyte protease inhibitor (SLPI) in estradiol valerate (EV) induced polycystic ovary. Park JJ, etal., Arch Pharm Res. 2011 Aug;34(8):1389-97. doi: 10.1007/s12272-011-0820-x. Epub 2011 Sep 11.
154. Serum MMP-2 and MMP-9 in patients with Behcet's disease: do their higher levels correlate to vasculo-Behcet's disease associated with aneurysm formation? Pay S, etal., Clin Exp Rheumatol. 2007 Jul-Aug;25(4 Suppl 45):S70-5.
155. Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China. Peihong S and Perry F, Ethiop Med J. 2007 Jan;45(1):79-83.
156. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
157. Expression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placenta. Petignat P, etal., Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1679-84.
158. Stretching and electrical stimulation regulate the metalloproteinase-2 in rat denervated skeletal muscle. Peviani SM, etal., Neurol Res. 2009 Aug 5.
159. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
160. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
161. Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia. Planas AM, etal., Neurobiol Dis. 2001 Oct;8(5):834-46.
162. ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. Podesser BK, etal., Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H984-91.
163. Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction. Polewicz D, etal., J Cell Mol Med. 2010 May 26.
164. Atrial extracellular matrix remodelling in patients with atrial fibrillation. Polyakova V, etal., J Cell Mol Med. 2008 Jan-Feb;12(1):189-208. doi: 10.1111/j.1582-4934.2008.00219.x. Epub 2008 Jan 10.
165. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
166. Fluid shear stress regulates the invasive potential of glioma cells via modulation of migratory activity and matrix metalloproteinase expression. Qazi H, etal., PLoS One. 2011;6(5):e20348. doi: 10.1371/journal.pone.0020348. Epub 2011 May 26.
167. Morphological changes of cerebral vessels and expression patterns of MMP-2 and MMP-9 on cerebrovascular wall of alcoholic rats. Qi Q, etal., Int J Clin Exp Pathol. 2014 Apr 15;7(5):1880-8. eCollection 2014.
168. Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis. Qin YH, etal., Pediatr Nephrol. 2009 Aug;24(8):1477-86. Epub 2009 Apr 9.
169. MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides. Raffetto JD, etal., J Surg Res. 2010 Apr;159(2):755-64. Epub 2008 Oct 24.
170. Temperospatial expression of matrix metalloproteinases 1, 2, 3, and 9 during early tooth development. Randall LE and Hall RC, Connect Tissue Res 2002;43(2-3):205-11.
171. Embryogenesis of the rat heart: the expression of collagenases. Ratajska A and Cleutjens JP, Basic Res Cardiol. 2002 May;97(3):189-97.
172. LncRNA H19 regulates smooth muscle cell functions and participates in the development of aortic dissection through sponging miR-193b-3p. Ren M, etal., Biosci Rep. 2021 Jan 29;41(1):BSR20202298. doi: 10.1042/BSR20202298.
173. MMP-2 and TIMP-2 in cutaneous melanoma: association with prognostic factors and description in cutaneous metastases. Rey MC, etal., Am J Dermatopathol. 2011 Jun;33(4):413-4. doi: 10.1097/DAD.0b013e3181e2e8d6.
174. GOA pipeline RGD automated data pipeline
175. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
176. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
177. Differential involvement of MMP-2 and VEGF during muscle stretch- versus shear stress-induced angiogenesis. Rivilis I, etal., Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1430-8.
178. Temporal changes in cardiac matrix metalloproteinase activity, oxidative stress, and TGF-beta in renovascular hypertension-induced cardiac hypertrophy. Rizzi E, etal., Exp Mol Pathol. 2013 Feb;94(1):1-9. doi: 10.1016/j.yexmp.2012.10.010. Epub 2012 Oct 13.
179. Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy. Roldan V, etal., Am Heart J. 2008 Jul;156(1):85-91.
180. A novel homozygous MMP2 mutation in a family with Winchester syndrome. Rouzier C, etal., Clin Genet. 2006 Mar;69(3):271-6.
181. The roles of matrix metalloproteinases-2, -7, -10 and tissue inhibitor of metalloproteinase-1 in the pathogenesis of oral lichen planus. Rubaci AH, etal., J Oral Pathol Med. 2012 Oct;41(9):689-96. doi: 10.1111/j.1600-0714.2012.01160.x. Epub 2012 May 3.
182. Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis. Sanders JS, etal., Am J Physiol Renal Physiol. 2007 Dec;293(6):F1927-34. Epub 2007 Sep 26.
183. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
184. Gelatinase expression and proteolytic activity in giant-cell arteritis. Segarra M, etal., Ann Rheum Dis. 2007 Nov;66(11):1429-35. Epub 2007 May 14.
185. Estrogen receptor alpha and matrix metalloproteinase 2 polymorphisms and age-related maculopathy in older women. Seitzman RL, etal., Am J Epidemiol. 2008 May 15;167(10):1217-25. doi: 10.1093/aje/kwn024. Epub 2008 Mar 20.
186. Antioxidant Vitamin C attenuates experimental abdominal aortic aneurysm development in an elastase-induced rat model. Shang T, etal., J Surg Res. 2014 May 1;188(1):316-25. doi: 10.1016/j.jss.2013.11.1105. Epub 2013 Dec 6.
187. Matrix metalloproteinase-2 contributes to tumor necrosis factor alpha induced apoptosis in cultured rat cardiac myocytes. Shen J, etal., Biochem Biophys Res Commun. 2006 Sep 8;347(4):1011-20. Epub 2006 Jul 12.
188. [Atorvastatin upregulates the expression of PPAR alpha/gamma and inhibits the hypertrophy of cardiac myocytes in vitro] Sheng L, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Dec;33(12):1080-4.
189. Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity. Shin HW, etal., Otolaryngol Head Neck Surg. 2009 Oct;141(4):442-7.
190. Immunohistochemical expression of vascular endothelial growth factor, matrix metalloproteinase 2, and matrix metalloproteinase 9 in cutaneous melanocytic lesions. Simonetti O, etal., Cancer. 2002 Nov 1;95(9):1963-70.
191. Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms. Sinha I, etal., Surgery. 2004 Aug;136(2):176-82.
192. Interactions of proteases, protease inhibitors, and the beta1 integrin/laminin gamma3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis. Siu MK and Cheng CY, Biol Reprod. 2004 Apr;70(4):945-64. Epub 2003 Nov 26.
193. Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Sivaramakrishnan V and Niranjali Devaraj S, Chem Biol Interact. 2009 Aug 14;180(3):353-9. Epub 2009 Feb 21.
194. Expression of matrix metalloproteases (MMP-2, MT1 -MMP) and their tissue inhibitor (TIMP-2) by rat sertoli cells in culture: implications for spermatogenesis. Slongo ML, etal., Biol Chem 2002 Jan;383(1):235-9.
195. Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms. Sluijter JP, etal., Stroke. 2006 Jan;37(1):235-9. Epub 2005 Dec 8.
196. Mechanisms regulating invasiveness and growth of endometriosis lesions in rat experimental model and in humans. Sotnikova NY, etal., Fertil Steril. 2010 May 15;93(8):2701-5. Epub 2010 Jan 8.
197. L-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9. Souza-Costa DC, etal., Chest. 2005 Nov;128(5):3705-10.
198. Urine vascular biomarkers in Sturge-Weber syndrome. Sreenivasan AK, etal., Vasc Med. 2013 Jun;18(3):122-8. doi: 10.1177/1358863X13486312.
199. Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder. Staack A, etal., BMC Urol. 2006 Aug 10;6:19.
200. 17beta-estradiol modulation of angiotensin II-stimulated response in cardiac fibroblasts. Stewart JA Jr, etal., J Mol Cell Cardiol. 2006 Jul;41(1):97-107. Epub 2006 Jun 12.
201. [mRNA expression analysis of metastatic markers in clear-cell renal cell carcinoma] Struckmann K, etal., Verh Dtsch Ges Pathol. 2005;89:178-83.
202. Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats. Sun H, etal., Diabetes Res Clin Pract. 2013 Apr;100(1):85-95. doi: 10.1016/j.diabres.2013.01.012. Epub 2013 Feb 4.
203. Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampus. Szklarczyk A, etal., J Neurosci 2002 Feb 1;22(3):920-30.
204. Serum levels of matrix metalloproteinases 2 and 9 and TGFBR2 gene screening in patients with ascending aortic dilatation. Símová J, etal., Folia Biol (Praha). 2013;59(4):154-61.
