Mmp2 (matrix metallopeptidase 2) - Rat Genome Database

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Gene: Mmp2 (matrix metallopeptidase 2) Rattus norvegicus
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Symbol: Mmp2
Name: matrix metallopeptidase 2
RGD ID: 621316
Description: Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in extracellular space. Used to study artery disease (multiple); conjunctivitis; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2); PARTICIPATES IN syndecan signaling pathway; gonadotropin-releasing hormone signaling pathway; urinary bladder cancer pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 72 kDa gelatinase; 72 KDa type IV collagenase; gelatinase A; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase-2; MMP-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Mmp2em2Mcwi  
Genetic Models: SS-Mmp2em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21914,154,657 - 14,182,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,850,377 - 15,877,927 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01921,045,167 - 21,072,719 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01923,990,811 - 24,019,370 (-)NCBIRnor_WKY
Rnor_6.01915,542,771 - 15,570,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,629,728 - 26,658,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,246,036 - 15,275,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1914,077,766 - 14,105,839 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IDA,IEP,ISO)
Acute Lung Injury  (IEP)
acute necrotizing pancreatitis  (IEP)
Acute Otitis Media  (ISO)
adrenoleukodystrophy  (ISO)
alcohol use disorder  (IEP)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aortic disease  (ISO)
aortic dissection  (ISO)
Aortic Rupture  (ISO)
aortic valve disease 2  (ISO)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IEP,ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
bone disease  (ISO)
Bone Neoplasms  (ISO)
brain ischemia  (IEP)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IEP)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chlamydophila Infections  (ISO)
cholangiocarcinoma  (IEP,ISO)
cholestasis  (IEP)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IDA,ISO)
Chronic Periodontitis  (IDA,ISO)
colon adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (IEP,ISO)
congestive heart failure  (IEP,ISO)
conjunctivitis  (IDA)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous leishmaniasis  (ISO)
Diabetic Nephropathies  (IEP)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Embolism  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (IEP)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (IEP,ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
extrahepatic cholestasis  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (IEP)
focal segmental glomerulosclerosis  (IEP)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (IEP)
genetic disease  (ISO)
glioblastoma  (ISO)
Gouty Arthritis  (ISO)
Graft Occlusion, Vascular  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
high grade glioma  (IEP)
Hydatidiform Mole  (ISO)
Hyperoxia  (IEP)
Hyperplasia  (IEP)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (IEP,ISO)
ischemia  (ISO)
Joubert syndrome  (ISO)
keratoconus  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (IDA)
leiomyoma  (ISO)
liver cirrhosis  (IEP,ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
Malignant Pleural Effusions  (ISO)
Mandibular Diseases  (ISO)
Marfan syndrome  (ISO)
Maxillary Diseases  (ISO)
Metabolic Bone Diseases  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocarditis  (ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neointima  (IEP,ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IEP,ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
Nose Neoplasms  (ISO)
ocular hypertension  (IEP)
Oral Lichen Planus  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteolysis  (ISO)
Osteolysis Hereditary Multicentric  (ISO)
osteonecrosis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (IEP)
Pneumococcal Meningitis  (IMP)
polycystic ovary syndrome  (IEP)
Polypoidal Choroidal Vasculopathy  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (IEP)
prostate cancer  (ISO)
pseudoxanthoma elasticum  (ISO)
pterygium  (ISO)
pulmonary embolism  (IDA)
pulmonary emphysema  (IEP,ISO)
pulmonary fibrosis  (ISO)
Puromycin Aminonucleoside Nephrosis  (IEP)
pyoderma gangrenosum  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (IDA)
respiratory syncytial virus infectious disease  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (IEP)
Sepsis  (IMP)
skin melanoma  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
stomach carcinoma  (IEP)
Stroke  (IEP,ISO)
Sturge-Weber syndrome  (ISO)
Subarachnoid Hemorrhage  (IDA)
Sweet syndrome  (ISO)
temporal arteritis  (ISO)
Testicular Germ Cell Tumor  (ISO)
thoracic aortic aneurysm  (IEP,ISO)
transient cerebral ischemia  (IDA,IEP)
transitional cell carcinoma  (ISO)
tropical spastic paraparesis  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (IEP,ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (IEP)
Venous Thrombosis  (IDA,IEP)
Weight Gain  (ISO)
