GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mmp2 | increases activity | EXP | | 6480464 | CTD | Oxygen deficiency results in increased activity of MMP2 protein | PMID:16980344 | Mmp2 | increases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in increased expression of MMP2 mRNA; Oxygen deficiency results in increased expression of MMP2 protein | PMID:16980344 PMID:26476374 PMID:31629700 | Mmp2 | multiple interactions | EXP | | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]]; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein; Mifepristone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]; MMP2 protein affects the susceptibility to [EDN1 protein co-treated with Oxygen deficiency]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein] | PMID:16980344 PMID:26476374 PMID:27274199 PMID:30229846 PMID:31629700 | Mmp2 | increases activity | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased activity of MMP2 protein | PMID:22534113 | Mmp2 | increases expression | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of MMP2 mRNA; Oxygen deficiency results in increased expression of MMP2 protein | PMID:22340517 PMID:24292262 PMID:26082309 PMID:26509796 PMID:29630948 | Mmp2 | multiple interactions | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein; [TNFRSF8 protein co-treated with Oxygen deficiency] results in decreased secretion of MMP2 protein; AKT1 protein modified form inhibits the reaction [trichostatin A inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of MMP2 protein]; genipin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; HIF1A protein promotes the reaction [Oxygen deficiency results in decreased expression of MMP2 mRNA]; marimastat inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; Oxygen deficiency results in increased expression of and results in increased activity of MMP2 protein; trichostatin A inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; trichostatin A inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein] | PMID:22340517 PMID:24292262 PMID:24518827 PMID:26082309 PMID:26509796 PMID:29630948 PMID:29984229 PMID:31816286 | Mmp2 | multiple interactions | ISO | Mmp2 (Mus musculus) | 6480464 | CTD | [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein; MMP2 protein affects the susceptibility to [EDN1 protein co-treated with Oxygen deficiency]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency] | PMID:16980344 PMID:22436003 | |
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