Mmp2 (matrix metallopeptidase 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mmp2 (matrix metallopeptidase 2) Mus musculus
Analyze
Symbol: Mmp2
Name: matrix metallopeptidase 2
RGD ID: 730822
MGI Page MGI
Description: Enables metalloendopeptidase activity. Involved in response to amyloid-beta. Acts upstream of or within several processes, including blood vessel maturation; bone trabecula formation; and collagen catabolic process. Located in several cellular components, including extracellular space; mitochondrion; and sarcomere. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart; jaw; and musculoskeletal system. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 72 kDa gelatinase; 72 kDa type IV collagenase; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; Clg; Clg4a; Ge; GelA; gelatinase A; matrix metalloproteinase 2; matrix metalloproteinase-2; MMP-; MMP-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,553,920 - 93,580,049 (+)NCBIGRCm39mm39
GRCm39 Ensembl893,553,919 - 93,580,048 (+)Ensembl
GRCm38892,827,290 - 92,853,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,827,291 - 92,853,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37895,351,227 - 95,377,319 (+)NCBIGRCm37mm9NCBIm37
MGSCv36895,716,456 - 95,742,548 (+)NCBImm8
Celera897,157,107 - 97,183,318 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute Otitis Media  (IEP)
adrenoleukodystrophy  (ISO)
alcohol use disorder  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (IEP,ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aortic disease  (ISO)
Aortic Rupture  (ISO)
aortic valve disease 2  (ISO)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IDA,ISO)
atherosclerosis  (IDA,ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
bone disease  (ISO)
Bone Neoplasms  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
carotid stenosis  (IEP)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chlamydophila Infections  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IDA,ISO)
Chronic Periodontitis  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
conjunctivitis  (ISO)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous leishmaniasis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (IDA)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Embolism  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
glioblastoma  (ISO)
Gouty Arthritis  (ISO)
Graft Occlusion, Vascular  (IEP)
head and neck squamous cell carcinoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (IDA)
high grade glioma  (ISO)
Hydatidiform Mole  (ISO)
Hyperoxia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (ISO)
ischemia  (IDA)
keratoconus  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
Malignant Pleural Effusions  (ISO)
Mammary Neoplasms, Experimental  (IDA,ISO)
Mandibular Diseases  (ISO)
Marfan syndrome  (IEP,ISO)
Maxillary Diseases  (ISO)
Metabolic Bone Diseases  (ISO)
Multiple Organ Failure  (IEP)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocarditis  (IDA)
myopia  (ISO)
Nasal Polyps  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
Nose Neoplasms  (ISO)
ocular hypertension  (ISO)
Oral Lichen Planus  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteolysis  (ISO)
Osteolysis Hereditary Multicentric  (ISO)
osteonecrosis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (IEP)
paracoccidioidomycosis  (IDA)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
Pneumococcal Meningitis  (ISO)
polycystic ovary syndrome  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
pseudoxanthoma elasticum  (ISO)
pterygium  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
pyoderma gangrenosum  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
respiratory syncytial virus infectious disease  (IEP)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sepsis  (ISO)
skin melanoma  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (ISO)
Stroke  (ISO)
Sturge-Weber syndrome  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sweet syndrome  (ISO)
temporal arteritis  (ISO)
Testicular Germ Cell Tumor  (ISO)
thoracic aortic aneurysm  (IDA,ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
tropical spastic paraparesis  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)
Venous Thrombosis  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3-hydroxypicolinic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-Nerolidylcatechol  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7-ketocholesterol  (ISO)