Winchester syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3-hydroxypicolinic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (EXP,ISO)
9,10-phenanthroquinone  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
ageladine A  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (EXP)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP)
alternariol  (ISO)
aluminium atom  (EXP)
aluminium oxide  (ISO)
aluminium(0)  (EXP)
AM-251  (ISO)
ambroxol  (EXP)
amitrole  (ISO)
ammonium chloride  (EXP)
anagliptin  (ISO)
andrographolide  (ISO)
anethole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arecoline  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
astemizole  (EXP)
atorvastatin calcium  (EXP,ISO)
azoxystrobin  (ISO)
Bacoside a  (EXP)
baicalein  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP)
betulin  (EXP)
betulinic acid  (EXP,ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
brazilein  (ISO)
brucine  (ISO)
bucladesine  (ISO)
bufalin  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium dichloride  (EXP,ISO)
cantharidin  (ISO)
capecitabine  (ISO)
capsaicin  (EXP,ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carvedilol  (EXP,ISO)
casticin  (ISO)
celastrol  (EXP)
celecoxib  (EXP,ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
Chebulagic acid  (EXP)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chlordecone  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (EXP)
columbamine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin B  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (EXP)
deguelin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP,ISO)
dieckol  (ISO)
diethyl maleate  (EXP)
dihydroartemisinin  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (ISO)
diosgenin  (EXP)
dioxygen  (EXP,ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP,ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
embelin  (ISO)
emetine  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP,ISO)
excitatory amino acid agonist  (ISO)
farrerol  (EXP)
fenbendazole  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferrichrome  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (ISO)
flavonol  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
fosinopril  (ISO)
fructose  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galactose  (EXP)
gallic acid  (EXP,ISO)
Genipin  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
Geraniin  (ISO)
geraniol  (EXP)
gingerol  (ISO)
Ginkgoic acid  (ISO)
ginsenoside Rg1  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Gly-His-Lys  (EXP)
glycidol  (EXP)
glycyrrhizinic acid  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
harmaline  (ISO)
heparin  (ISO)
hesperidin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hinokiflavone  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (EXP)
ICI 118551  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irigenin  (ISO)
irinotecan  (ISO)
iron trichloride  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
juglone  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
lasofoxifene  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP)
letrozole  (ISO)
leuprolide  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (EXP)
lithocholic acid  (ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mannuronic acid  (EXP)
marimastat  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
Methanandamide  (ISO)
methotrexate  (EXP)
methyl caffeate  (ISO)
methylcobalamin  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoprolol  (EXP,ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP,ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
morin  (EXP)
morusin  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naproxen  (EXP)
naringin  (ISO)
Neferine  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitroglycerin  (ISO)
Nonylphenol  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
oridonin  (ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-cresol  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
phenanthrolines  (EXP)
phenethyl caffeate  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phosphatidylcholine  (EXP)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirfenidone  (EXP)
piroxicam  (ISO)
platycodin D  (EXP)
plumbagin  (ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prazosin  (EXP)
prednisolone  (EXP)
prinomastat  (ISO)
probucol  (ISO)
progesterone  (ISO)
propanal  (ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP)
ramipril  (EXP)
razoxane  (EXP)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rhodotorulic acid  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
S-adenosyl-L-homocysteine  (EXP,ISO)
S-allylcysteine  (EXP)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
sanguinarine  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
serpentine asbestos  (ISO)
silibinin  (EXP,ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
solasodine  (ISO)
Sophoricoside  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
squalene  (EXP)
streptozocin  (EXP,ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
taurocholic acid  (ISO)
tebuconazole  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
terazosin  (EXP)
terbinafine  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