205. Age-related changes in the expression of gelatinase and tissue inhibitor of metalloproteinase genes in mandibular condylar, growth plate, and articular cartilage in rats. Takahashi I, etal., J Mol Histol. 2005 Jun;36(5):355-66. Epub 2005 Oct 6.
206. MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Tchetverikov I, etal., Ann Rheum Dis. 2004 Jul;63(7):881-3.
207. Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction. Thibert KA, etal., PLoS One. 2012;7(11):e50430. doi: 10.1371/journal.pone.0050430. Epub 2012 Nov 21.
208. Expression of metalloproteinase-2 (gelatinase A) in labial salivary glands of patients with Sjogren's syndrome with HTLV-I infection. Tominaga M, etal., Clin Exp Rheumatol. 1999 Jul-Aug;17(4):463-6.
209. Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry. Trudel D, etal., Hum Pathol. 2008 Mar 7;.
210. Serum levels of matrix metalloproteinase-2 as a marker of intimal hyperplasia. Tummers AM, etal., J Surg Res. 2010 May 1;160(1):9-13. Epub 2009 May 13.
211. Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. Umar S, etal., Pathol Res Pract. 2007;203(12):863-72. Epub 2007 Oct 29.
212. Effects of cisplatin on matrix metalloproteinase-2 in transformed thyroid cells. Urso L, etal., Biochem Pharmacol. 2010 Mar 15;79(6):810-6. Epub 2009 Oct 27.
213. Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer. Vaish V, etal., Cell Biochem Biophys. 2013 Jun;66(2):205-27. doi: 10.1007/s12013-012-9469-4.
214. Evaluation of molecular markers in a rat model of mammary carcinogenesis. Vinothini G, etal., Oncol Res. 2009;17(10):483-93.
215. Increased expression of matrix metalloproteinases in the murine zymosan-induced multiple organ dysfunction syndrome. Volman TJ, etal., J Pathol. 2004 Aug;203(4):968-75.
216. Matrix metalloproteinases and their inhibitors in different acute stroke subtypes. Vukasovic I, etal., Clin Chem Lab Med. 2006;44(4):428-34.
217. [Detection of the activity of MMP2 and MMP9 in middle ear cholesteatoma]. Wang H, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Oct;18(10):620-2.
218. [Expression of matrix metalloproteinase-2,9 in cholesteatoma from different positions]. Wang J and Yu LS, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;44(1):44-8.
219. Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging. Wang M and Lakatta EG, Hypertension 2002 Apr;39(4):865-73.
220. Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway. Wang TL, etal., J Mol Cell Cardiol. 2004 Sep;37(3):785-94.
221. Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury. Wang W, etal., Circulation 2002 Sep 17;106(12):1543-9.
222. Interleukin-lbeta Induces Migration of Rat Arterial Smooth Muscle Cells Through a Mechanism Involving Increased Matrix Metalloproteinase-2 Activity. Wang Z, etal., J Surg Res. 2010 Jan 5.
223. Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury. Webb KE, etal., Arterioscler Thromb Vasc Biol. 1997 Sep;17(9):1837-44.
224. Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families. Wojciechowski R, etal., Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4989-95. doi: 10.1167/iovs.10-5474. Epub 2010 May 19.
225. The expression of CD40-CD40L and activities of matrix metalloproteinases in atherosclerotic rats. Wu M and Li YG, Mol Cell Biochem. 2006 Jan;282(1-2):141-6.
226. Cariporide, a specific Na/H(+) exchanger 1 blocker, inhibits neointimal proliferation induced by advanced glycation end products in a balloon injury rat model. Wu S, etal., Pharmacology. 2013;91(3-4):123-30. doi: 10.1159/000346128. Epub 2013 Jan 23.
227. Prediction of prognosis in gallbladder carcinoma by CD147 and MMP-2 immunohistochemistry. Wu W, etal., Med Oncol. 2009;26(2):117-23. Epub 2008 Jul 30.
228. [Effects of ru'ai shuhou recipe on the matrix metalloproteinases and the inhibitive factors in the recurrence and metastasis of HER2 positive breast cancer]. Wu XQ, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Nov;32(11):1526-30.
229. Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome. Xiong W, etal., J Vasc Surg. 2008 Jan;47(1):166-72; discussion 172. doi: 10.1016/j.jvs.2007.09.016.
230. Effects of Acupuncture at GV20 and ST36 on the Expression of Matrix Metalloproteinase 2, Aquaporin 4, and Aquaporin 9 in Rats Subjected to Cerebral Ischemia/Reperfusion Injury. Xu H, etal., PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014.
231. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology Xu SL, etal., Zhonghua Yan Ke Za Zhi. 2009 Mar;45(3):260-5.
232. [Effect of interferon-gamma on transforming growth factor beta/Smad signal pathway and expression of matrix metalloproteinase-2 and tissue inhibitors of matrix metalloproteinase-2 in cultured rat mesangial cells] Xue AM, etal., Zhonghua Bing Li Xue Za Zhi. 2007 Jun;36(6):405-9.
233. Long-term overexpression of membrane type-1 matrix metalloproteinase and matrix metalloproteinase-2 in oleic acid-induced pancreatitis in rats. Yamaguchi T, etal., Pancreas 2002 May;24(4):348-56.
234. Adventitial transduction of lentivirus-shRNA-VEGF-A in arteriovenous fistula reduces venous stenosis formation. Yang B, etal., Kidney Int. 2014 Feb;85(2):289-306. doi: 10.1038/ki.2013.290. Epub 2013 Aug 7.
235. Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice. Yang B, etal., PLoS One. 2019 Feb 21;14(2):e0201504. doi: 10.1371/journal.pone.0201504. eCollection 2019.
236. Imbalance of matrix metalloproteinases/tissue inhibitor of metalloproteinase-1 and loss of fibronectin expression in patients with congestive heart failure. Yang DC, etal., Cardiology. 2010;116(2):133-41. doi: 10.1159/000317245. Epub 2010 Jul 1.
237. Effects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal cord edema after spinal cord injury. Yang J, etal., Life Sci. 2013 Dec 18;93(25-26):1033-8.
238. Increased expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts with disease progression and activation of protein kinase C. Yang SF, etal., Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4588-96. doi: 10.1167/iovs.08-3147. Epub 2009 May 6.
239. Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice. Yang Y, etal., Aging (Albany NY). 2019 Nov 22;11(22):10016-10030. doi: 10.18632/aging.102388. Epub 2019 Nov 22.
240. Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. Yang Y, etal., J Neurochem. 2010 Jan;112(1):134-49. Epub 2009 Oct 15.
241. The effect of corticosteroid on metalloproteinase levels of nasal polyposis. Yigit O, etal., Laryngoscope. 2011 Mar;121(3):667-73. doi: 10.1002/lary.21462. Epub 2011 Feb 8.
242. Nan fang yi ke da xue xue bao = Journal of Southern Medical University Yin CY, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Nov;29(11):2205-7.
243. Matrix metalloproteinase-2 in pancreatic juice for diagnosis of pancreatic cancer. Yokoyama M, etal., Pancreas. 2002 May;24(4):344-7.
244. Aging is associated with increased activities of matrix metalloproteinase-2 and -9 in tenocytes. Yu TY, etal., BMC Musculoskelet Disord. 2013 Jan 2;14:2. doi: 10.1186/1471-2474-14-2.
245. Analysis of MMP2 promoter polymorphisms in patients with pseudoxanthoma elasticum. Zarbock R, etal., Clin Chim Acta. 2010 Oct 9;411(19-20):1487-90. doi: 10.1016/j.cca.2010.06.006. Epub 2010 Jun 10.
246. Serum levels of matrix metalloproteinase 2 and matrix metalloproteinase 9 elevated in polypoidal choroidal vasculopathy but not in age-related macular degeneration. Zeng R, etal., Mol Vis. 2013;19:729-36. Epub 2013 Mar 21.
247. Expression of matrix metalloproteinase 2 and extracellular matrix metalloproteinase inducer are unfavorable postoperative prognostic factors in intrahepatic cholangiocarcinoma. Zhang C, etal., Pathol Oncol Res. 2010 Mar;16(1):47-53. Epub 2009 Jul 25.
248. [Expression of trophoblast invasion related genes mRNA and protein in human placenta in preeclampsia]. Zhang H, etal., Zhonghua Fu Chan Ke Za Zhi. 2006 Aug;41(8):509-13.