9,10-phenanthroquinone  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ageladine A  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
ambroxol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anagliptin  (ISO)
andrographolide  (EXP)
anethole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
astemizole  (ISO)
atorvastatin calcium  (EXP,ISO)
azoxystrobin  (ISO)
Bacoside a  (ISO)
baicalein  (EXP,ISO)
beclomethasone  (ISO)
benazepril  (ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
betulinic acid  (EXP,ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP,ISO)
boric acid  (EXP)
brazilein  (ISO)
brucine  (EXP,ISO)
bucladesine  (ISO)
bufalin  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium dichloride  (EXP,ISO)
cantharidin  (ISO)
capecitabine  (ISO)
capsaicin  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
carfilzomib  (ISO)
carvedilol  (ISO)
casticin  (EXP,ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGS-21680  (ISO)
Chebulagic acid  (ISO)
chenodeoxycholic acid  (EXP)
chitosan  (ISO)
chlordecone  (EXP)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
chrysin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
columbamine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP,ISO)
cucurbitacin B  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dieckol  (ISO)
diethyl maleate  (ISO)
dihydroartemisinin  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
divanadium pentaoxide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP,ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
embelin  (ISO)
emetine  (ISO)
entinostat  (EXP,ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
excitatory amino acid agonist  (EXP)
farrerol  (ISO)
fenofibrate  (ISO)
ferric oxide  (EXP)
ferrichrome  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (EXP,ISO)
flavonol  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
fosinopril  (EXP)
fructose  (EXP)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (ISO)
galactose  (ISO)
gallic acid  (ISO)
Genipin  (ISO)
Geniposide pentaacetate  (ISO)
genistein  (ISO)
Geraniin  (ISO)
gingerol  (ISO)
Ginkgoic acid  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
Gly-His-Lys  (ISO)
glycidol  (ISO)
glycyrrhizinic acid  (EXP)
graphene oxide  (EXP)
graphite  (ISO)
heparin  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hinokiflavone  (EXP,ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
ibuprofen  (ISO)
ICI 118551  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
irigenin  (ISO)
iron trichloride  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
juglone  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (ISO)
L-methionine  (EXP)
lasofoxifene  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
leuprolide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithocholic acid  (EXP,ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
mannuronic acid  (ISO)
marimastat  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
Methanandamide  (ISO)
methotrexate  (ISO)
methyl caffeate  (ISO)
methylcobalamin  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoprolol  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
morin  (ISO)
morusin  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
naringin  (ISO)
Neferine  (ISO)
nerolidol  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitroglycerin  (ISO)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
oleanolic acid  (ISO)
oleic acid  (ISO)
omeprazole  (ISO)
oridonin  (ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxytocin  (ISO)
ozone  (EXP,ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (EXP)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
phenanthrolines  (ISO)
phenethyl caffeate  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phosphatidylcholine  (ISO)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
piroxicam  (EXP)
platycodin D  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
prazosin  (ISO)
prednisolone  (ISO)
prinomastat  (ISO)
probucol  (ISO)
progesterone  (ISO)
propanal  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
pterostilbene  (EXP)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (ISO)
ramipril  (ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rhodotorulic acid  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
rutin  (EXP,ISO)
S-adenosyl-L-homocysteine  (EXP,ISO)
S-allylcysteine  (ISO)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
sanguinarine  (ISO)
saxagliptin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
solasodine  (ISO)
Sophoricoside  (EXP)