tomatidine  (ISO)
Tomentosin  (ISO)
topotecan  (EXP)
trans-anethole  (ISO)
trans-cinnamic acid  (ISO)
trans-rhaponticin  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triciribine  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropisetron  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (EXP,ISO)
Ursonic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
varespladib methyl  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEP)
blood vessel maturation  (IEA,ISO)
bone trabecula formation  (IEA,ISO)
cell migration  (IMP)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to cytokine stimulus  (IEP)
cellular response to estradiol stimulus  (IMP)
cellular response to fluid shear stress  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to reactive oxygen species  (IEA,ISO)
cellular response to UV-A  (IEA,ISO,ISS)
collagen catabolic process  (IBA,IDA,IEA,ISO)
embryo implantation  (IEA,ISO)
endodermal cell differentiation  (IEA,ISO)
extracellular matrix organization  (IBA)
face morphogenesis  (IEA,ISO)
female pregnancy  (IEP)
heart development  (IDA)
intramembranous ossification  (IEA,ISO)
luteinization  (IEP)
macrophage chemotaxis  (IDA)
negative regulation of cell adhesion  (IDA)
negative regulation of vasoconstriction  (IDA)
ovarian follicle development  (IDA)
ovulation from ovarian follicle  (IEP)
parturition  (IEP)
peripheral nervous system axon regeneration  (IDA)
positive regulation of apoptotic process  (IDA)
positive regulation of cell migration  (IMP)
positive regulation of innate immune response  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
prostate gland epithelium morphogenesis  (IMP)
protein catabolic process  (IDA)
proteolysis  (IDA,IEA,ISO)
response to activity  (IEP)
response to amyloid-beta  (IEA,ISO)
response to cytokine  (IEP)
response to electrical stimulus  (IEP)
response to estrogen  (IDA)
response to hydrogen peroxide  (IDA)
response to hyperoxia  (IEP)
response to hypoxia  (IBA,IDA,IEA,ISO)
response to mechanical stimulus  (IDA)
response to nicotine  (IEP)
response to oxidative stress  (IDA)
response to retinoic acid  (IEP)
response to xenobiotic stimulus  (IDA,IEP)
skeletal system morphogenesis  (ISO)
tissue remodeling  (IBA,IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
3. Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Alfonso-Jaume MA, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1838-46. Epub 2006 May 12.
4. Downregulation of remodelling enzymatic activity induced by an angiotensin-converting enzyme inhibitor (perindopril) reduces the degeneration of experimental abdominal aortic aneurysms in a rat model. Alsac JM, etal., Eur J Vasc Endovasc Surg. 2011 Apr;41(4):474-80. doi: 10.1016/j.ejvs.2010.12.007. Epub 2011 Jan 20.
5. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
6. Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
7. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
8. Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats. Barichello T, etal., Exp Biol Med (Maywood). 2014 Feb;239(2):225-31. doi: 10.1177/1535370213508354. Epub 2014 Jan 13.
9. Delayed cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-alpha activation in rat hearts subjected to global ischaemia-reperfusion. Barlaka E, etal., Can J Physiol Pharmacol. 2013 Aug;91(8):608-16. doi: 10.1139/cjpp-2012-0412. Epub 2013 Mar 3.
10. The involvement of oxidants and NF-kappaB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. Ben-David D, etal., Inflamm Res. 2012 Jul;61(7):673-88. doi: 10.1007/s00011-012-0461-7. Epub 2012 Mar 13.
11. Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy. Beranek M, etal., Mol Vis. 2008 Jun 14;14:1114-21.
12. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Bergman MR, etal., Biochem J 2003 Feb 1;369(Pt 3):485-96.
13. Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. Bhattacharyya SS, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Jul;8(7):645-54.
14. Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium. Bogusiewicz M, etal., Gynecol Endocrinol. 2007 Sep;23(9):541-6.
15. Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are prognostic factors in cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV) or virus persistence after treatment of CIN. Branca M, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1543-56.
16. MMP-2 regulates rat ventral prostate development in vitro. Bruni-Cardoso A, etal., Dev Dyn. 2010 Mar;239(3):737-46.
17. Stromal remodelling is required for progressive involution of the rat ventral prostate after castration: Identification of a matrix metalloproteinase-dependent apoptotic wave. Bruni-Cardoso A, etal., Int J Androl. 2009 Nov 10.
18. Vascular extracellular matrix remodeling in cerebral aneurysms. Bruno G, etal., J Neurosurg. 1998 Sep;89(3):431-40.
19. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
20. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
21. Remodeling of experimental arteriovenous fistula with increased matrix metalloproteinase expression in rats. Chan CY, etal., J Vasc Surg. 2007 Apr;45(4):804-11.
22. Effects of hypoxia, hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 in hepatic stellate cells. Chen PS, etal., World J Gastroenterol 2001 Oct;7(5):647-51.
23. Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. Chen Y, etal., Eur Respir J. 2010 Apr;35(4):904-12. Epub 2009 Nov 6.
24. Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Cheng S, etal., Biochem J 2002 Sep 15;366(Pt 3):807-16.
25. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis. Cheung C, etal., Cardiovasc Pathol. 2006 Mar-Apr;15(2):63-74.
26. Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion. Cho KO, etal., J Neurosci Res. 2006 Feb 1;83(2):285-91.
27. Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis. Choi EY, etal., Exp Mol Med. 2002 Dec 31;34(6):391-400.
28. Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma. Christopoulos TA, etal., Oncol Rep. 2007 Oct;18(4):855-60.
29. The clinical significance of gelatinase B in gouty arthritis of the knee. Chu SC, etal., Clin Chim Acta. 2004 Jan;339(1-2):77-83.
30. Regulation of collagen degradation in the rat myocardium after infarction. Cleutjens JP, etal., J Mol Cell Cardiol. 1995 Jun;27(6):1281-92.
31. Thrombus versus Wall Biological Activities in Experimental Aortic Aneurysms. Coutard M, etal., J Vasc Res. 2009 Dec 16;47(4):355-366.
32. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Covington MD, etal., Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51. Epub 2005 Aug 2.
33. Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. Dahi S, etal., J Vasc Surg. 2005 Sep;42(3):539-45.
34. Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood-brain barrier dysfunction in an animal model of severe sepsis. Dal-Pizzol F, etal., Mol Neurobiol. 2013 Aug;48(1):62-70. doi: 10.1007/s12035-013-8433-7. Epub 2013 Mar 12.
35. Calcaneal tendon regions exhibit different MMP-2 activation after vertical jumping and treadmill running. De Mello Malheiro OC, etal., Anat Rec (Hoboken). 2009 Oct;292(10):1656-62.
36. Matrix metalloproteinase-2 promoter polymorphism is associated with breast cancer in a Mexican population. Delgado-Enciso I, etal., Gynecol Obstet Invest. 2008;65(1):68-72. Epub 2007 Sep 13.
37. Characterisation of matrix metalloproteinases and the effects of a broad-spectrum inhibitor (BB-1101) in peripheral nerve regeneration. Demestre M, etal., Neuroscience. 2004;124(4):767-79.
38. Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in diabetic and healthy subjects. Derosa G, etal., Diabetes Metab. 2007 Apr;33(2):129-34. Epub 2007 Feb 22.
39. Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension. Derosa G, etal., Endothelium. 2006 May-Jun;13(3):227-31.
40. Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions. Di Carlo A, etal., Oncol Rep. 2007 Aug;18(2):425-31.
41. Nonstenotic bicuspid aortic valve is associated with elevated plasma asymmetric dimethylarginine. Drapisz S, etal., J Cardiovasc Med (Hagerstown). 2013 Jun;14(6):446-52. doi: 10.2459/JCM.0b013e3283588dfa.
42. Effect of a specific endothelin receptor A antagonist and an angiotensin-converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis. Ebihara I, etal., Nephrol Dial Transplant. 1997 May;12(5):1001-6.
43. Noninvasive diagnosis of bladder cancer by detection of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitor (TIMP-2) in urine. Eissa S, etal., Eur Urol. 2007 Nov;52(5):1388-96. Epub 2007 Apr 10.
44. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
45. Changes in the expression of MMP2, MMP9, and ColIV in stromal cells in oral squamous tongue cell carcinoma: relationships and prognostic implications. Fan HX, etal., J Exp Clin Cancer Res. 2012 Oct 29;31:90. doi: 10.1186/1756-9966-31-90.
46. Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells. Fan WH and Karnovsky MJ, J Biol Chem 2002 Mar 22;277(12):9800-5.
47. MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS. Fang L, etal., J Neurol Sci. 2010 Jul 15;294(1-2):51-6. doi: 10.1016/j.jns.2010.04.005. Epub 2010 May 4.
48. The study of ISO induced heart failure rat model. Feng W and Li W, Exp Mol Pathol. 2010 Apr;88(2):299-304. Epub 2009 Nov 10.
