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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:6980
Term: monocrotaline
Definition: A pyrrolizidine alkaloid that has formula C16H23NO6.
Chemical ID: MESH:D016686
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases expressionEXP 6480464CTDMonocrotaline results in increased expression of MMP2 mRNAPMID:22022327
Mmp2multiple interactionsEXP 6480464CTDSimvastatin inhibits the reaction [Monocrotaline results in increased expression of MMP2 mRNA]PMID:22022327
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of MMP2 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP2 mRNAPMID:31470032
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