sorafenib  (EXP)
sphingosine 1-phosphate  (ISO)
squalene  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sumatriptan  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
taurocholic acid  (ISO)
tebuconazole  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
terazosin  (ISO)
terbinafine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (EXP)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium atom  (ISO)
titanium dioxide  (EXP)
tolfenamic acid  (ISO)
tomatidine  (ISO)
Tomentosin  (ISO)
topotecan  (ISO)
trans-anethole  (ISO)
trans-cinnamic acid  (EXP)
trans-rhaponticin  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triciribine  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
troglitazone  (EXP,ISO)
tropisetron  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
Ursonic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis  (IEA,ISO)
blood vessel maturation  (IGI)
bone trabecula formation  (IGI)
cell migration  (ISO)
cellular response to amino acid stimulus  (IDA)
cellular response to cytokine stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to reactive oxygen species  (IMP)
cellular response to UV-A  (ISO)
collagen catabolic process  (IBA,IMP,ISO)
embryo implantation  (IDA)
endodermal cell differentiation  (ISO)
extracellular matrix organization  (IBA)
face morphogenesis  (IGI)
female pregnancy  (ISO)
heart development  (ISO)
intramembranous ossification  (IGI)
luteinization  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of vasoconstriction  (ISO)
ovarian follicle development  (ISO)
ovulation from ovarian follicle  (ISO)
parturition  (ISO)
peripheral nervous system axon regeneration  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of innate immune response  (IDA)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
prostate gland epithelium morphogenesis  (ISO)
protein catabolic process  (ISO)
proteolysis  (IBA,ISO)
response to activity  (ISO)
response to amyloid-beta  (IDA)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (IBA,IDA,ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to oxidative stress  (ISO)
response to radiation  (ISO)
response to retinoic acid  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal system morphogenesis  (IGI)
tissue remodeling  (IBA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal aorta morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal aorta wall morphology  (IAGP)
abnormal articular cartilage morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IEA)
abnormal cardiovascular system physiology  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal coronal suture morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal heart morphology  (IEA)
abnormal induced retinal neovascularization  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal kidney morphology  (IEA)
abnormal lambdoid suture morphology  (IAGP)
abnormal lymph node morphology  (IEA)
abnormal response to cardiac infarction  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal seminal vesicle morphology  (IEA)
abnormal skeletal muscle morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skin morphology  (IEA)
abnormal spleen morphology  (IEA)
abnormal stomach morphology  (IEA)
abnormal trabecular bone morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
aortitis  (IAGP)
arthritis  (IAGP)
brain inflammation  (IAGP)
broad snout  (IAGP)
cataract  (IEA)
coronal suture sclerosis  (IAGP)
cyanosis  (IAGP)
decreased angiogenesis  (IAGP)
decreased birth weight  (IAGP)
decreased body length  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IAGP)
decreased bone volume  (IAGP)
decreased inflammatory response  (IAGP)
decreased length of long bones  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased prepulse inhibition  (IEA)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to induced choroidal neovascularization  (IAGP)
decreased tumor growth/size  (IAGP)
delayed muscle development  (IAGP)
dilated heart left ventricle  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart  (IEA)
enlarged lymph nodes  (IEA)
enlarged spleen  (IEA)
enlarged stomach  (IEA)
impaired lung alveolus development  (IAGP)
increased inner canthal distance  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to induced aneurysm formation  (IAGP)
lambdoid suture sclerosis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
sagittal suture sclerosis  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short snout  (IAGP)
small kidney  (IEA)
thin diaphragm muscle  (IAGP)
References