249. rAAV2-TGF-beta(3) Decreases Collagen Synthesis and Deposition in the Liver of Experimental Hepatic Fibrosis Rat. Zhang Y, etal., Dig Dis Sci. 2010 Jan 28.
250. Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis. Zhang YB, etal., Chin J Traumatol. 2010 Jun 1;13(3):188-92.
251. [Expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model] Zhao XQ, etal., Hua Xi Kou Qiang Yi Xue Za Zhi. 2006 Jun;24(3):202-5.
252. Expression of matrix metalloproteinase -2, -9 and tissue inhibitors of metalloproteinase -1, -2, -3 mRNAs in rat uterus during early pregnancy. Zhao YG, etal., Mol Reprod Dev 2002 Jun;62(2):149-58.
253. [Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma]. Zheng Y, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Apr;46(4):299-302.
254. Expression of matrix metalloproteinase and its tissue inhibitor in haemangioma. Zhong S, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):614-9. doi: 10.1007/s11596-009-0516-3. Epub 2009 Oct 11.
Additional References at PubMed
PMID:11747814   PMID:11824471   PMID:11824476   PMID:12419962   PMID:12477932   PMID:12617792   PMID:12747454   PMID:12970340   PMID:14512418   PMID:15038770   PMID:15051632   PMID:15052653  
PMID:15075185   PMID:15212943   PMID:15255544   PMID:15269222   PMID:15300910   PMID:15480899   PMID:15509661   PMID:15522203   PMID:15609629   PMID:15615723   PMID:15621209   PMID:15637127  
PMID:15652546   PMID:15655118   PMID:15728709   PMID:15793858   PMID:15802562   PMID:15863497   PMID:15956706   PMID:16047157   PMID:16097048   PMID:16148033   PMID:16200464   PMID:16337314  
PMID:16377938   PMID:16484357   PMID:16575906   PMID:16680016   PMID:16680367   PMID:16690877   PMID:16707552   PMID:16707787   PMID:16738242   PMID:16815061   PMID:16816895   PMID:16854986  
PMID:16951163   PMID:17008622   PMID:17028444   PMID:17064783   PMID:17122420   PMID:17143608   PMID:17158653   PMID:17188498   PMID:17308006   PMID:17332085   PMID:17349656   PMID:17382917  
PMID:17428795   PMID:17440987   PMID:17496904   PMID:17505812   PMID:17561096   PMID:17607299   PMID:17644578   PMID:17684756   PMID:17854826   PMID:17903365   PMID:17960656   PMID:17986262  
PMID:17987394   PMID:18000599   PMID:18031717   PMID:18052689   PMID:18071296   PMID:18075836   PMID:18247145   PMID:18264108   PMID:18279587   PMID:18293392   PMID:18320202   PMID:18327702  
PMID:18332633   PMID:18347835   PMID:18354258   PMID:18403250   PMID:18415800   PMID:18433461   PMID:18436234   PMID:18492766   PMID:18509851   PMID:18556655   PMID:18562481   PMID:18580857  
PMID:18615687   PMID:18667463   PMID:18668563   PMID:18675881   PMID:18678246   PMID:18765931   PMID:18769934   PMID:18814268   PMID:18836702   PMID:18846548   PMID:18935914   PMID:18983773  
PMID:19041098   PMID:19052882   PMID:19076167   PMID:19085832   PMID:19132994   PMID:19148693   PMID:19184368   PMID:19189315   PMID:19248829   PMID:19258038   PMID:19259351   PMID:19272247  
PMID:19301225   PMID:19306293   PMID:19345729   PMID:19375723   PMID:19391111   PMID:19426551   PMID:19462901   PMID:19513542   PMID:19524937   PMID:19581512   PMID:19592018   PMID:19693770  
PMID:19734212   PMID:19767806   PMID:19838811   PMID:19846754   PMID:19861263   PMID:19948826   PMID:19958643   PMID:20036218   PMID:20059586   PMID:20134035   PMID:20173666   PMID:20371878  
PMID:20388014   PMID:20543091   PMID:20548288   PMID:20551380   PMID:20683769   PMID:20853596   PMID:20887714   PMID:20939987   PMID:20940000   PMID:21039990   PMID:21041693   PMID:21141515  
PMID:21165643   PMID:21171825   PMID:21176109   PMID:21186625   PMID:21212518   PMID:21220710   PMID:21308405   PMID:21354273   PMID:21355315   PMID:21376707   PMID:21385940   PMID:21414971  
PMID:21461559   PMID:21468558   PMID:21505995   PMID:21536992   PMID:21595847   PMID:21814480   PMID:21876619   PMID:21882490   PMID:21884701   PMID:21895415   PMID:21952436   PMID:22045122  
PMID:22045123   PMID:22071631   PMID:22083546   PMID:22092673   PMID:22094487   PMID:22095325   PMID:22098918   PMID:22105553   PMID:22110735   PMID:22135757   PMID:22197817   PMID:22199370  
PMID:22207560   PMID:22342460   PMID:22345572   PMID:22378877   PMID:22419075   PMID:22449415   PMID:22496348   PMID:22509276   PMID:22618526   PMID:22634718   PMID:22773570   PMID:22897943  
