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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:50469
Term: EC 3.1.1.4 (phospholipase A2) inhibitor
Definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of phospholipase A2 (EC 3.1.1.4).
Chemical ID: MESH:D064801
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDPhospholipase A2 Inhibitors results in decreased expression of MMP2 mRNAPMID:19765281
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDPhospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP2 protein]PMID:19765281
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