49. Azithromycin reduces inflammation in a rat model of acute conjunctivitis. Fernandez-Robredo P, etal., Mol Vis. 2013;19:153-65. Epub 2013 Jan 28.
50. MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. Filippov S, etal., J Exp Med. 2005 Sep 5;202(5):663-71.
51. The role of matrix metalloproteinases 2 and 9 during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Fracalossi AC, etal., J Mol Histol. 2010 Feb;41(1):19-25. Epub 2010 Mar 6.
52. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
53. Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease. Friese RS, etal., Clin Exp Hypertens. 2009 Oct;31(7):521-33. doi: 10.3109/10641960802668730.
54. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Ganguly K, etal., Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30.
55. Dynamic changes of matrix metalloproteinases in rat liver during the development of diethylnitrosamine-induced hepatocarcinoma. Gao Y, etal., Di Yi Jun Yi Da Xue Xue Bao 2002 Oct;22(10):865-8.
56. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
57. Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26.
58. Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of metalloproteinase-1 predicts outcome in patients with congestive heart failure. George J, etal., Am Heart J. 2005 Sep;150(3):484-7.
59. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
60. Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions. Graesslin O, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1911-7.
61. Fetal MMP2/MMP9 polymorphisms and intrauterine growth restriction risk. Gremlich S, etal., J Reprod Immunol. 2007 Jun;74(1-2):143-51. Epub 2007 Mar 23.
62. Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. Gress TM, etal., Int J Cancer. 1995 Aug 9;62(4):407-13.
63. Chinese yellow wine and red wine inhibit matrix metalloproteinase-2 and improve atherosclerotic plaque in LDL receptor knockout mice. Guo H, etal., Cardiovasc Ther. 2010 Jun;28(3):161-8. doi: 10.1111/j.1755-5922.2009.00132.x. Epub 2010 Mar 31.
64. Tissue-specific enhancer-promoter interactions regulate high level constitutive expression of matrix metalloproteinase 2 by glomerular mesangial cells. Harendza S, etal., J Biol Chem 1995 Aug 11;270(32):18786-96.
65. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. He H, etal., Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
66. Induction of Matrix Metalloproteinase-2 Enhances Systemic Vasoconstriction after Hypoxia. He JZ, etal., Am J Physiol Heart Circ Physiol. 2006 Sep 15;.
67. Interstitial fibrosis in the heart: differences in extracellular matrix proteins and matrix metalloproteinases in end-stage dilated, ischaemic and valvular cardiomyopathy. Herpel E, etal., Histopathology. 2006 May;48(6):736-47.
68. Matrix metalloproteinase 2 polymorphisms in a caucasian population with abdominal aortic aneurysm. Hinterseher I, etal., J Surg Res. 2006 Jun 15;133(2):121-8. Epub 2006 Feb 3.
69. Matrix metalloproteinase-2 and epidermal growth factor are decreased in platelets of Alzheimer patients. Hochstrasser T, etal., Curr Alzheimer Res. 2012 Oct;9(8):982-9.
70. Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization. Hosford GE, etal., Pediatr Res. 2004 Jul;56(1):26-34. Epub 2004 May 5.
71. Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Hosomi N, etal., Neuroscience. 2005;134(1):225-31.
72. Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis. Hsu CC and Lai SC, Int J Exp Pathol. 2007 Dec;88(6):437-43.
73. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
74. Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms. Ikonomidis JS, etal., Circulation. 2005 Aug 30;112(9 Suppl):I242-8.
75. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
76. Interleukin-1beta enhanced action of kinins on extracellular matrix of spontaneous hypertensive rat cardiac fibroblasts. Imai C, etal., Clin Exp Hypertens 2005 Jan;27(1):59-69.
77. Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Iniesta P, etal., Oncol Rep. 2007 Jan;17(1):217-23.
78. Evidence for the involvement of matrix metalloproteinases in the cardiovascular effects produced by nicotine. Jacob-Ferreira AL, etal., Eur J Pharmacol. 2010 Feb 10;627(1-3):216-22. Epub 2009 Oct 30.
79. Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma. Jan YY, etal., Ann Surg. 2004 Jul;240(1):89-94.
80. Membrane type 1-matrix metalloproteinase (MMP)-associated MMP-2 activation increases in the rat ovary in response to an ovulatory dose of human chorionic gonadotropin. Jo M, etal., Biol Reprod. 2004 Apr;70(4):1024-32. Epub 2003 Dec 10.
81. Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. Johanns M, etal., Sci Rep. 2017 Jun 28;7(1):4328. doi: 10.1038/s41598-017-04648-y.
82. Matrix metalloproteinases are down-regulated in rat lenses exposed to oxidative stress. John M, etal., Exp Eye Res. 2004 Dec;79(6):839-46.
83. Magnetic brain stimulation upregulates adhesion and prevents Eae: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target. Jovanova-Nesic K, etal., Int J Neurosci. 2009;119(9):1399-418.
84. Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer. Juuti A, etal., Oncology. 2006;71(1-2):61-8. Epub 2007 Mar 21.
85. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
86. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Kassiri Z, etal., Circ Res. 2005 Aug 19;97(4):380-90. Epub 2005 Jul 21.
87. Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. Kawata N, etal., Urology. 2007 Jun;69(6):1049-53.
88. Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
89. Aortic adaptation to pregnancy: elevated expression of matrix metalloproteinases-2 and -3 in rat gestation. Kelly BA, etal., Mol Hum Reprod. 2004 May;10(5):331-7. Epub 2004 Mar 25.
90. The imbalanced expression of matrix metalloproteinases in nephrogenic systemic fibrosis. Kelly BC, etal., J Am Acad Dermatol. 2010 Sep;63(3):483-9. doi: 10.1016/j.jaad.2009.09.006.
91. Role of TGF-beta1, extracellular matrix, and matrix metalloproteinase in the healing process of the pancreas after induction of acute necrotizing pancreatitis using arginine in rats. Kihara Y, etal., Pancreas. 2001 Oct;23(3):288-95.
92. PAF enhances MMP-2 production in rat aortic VSMCs via a beta-arrestin2-dependent ERK signaling pathway. Kim YH, etal., J Lipid Res. 2013 Oct;54(10):2678-86. doi: 10.1194/jlr.M037176. Epub 2013 Aug 2.
93. Immunohistochemical changes in matrix metalloproteinase-2 and 9 during small bowel allograft rejection in rats. Kimizuka K, etal., Transplant Proc 2002 May;34(3):1047-8.
94. Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy. Kizaki K, etal., Biol Pharm Bull. 2005 Dec;28(12):2331-4.
95. Low serum level of pro-matrix metalloproteinase 2 correlates with aggressive behavior in breast carcinoma. Kuvaja P, etal., Hum Pathol. 2006 Oct;37(10):1316-23. Epub 2006 Jul 26.
96. Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) inhibits experimental choroidal neovascularization in vivo and VEGF-induced cell migration and tube formation in vitro. Lai K, etal., Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5702-12. doi: 10.1167/iovs.10-6370.
97. Preconditioning decreases ischemia/reperfusion-induced release and activation of matrix metalloproteinase-2. Lalu MM, etal., Biochem Biophys Res Commun 2002 Aug 30;296(4):937-41.
98. Melissa officinalis extract inhibits laser-induced choroidal neovascularization in a rat model. Lee EK, etal., PLoS One. 2014 Oct 14;9(10):e110109. doi: 10.1371/journal.pone.0110109. eCollection 2014.
99. Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats. Lee MF, etal., Food Chem. 2013 Jun 1;138(2-3):802-7. doi: 10.1016/j.foodchem.2012.11.094. Epub 2012 Dec 1.
100. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
101. The role of matrix metalloproteinases in extracellular matrix remodelling in chronic obstructive pulmonary disease rat models Li H, etal., Zhonghua Nei Ke Za Zhi 2002 Jun;41(6):393-8.
102. Prognostic value of matrix metalloproteinases (MMP-2 and MMP-9) in patients with lymph node-negative breast carcinoma. Li HC, etal., Breast Cancer Res Treat. 2004 Nov;88(1):75-85.
103. Effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice. Li W and Shen HH, Chin Med J (Engl). 2007 Jan 5;120(1):5-11.
104. [Retinoic acid diminished the expression of lung tissue matrix metalloproteinase-2 and matrix metalloproteinase-9 in hyperoxia-exposed premature rats through regulating mitogen-activated protein kinases]. Li WB, etal., Zhonghua Er Ke Za Zhi. 2008 May;46(5):347-53.