PMID:22914642   PMID:22974613   PMID:23006733   PMID:23088810   PMID:23154389   PMID:23179310   PMID:23383440   PMID:23399998   PMID:23404084   PMID:23481598   PMID:23500774   PMID:23621950  
PMID:23676944   PMID:23790633   PMID:23845380   PMID:23891690   PMID:23950935   PMID:23979707   PMID:23988659   PMID:24006456   PMID:24062440   PMID:24114974   PMID:24160412   PMID:24194850  
PMID:24236012   PMID:24375642   PMID:24380732   PMID:24440697   PMID:24560960   PMID:24685074   PMID:24704473   PMID:24722316   PMID:24769238   PMID:24784232   PMID:24792035   PMID:24907869  
PMID:24935409   PMID:24988912   PMID:25004875   PMID:25013773   PMID:25028660   PMID:25077715   PMID:25108165   PMID:25158309   PMID:25326689   PMID:25343559   PMID:25451385   PMID:25537973  
PMID:25539555   PMID:25597185   PMID:25605162   PMID:25623089   PMID:25816715   PMID:25867313   PMID:25897215   PMID:25987498   PMID:26258010   PMID:26318311   PMID:26333546   PMID:26363453  
PMID:26547079   PMID:26567576   PMID:26598508   PMID:26770971   PMID:27035767   PMID:27079252   PMID:27199120   PMID:27239047   PMID:27322513   PMID:27323108   PMID:27531060   PMID:27893855  
PMID:27902934   PMID:28003226   PMID:28164126   PMID:28223495   PMID:28259914   PMID:28374979   PMID:28488074   PMID:28501723   PMID:28645189   PMID:28912068   PMID:28912710   PMID:28989027  
PMID:29075637   PMID:29210076   PMID:29302675   PMID:29308554   PMID:29345720   PMID:29462885   PMID:29504102   PMID:29604590   PMID:29955613   PMID:30061060   PMID:30239560   PMID:30339939  
PMID:30399409   PMID:30410547   PMID:30627903   PMID:30769782   PMID:30908945   PMID:31075261   PMID:31115509   PMID:31373602   PMID:31397222   PMID:31506724   PMID:31680487   PMID:31746394  
PMID:31834839   PMID:31982869   PMID:32016994   PMID:32328952   PMID:32538742   PMID:32540483   PMID:32686511   PMID:33023122   PMID:33611790   PMID:33954182   PMID:33968038   PMID:34077763  
PMID:34630739   PMID:36723739   PMID:36988559   PMID:37607602   PMID:37700592   PMID:38388415  


Genomics

Comparative Map Data
Mmp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,327,643 - 30,355,856 (-)NCBIGRCr8
mRatBN7.21914,154,657 - 14,182,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,850,377 - 15,877,927 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01921,045,167 - 21,072,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,990,811 - 24,019,370 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,542,771 - 15,570,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,629,728 - 26,658,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,246,036 - 15,275,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1914,077,766 - 14,105,839 (-)NCBICelera
Cytogenetic Map19p11NCBI
MMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381655,478,830 - 55,506,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1655,389,700 - 55,506,691 (+)EnsemblGRCh38hg38GRCh38
GRCh371655,512,742 - 55,540,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,070,589 - 54,098,104 (+)NCBINCBI36Build 36hg18NCBI36
Build 341654,070,603 - 54,097,652NCBI
Celera1640,027,315 - 40,054,814 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1641,400,533 - 41,427,983 (+)NCBIHuRef
CHM1_11656,920,344 - 56,947,845 (+)NCBICHM1_1
T2T-CHM13v2.01661,276,956 - 61,304,813 (+)NCBIT2T-CHM13v2.0
Mmp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,553,920 - 93,580,049 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,553,919 - 93,580,048 (+)EnsemblGRCm39 Ensembl
GRCm38892,827,290 - 92,853,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,827,291 - 92,853,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37895,351,227 - 95,377,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36895,716,456 - 95,742,548 (+)NCBIMGSCv36mm8
Celera897,157,107 - 97,183,318 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.99NCBI
Mmp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543313,024,418 - 13,052,775 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543313,024,844 - 13,050,041 (+)NCBIChiLan1.0ChiLan1.0
MMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21864,904,348 - 64,934,250 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11670,825,738 - 70,852,751 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01635,711,866 - 35,738,881 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11654,817,228 - 54,844,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1654,812,694 - 54,844,279 (+)Ensemblpanpan1.1panPan2
MMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,471,092 - 60,492,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,471,257 - 60,494,113 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,105,772 - 57,130,788 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,016,206 - 61,041,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,016,193 - 61,041,733 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,844,808 - 57,869,825 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,869,067 - 58,894,067 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,747,357 - 59,772,363 (-)NCBIUU_Cfam_GSD_1.0
Mmp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934951,763,246 - 51,787,737 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364757,801,277 - 7,825,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364757,801,356 - 7,825,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl630,058,595 - 30,086,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1630,059,247 - 30,087,031 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2627,526,396 - 27,553,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI
MMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1541,264,382 - 41,291,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl541,264,354 - 41,291,004 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604735,055,095 - 35,082,722 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247571,448,698 - 1,479,255 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247571,450,680 - 1,479,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp2
288 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000022679
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat

Markers in Region
RH130872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21914,154,763 - 14,154,951 (+)MAPPERmRatBN7.2
Rnor_6.01915,542,878 - 15,543,065NCBIRnor6.0
Rnor_5.01926,629,835 - 26,630,022UniSTSRnor5.0
RGSC_v3.41915,246,143 - 15,246,330UniSTSRGSC3.4
Celera1914,077,873 - 14,078,060UniSTS
Cytogenetic Map19p11UniSTS
PMC18111P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21914,154,843 - 14,154,993 (+)MAPPERmRatBN7.2
Rnor_6.01915,542,958 - 15,543,107NCBIRnor6.0
Rnor_5.01926,629,915 - 26,630,064UniSTSRnor5.0
RGSC_v3.41915,246,223 - 15,246,372UniSTSRGSC3.4
Celera1914,077,953 - 14,078,102UniSTS
Cytogenetic Map19p11UniSTS


Genetic Models
This gene Mmp2 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 25 14 8 14 8 11 49 28 33 11 8
Low 32 27 11 27 25 7 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000022679   ⟹   ENSRNOP00000022679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)Ensembl
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100137   ⟹   ENSRNOP00000077106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)Ensembl
RefSeq Acc Id: NM_031054   ⟹   NP_112316
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,327,643 - 30,355,856 (-)NCBI
mRatBN7.21914,154,657 - 14,182,870 (-)NCBI
Rnor_6.01915,542,771 - 15,570,589 (-)NCBI
Rnor_5.01926,629,728 - 26,658,966 (-)NCBI
RGSC_v3.41915,246,036 - 15,275,061 (-)RGD
Celera1914,077,766 - 14,105,839 (-)RGD
Sequence:
RefSeq Acc Id: NP_112316   ⟸   NM_031054
- Peptide Label: precursor
- UniProtKB: P97581 (UniProtKB/Swiss-Prot),   Q6GMM9 (UniProtKB/Swiss-Prot),   P33436 (UniProtKB/Swiss-Prot),   A6KD58 (UniProtKB/TrEMBL),   E9PSM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022679   ⟸   ENSRNOT00000022679
RefSeq Acc Id: ENSRNOP00000077106   ⟸   ENSRNOT00000100137
Protein Domains
Fibronectin type-II

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33436-F1-model_v2 AlphaFold P33436 1-662 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700969
Promoter ID:EPDNEW_R11492
Type:initiation region
Name:Mmp2_2
Description:matrix metallopeptidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11493  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01915,570,510 - 15,570,570EPDNEW
RGD ID:13700970
Promoter ID:EPDNEW_R11493
Type:initiation region
