Mmp2 (matrix metallopeptidase 2) - Rat Genome Database

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Gene: Mmp2 (matrix metallopeptidase 2) Mus musculus
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Symbol: Mmp2
Name: matrix metallopeptidase 2
RGD ID: 730822
MGI Page MGI
Description: Enables metalloendopeptidase activity. Involved in response to amyloid-beta. Acts upstream of or within several processes, including blood vessel maturation; bone trabecula formation; and collagen catabolic process. Located in plasma membrane and sarcomere. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and musculoskeletal system. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 72 kDa gelatinase; 72 kDa type IV collagenase; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; Clg; Clg4a; Ge; GelA; gelatinase A; matrix metalloproteinase 2; matrix metalloproteinase-2; MMP-; MMP-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,553,920 - 93,580,049 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,553,919 - 93,580,048 (+)EnsemblGRCm39 Ensembl
GRCm38892,827,290 - 92,853,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,827,291 - 92,853,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37895,351,227 - 95,377,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36895,716,456 - 95,742,548 (+)NCBIMGSCv36mm8
Celera897,157,107 - 97,183,318 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute Otitis Media  (IEP)
adrenoleukodystrophy  (ISO)
alcohol use disorder  (ISO)
alcoholic liver cirrhosis  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (IEP,ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aortic disease  (ISO)
aortic dissection  (IEP)
Aortic Rupture  (ISO)
aortic valve disease 2  (ISO)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IDA,ISO)
atherosclerosis  (IDA,ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
bone disease  (ISO)
Bone Neoplasms  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
carotid stenosis  (IEP)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chlamydophila Infections  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IDA,ISO)
Chronic Periodontitis  (ISO)
colon adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
conjunctivitis  (ISO)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous leishmaniasis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (IDA)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Embolism  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IDA,ISO)
extrahepatic cholestasis  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Gouty Arthritis  (ISO)
Graft Occlusion, Vascular  (IEP)
head and neck squamous cell carcinoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (IDA)
high grade glioma  (ISO)
Hydatidiform Mole  (ISO)
Hyperoxia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (ISO)
ischemia  (IDA)
Joubert syndrome 1  (ISO)
keratoconus  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
Malignant Pleural Effusions  (ISO)
Mandibular Diseases  (ISO)
Marfan syndrome  (IEP,ISO)
Maxillary Diseases  (ISO)
Metabolic Bone Diseases  (ISO)
Multiple Organ Failure  (IEP)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocarditis  (IDA)
myopia  (ISO)
Nasal Polyps  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
Nose Neoplasms  (ISO)
ocular hypertension  (ISO)
Oral Lichen Planus  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteolysis  (ISO)
Osteolysis Hereditary Multicentric  (ISO)
osteonecrosis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (IEP)
paracoccidioidomycosis  (IDA)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
Pneumococcal Meningitis  (ISO)
polycystic ovary syndrome  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
proteinuria  (ISO)
pseudoxanthoma elasticum  (ISO)
pterygium  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
pyoderma gangrenosum  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
respiratory syncytial virus infectious disease  (IEP)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sepsis  (ISO)
skin melanoma  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (ISO)
Stroke  (ISO)
Sturge-Weber syndrome  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sweet syndrome  (ISO)
temporal arteritis  (ISO)
Testicular Germ Cell Tumor  (ISO)
thoracic aortic aneurysm  (IDA,ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
traumatic brain injury  (ISO)
tropical spastic paraparesis  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)
Venous Thrombosis  (ISO)
Weight Gain  (ISO)
Winchester syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (EXP)
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP)
1-hydroxy-1-norresistomycin  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3-hydroxypicolinic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-Nerolidylcatechol  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
9,10-phenanthroquinone  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ageladine A  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allyl isothiocyanate  (ISO)
alpha-D-galactose  (ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
ambroxol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anagliptin  (ISO)
andrographolide  (EXP,ISO)
anethole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
astemizole  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
Bacoside a  (ISO)
baicalein  (EXP,ISO)
beclomethasone  (ISO)
benazepril  (ISO)
benomyl  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-aminopropionitrile  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
betulinic acid  (EXP,ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (EXP)
brazilein  (ISO)
brucine  (EXP,ISO)
bucladesine  (ISO)
bufalin  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium dichloride  (EXP,ISO)
cannabidiol  (ISO)
cantharidin  (EXP,ISO)
capecitabine  (ISO)
capsaicin  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
carfilzomib  (ISO)
carvedilol  (ISO)
carvone  (ISO)
casticin  (EXP,ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
Chebulagic acid  (ISO)
chenodeoxycholic acid  (EXP)
CHIR 99021  (ISO)
chitosan  (ISO)
chlordecone  (EXP)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
chrysin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
columbamine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP,ISO)
cucurbitacin B  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
diethyl maleate  (ISO)
dihydroartemisinin  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
disodium cromoglycate  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
divanadium pentaoxide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP,ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
embelin  (ISO)
emetine  (ISO)
endosulfan  (ISO)
entinostat  (EXP,ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
excitatory amino acid agonist  (EXP)
farrerol  (ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
ferric oxide  (EXP)
ferrichrome  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (EXP,ISO)
flavonol  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
fosinopril  (EXP)
fructose  (EXP)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (ISO)
galactose  (ISO)
gallic acid  (ISO)
Garcinol  (ISO)
gatifloxacin  (ISO)
Genipin  (ISO)
Geniposide pentaacetate  (ISO)
genistein  (ISO)
Geraniin  (ISO)
geraniol  (ISO)
gingerol  (ISO)
Ginkgoic acid  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
Gly-His-Lys  (ISO)
glycidol  (ISO)
glycyrrhizinic acid  (EXP)
graphene oxide  (EXP)
graphite  (ISO)
harmaline  (EXP)
heparin  (ISO)
hesperidin  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hinokiflavone  (EXP,ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
ICI 118551  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
inulin  (EXP)
irigenin  (ISO)
irinotecan  (ISO)
iron trichloride  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
JTE-013  (ISO)
juglone  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (ISO)
L-methionine  (EXP)
lasofoxifene  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
leuprolide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithocholic acid  (EXP,ISO)
loliolide  (ISO)
lomefloxacin  (ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
mannuronic acid  (ISO)
marimastat  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
Methanandamide  (ISO)
methotrexate  (ISO)
methyl caffeate  (ISO)
methylcobalamin  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoprolol  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
morin  (ISO)
morusin  (ISO)
moxifloxacin  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
naringin  (ISO)
Neferine  (ISO)
nerolidol  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitroglycerin  (ISO)
Nonylphenol  (ISO)
NORCANTHARIDIN  (EXP)
norfloxacin  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
oleanolic acid  (ISO)
oleic acid  (ISO)
omeprazole  (ISO)
oridonin  (ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxytocin  (ISO)
ozone  (EXP,ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (EXP)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
phenanthrolines  (ISO)
phenethyl caffeate  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phosphatidylcholine  (ISO)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