105. [Effects of unfractionated heparin on expression of metalloproteinase-2 and -9 in acute lung injury rats]. Li X, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Oct;24(10):608-11.
106. [Association of SNPs in the promoter of MMP-2 and TIMP-2 genes with epithelial ovarian cancer.] Li XL, etal., Yi Chuan. 2008 Apr;30(4):455-62.
107. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
108. Early activation of myocardial matrix metalloproteinases and degradation of cardiac troponin I after experimental subarachnoid hemorrhage. Lin NN, etal., J Surg Res. 2013 Jan;179(1):e41-8. doi: 10.1016/j.jss.2012.02.008. Epub 2012 Mar 28.
109. Distinct expression of gelatinase A [matrix metalloproteinase (MMP)-2], collagenase-3 (MMP-13), membrane type MMP 1 (MMP-14), and tissue inhibitor of MMPs type 1 mediated by physiological signals during formation and regression of the rat corpus luteum. Liu K, etal., Endocrinology. 1999 Nov;140(11):5330-8.
110. [Influence of periodontal therapy on serum interleukin-6 and carotid metalloproteinases in animals with chronic periodontitis associated with atherosclerosis]. Liu Y, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2014 Mar;49(3):155-60.
111. Evidence that MMP-2 and TIMP-2 are at play in the FSH-induced changes in Sertoli cells. Longin J and Le Magueresse-Battistoni B, Mol Cell Endocrinol 2002 Mar 28;189(1-2):25-35.
112. Elevated expression of both MDR1 and MMP-2 genes in metastasized lymph node of invasive ductal breast cancer. Lu LS, etal., Eur Rev Med Pharmacol Sci. 2012 Dec;16(15):2037-43.
113. Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. Machado LS, etal., BMC Neurosci. 2006 Jul 17;7:56.
114. 17beta-Estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts. Mahmoodzadeh S, etal., Cardiovasc Res. 2010 Mar 1;85(4):719-28. Epub 2009 Oct 27.
115. Matrix metalloproteinases and their impact on sinusal extension in chronic rhinosinusitis with nasal polyps. Malinsky RR, etal., Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1345-8. doi: 10.1007/s00405-012-2219-9. Epub 2012 Oct 12.
116. Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Manase K, etal., Reprod Biol Endocrinol. 2006 Jun 2;4:32.
117. Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. Manikandan P, etal., Life Sci. 2010 Apr 29.
118. Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats. Mao JW, etal., World J Gastroenterol. 2012 Dec 21;18(47):7063-9. doi: 10.3748/wjg.v18.i47.7063.
119. Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression. Maretti-Mira AC, etal., Clin Exp Immunol. 2011 Feb;163(2):207-14. doi: 10.1111/j.1365-2249.2010.04285.x. Epub 2010 Nov 22.
120. Homology cloning of rat 72 kDa type IV collagenase: cytokine and second-messenger inducibility in glomerular mesangial cells. Marti HP, etal., Biochem J 1993 Apr 15;291 ( Pt 2):441-6.
121. Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis. Martinez-Torres FJ, etal., Neurosci Lett. 2004 Sep 30;368(3):274-8.
122. Inflammatory cells, cytokines and matrix metalloproteinases in amicrobial pustulosis of the folds and other neutrophilic dermatoses. Marzano AV, etal., Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2):451-60.
123. Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas. Matsuyama Y, etal., J Surg Oncol. 2002 Jun;80(2):105-10.
124. Basal membrane remodeling during follicle histogenesis in the rat ovary: contribution of proteinases of the MMP and PA families. Mazaud S, etal., Dev Biol. 2005 Jan 15;277(2):403-16.
125. Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis. Medina C, etal., Am J Physiol Gastrointest Liver Physiol 2003 Jan;284(1):G116-22.
126. Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Mendes O, etal., Clin Exp Metastasis. 2005;22(3):237-46.
127. Combinatorial interactions of p53, activating protein-2, and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells. Mertens PR, etal., J Biol Chem 2002 Jul 12;277(28):24875-82.
128. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
129. Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency. Misra S, etal., J Vasc Interv Radiol. 2010 Aug;21(8):1255-61. doi: 10.1016/j.jvir.2010.02.043. Epub 2010 Jul 3.