References - curated
1. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
3. Alfonso-Jaume MA, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1838-46. Epub 2006 May 12.
4. Alsac JM, etal., Eur J Vasc Endovasc Surg. 2011 Apr;41(4):474-80. doi: 10.1016/j.ejvs.2010.12.007. Epub 2011 Jan 20.
5. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
6. Barichello T, etal., Exp Biol Med (Maywood). 2014 Feb;239(2):225-31. doi: 10.1177/1535370213508354. Epub 2014 Jan 13.
7. Barlaka E, etal., Can J Physiol Pharmacol. 2013 Aug;91(8):608-16. doi: 10.1139/cjpp-2012-0412. Epub 2013 Mar 3.
8. Beranek M, etal., Mol Vis. 2008 Jun 14;14:1114-21.
9. Bhattacharyya SS, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Jul;8(7):645-54.
10. Bogusiewicz M, etal., Gynecol Endocrinol. 2007 Sep;23(9):541-6.
11. Branca M, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1543-56.
12. Bruno G, etal., J Neurosurg. 1998 Sep;89(3):431-40.
13. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
14. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
15. Chan CY, etal., J Vasc Surg. 2007 Apr;45(4):804-11.
16. Chen Y, etal., Eur Respir J. 2010 Apr;35(4):904-12. Epub 2009 Nov 6.
17. Cheung C, etal., Cardiovasc Pathol. 2006 Mar-Apr;15(2):63-74.
18. Cho KO, etal., J Neurosci Res. 2006 Feb 1;83(2):285-91.
19. Choi EY, etal., Exp Mol Med. 2002 Dec 31;34(6):391-400.
20. Christopoulos TA, etal., Oncol Rep. 2007 Oct;18(4):855-60.
21. Chu SC, etal., Clin Chim Acta. 2004 Jan;339(1-2):77-83.
22. Coutard M, etal., J Vasc Res. 2009 Dec 16;47(4):355-366.
23. Covington MD, etal., Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51. Epub 2005 Aug 2.
24. Dahi S, etal., J Vasc Surg. 2005 Sep;42(3):539-45.
25. Dal-Pizzol F, etal., Mol Neurobiol. 2013 Aug;48(1):62-70. doi: 10.1007/s12035-013-8433-7. Epub 2013 Mar 12.
26. Delgado-Enciso I, etal., Gynecol Obstet Invest. 2008;65(1):68-72. Epub 2007 Sep 13.
27. Derosa G, etal., Diabetes Metab. 2007 Apr;33(2):129-34. Epub 2007 Feb 22.
28. Derosa G, etal., Endothelium. 2006 May-Jun;13(3):227-31.
29. Di Carlo A, etal., Oncol Rep. 2007 Aug;18(2):425-31.
30. Drapisz S, etal., J Cardiovasc Med (Hagerstown). 2013 Jun;14(6):446-52. doi: 10.2459/JCM.0b013e3283588dfa.
31. Ebihara I, etal., Nephrol Dial Transplant. 1997 May;12(5):1001-6.
32. Eissa S, etal., Eur Urol. 2007 Nov;52(5):1388-96. Epub 2007 Apr 10.
33. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
34. Fan HX, etal., J Exp Clin Cancer Res. 2012 Oct 29;31:90. doi: 10.1186/1756-9966-31-90.
35. Fang L, etal., J Neurol Sci. 2010 Jul 15;294(1-2):51-6. doi: 10.1016/j.jns.2010.04.005. Epub 2010 May 4.
36. Fernandez-Robredo P, etal., Mol Vis. 2013;19:153-65. Epub 2013 Jan 28.
37. Filippov S, etal., J Exp Med. 2005 Sep 5;202(5):663-71.
38. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
39. Friese RS, etal., Clin Exp Hypertens. 2009 Oct;31(7):521-33. doi: 10.3109/10641960802668730.
40. Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26.
41. George J, etal., Am Heart J. 2005 Sep;150(3):484-7.
42. Graesslin O, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1911-7.
43. Gremlich S, etal., J Reprod Immunol. 2007 Jun;74(1-2):143-51. Epub 2007 Mar 23.
44. Gress TM, etal., Int J Cancer. 1995 Aug 9;62(4):407-13.
45. Guo H, etal., Cardiovasc Ther. 2010 Jun;28(3):161-8. doi: 10.1111/j.1755-5922.2009.00132.x. Epub 2010 Mar 31.
46. He H, etal., Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
47. Herpel E, etal., Histopathology. 2006 May;48(6):736-47.
48. Hinterseher I, etal., J Surg Res. 2006 Jun 15;133(2):121-8. Epub 2006 Feb 3.
49. Hochstrasser T, etal., Curr Alzheimer Res. 2012 Oct;9(8):982-9.
50. Hosford GE, etal., Pediatr Res. 2004 Jul;56(1):26-34. Epub 2004 May 5.
51. Hosomi N, etal., Neuroscience. 2005;134(1):225-31.
52. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
53. Ikonomidis JS, etal., Circulation. 2005 Aug 30;112(9 Suppl):I242-8.
54. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
55. Iniesta P, etal., Oncol Rep. 2007 Jan;17(1):217-23.
56. Jan YY, etal., Ann Surg. 2004 Jul;240(1):89-94.
57. Jovanova-Nesic K, etal., Int J Neurosci. 2009;119(9):1399-418.
58. Juuti A, etal., Oncology. 2006;71(1-2):61-8. Epub 2007 Mar 21.
59. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
60. Kassiri Z, etal., Circ Res. 2005 Aug 19;97(4):380-90. Epub 2005 Jul 21.
61. Kawata N, etal., Urology. 2007 Jun;69(6):1049-53.
62. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
63. Kelly BC, etal., J Am Acad Dermatol. 2010 Sep;63(3):483-9. doi: 10.1016/j.jaad.2009.09.006.
64. Kihara Y, etal., Pancreas. 2001 Oct;23(3):288-95.
65. Kizaki K, etal., Biol Pharm Bull. 2005 Dec;28(12):2331-4.
66. Kuvaja P, etal., Hum Pathol. 2006 Oct;37(10):1316-23. Epub 2006 Jul 26.
67. Lai K, etal., Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5702-12. doi: 10.1167/iovs.10-6370.
68. Lee EK, etal., PLoS One. 2014 Oct 14;9(10):e110109. doi: 10.1371/journal.pone.0110109. eCollection 2014.
69. Lee MF, etal., Food Chem. 2013 Jun 1;138(2-3):802-7. doi: 10.1016/j.foodchem.2012.11.094. Epub 2012 Dec 1.
70. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
71. Li HC, etal., Breast Cancer Res Treat. 2004 Nov;88(1):75-85.
72. Li W and Shen HH, Chin Med J (Engl). 2007 Jan 5;120(1):5-11.
73. Li X, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Oct;24(10):608-11.
74. Li XL, etal., Yi Chuan. 2008 Apr;30(4):455-62.
75. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
76. Lin NN, etal., J Surg Res. 2013 Jan;179(1):e41-8. doi: 10.1016/j.jss.2012.02.008. Epub 2012 Mar 28.
77. Liu Y, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2014 Mar;49(3):155-60.
78. Lu LS, etal., Eur Rev Med Pharmacol Sci. 2012 Dec;16(15):2037-43.
79. Malinsky RR, etal., Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1345-8. doi: 10.1007/s00405-012-2219-9. Epub 2012 Oct 12.
80. Manikandan P, etal., Life Sci. 2010 Apr 29.
81. Mao JW, etal., World J Gastroenterol. 2012 Dec 21;18(47):7063-9. doi: 10.3748/wjg.v18.i47.7063.
82. Maretti-Mira AC, etal., Clin Exp Immunol. 2011 Feb;163(2):207-14. doi: 10.1111/j.1365-2249.2010.04285.x. Epub 2010 Nov 22.
83. Martinez-Torres FJ, etal., Neurosci Lett. 2004 Sep 30;368(3):274-8.
84. Marzano AV, etal., Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2):451-60.
85. Matsuyama Y, etal., J Surg Oncol. 2002 Jun;80(2):105-10.
86. Mendes O, etal., Clin Exp Metastasis. 2005;22(3):237-46.
87. MGD data from the GO Consortium
88. MGD IEA
89. Misra S, etal., J Vasc Interv Radiol. 2010 Aug;21(8):1255-61. doi: 10.1016/j.jvir.2010.02.043. Epub 2010 Jul 3.
90. Mitropoulos D, etal., Eur Urol. 2007 Feb;51(2):447-56; discussion 456. Epub 2006 Jul 5.
91. Miyake JA, etal., Lipids Health Dis. 2009 Mar 17;8:8. doi: 10.1186/1476-511X-8-8.
92. Muhs BE, etal., J Surg Res. 2003 May 1;111(1):8-15.
93. Murugan RS, etal., Anticancer Res. 2009 Jun;29(6):2301-5.
94. Nakano A, etal., J Neurosurg. 1995 Aug;83(2):298-307.
95. Niebroj-Dobosz I, etal., Eur J Neurol. 2010 Feb;17(2):226-31. doi: 10.1111/j.1468-1331.2009.02775.x. Epub 2009 Oct 1.
96. Nishikaku AS, etal., Int J Exp Pathol. 2009 Oct;90(5):527-37. doi: 10.1111/j.1365-2613.2009.00663.x.
97. Noda K, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):2163-70.
98. Norgauer J, etal., Br J Dermatol. 2002 Dec;147(6):1180-6.
99. OMIM Disease Annotation Pipeline
100. Orimoto AM, etal., J Cutan Pathol. 2008 Mar;35(3):285-91. doi: 10.1111/j.1600-0560.2007.00810.x.
101. Orlandi A, etal., Am J Pathol. 2005 Jun;166(6):1619-28.
102. Ortak H, etal., Cornea. 2012 Sep;31(9):1048-51. doi: 10.1097/ICO.0b013e318254c028.
103. Ortak H, etal., Exp Eye Res. 2013 Aug;113:151-5. doi: 10.1016/j.exer.2013.06.009. Epub 2013 Jun 18.
104. Ortak H, etal., Ophthalmic Genet. 2013 Dec;34(4):217-22. doi: 10.3109/13816810.2013.781192. Epub 2013 Mar 28.
105. Pannu H, etal., J Neurosurg. 2006 Sep;105(3):418-23.
106. Park JJ, etal., Arch Pharm Res. 2011 Aug;34(8):1389-97. doi: 10.1007/s12272-011-0820-x. Epub 2011 Sep 11.
107. Pay S, etal., Clin Exp Rheumatol. 2007 Jul-Aug;25(4 Suppl 45):S70-5.
108. Peihong S and Perry F, Ethiop Med J. 2007 Jan;45(1):79-83.
109. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
110. Petignat P, etal., Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1679-84.
111. Pipeline to import KEGG annotations from KEGG into RGD
112. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
113. Planas AM, etal., Neurobiol Dis. 2001 Oct;8(5):834-46.
114. Podesser BK, etal., Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H984-91.
115. Polyakova V, etal., J Cell Mol Med. 2008 Jan-Feb;12(1):189-208. doi: 10.1111/j.1582-4934.2008.00219.x. Epub 2008 Jan 10.
116. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
117. Qi Q, etal., Int J Clin Exp Pathol. 2014 Apr 15;7(5):1880-8. eCollection 2014.
118. Qin YH, etal., Pediatr Nephrol. 2009 Aug;24(8):1477-86. Epub 2009 Apr 9.
119. Rey MC, etal., Am J Dermatopathol. 2011 Jun;33(4):413-4. doi: 10.1097/DAD.0b013e3181e2e8d6.
120. RGD automated import pipeline
121. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
122. RGD automated import pipeline for gene-chemical interactions
123. Rizzi E, etal., Exp Mol Pathol. 2013 Feb;94(1):1-9. doi: 10.1016/j.yexmp.2012.10.010. Epub 2012 Oct 13.
124. Roldan V, etal., Am Heart J. 2008 Jul;156(1):85-91.
125. Rouzier C, etal., Clin Genet. 2006 Mar;69(3):271-6.
126. Rubaci AH, etal., J Oral Pathol Med. 2012 Oct;41(9):689-96. doi: 10.1111/j.1600-0714.2012.01160.x. Epub 2012 May 3.
127. Sanders JS, etal., Am J Physiol Renal Physiol. 2007 Dec;293(6):F1927-34. Epub 2007 Sep 26.
128. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
129. Segarra M, etal., Ann Rheum Dis. 2007 Nov;66(11):1429-35. Epub 2007 May 14.
130. Seitzman RL, etal., Am J Epidemiol. 2008 May 15;167(10):1217-25. doi: 10.1093/aje/kwn024. Epub 2008 Mar 20.
131. Shang T, etal., J Surg Res. 2014 May 1;188(1):316-25. doi: 10.1016/j.jss.2013.11.1105. Epub 2013 Dec 6.
132. Shin HW, etal., Otolaryngol Head Neck Surg. 2009 Oct;141(4):442-7.
133. Simonetti O, etal., Cancer. 2002 Nov 1;95(9):1963-70.
134. Sinha I, etal., Surgery. 2004 Aug;136(2):176-82.
135. Sivaramakrishnan V and Niranjali Devaraj S, Chem Biol Interact. 2009 Aug 14;180(3):353-9. Epub 2009 Feb 21.
136. Sluijter JP, etal., Stroke. 2006 Jan;37(1):235-9. Epub 2005 Dec 8.