piroxicam  (EXP)
platycodin D  (ISO)
plumbagin  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
prazosin  (ISO)
prednisolone  (ISO)
prinomastat  (ISO)
probucol  (ISO)
progesterone  (ISO)
propanal  (ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
pterostilbene  (EXP)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ramipril  (ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rhodotorulic acid  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
rutin  (EXP,ISO)
S-adenosyl-L-homocysteine  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (ISO)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
sanguinarine  (ISO)
saxagliptin  (ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
scoparone  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
serpentine asbestos  (EXP,ISO)
Shikonin  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium silicate  (ISO)
solasodine  (ISO)
Sophoricoside  (EXP)
sorafenib  (EXP)
sparfloxacin  (ISO)
sphingosine 1-phosphate  (ISO)
squalene  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sumatriptan  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
taurocholic acid  (ISO)
tebuconazole  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
terazosin  (ISO)
terbinafine  (ISO)
testosterone  (ISO)
tetracaine  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (EXP)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
thyroxine  (ISO)
titanium atom  (ISO)
titanium dioxide  (EXP)
tolfenamic acid  (ISO)
tomatidine  (ISO)
Tomentosin  (ISO)
topotecan  (ISO)
trans-anethole  (ISO)
trans-cinnamic acid  (EXP)
trans-rhaponticin  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triciribine  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
troglitazone  (EXP,ISO)
tropisetron  (ISO)
tyrphostin AG 1478  (ISO)
ubiquinone-0  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP,ISO)
Ursonic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
varespladib methyl  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
blood vessel maturation  (IGI)
bone trabecula formation  (IGI)
cell migration  (ISO)
cellular response to amino acid stimulus  (IDA)
cellular response to cytokine stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to reactive oxygen species  (IMP)
cellular response to UV-A  (ISO)
collagen catabolic process  (IBA,IMP,ISO)
embryo implantation  (IDA)
endodermal cell differentiation  (ISO)
extracellular matrix organization  (IBA)
face morphogenesis  (IGI)
female pregnancy  (ISO)
heart development  (ISO)
intramembranous ossification  (IGI)
luteinization  (ISO)
macrophage chemotaxis  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of vasoconstriction  (ISO)
ovarian follicle development  (ISO)
ovulation from ovarian follicle  (ISO)
parturition  (ISO)
peripheral nervous system axon regeneration  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of innate immune response  (IDA)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
prostate gland epithelium morphogenesis  (ISO)
protein catabolic process  (ISO)
proteolysis  (ISO)
response to activity  (ISO)
response to amyloid-beta  (IDA)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (IBA,IDA,ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to oxidative stress  (ISO)
response to retinoic acid  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal system morphogenesis  (IGI)
tissue remodeling  (IBA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal aorta morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal aorta wall morphology  (IAGP)
abnormal articular cartilage morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IEA)
abnormal cardiovascular system physiology  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal coronal suture morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal heart morphology  (IEA)
abnormal induced retina neovascularization  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal kidney morphology  (IEA)
abnormal lambdoid suture morphology  (IAGP)
abnormal lymph node morphology  (IEA)
abnormal response to cardiac infarction  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal seminal vesicle morphology  (IEA)
abnormal skeletal muscle morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skin morphology  (IEA)
abnormal spleen morphology  (IEA)
abnormal stomach morphology  (IEA)
abnormal trabecular bone morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vitreous body morphology  (IEA)
aortitis  (IAGP)
arthritis  (IAGP)
brain inflammation  (IAGP)
broad snout  (IAGP)
cataract  (IEA)
coronal suture sclerosis  (IAGP)
cyanosis  (IAGP)
decreased angiogenesis  (IAGP)
decreased birth weight  (IAGP)
decreased body length  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IAGP)
decreased bone volume  (IAGP)
decreased grip strength  (IEA)
decreased inflammatory response  (IAGP)
decreased length of long bones  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased prepulse inhibition  (IEA)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to induced choroidal neovascularization  (IAGP)
decreased tumor growth/size  (IAGP)
delayed muscle development  (IAGP)
dilated heart left ventricle  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart  (IEA)
enlarged lymph nodes  (IEA)
enlarged spleen  (IEA)
enlarged stomach  (IEA)
impaired lung alveolus development  (IAGP)
increased inner canthal distance  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to induced aneurysm formation  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
lambdoid suture sclerosis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
sagittal suture sclerosis  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short snout  (IAGP)
small kidney  (IEA)
thin diaphragm muscle  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration. Abdul-Muneer PM, etal., Brain Behav Immun. 2017 Jan;59:190-199. doi: 10.1016/j.bbi.2016.09.002. Epub 2016 Sep 7.
2. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
3. Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
4. Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Alfonso-Jaume MA, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1838-46. Epub 2006 May 12.
5. Downregulation of remodelling enzymatic activity induced by an angiotensin-converting enzyme inhibitor (perindopril) reduces the degeneration of experimental abdominal aortic aneurysms in a rat model. Alsac JM, etal., Eur J Vasc Endovasc Surg. 2011 Apr;41(4):474-80. doi: 10.1016/j.ejvs.2010.12.007. Epub 2011 Jan 20.
6. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
7. Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
8. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
9. Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats. Barichello T, etal., Exp Biol Med (Maywood). 2014 Feb;239(2):225-31. doi: 10.1177/1535370213508354. Epub 2014 Jan 13.
10. Delayed cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-alpha activation in rat hearts subjected to global ischaemia-reperfusion. Barlaka E, etal., Can J Physiol Pharmacol. 2013 Aug;91(8):608-16. doi: 10.1139/cjpp-2012-0412. Epub 2013 Mar 3.
11. Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy. Beranek M, etal., Mol Vis. 2008 Jun 14;14:1114-21.
12. Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. Bhattacharyya SS, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Jul;8(7):645-54.
13. Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium. Bogusiewicz M, etal., Gynecol Endocrinol. 2007 Sep;23(9):541-6.
14. Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are prognostic factors in cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV) or virus persistence after treatment of CIN. Branca M, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1543-56.
15. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
16. Vascular extracellular matrix remodeling in cerebral aneurysms. Bruno G, etal., J Neurosurg. 1998 Sep;89(3):431-40.
17. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
18. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
19. Remodeling of experimental arteriovenous fistula with increased matrix metalloproteinase expression in rats. Chan CY, etal., J Vasc Surg. 2007 Apr;45(4):804-11.
20. Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. Chen Y, etal., Eur Respir J. 2010 Apr;35(4):904-12. Epub 2009 Nov 6.
21. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis. Cheung C, etal., Cardiovasc Pathol. 2006 Mar-Apr;15(2):63-74.
22. Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion. Cho KO, etal., J Neurosci Res. 2006 Feb 1;83(2):285-91.
23. Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis. Choi EY, etal., Exp Mol Med. 2002 Dec 31;34(6):391-400.
24. Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma. Christopoulos TA, etal., Oncol Rep. 2007 Oct;18(4):855-60.
25. The clinical significance of gelatinase B in gouty arthritis of the knee. Chu SC, etal., Clin Chim Acta. 2004 Jan;339(1-2):77-83.
26. Thrombus versus Wall Biological Activities in Experimental Aortic Aneurysms. Coutard M, etal., J Vasc Res. 2009 Dec 16;47(4):355-366.
27. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Covington MD, etal., Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51. Epub 2005 Aug 2.
28. Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. Dahi S, etal., J Vasc Surg. 2005 Sep;42(3):539-45.
29. Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood-brain barrier dysfunction in an animal model of severe sepsis. Dal-Pizzol F, etal., Mol Neurobiol. 2013 Aug;48(1):62-70. doi: 10.1007/s12035-013-8433-7. Epub 2013 Mar 12.
30. Matrix metalloproteinase-2 promoter polymorphism is associated with breast cancer in a Mexican population. Delgado-Enciso I, etal., Gynecol Obstet Invest. 2008;65(1):68-72. Epub 2007 Sep 13.
31. Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in diabetic and healthy subjects. Derosa G, etal., Diabetes Metab. 2007 Apr;33(2):129-34. Epub 2007 Feb 22.
32. Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension. Derosa G, etal., Endothelium. 2006 May-Jun;13(3):227-31.
33. Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions. Di Carlo A, etal., Oncol Rep. 2007 Aug;18(2):425-31.
34. Nonstenotic bicuspid aortic valve is associated with elevated plasma asymmetric dimethylarginine. Drapisz S, etal., J Cardiovasc Med (Hagerstown). 2013 Jun;14(6):446-52. doi: 10.2459/JCM.0b013e3283588dfa.
35. Effect of a specific endothelin receptor A antagonist and an angiotensin-converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis. Ebihara I, etal., Nephrol Dial Transplant. 1997 May;12(5):1001-6.
36. Noninvasive diagnosis of bladder cancer by detection of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitor (TIMP-2) in urine. Eissa S, etal., Eur Urol. 2007 Nov;52(5):1388-96. Epub 2007 Apr 10.
37. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
38. Changes in the expression of MMP2, MMP9, and ColIV in stromal cells in oral squamous tongue cell carcinoma: relationships and prognostic implications. Fan HX, etal., J Exp Clin Cancer Res. 2012 Oct 29;31:90. doi: 10.1186/1756-9966-31-90.
39. MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS. Fang L, etal., J Neurol Sci. 2010 Jul 15;294(1-2):51-6. doi: 10.1016/j.jns.2010.04.005. Epub 2010 May 4.
40. Azithromycin reduces inflammation in a rat model of acute conjunctivitis. Fernandez-Robredo P, etal., Mol Vis. 2013;19:153-65. Epub 2013 Jan 28.
41. MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. Filippov S, etal., J Exp Med. 2005 Sep 5;202(5):663-71.
42. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
43. Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease. Friese RS, etal., Clin Exp Hypertens. 2009 Oct;31(7):521-33. doi: 10.3109/10641960802668730.
44. Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26.
45. Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of metalloproteinase-1 predicts outcome in patients with congestive heart failure. George J, etal., Am Heart J. 2005 Sep;150(3):484-7.
46. Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions. Graesslin O, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1911-7.
47. Fetal MMP2/MMP9 polymorphisms and intrauterine growth restriction risk. Gremlich S, etal., J Reprod Immunol. 2007 Jun;74(1-2):143-51. Epub 2007 Mar 23.
48. Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. Gress TM, etal., Int J Cancer. 1995 Aug 9;62(4):407-13.
49. Chinese yellow wine and red wine inhibit matrix metalloproteinase-2 and improve atherosclerotic plaque in LDL receptor knockout mice. Guo H, etal., Cardiovasc Ther. 2010 Jun;28(3):161-8. doi: 10.1111/j.1755-5922.2009.00132.x. Epub 2010 Mar 31.
50. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. He H, etal., Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
51. Interstitial fibrosis in the heart: differences in extracellular matrix proteins and matrix metalloproteinases in end-stage dilated, ischaemic and valvular cardiomyopathy. Herpel E, etal., Histopathology. 2006 May;48(6):736-47.
52. Matrix metalloproteinase 2 polymorphisms in a caucasian population with abdominal aortic aneurysm. Hinterseher I, etal., J Surg Res. 2006 Jun 15;133(2):121-8. Epub 2006 Feb 3.
53. Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and Diabetes-Induced Nephropathy. Hirata T, etal., J Cardiovasc Pharmacol. 2023 Aug 25. doi: 10.1097/FJC.0000000000001473.
54. Matrix metalloproteinase-2 and epidermal growth factor are decreased in platelets of Alzheimer patients. Hochstrasser T, etal., Curr Alzheimer Res. 2012 Oct;9(8):982-9.
55. Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization. Hosford GE, etal., Pediatr Res. 2004 Jul;56(1):26-34. Epub 2004 May 5.
56. Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Hosomi N, etal., Neuroscience. 2005;134(1):225-31.
57. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
58. Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms. Ikonomidis JS, etal., Circulation. 2005 Aug 30;112(9 Suppl):I242-8.
59. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
60. Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Iniesta P, etal., Oncol Rep. 2007 Jan;17(1):217-23.
61. Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma. Jan YY, etal., Ann Surg. 2004 Jul;240(1):89-94.
62. Magnetic brain stimulation upregulates adhesion and prevents Eae: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target. Jovanova-Nesic K, etal., Int J Neurosci. 2009;119(9):1399-418.
63. Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer. Juuti A, etal., Oncology. 2006;71(1-2):61-8. Epub 2007 Mar 21.
64. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
65. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Kassiri Z, etal., Circ Res. 2005 Aug 19;97(4):380-90. Epub 2005 Jul 21.
66. Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. Kawata N, etal., Urology. 2007 Jun;69(6):1049-53.
67. Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
68. The imbalanced expression of matrix metalloproteinases in nephrogenic systemic fibrosis. Kelly BC, etal., J Am Acad Dermatol. 2010 Sep;63(3):483-9. doi: 10.1016/j.jaad.2009.09.006.
69. Role of TGF-beta1, extracellular matrix, and matrix metalloproteinase in the healing process of the pancreas after induction of acute necrotizing pancreatitis using arginine in rats. Kihara Y, etal., Pancreas. 2001 Oct;23(3):288-95.
70. Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy. Kizaki K, etal., Biol Pharm Bull. 2005 Dec;28(12):2331-4.
71. Low serum level of pro-matrix metalloproteinase 2 correlates with aggressive behavior in breast carcinoma. Kuvaja P, etal., Hum Pathol. 2006 Oct;37(10):1316-23. Epub 2006 Jul 26.
72. Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) inhibits experimental choroidal neovascularization in vivo and VEGF-induced cell migration and tube formation in vitro. Lai K, etal., Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5702-12. doi: 10.1167/iovs.10-6370.
73. Melissa officinalis extract inhibits laser-induced choroidal neovascularization in a rat model. Lee EK, etal., PLoS One. 2014 Oct 14;9(10):e110109. doi: 10.1371/journal.pone.0110109. eCollection 2014.
74. Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats. Lee MF, etal., Food Chem. 2013 Jun 1;138(2-3):802-7. doi: 10.1016/j.foodchem.2012.11.094. Epub 2012 Dec 1.
75. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
76. Prognostic value of matrix metalloproteinases (MMP-2 and MMP-9) in patients with lymph node-negative breast carcinoma. Li HC, etal., Breast Cancer Res Treat. 2004 Nov;88(1):75-85.
77. Effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice. Li W and Shen HH, Chin Med J (Engl). 2007 Jan 5;120(1):5-11.
78. [Effects of unfractionated heparin on expression of metalloproteinase-2 and -9 in acute lung injury rats]. Li X, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Oct;24(10):608-11.
79. [Association of SNPs in the promoter of MMP-2 and TIMP-2 genes with epithelial ovarian cancer.] Li XL, etal., Yi Chuan. 2008 Apr;30(4):455-62.
80. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
81. Early activation of myocardial matrix metalloproteinases and degradation of cardiac troponin I after experimental subarachnoid hemorrhage. Lin NN, etal., J Surg Res. 2013 Jan;179(1):e41-8. doi: 10.1016/j.jss.2012.02.008. Epub 2012 Mar 28.
82. [Influence of periodontal therapy on serum interleukin-6 and carotid metalloproteinases in animals with chronic periodontitis associated with atherosclerosis]. Liu Y, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2014 Mar;49(3):155-60.
83. Elevated expression of both MDR1 and MMP-2 genes in metastasized lymph node of invasive ductal breast cancer. Lu LS, etal., Eur Rev Med Pharmacol Sci. 2012 Dec;16(15):2037-43.
84. Matrix metalloproteinases and their impact on sinusal extension in chronic rhinosinusitis with nasal polyps. Malinsky RR, etal., Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1345-8. doi: 10.1007/s00405-012-2219-9. Epub 2012 Oct 12.
85. Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. Manikandan P, etal., Life Sci. 2010 Apr 29.
86. Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats. Mao JW, etal., World J Gastroenterol. 2012 Dec 21;18(47):7063-9. doi: 10.3748/wjg.v18.i47.7063.
87. Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression. Maretti-Mira AC, etal., Clin Exp Immunol. 2011 Feb;163(2):207-14. doi: 10.1111/j.1365-2249.2010.04285.x. Epub 2010 Nov 22.
88. Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis. Martinez-Torres FJ, etal., Neurosci Lett. 2004 Sep 30;368(3):274-8.
89. Inflammatory cells, cytokines and matrix metalloproteinases in amicrobial pustulosis of the folds and other neutrophilic dermatoses. Marzano AV, etal., Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2):451-60.
90. Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas. Matsuyama Y, etal., J Surg Oncol. 2002 Jun;80(2):105-10.
91. Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Mendes O, etal., Clin Exp Metastasis. 2005;22(3):237-46.
92. MGDs mouse GO annotations MGD data from the GO Consortium
93. MGD IEA MGD IEA
94. Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency. Misra S, etal., J Vasc Interv Radiol. 2010 Aug;21(8):1255-61. doi: 10.1016/j.jvir.2010.02.043. Epub 2010 Jul 3.
95. Terazosin modifies the content of glycosaminoglycans and the activity of matrix metalloproteinase 2 in the rat ventral prostate. Mitropoulos D, etal., Eur Urol. 2007 Feb;51(2):447-56; discussion 456. Epub 2006 Jul 5.
96. Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. Miyake JA, etal., Lipids Health Dis. 2009 Mar 17;8:8. doi: 10.1186/1476-511X-8-8.
97. Temporal expression and activation of matrix metalloproteinases-2, -9, and membrane type 1-matrix metalloproteinase following acute hindlimb ischemia. Muhs BE, etal., J Surg Res. 2003 May 1;111(1):8-15.
98. Black tea polyphenols target matrix metalloproteinases, RECK, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model. Murugan RS, etal., Anticancer Res. 2009 Jun;29(6):2301-5.
99. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. Nakano A, etal., J Neurosurg. 1995 Aug;83(2):298-307.
100. Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Niebroj-Dobosz I, etal., Eur J Neurol. 2010 Feb;17(2):226-31. doi: 10.1111/j.1468-1331.2009.02775.x. Epub 2009 Oct 1.
101. Matrix metalloproteinases with gelatinolytic activity induced by Paracoccidioides brasiliensis infection. Nishikaku AS, etal., Int J Exp Pathol. 2009 Oct;90(5):527-37. doi: 10.1111/j.1365-2613.2009.00663.x.
102. Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy. Noda K, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):2163-70.
103. Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers. Norgauer J, etal., Br J Dermatol. 2002 Dec;147(6):1180-6.
104. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
105. High numbers of human skin cancers express MMP2 and several integrin genes. Orimoto AM, etal., J Cutan Pathol. 2008 Mar;35(3):285-91. doi: 10.1111/j.1600-0560.2007.00810.x.
106. Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas. Orlandi A, etal., Am J Pathol. 2005 Jun;166(6):1619-28.
107. The relation between keratoconus and plasma levels of MMP-2, zinc, and SOD. Ortak H, etal., Cornea. 2012 Sep;31(9):1048-51. doi: 10.1097/ICO.0b013e318254c028.
108. Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion. Ortak H, etal., Exp Eye Res. 2013 Aug;113:151-5. doi: 10.1016/j.exer.2013.06.009. Epub 2013 Jun 18.
109. The role of MMP2 (-1306C>T) and TIMP2 (-418 G>C) promoter variants in age-related macular degeneration. Ortak H, etal., Ophthalmic Genet. 2013 Dec;34(4):217-22. doi: 10.3109/13816810.2013.781192. Epub 2013 Mar 28.
110. The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. Pannu H, etal., J Neurosurg. 2006 Sep;105(3):418-23.
111. Induction of secretory leukocyte protease inhibitor (SLPI) in estradiol valerate (EV) induced polycystic ovary. Park JJ, etal., Arch Pharm Res. 2011 Aug;34(8):1389-97. doi: 10.1007/s12272-011-0820-x. Epub 2011 Sep 11.
112. Serum MMP-2 and MMP-9 in patients with Behcet's disease: do their higher levels correlate to vasculo-Behcet's disease associated with aneurysm formation? Pay S, etal., Clin Exp Rheumatol. 2007 Jul-Aug;25(4 Suppl 45):S70-5.
113. Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China. Peihong S and Perry F, Ethiop Med J. 2007 Jan;45(1):79-83.
114. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
115. Expression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placenta. Petignat P, etal., Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1679-84.
116. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
117. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
118. Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia. Planas AM, etal., Neurobiol Dis. 2001 Oct;8(5):834-46.
119. ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. Podesser BK, etal., Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H984-91.
120. Atrial extracellular matrix remodelling in patients with atrial fibrillation. Polyakova V, etal., J Cell Mol Med. 2008 Jan-Feb;12(1):189-208. doi: 10.1111/j.1582-4934.2008.00219.x. Epub 2008 Jan 10.
121. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
122. Morphological changes of cerebral vessels and expression patterns of MMP-2 and MMP-9 on cerebrovascular wall of alcoholic rats. Qi Q, etal., Int J Clin Exp Pathol. 2014 Apr 15;7(5):1880-8. eCollection 2014.
123. Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis. Qin YH, etal., Pediatr Nephrol. 2009 Aug;24(8):1477-86. Epub 2009 Apr 9.
124. LncRNA H19 regulates smooth muscle cell functions and participates in the development of aortic dissection through sponging miR-193b-3p. Ren M, etal., Biosci Rep. 2021 Jan 29;41(1):BSR20202298. doi: 10.1042/BSR20202298.