130. Terazosin modifies the content of glycosaminoglycans and the activity of matrix metalloproteinase 2 in the rat ventral prostate. Mitropoulos D, etal., Eur Urol. 2007 Feb;51(2):447-56; discussion 456. Epub 2006 Jul 5.
131. Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. Miyake JA, etal., Lipids Health Dis. 2009 Mar 17;8:8. doi: 10.1186/1476-511X-8-8.
132. Temporal expression and activation of matrix metalloproteinases-2, -9, and membrane type 1-matrix metalloproteinase following acute hindlimb ischemia. Muhs BE, etal., J Surg Res. 2003 May 1;111(1):8-15.
133. Black tea polyphenols target matrix metalloproteinases, RECK, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model. Murugan RS, etal., Anticancer Res. 2009 Jun;29(6):2301-5.
134. Expression of matrix metalloproteinase-9 associated with ets-1 proto-oncogene in rat tubulointerstitial cells. Naito T, etal., Nephrol Dial Transplant. 2005 Nov;20(11):2333-48. Epub 2005 Jul 26.
135. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. Nakano A, etal., J Neurosurg. 1995 Aug;83(2):298-307.
136. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
137. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
138. Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Niebroj-Dobosz I, etal., Eur J Neurol. 2010 Feb;17(2):226-31. doi: 10.1111/j.1468-1331.2009.02775.x. Epub 2009 Oct 1.
139. Matrix metalloproteinases with gelatinolytic activity induced by Paracoccidioides brasiliensis infection. Nishikaku AS, etal., Int J Exp Pathol. 2009 Oct;90(5):527-37. doi: 10.1111/j.1365-2613.2009.00663.x.
140. Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy. Noda K, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):2163-70.
141. Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers. Norgauer J, etal., Br J Dermatol. 2002 Dec;147(6):1180-6.
142. Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. O'Brien J, etal., Am J Pathol. 2010 Mar;176(3):1241-55. Epub 2010 Jan 28.
143. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
144. High numbers of human skin cancers express MMP2 and several integrin genes. Orimoto AM, etal., J Cutan Pathol. 2008 Mar;35(3):285-91. doi: 10.1111/j.1600-0560.2007.00810.x.
145. Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas. Orlandi A, etal., Am J Pathol. 2005 Jun;166(6):1619-28.
146. The relation between keratoconus and plasma levels of MMP-2, zinc, and SOD. Ortak H, etal., Cornea. 2012 Sep;31(9):1048-51. doi: 10.1097/ICO.0b013e318254c028.
147. Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion. Ortak H, etal., Exp Eye Res. 2013 Aug;113:151-5. doi: 10.1016/j.exer.2013.06.009. Epub 2013 Jun 18.
148. The role of MMP2 (-1306C>T) and TIMP2 (-418 G>C) promoter variants in age-related macular degeneration. Ortak H, etal., Ophthalmic Genet. 2013 Dec;34(4):217-22. doi: 10.3109/13816810.2013.781192. Epub 2013 Mar 28.
149. The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. Pannu H, etal., J Neurosurg. 2006 Sep;105(3):418-23.
150. Induction of secretory leukocyte protease inhibitor (SLPI) in estradiol valerate (EV) induced polycystic ovary. Park JJ, etal., Arch Pharm Res. 2011 Aug;34(8):1389-97. doi: 10.1007/s12272-011-0820-x. Epub 2011 Sep 11.
151. Serum MMP-2 and MMP-9 in patients with Behcet's disease: do their higher levels correlate to vasculo-Behcet's disease associated with aneurysm formation? Pay S, etal., Clin Exp Rheumatol. 2007 Jul-Aug;25(4 Suppl 45):S70-5.
152. Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China. Peihong S and Perry F, Ethiop Med J. 2007 Jan;45(1):79-83.
153. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
154. Expression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placenta. Petignat P, etal., Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1679-84.
155. Stretching and electrical stimulation regulate the metalloproteinase-2 in rat denervated skeletal muscle. Peviani SM, etal., Neurol Res. 2009 Aug 5.
156. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
157. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
158. Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia. Planas AM, etal., Neurobiol Dis. 2001 Oct;8(5):834-46.
159. ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat.