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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:310312
Term: isoliquiritigenin
Definition: A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.
Chemical ID: MESH:C040920
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionISORGD:7308216480464CTDisoliquiritigenin results in decreased expression of MMP2 mRNA, isoliquiritigenin results in decreased expression of MMP2 protein

PMID:25094029
Mmp2multiple interactionsISORGD:7308216480464CTD20-hydroxyeicosa-5(Z), 14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA], 20-hydroxyeicosa-5(Z), 14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein], AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA], AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein], CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA], CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein], Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA], Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]

PMID:25094029
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.