125. MMP-2 and TIMP-2 in cutaneous melanoma: association with prognostic factors and description in cutaneous metastases. Rey MC, etal., Am J Dermatopathol. 2011 Jun;33(4):413-4. doi: 10.1097/DAD.0b013e3181e2e8d6.
126. Mouse MP Annotation Import Pipeline RGD automated import pipeline
127. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
128. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
129. Temporal changes in cardiac matrix metalloproteinase activity, oxidative stress, and TGF-beta in renovascular hypertension-induced cardiac hypertrophy. Rizzi E, etal., Exp Mol Pathol. 2013 Feb;94(1):1-9. doi: 10.1016/j.yexmp.2012.10.010. Epub 2012 Oct 13.
130. Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy. Roldan V, etal., Am Heart J. 2008 Jul;156(1):85-91.
131. A novel homozygous MMP2 mutation in a family with Winchester syndrome. Rouzier C, etal., Clin Genet. 2006 Mar;69(3):271-6.
132. The roles of matrix metalloproteinases-2, -7, -10 and tissue inhibitor of metalloproteinase-1 in the pathogenesis of oral lichen planus. Rubaci AH, etal., J Oral Pathol Med. 2012 Oct;41(9):689-96. doi: 10.1111/j.1600-0714.2012.01160.x. Epub 2012 May 3.
133. Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis. Sanders JS, etal., Am J Physiol Renal Physiol. 2007 Dec;293(6):F1927-34. Epub 2007 Sep 26.
134. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
135. Gelatinase expression and proteolytic activity in giant-cell arteritis. Segarra M, etal., Ann Rheum Dis. 2007 Nov;66(11):1429-35. Epub 2007 May 14.
136. Estrogen receptor alpha and matrix metalloproteinase 2 polymorphisms and age-related maculopathy in older women. Seitzman RL, etal., Am J Epidemiol. 2008 May 15;167(10):1217-25. doi: 10.1093/aje/kwn024. Epub 2008 Mar 20.
137. Antioxidant Vitamin C attenuates experimental abdominal aortic aneurysm development in an elastase-induced rat model. Shang T, etal., J Surg Res. 2014 May 1;188(1):316-25. doi: 10.1016/j.jss.2013.11.1105. Epub 2013 Dec 6.
138. Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity. Shin HW, etal., Otolaryngol Head Neck Surg. 2009 Oct;141(4):442-7.
139. Immunohistochemical expression of vascular endothelial growth factor, matrix metalloproteinase 2, and matrix metalloproteinase 9 in cutaneous melanocytic lesions. Simonetti O, etal., Cancer. 2002 Nov 1;95(9):1963-70.
140. Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms. Sinha I, etal., Surgery. 2004 Aug;136(2):176-82.
141. Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Sivaramakrishnan V and Niranjali Devaraj S, Chem Biol Interact. 2009 Aug 14;180(3):353-9. Epub 2009 Feb 21.
142. Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms. Sluijter JP, etal., Stroke. 2006 Jan;37(1):235-9. Epub 2005 Dec 8.
143. Mechanisms regulating invasiveness and growth of endometriosis lesions in rat experimental model and in humans. Sotnikova NY, etal., Fertil Steril. 2010 May 15;93(8):2701-5. Epub 2010 Jan 8.
144. L-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9. Souza-Costa DC, etal., Chest. 2005 Nov;128(5):3705-10.
145. Urine vascular biomarkers in Sturge-Weber syndrome. Sreenivasan AK, etal., Vasc Med. 2013 Jun;18(3):122-8. doi: 10.1177/1358863X13486312.
146. Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder. Staack A, etal., BMC Urol. 2006 Aug 10;6:19.
147. [mRNA expression analysis of metastatic markers in clear-cell renal cell carcinoma] Struckmann K, etal., Verh Dtsch Ges Pathol. 2005;89:178-83.
148. Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats. Sun H, etal., Diabetes Res Clin Pract. 2013 Apr;100(1):85-95. doi: 10.1016/j.diabres.2013.01.012. Epub 2013 Feb 4.
149. Serum levels of matrix metalloproteinases 2 and 9 and TGFBR2 gene screening in patients with ascending aortic dilatation. Símová J, etal., Folia Biol (Praha). 2013;59(4):154-61.
150. MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Tchetverikov I, etal., Ann Rheum Dis. 2004 Jul;63(7):881-3.
151. Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction. Thibert KA, etal., PLoS One. 2012;7(11):e50430. doi: 10.1371/journal.pone.0050430. Epub 2012 Nov 21.
152. Expression of metalloproteinase-2 (gelatinase A) in labial salivary glands of patients with Sjogren's syndrome with HTLV-I infection. Tominaga M, etal., Clin Exp Rheumatol. 1999 Jul-Aug;17(4):463-6.
153. Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry. Trudel D, etal., Hum Pathol. 2008 Mar 7;.
154. Serum levels of matrix metalloproteinase-2 as a marker of intimal hyperplasia. Tummers AM, etal., J Surg Res. 2010 May 1;160(1):9-13. Epub 2009 May 13.
155. Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. Umar S, etal., Pathol Res Pract. 2007;203(12):863-72. Epub 2007 Oct 29.
156. Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer. Vaish V, etal., Cell Biochem Biophys. 2013 Jun;66(2):205-27. doi: 10.1007/s12013-012-9469-4.
157. Evaluation of molecular markers in a rat model of mammary carcinogenesis. Vinothini G, etal., Oncol Res. 2009;17(10):483-93.
158. Increased expression of matrix metalloproteinases in the murine zymosan-induced multiple organ dysfunction syndrome. Volman TJ, etal., J Pathol. 2004 Aug;203(4):968-75.
159. Matrix metalloproteinases and their inhibitors in different acute stroke subtypes. Vukasovic I, etal., Clin Chem Lab Med. 2006;44(4):428-34.
160. [Detection of the activity of MMP2 and MMP9 in middle ear cholesteatoma]. Wang H, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Oct;18(10):620-2.
161. [Expression of matrix metalloproteinase-2,9 in cholesteatoma from different positions]. Wang J and Yu LS, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;44(1):44-8.
162. Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury. Webb KE, etal., Arterioscler Thromb Vasc Biol. 1997 Sep;17(9):1837-44.
163. Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families. Wojciechowski R, etal., Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4989-95. doi: 10.1167/iovs.10-5474. Epub 2010 May 19.
164. The expression of CD40-CD40L and activities of matrix metalloproteinases in atherosclerotic rats. Wu M and Li YG, Mol Cell Biochem. 2006 Jan;282(1-2):141-6.
165. Cariporide, a specific Na/H(+) exchanger 1 blocker, inhibits neointimal proliferation induced by advanced glycation end products in a balloon injury rat model. Wu S, etal., Pharmacology. 2013;91(3-4):123-30. doi: 10.1159/000346128. Epub 2013 Jan 23.
166. Prediction of prognosis in gallbladder carcinoma by CD147 and MMP-2 immunohistochemistry. Wu W, etal., Med Oncol. 2009;26(2):117-23. Epub 2008 Jul 30.
167. [Effects of ru'ai shuhou recipe on the matrix metalloproteinases and the inhibitive factors in the recurrence and metastasis of HER2 positive breast cancer]. Wu XQ, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Nov;32(11):1526-30.
168. Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome. Xiong W, etal., J Vasc Surg. 2008 Jan;47(1):166-72; discussion 172. doi: 10.1016/j.jvs.2007.09.016.
169. Effects of Acupuncture at GV20 and ST36 on the Expression of Matrix Metalloproteinase 2, Aquaporin 4, and Aquaporin 9 in Rats Subjected to Cerebral Ischemia/Reperfusion Injury. Xu H, etal., PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014.
170. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology Xu SL, etal., Zhonghua Yan Ke Za Zhi. 2009 Mar;45(3):260-5.
171. Adventitial transduction of lentivirus-shRNA-VEGF-A in arteriovenous fistula reduces venous stenosis formation. Yang B, etal., Kidney Int. 2014 Feb;85(2):289-306. doi: 10.1038/ki.2013.290. Epub 2013 Aug 7.
172. Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice. Yang B, etal., PLoS One. 2019 Feb 21;14(2):e0201504. doi: 10.1371/journal.pone.0201504. eCollection 2019.
173. Imbalance of matrix metalloproteinases/tissue inhibitor of metalloproteinase-1 and loss of fibronectin expression in patients with congestive heart failure. Yang DC, etal., Cardiology. 2010;116(2):133-41. doi: 10.1159/000317245. Epub 2010 Jul 1.
174. Effects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal cord edema after spinal cord injury. Yang J, etal., Life Sci. 2013 Dec 18;93(25-26):1033-8.
175. Increased expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts with disease progression and activation of protein kinase C. Yang SF, etal., Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4588-96. doi: 10.1167/iovs.08-3147. Epub 2009 May 6.
176. Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice. Yang Y, etal., Aging (Albany NY). 2019 Nov 22;11(22):10016-10030. doi: 10.18632/aging.102388. Epub 2019 Nov 22.
177. Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. Yang Y, etal., J Neurochem. 2010 Jan;112(1):134-49. Epub 2009 Oct 15.
178. The effect of corticosteroid on metalloproteinase levels of nasal polyposis. Yigit O, etal., Laryngoscope. 2011 Mar;121(3):667-73. doi: 10.1002/lary.21462. Epub 2011 Feb 8.
179. Matrix metalloproteinase-2 in pancreatic juice for diagnosis of pancreatic cancer. Yokoyama M, etal., Pancreas. 2002 May;24(4):344-7.
180. Analysis of MMP2 promoter polymorphisms in patients with pseudoxanthoma elasticum. Zarbock R, etal., Clin Chim Acta. 2010 Oct 9;411(19-20):1487-90. doi: 10.1016/j.cca.2010.06.006. Epub 2010 Jun 10.
181. Serum levels of matrix metalloproteinase 2 and matrix metalloproteinase 9 elevated in polypoidal choroidal vasculopathy but not in age-related macular degeneration. Zeng R, etal., Mol Vis. 2013;19:729-36. Epub 2013 Mar 21.
182. Expression of matrix metalloproteinase 2 and extracellular matrix metalloproteinase inducer are unfavorable postoperative prognostic factors in intrahepatic cholangiocarcinoma. Zhang C, etal., Pathol Oncol Res. 2010 Mar;16(1):47-53. Epub 2009 Jul 25.
183. [Expression of trophoblast invasion related genes mRNA and protein in human placenta in preeclampsia]. Zhang H, etal., Zhonghua Fu Chan Ke Za Zhi. 2006 Aug;41(8):509-13.
184. rAAV2-TGF-beta(3) Decreases Collagen Synthesis and Deposition in the Liver of Experimental Hepatic Fibrosis Rat. Zhang Y, etal., Dig Dis Sci. 2010 Jan 28.
185. Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis. Zhang YB, etal., Chin J Traumatol. 2010 Jun 1;13(3):188-92.
186. [Expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model] Zhao XQ, etal., Hua Xi Kou Qiang Yi Xue Za Zhi. 2006 Jun;24(3):202-5.
187. [Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma]. Zheng Y, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Apr;46(4):299-302.
188. Expression of matrix metalloproteinase and its tissue inhibitor in haemangioma. Zhong S, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):614-9. doi: 10.1007/s11596-009-0516-3. Epub 2009 Oct 11.
Additional References at PubMed
PMID:1373140   PMID:1471951   PMID:2744464   PMID:7626795   PMID:7669731   PMID:7894006   PMID:8015608   PMID:8144618   PMID:8674412   PMID:8743942   PMID:8872958   PMID:9069116  
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PMID:12193736   PMID:12208863   PMID:12220955   PMID:12237117   PMID:12368215   PMID:12419962   PMID:12453184   PMID:12466851   PMID:12473670   PMID:12477932   PMID:12482397   PMID:12506102  
PMID:12557216   PMID:12591918   PMID:12735482   PMID:12750313   PMID:12775562   PMID:12805379   PMID:12815621   PMID:12821796   PMID:12939223   PMID:12950084   PMID:12963732   PMID:12975354  
PMID:14551157   PMID:14561647   PMID:14563686   PMID:14585355   PMID:14638740   PMID:14675176   PMID:14729404   PMID:14729463   PMID:14736853   PMID:14756057   PMID:14993222   PMID:15047130  
PMID:15059974   PMID:15064723   PMID:15075248   PMID:15212943   PMID:15220345   PMID:15265790   PMID:15277330   PMID:15343380   PMID:15355971   PMID:15474357   PMID:15489334   PMID:15502710  
PMID:15508185   PMID:15522913   PMID:15536133   PMID:15543606   PMID:15545316   PMID:15545515   PMID:15550552   PMID:15572153   PMID:15618213   PMID:15670768   PMID:15670794   PMID:15707406  
PMID:15711638   PMID:15734845   PMID:15739229   PMID:15748894   PMID:15760390   PMID:15760903   PMID:15763341   PMID:15782199   PMID:15805464   PMID:15823918   PMID:15843578   PMID:15862156  
PMID:15937097   PMID:16007210   PMID:16018191   PMID:16047212   PMID:16093645   PMID:16113801   PMID:16141072   PMID:16141073   PMID:16183043   PMID:16219541   PMID:16236725   PMID:16244581  
PMID:16258061   PMID:16397239   PMID:16428450   PMID:16469749   PMID:16474180   PMID:16505197   PMID:16509766   PMID:16551362   PMID:16556856   PMID:16585265   PMID:16602821   PMID:16607611  
PMID:16650610   PMID:16678100   PMID:16680826   PMID:16691565   PMID:16785994   PMID:16825197   PMID:16845676   PMID:16847049   PMID:16887049   PMID:16951375   PMID:16959767   PMID:16980344  
PMID:17005848   PMID:17008622   PMID:17065436   PMID:17081126   PMID:17082650   PMID:17136358   PMID:17158653   PMID:17210124   PMID:17215487   PMID:17251494   PMID:17283058   PMID:17303760  
PMID:17307908   PMID:17322177   PMID:17344928   PMID:17348864   PMID:17349656   PMID:17382917   PMID:17386921   PMID:17400654   PMID:17412577   PMID:17440987   PMID:17442971   PMID:17460063  
PMID:17472698   PMID:17475219   PMID:17483344   PMID:17498626   PMID:17561096   PMID:17587297   PMID:17623663   PMID:17623673   PMID:17633135   PMID:17638886   PMID:17641224   PMID:17681721  
PMID:17682049   PMID:17692316   PMID:17709990   PMID:17908800   PMID:17960656   PMID:17965409   PMID:17979883   PMID:18003950   PMID:18043506   PMID:18060646   PMID:18069628   PMID:18160708  
PMID:18222481   PMID:18264108   PMID:18267097   PMID:18274672   PMID:18303576   PMID:18340378   PMID:18359864   PMID:18364034   PMID:18445063   PMID:18458097   PMID:18472181   PMID:18492766  
PMID:18556655   PMID:18559979   PMID:18596727   PMID:18627313   PMID:18639653   PMID:18667463   PMID:18669618   PMID:18704294   PMID:18757369   PMID:18762577   PMID:18817873   PMID:18835790  
PMID:18987327   PMID:19010778   PMID:19015235   PMID:19038858   PMID:19038859   PMID:19051246   PMID:19074020   PMID:19092727   PMID:19147652   PMID:19171847   PMID:19180798   PMID:19221044  
PMID:19276073   PMID:19287959   PMID:19375650   PMID:19509016   PMID:19542530   PMID:19578738   PMID:19580633   PMID:19581512   PMID:19594013   PMID:19724919   PMID:19764560   PMID:19780201  
PMID:19790245   PMID:19795413   PMID:19795511   PMID:19808257   PMID:19828778   PMID:19884566   PMID:19913533   PMID:19915515   PMID:19940766   PMID:19995958   PMID:20037812   PMID:20056917  
PMID:20093499   PMID:20101710   PMID:20107604   PMID:20152179   PMID:20163454   PMID:20165883   PMID:20181883   PMID:20189954   PMID:20215503   PMID:20223936   PMID:20230750   PMID:20232295  
PMID:20305284   PMID:20353950   PMID:20375993   PMID:20398633   PMID:20407871   PMID:20516072   PMID:20548288   PMID:20551517   PMID:20563750   PMID:20616008   PMID:20637190   PMID:20639459  
PMID:20679550   PMID:20683677   PMID:20829506   PMID:20839326   PMID:20845081   PMID:20886179   PMID:20934971   PMID:20937816   PMID:20956976   PMID:20978081   PMID:21039989   PMID:21041693  
PMID:21079048   PMID:21132408   PMID:21135056   PMID:21135236   PMID:21158073   PMID:21179735   PMID:21231833   PMID:21241594   PMID:21267068   PMID:21300023   PMID:21320869   PMID:21334624  
PMID:21343160   PMID:21354273   PMID:21376707   PMID:21418186   PMID:21421844   PMID:21454403   PMID:21508260   PMID:21567073   PMID:21611966   PMID:21641389   PMID:21704005   PMID:21750040  
PMID:21775118   PMID:21836084   PMID:21837459   PMID:21858843   PMID:21864729   PMID:21865464   PMID:21873635   PMID:21900575   PMID:21903356   PMID:21904637   PMID:21906275   PMID:21986284  
PMID:21986287   PMID:22014525   PMID:22171010   PMID:22238668   PMID:22378877   PMID:22396544   PMID:22421441   PMID:22464947   PMID:22483803   PMID:22490679   PMID:22509276   PMID:22521821  
PMID:22550139   PMID:22614125   PMID:22688677   PMID:22714107   PMID:22917927   PMID:22932696   PMID:23028104   PMID:23048035   PMID:23089194   PMID:23091646   PMID:23144462   PMID:23225890  
PMID:23306080   PMID:23312504   PMID:23322905   PMID:23334579   PMID:23349620   PMID:23354118   PMID:23398532   PMID:23421805   PMID:23465590   PMID:23482328   PMID:23490298   PMID:23509775  
PMID:23523587   PMID:23548779   PMID:23664424   PMID:23702312   PMID:23806407   PMID:23811845   PMID:23824573   PMID:23874529   PMID:23884892   PMID:23936390   PMID:23940733   PMID:24006456  
PMID:24028490   PMID:24035828   PMID:24062440   PMID:24095877   PMID:24141049   PMID:24174624   PMID:24176640   PMID:24195673   PMID:24278461   PMID:24291175   PMID:24333535   PMID:24373743  
PMID:24375642   PMID:24508733   PMID:24611815   PMID:24631289   PMID:24652381   PMID:24694005   PMID:24706882   PMID:24814605   PMID:24905939   PMID:24909139   PMID:24971735   PMID:25015352  
PMID:25149191   PMID:25150065   PMID:25157440   PMID:25193593   PMID:25204377   PMID:25352026   PMID:25361902   PMID:25381636   PMID:25405459   PMID:25469981   PMID:25512019   PMID:25572963  
PMID:25574848   PMID:25576870   PMID:25613181   PMID:25636537   PMID:25646300   PMID:25657308   PMID:25703139   PMID:25704809   PMID:25733533   PMID:25770908   PMID:25778400   PMID:25794647  
PMID:25820137   PMID:25824133   PMID:25869489   PMID:25920569   PMID:25961753   PMID:25986148   PMID:26133107   PMID:26213293   PMID:26244298   PMID:26318311   PMID:26355684   PMID:26378152  
PMID:26390284   PMID:26438731   PMID:26451090   PMID:26471094   PMID:26510894   PMID:26546710   PMID:26567374   PMID:26588471   PMID:26673451   PMID:26881424   PMID:26968737   PMID:26985676  
PMID:26989874   PMID:27001612   PMID:27038751   PMID:27164414   PMID:27265328   PMID:27306493   PMID:27363580   PMID:27453531   PMID:27468657   PMID:27601324   PMID:27633994   PMID:27732850  
PMID:27831901   PMID:27915985   PMID:27919822   PMID:28053109   PMID:28118605   PMID:28179581   PMID:28223495   PMID:28237967   PMID:28320710   PMID:28331061   PMID:28348418   PMID:28400434  
PMID:28593951   PMID:28611024   PMID:28639940   PMID:28642362   PMID:28666838   PMID:28669039   PMID:28766880   PMID:28800037   PMID:28821434   PMID:28827401   PMID:28883215   PMID:28912710  
PMID:28992079   PMID:29016715   PMID:29064547   PMID:29065106   PMID:29158162   PMID:29190653   PMID:29267523   PMID:29322806   PMID:29366755   PMID:29377313   PMID:29415171   PMID:29428733  
PMID:29456135   PMID:29567669   PMID:29743679   PMID:29749704   PMID:29803830   PMID:29913136   PMID:30061417   PMID:30135249   PMID:30248101   PMID:30269950   PMID:30283358   PMID:30297691  
PMID:30389913   PMID:30503336   PMID:30550785   PMID:30572657   PMID:30578393   PMID:30676070   PMID:30723388   PMID:30822518   PMID:30993494   PMID:31061823   PMID:31286822   PMID:31424120  
PMID:31434798   PMID:31461499   PMID:31600777   PMID:31634485   PMID:31699373   PMID:31726690   PMID:32067275   PMID:32208990   PMID:32325033   PMID:32344273   PMID:32523119   PMID:32591430  
PMID:32732898   PMID:32784053   PMID:32825931   PMID:32882513   PMID:33057440   PMID:33470127   PMID:33763067   PMID:33811421   PMID:33871356   PMID:33891967   PMID:33903225   PMID:33929320  
PMID:34001241   PMID:34323105   PMID:34359839   PMID:34482531   PMID:34586381   PMID:34767447   PMID:35269933   PMID:35493520   PMID:35705936   PMID:35802383   PMID:35804363   PMID:36261075  
PMID:36414704   PMID:36465133   PMID:36607591   PMID:37047672   PMID:37312667   PMID:37454877   PMID:37495895   PMID:37700592   PMID:37701782   PMID:37889501   PMID:37939860   PMID:37948457  
PMID:38069145  


Genomics

Comparative Map Data
Mmp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,553,920 - 93,580,049 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,553,919 - 93,580,048 (+)EnsemblGRCm39 Ensembl
GRCm38892,827,290 - 92,853,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,827,291 - 92,853,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37895,351,227 - 95,377,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36895,716,456 - 95,742,548 (+)NCBIMGSCv36mm8
Celera897,157,107 - 97,183,318 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.99NCBI
MMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381655,478,830 - 55,506,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1655,389,700 - 55,506,691 (+)EnsemblGRCh38hg38GRCh38
GRCh371655,512,742 - 55,540,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,070,589 - 54,098,104 (+)NCBINCBI36Build 36hg18NCBI36
Build 341654,070,603 - 54,097,652NCBI
Celera1640,027,315 - 40,054,814 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1641,400,533 - 41,427,983 (+)NCBIHuRef
CHM1_11656,920,344 - 56,947,845 (+)NCBICHM1_1
T2T-CHM13v2.01661,276,956 - 61,304,813 (+)NCBIT2T-CHM13v2.0
Mmp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,327,643 - 30,355,856 (-)NCBIGRCr8
mRatBN7.21914,154,657 - 14,182,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,850,377 - 15,877,927 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01921,045,167 - 21,072,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,990,811 - 24,019,370 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,542,771 - 15,570,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,629,728 - 26,658,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,246,036 - 15,275,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1914,077,766 - 14,105,839 (-)NCBICelera
Cytogenetic Map19p11NCBI
Mmp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543313,024,418 - 13,052,775 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543313,024,844 - 13,050,041 (+)NCBIChiLan1.0ChiLan1.0
MMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21864,904,348 - 64,934,250 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11670,825,738 - 70,852,751 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01635,711,866 - 35,738,881 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11654,817,228 - 54,844,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1654,812,694 - 54,844,279 (+)Ensemblpanpan1.1panPan2
MMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,471,092 - 60,492,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,471,257 - 60,494,113 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,105,772 - 57,130,788 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,016,206 - 61,041,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,016,193 - 61,041,733 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,844,808 - 57,869,825 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,869,067 - 58,894,067 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,747,357 - 59,772,363 (-)NCBIUU_Cfam_GSD_1.0
Mmp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934951,763,246 - 51,787,737 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364757,801,277 - 7,825,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364757,801,356 - 7,825,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl630,058,595 - 30,086,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1630,059,247 - 30,087,031 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2627,526,396 - 27,553,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI
MMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1541,264,382 - 41,291,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl541,264,354 - 41,291,004 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604735,055,095 - 35,082,722 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247571,448,698 - 1,479,255 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247571,450,680 - 1,479,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp2
863 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:348
Count of miRNA genes:232
Interacting mature miRNAs:267
Transcripts:ENSMUST00000034187
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse

Markers in Region
Mmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
cM Map844.0UniSTS
cM Map842.9UniSTS
M84324  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38892,853,251 - 92,853,394UniSTSGRCm38
MGSCv37895,377,150 - 95,377,293UniSTSGRCm37
Celera897,183,149 - 97,183,292UniSTS
Cytogenetic Map8C5UniSTS
cM Map844.0UniSTS
Whitehead/MRC_RH81079.9UniSTS
Mmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
cM Map842.9UniSTS
Mmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
Mmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
Mmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB125668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC121604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  AK201746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  AK201951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  AK203248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  AK203919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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RefSeq Acc Id: ENSMUST00000034187   ⟹   ENSMUSP00000034187
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl893,553,919 - 93,580,048 (+)Ensembl
GRCm38.p6 Ensembl892,827,291 - 92,853,420 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211308
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl893,570,159 - 93,579,630 (+)Ensembl
GRCm38.p6 Ensembl892,843,531 - 92,853,002 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211567   ⟹   ENSMUSP00000147838
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl893,570,578 - 93,580,047 (+)Ensembl
GRCm38.p6 Ensembl892,843,950 - 92,853,419 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211691
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl893,566,812 - 93,579,512 (+)Ensembl
GRCm38.p6 Ensembl892,840,184 - 92,852,884 (+)Ensembl
RefSeq Acc Id: NM_008610   ⟹   NP_032636
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39893,553,925 - 93,580,049 (+)NCBI
GRCm38892,827,297 - 92,853,421 (+)NCBI
MGSCv37895,351,227 - 95,377,319 (+)RGD
Celera897,157,107 - 97,183,318 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530751   ⟹   XP_006530814
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39893,553,920 - 93,580,048 (+)NCBI
GRCm38892,827,290 - 92,853,420 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032636   ⟸   NM_008610
- Peptide Label: preproprotein
- UniProtKB: P33434 (UniProtKB/Swiss-Prot),   Q3UG07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530814   ⟸   XM_006530751
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000034187   ⟸   ENSMUST00000034187
RefSeq Acc Id: ENSMUSP00000147838   ⟸   ENSMUST00000211567
Protein Domains
Fibronectin type-II

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33434-F1-model_v2 AlphaFold P33434 1-662 view protein structure

Promoters
RGD ID:8667857
Promoter ID:EPDNEW_M11959
Type:initiation region
Name:Mmp2_1
Description:Mus musculus matrix metallopeptidase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38892,827,367 - 92,827,427EPDNEW
RGD ID:6843485
Promoter ID:MM_KWN:55273
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   MEF_B4,   MEF_B6
Transcripts:NM_008610
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36895,350,371 - 95,351,422 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97009 AgrOrtholog
Ensembl Genes ENSMUSG00000031740 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034187 ENTREZGENE
  ENSMUST00000034187.9 UniProtKB/Swiss-Prot
  ENSMUST00000211567.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN_type2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97009 ENTREZGENE
NCBI Gene 17390 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10201:SF29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmp2 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FNTYPEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART FN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GS88_MOUSE UniProtKB/TrEMBL
  MMP2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UG07 ENTREZGENE, UniProtKB/TrEMBL
  Q6GXA5_MOUSE UniProtKB/TrEMBL
  Q75UT7_MOUSE UniProtKB/TrEMBL