Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases activityEXP 6480464CTDOxygen deficiency results in increased activity of MMP2 proteinPMID:16980344
Mmp2increases expressionEXP 6480464CTDOxygen deficiency results in increased expression of MMP2 mRNA; Oxygen deficiency results in increased expression of MMP2 proteinPMID:16980344 PMID:26476374 PMID:31629700
Mmp2multiple interactionsEXP 6480464CTD2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]]; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein; Mifepristone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]; MMP2 protein affects the susceptibility to [EDN1 protein co-treated with Oxygen deficiency]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]PMID:16980344 PMID:26476374 PMID:27274199 PMID:30229846 PMID:31629700
Mmp2increases activityISOMMP2 (Homo sapiens)6480464CTDOxygen deficiency results in increased activity of MMP2 proteinPMID:22534113
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of MMP2 mRNA; Oxygen deficiency results in increased expression of MMP2 proteinPMID:22340517 PMID:24292262 PMID:26082309 PMID:26509796 PMID:29630948
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein; [TNFRSF8 protein co-treated with Oxygen deficiency] results in decreased secretion of MMP2 protein; AKT1 protein modified form inhibits the reaction [trichostatin A inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of MMP2 protein]; genipin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; HIF1A protein promotes the reaction [Oxygen deficiency results in decreased expression of MMP2 mRNA]; marimastat inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; Oxygen deficiency results in increased expression of and results in increased activity of MMP2 protein; trichostatin A inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; trichostatin A inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]PMID:22340517 PMID:24292262 PMID:24518827 PMID:26082309 PMID:26509796 PMID:29630948 PMID:29984229 PMID:31816286
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein; MMP2 protein affects the susceptibility to [EDN1 protein co-treated with Oxygen deficiency]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]PMID:16980344 PMID:22436003
Go Back to source page   Continue to Ontology report