Mmp3 (matrix metallopeptidase 3) - Rat Genome Database

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Gene: Mmp3 (matrix metallopeptidase 3) Rattus norvegicus
Analyze
Symbol: Mmp3
Name: matrix metallopeptidase 3
RGD ID: 621317
Description: Predicted to enable endopeptidase activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to interleukin-1; and response to estradiol. Located in cell body; dendrite; and extracellular space. Part of protein-containing complex. Biomarker of several diseases, including abdominal aortic aneurysm; degenerative disc disease; gastric ulcer; glomerulonephritis (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3); PARTICIPATES IN rheumatoid arthritis pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: matrix metalloproteinase 3; matrix metalloproteinase-3; MMP-3; PTR1 protein; SL-1; stromelysin-1; transin-1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.284,640,397 - 4,653,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,640,416 - 4,653,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,600,140 - 8,613,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,897,910 - 6,911,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,900,079 - 4,913,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,676,608 - 5,698,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,676,665 - 5,698,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,680,382 - 5,701,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,315,601 - 4,329,146 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,315,600 - 4,329,146 (+)NCBI
Celera86,200,234 - 6,213,783 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
Acute Otitis Media  (ISO)
allergic contact dermatitis  (IEP,ISO)
Alport syndrome  (ISO)
arteriosclerosis  (ISO)
asphyxiating thoracic dystrophy  (ISO)
ataxia telangiectasia  (ISO)
atrial fibrillation  (ISO)
Brain Hypoxia-Ischemia  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Carotid Artery Injuries  (IEP)
carotid stenosis  (ISO)
cartilage disease  (IEP)
cataract  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Allograft Nephropathy  (ISO)
cognitive disorder  (IEP)
colon cancer  (IEP)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
conjunctivochalasis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
crescentic glomerulonephritis  (IEP)
degenerative disc disease  (IEP)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dry eye syndrome  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP)
esophagus adenocarcinoma  (ISO)
Experimental Arthritis  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP)
Experimental Mammary Neoplasms  (IMP)
gastric ulcer  (IEP)
genetic disease  (ISO)
glomerulonephritis  (IEP,ISO)
Gouty Arthritis  (ISO)
Hyperalgesia  (IMP,ISO)
idiopathic pulmonary fibrosis  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
intellectual disability  (ISO)
Knee Osteoarthritis  (IMP)
lung cancer  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IEP)
osteoarthritis  (ISO)
Parkinsonism  (IEP)
Penetrating Wounds  (IEP)
periodontitis  (IEP)
Peripheral Nerve Injuries  (IEP)
peripheral nervous system disease  (ISO)
polymyalgia rheumatica  (ISO)
primary biliary cholangitis  (IEP)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
rheumatoid arthritis  (ISO)
Sjogren's syndrome  (ISO)
Stroke  (IEP)
systemic scleroderma  (ISO)
Takayasu's arteritis  (ISO)
Tendon Injuries  (IEP)
thrombosis  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (IEP)
Ulcer  (ISO)
Venous Thrombosis  (IEP)
von Hippel-Lindau disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (EXP)
3-hydroxypicolinic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-iodotubercidin  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetylsalicylic acid  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
azithromycin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
BQ 123  (ISO)
Butylparaben  (EXP)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloramphenicol  (ISO)
chlorothalonil  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dieckol  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
doxycycline  (ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
enalapril  (ISO)
endosulfan  (EXP,ISO)
enzacamene  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fucoidan  (ISO)
galaxolide  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
geraniol  (ISO)
glycitein  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
HU-308  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irigenin  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
L-proline betaine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
loliolide  (ISO)
lovastatin  (ISO)
malathion  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
megestrol acetate  (EXP)
melittin  (ISO)
Methanandamide  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
mibolerone  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
Morroniside  (ISO)
moxifloxacin  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
NSC 23766  (ISO)
ofloxacin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
PD 168393  (ISO)
phenethyl caffeate  (EXP,ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
prinomastat  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
resorcinol  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
streptozocin  (EXP,ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
trametinib  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
varespladib methyl  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Changes in matrix metalloproteinases and their inhibitors in kidney transplant recipients. Ahmed AK, etal., Exp Clin Transplant. 2012 Aug;10(4):332-43.
2. Type 2 diabetes impairs tendon repair after injury in a rat model. Ahmed AS, etal., J Appl Physiol (1985). 2012 Dec 1;113(11):1784-91. doi: 10.1152/japplphysiol.00767.2012. Epub 2012 Oct 4.
3. Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. Bousserouel S, etal., Oncol Rep. 2010 Feb;23(2):511-7.
4. Novel phosphoinositide 3-kinase delta,gamma inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. Boyle DL, etal., J Pharmacol Exp Ther. 2014 Feb;348(2):271-80. doi: 10.1124/jpet.113.205955. Epub 2013 Nov 15.
5. Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis. Bradbury PA, etal., Carcinogenesis. 2009 May;30(5):793-8. doi: 10.1093/carcin/bgp065. Epub 2009 Mar 25.
6. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
7. Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. Candelario-Jalil E, etal., J Pharmacol Exp Ther. 2007 Nov;323(2):488-98. Epub 2007 Aug 17.
8. Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjogren's syndrome. Chen WS, etal., J Rheumatol. 2009 May;36(5):989-96. doi: 10.3899/jrheum.080733. Epub 2009 Mar 30.
9. Expression of matrix metalloproteinase-3 in the rat cervix during pregnancy and in response to prostaglandin E2. Chien EK, etal., Am J Obstet Gynecol. 2005 Jan;192(1):309-17.
10. Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model. Chou LW, etal., Arthritis Res Ther. 2011 Jun 16;13(3):R90. doi: 10.1186/ar3365.
11. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. Christianson CA, etal., Neuroscience. 2012 Jan 3;200:199-210. doi: 10.1016/j.neuroscience.2011.10.019. Epub 2011 Oct 20.
12. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. Cozzolino M, etal., Nephrol Dial Transplant. 2009 Jul;24(7):2207-12. doi: 10.1093/ndt/gfp061. Epub 2009 Feb 16.
13. Cholinoceptor modulation on nitric oxide regulates prostaglandin E(2) and metalloproteinase-3 production in experimentally induced inflammation of rat dental pulp. De Couto Pita A, etal., J Endod. 2009 Apr;35(4):529-36.
14. Regulation of matrix metalloproteinase expression by dynamic tensile strain in rat fibrochondrocytes. Deschner J, etal., Osteoarthritis Cartilage. 2006 Mar;14(3):264-72. Epub 2005 Nov 14.
15. Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve. Gantus MA, etal., Brain Res. 2006 Nov 29;1122(1):36-46. Epub 2006 Oct 6.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. A multigenic approach to predict breast cancer risk. Gerger A, etal., Breast Cancer Res Treat. 2007 Aug;104(2):159-64. Epub 2006 Oct 21.
18. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. Ghilardi G, etal., Stroke. 2002 Oct;33(10):2408-12.
19. Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM). Goncharova EA, etal., Sci Transl Med. 2012 Oct 3;4(154):154ra134. doi: 10.1126/scitranslmed.3003840.
20. Gene expression profiling of skin and draining lymph nodes of rats affected with cutaneous contact hypersensitivity. Hartmann B, etal., Inflamm Res. 2006 Aug;55(8):322-34.
21. Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma. Hirata H, etal., Carcinogenesis. 2004 Dec;25(12):2379-84. Epub 2004 Aug 19.
22. Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease. Horne BD, etal., Am Heart J. 2007 Oct;154(4):751-8.
23. Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up. Houseman M, etal., Arthritis Res Ther. 2012 Feb 7;14(1):R30. doi: 10.1186/ar3734.
24. Diagnosis and assessment of Takayasu arteritis by multiple biomarkers. Ishihara T, etal., Circ J. 2013;77(2):477-83. Epub 2012 Oct 26.
25. Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke. Ishrat T, etal., Neurochem Res. 2013 Dec;38(12):2668-77. doi: 10.1007/s11064-013-1185-y. Epub 2013 Nov 6.
26. Myelin loss associated with neuroinflammation in hypertensive rats. Jalal FY, etal., Stroke. 2012 Apr;43(4):1115-22. doi: 10.1161/STROKEAHA.111.643080. Epub 2012 Feb 23.
27. Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat. Jeong WI, etal., Anticancer Res. 2006 Sep-Oct;26(5A):3517-26.
28. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
29. Production and degradation of extracellular matrix in reversible glomerular lesions in rat model of habu snake venom-induced glomerulonephritis. Kawazu T, etal., Med Mol Morphol. 2012 Dec;45(4):190-8. doi: 10.1007/s00795-011-0559-y. Epub 2012 Dec 7.
30. Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
31. Honokiol inhibits the progression of collagen-induced arthritis by reducing levels of pro-inflammatory cytokines and matrix metalloproteinases and blocking oxidative tissue damage. Kim KR, etal., J Pharmacol Sci. 2010;114(1):69-78. Epub 2010 Aug 10.
32. Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes. Koyama Y and Tanaka K, Biochem Biophys Res Commun. 2008 Jul 11;371(4):659-63. Epub 2008 Apr 23.
33. Pleural fluid analysis of lung cancer vs benign inflammatory disease patients. Kremer R, etal., Br J Cancer. 2010 Mar 30;102(7):1180-4. Epub 2010 Mar 9.
34. The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer. Krippl P, etal., Clin Cancer Res. 2004 May 15;10(10):3518-20.
35. Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Leong DJ, etal., Matrix Biol. 2010 Feb 12.
36. Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells. Li YY, etal., Cardiovasc Res. 1999 Apr;42(1):162-72.
37. Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats. Liang QQ, etal., J Pharmacol Sci. 2010;113(1):23-31.
38. Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine. Liang QQ, etal., Spine (Phila Pa 1976). 2011 Jan 1;36(1):E14-9. doi: 10.1097/BRS.0b013e3181d2dec2.
39. Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. Lievre A, etal., BMC Cancer. 2006 Nov 24;6:270.
40. Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients. Lin CC, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1805-14. doi: 10.2215/CJN.01500210. Epub 2010 Jul 8.
41. MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation. Lombardi F, etal., J Cardiovasc Med (Hagerstown). 2011 Jan;12(1):37-42. doi: 10.2459/JCM.0b013e3283403366.
42. The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc. MacLean JJ, etal., J Orthop Res. 2005 Sep;23(5):1120-7. Epub 2005 Apr 9.
43. Levels of circulating collagenase, stromelysin-1, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis. Relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation. Manicourt DH, etal., Arthritis Rheum. 1995 Aug;38(8):1031-9.
44. Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. Manicourt DH, etal., Drugs R D. 2005;6(5):261-71.
45. Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. Matrisian LM, etal., EMBO J 1985 Jun;4(6):1435-40.
46. Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Mendes O, etal., Clin Exp Metastasis. 2005;22(3):237-46.
47. Identification of a calcium-dependent matrix metalloproteinase complex in rat chorioallantoid membranes during labour. Meraz-Cruz N, etal., Mol Hum Reprod. 2006 Oct;12(10):633-41. Epub 2006 Aug 25.
48. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
49. Renal expression of the Ets-1 proto-oncogene during progression of rat crescentic glomerulonephritis. Naito T, etal., J Am Soc Nephrol. 2000 Dec;11(12):2243-55.
50. Expression of matrix metalloproteinase-9 associated with ets-1 proto-oncogene in rat tubulointerstitial cells. Naito T, etal., Nephrol Dial Transplant. 2005 Nov;20(11):2333-48. Epub 2005 Jul 26.
51. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
52. Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats. Ni GX, etal., Arthritis Res Ther. 2011;13(6):R192. doi: 10.1186/ar3521. Epub 2011 Nov 24.
53. Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis. Nishijima C, etal., Clin Exp Immunol. 2004 Nov;138(2):357-63.
54. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
55. Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease. Park JA, etal., J Korean Med Sci. 2005 Aug;20(4):607-11.
56. Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a PUTATIVE mechanism of postsynaptic plasticity. Pauly T, etal., PLoS One. 2008 Jul 16;3(7):e2681.
57. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
58. Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. Pollanen PJ, etal., Atherosclerosis. 2005 May;180(1):73-8. Epub 2004 Dec 18.
59. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
60. Temperospatial expression of matrix metalloproteinases 1, 2, 3, and 9 during early tooth development. Randall LE and Hall RC, Connect Tissue Res 2002;43(2-3):205-11.
61. GOA pipeline RGD automated data pipeline
62. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
63. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
64. Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. Ribbens C, etal., Ann Rheum Dis. 2002 Feb;61(2):161-6.
65. Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. Ricketts C, etal., PLoS One. 2009 Jun 24;4(6):e6037. doi: 10.1371/journal.pone.0006037.
66. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Russo LA, etal., Reprod Biol Endocrinol. 2009 Nov 4;7:124.
67. Full and partial peroxisome proliferation-activated receptor-gamma agonists, but not delta agonist, rescue of dopaminergic neurons in the 6-OHDA parkinsonian model is associated with inhibition of microglial activation and MMP expression. Sadeghian M, etal., J Neuroimmunol. 2012 May 15;246(1-2):69-77. doi: 10.1016/j.jneuroim.2012.03.010. Epub 2012 Apr 11.
68. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Saghizadeh M, etal., Am J Pathol. 2001 Feb;158(2):723-34.
69. Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis. Sanders JS, etal., Nephrol Dial Transplant. 2004 Jun;19(6):1412-9. Epub 2004 Mar 19.
70. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
71. Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity. Slavkovsky R, etal., Wound Repair Regen. 2011 Jul-Aug;19(4):515-25. doi: 10.1111/j.1524-475X.2011.00703.x. Epub 2011 Jun 7.
72. Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion. Sole S, etal., J Neuropathol Exp Neurol. 2004 Apr;63(4):338-49.
73. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Sternlicht MD, etal., Cell. 1999 Jul 23;98(2):137-46.
74. In situ hybridization studies of matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-1 and type IV collagen in diabetic nephropathy. Suzuki D, etal., Kidney Int. 1997 Jul;52(1):111-9.
75. Modulation of matrix metalloproteinase-9 in hepatic stellate cells by three-dimensional type I collagen: its activation and signaling pathway. Takahara T, etal., Hepatol Res. 2003 Aug;26(4):318-326.
76. [Effects of matrix metalloproteinase-3, osteopontin, and tissue inhibitor of metalloproteinase-1 in the formation of cataract]. Tan Q, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Oct;31(5):737-41.
77. Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in patients with malignant melanoma. Tas F, etal., Med Oncol. 2005;22(1):39-44.
78. MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Tchetverikov I, etal., Ann Rheum Dis. 2004 Jul;63(7):881-3.
79. The association of serum matrix metalloproteinases and their tissue inhibitor levels with scleroderma disease severity. Toubi E, etal., Clin Exp Rheumatol. 2002 Mar-Apr;20(2):221-4.
80. Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa/fa obese rats after treatment with swertiamarin. Vaidya H, etal., Exp Clin Cardiol. 2012 Spring;17(1):12-6.
81. [Effects of glutamine on matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-3 expressions in myocardium of rats with sepsis] Wang H, etal., Zhonghua Er Ke Za Zhi. 2006 Aug;44(8):587-91.
82. Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Wang M, etal., Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6885-9.
83. Therapeutic effects of p75 tumor necrosis factor receptor monoclonal antibody on a rat model of traumatic arthritis. Wang YX, etal., J Surg Res. 2014 Jan;186(1):234-9. doi: 10.1016/j.jss.2013.07.047. Epub 2013 Aug 20.
84. The role of oxidative stress and inflammation in conjunctivochalasis. Ward SK, etal., Invest Ophthalmol Vis Sci. 2010 Apr;51(4):1994-2002. doi: 10.1167/iovs.09-4130. Epub 2009 Dec 17.
85. Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury. Webb KE, etal., Arterioscler Thromb Vasc Biol. 1997 Sep;17(9):1837-44.
86. [Effect of progesterone on MMP-3 expression in neonatal rat brain after hypoxic-ischemia]. Xu CY, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Aug;26(3):370-3.
87. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Yamashita CM, etal., Am J Pathol. 2011 Oct;179(4):1733-45. doi: 10.1016/j.ajpath.2011.06.041. Epub 2011 Aug 24.
88. Imbalance of matrix metalloproteinases/tissue inhibitor of metalloproteinase-1 and loss of fibronectin expression in patients with congestive heart failure. Yang DC, etal., Cardiology. 2010;116(2):133-41. doi: 10.1159/000317245. Epub 2010 Jul 1.
89. Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. Zeisberg M, etal., PLoS Med. 2006 Apr;3(4):e100. Epub 2006 Mar 7.
90. NK cells promote Th-17 mediated corneal barrier disruption in dry eye. Zhang X, etal., PLoS One. 2012;7(5):e36822. doi: 10.1371/journal.pone.0036822. Epub 2012 May 8.
91. Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis. Zhang YB, etal., Chin J Traumatol. 2010 Jun 1;13(3):188-92.
92. Matrix metalloproteinase-3 accelerates wound healing following dental pulp injury. Zheng L, etal., Am J Pathol. 2009 Nov;175(5):1905-14. Epub 2009 Oct 15.
93. MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3. Zheng X, etal., Cancer Lett. 2013 Feb 28;329(2):146-54. doi: 10.1016/j.canlet.2012.10.026. Epub 2012 Nov 7.
94. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology Zhong LJ, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2009 Aug;44(8):464-8.
95. Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study. Zhou X, etal., Thromb Haemost. 2004 Oct;92(4):867-73.
Additional References at PubMed
PMID:1963430   PMID:2431284   PMID:2841336   PMID:9573338   PMID:11869290   PMID:12867428   PMID:15044600   PMID:15504731   PMID:15698619   PMID:15863497   PMID:16150423   PMID:17456343  
PMID:17539323   PMID:18072934   PMID:18172013   PMID:18404723   PMID:18754875   PMID:18765931   PMID:18832569   PMID:19022250   PMID:19389428   PMID:19397203   PMID:19463894   PMID:20162718  
PMID:20548288   PMID:20969476   PMID:21055467   PMID:21330369   PMID:22615070   PMID:22961837   PMID:23086831   PMID:23277113   PMID:23845380   PMID:24006456   PMID:25062286   PMID:25536219  
PMID:26047379   PMID:26075533   PMID:26087281   PMID:27339256   PMID:27425890   PMID:28265573   PMID:28753453   PMID:29197741   PMID:29462373   PMID:29523370   PMID:29928874   PMID:31493243  
PMID:33130223   PMID:33655326   PMID:34656826   PMID:36509234  


Genomics

Comparative Map Data
Mmp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.284,640,397 - 4,653,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,640,416 - 4,653,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,600,140 - 8,613,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,897,910 - 6,911,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,900,079 - 4,913,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,676,608 - 5,698,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,676,665 - 5,698,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,680,382 - 5,701,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,315,601 - 4,329,146 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,315,600 - 4,329,146 (+)NCBI
Celera86,200,234 - 6,213,783 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,835,801 - 102,843,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,835,801 - 102,843,609 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,706,532 - 102,714,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,211,738 - 102,219,552 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,211,742 - 102,219,550NCBI
Celera1199,868,135 - 99,875,949 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,634,450 - 98,642,264 (-)NCBIHuRef
CHM1_111102,589,497 - 102,597,317 (-)NCBICHM1_1
T2T-CHM13v2.011102,839,570 - 102,847,378 (-)NCBIT2T-CHM13v2.0
Mmp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,445,822 - 7,455,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm39 Ensembl
GRCm3897,445,822 - 7,455,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,445,822 - 7,455,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,445,822 - 7,455,975 (+)NCBIMGSCv36mm8
Celera94,846,374 - 4,856,527 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
MMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan111104,717,742 - 104,725,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,776,729 - 97,784,549 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,267,561 - 101,275,432 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,267,566 - 101,275,354 (-)Ensemblpanpan1.1panPan2
MMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,949,631 - 28,957,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,949,631 - 28,958,222 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,898,123 - 28,906,399 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,000,797 - 29,009,079 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,000,797 - 29,009,386 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,035,847 - 29,044,131 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0528,915,267 - 28,923,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,090,249 - 29,098,533 (+)NCBIUU_Cfam_GSD_1.0
MMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,216,156 - 94,224,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,216,173 - 94,224,264 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,654,560 - 31,662,871 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462487839,358 - 47,075 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462487839,282 - 47,386 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp3
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:26
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000012310
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 6 3 4 10
Below cutoff 3 4 14 7 11 7 6 8 26 13 20 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012310   ⟹   ENSRNOP00000012310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl85,676,665 - 5,698,237 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091704   ⟹   ENSRNOP00000075241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,640,416 - 4,653,961 (+)Ensembl
Rnor_6.0 Ensembl85,686,298 - 5,698,579 (+)Ensembl
RefSeq Acc Id: NM_133523   ⟹   NP_598207
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.284,640,416 - 4,653,961 (+)NCBI
Rnor_6.085,676,608 - 5,698,579 (+)NCBI
Rnor_5.085,680,382 - 5,701,427 (+)NCBI
RGSC_v3.484,315,601 - 4,329,146 (+)RGD
Celera86,200,234 - 6,213,783 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080743   ⟹   XP_038936671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.284,640,397 - 4,653,963 (+)NCBI
Protein Sequences
Protein RefSeqs NP_598207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936671 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA26448 (Get FASTA)   NCBI Sequence Viewer  
  EDL78534 (Get FASTA)   NCBI Sequence Viewer  
  EDL78535 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075241
  ENSRNOP00000075241.2
GenBank Protein P03957 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_598207   ⟸   NM_133523
- Peptide Label: preproprotein
- UniProtKB: A6JN31 (UniProtKB/TrEMBL),   A0A0G2KA34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012310   ⟸   ENSRNOT00000012310
RefSeq Acc Id: ENSRNOP00000075241   ⟸   ENSRNOT00000091704
RefSeq Acc Id: XP_038936671   ⟸   XM_039080743
- Peptide Label: isoform X1
- UniProtKB: A6JN31 (UniProtKB/TrEMBL),   A0A0G2KA34 (UniProtKB/TrEMBL)
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P03957-F1-model_v2 AlphaFold P03957 1-475 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695737
Promoter ID:EPDNEW_R6257
Type:single initiation site
Name:Mmp3_1
Description:matrix metallopeptidase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.085,676,607 - 5,676,667EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621317 AgrOrtholog
BioCyc Gene G2FUF-31789 BioCyc
Ensembl Genes ENSRNOG00000032626 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091704 ENTREZGENE
  ENSRNOT00000091704.2 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171045 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROMELYSIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MMP3 RGD
PhenoGen Mmp3 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032626 RatGTEx
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KA34 ENTREZGENE, UniProtKB/TrEMBL
  A6JN31 ENTREZGENE, UniProtKB/TrEMBL
  MMP3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Mmp3  matrix metallopeptidase 3    matrix metalloproteinase 3  Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mmp3  matrix metalloproteinase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may have an important role during early tooth development 729121