Name:Mmp2_1
Description:matrix metallopeptidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11492  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01915,570,614 - 15,570,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621316 AgrOrtholog
BioCyc Gene G2FUF-6398 BioCyc
Ensembl Genes ENSRNOG00000016695 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055019436 UniProtKB/Swiss-Prot
  ENSRNOG00060017036 UniProtKB/Swiss-Prot
  ENSRNOG00065014715 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022679 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000022679.7 UniProtKB/Swiss-Prot
  ENSRNOT00000100137.1 UniProtKB/TrEMBL
  ENSRNOT00055033172 UniProtKB/Swiss-Prot
  ENSRNOT00060029131 UniProtKB/Swiss-Prot
  ENSRNOT00065024330 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100171 IMAGE-MGC_LOAD
InterPro FN_type2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91653 IMAGE-MGC_LOAD
NCBI Gene 81686 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10201:SF29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmp2 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FNTYPEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016695 RatGTEx
  ENSRNOG00055019436 RatGTEx
  ENSRNOG00060017036 RatGTEx
  ENSRNOG00065014715 RatGTEx
SMART FN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0Q9_RAT UniProtKB/TrEMBL
  A6KD58 ENTREZGENE, UniProtKB/TrEMBL
  E9PSM5 ENTREZGENE, UniProtKB/TrEMBL
  MMP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97581 ENTREZGENE
  Q6GMM9 ENTREZGENE
UniProt Secondary P97581 UniProtKB/Swiss-Prot
  Q6GMM9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Mmp2  matrix metallopeptidase 2    matrix metalloproteinase 2 (72 KDa type IV collagenase)  Name updated 1299863 APPROVED
2002-08-07 Mmp2        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in vascular diseases with advanced aging 70546
gene_disease highly expressed in experimental models of ventricular failure and in cardiac extracts from patients with ischaemic cardiomyopathy 629541
gene_disease high expression correlates with hepatic fibrosis, chronic glomerulosclerosis, neoangiogenesis and distal metastasis formation 628551
gene_disease increased expression is observed in rheumatoid arthiritis and periodontal disease, highly expressed in patients with ulcerative colitis 628551
gene_expression present in the brain gray matter 70539
gene_expression expressed in aortic cells 70546
gene_expression expressed in the colonic wall tissue of colotic and normal rats 628551
gene_function zinc and calcium-dependent endopeptidase, secreted as a zymogen 625578
gene_function zinc and calcium-dependent endopeptidase, secreted as a zymogen 628551
gene_process has a role in vascular disease remodeling, tumor invasion and facilitates SMC migration 70546
gene_process degrades type IV collagen and gelatine 628551
gene_process involved in tissue destruction and remodelling 628551
gene_process palys a role in extracellular matrix proteolysis and increased cell invasiveness in many cell types including endothelial cells 625663
gene_process plays a role in growth, angiogenesis, and extracellular matrix turnover; can degrade multiple components of basement membranes, including type IV and V collagens and laminin 625578
gene_product member of zinc-binding proteinases 629541
gene_protein 72 kDa 629541
gene_regulation expression in neoplastic cells is regulated by the combinatorial interactions of p53, activating Protein-2, and YB-1 with a single enhancer element 628551
gene_regulation released by several cells in response to inflammatory cytokines such as interleukin-1 and tumor necrosis factor-alpha 628551
gene_regulation protein level increases during muscle stretch but not after shear stress activation and is independent of VEGF signaling 628551
gene_regulation expression regulated by gene transcription, mRNA stability, activation of proenzyme and inhibition/activation of enzyme through the tissue inhibitors of metalloproteinases 628551
gene_regulation after exposure of cultured cardiac fibroblasts to IL-1 beta, expression was enhanced in cells of both SHR and WKY strains to equivalent levels as measured by both semiquantitative PCR and zymographic studies 1358958