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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases activityEXP 6480464CTDArsenic Trioxide results in decreased activity of MMP2 proteinPMID:18294404
Mmp2multiple interactionsEXP 6480464CTDArsenic Trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Arsenic Trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [Arsenic Trioxide results in decreased activity of MMP2 protein]PMID:18294404
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of MMP2 proteinPMID:18294404 PMID:21969006 PMID:24680928 PMID:27039805
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of MMP2 mRNA; Arsenic Trioxide results in decreased expression of MMP2 proteinPMID:15553829 PMID:15962302 PMID:16624393 PMID:17512576 PMID:19236750 PMID:21540248 PMID:21969006 PMID:23232515 PMID:23253724 PMID:23851143 PMID:24680928 PMID:27039805
Mmp2decreases expressionISOMmp2 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of MMP2 proteinPMID:19822495
Mmp2increases activityISOMMP2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased activity of MMP2 proteinPMID:30748021
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of MMP2 proteinPMID:25728215
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD[acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased activity of MMP2 protein; [acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased expression of MMP2 mRNA; [acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased secretion of MMP2 protein; [Arsenic Trioxide co-treated with Silybin] results in decreased activity of MMP2 protein; [Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP2 mRNA; [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of MMP2 mRNA; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased secretion of MMP2 protein]; Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP2 protein]; Arsenic Trioxide inhibits the reaction [TNF protein results in increased expression of MMP2 mRNA]; Arsenic Trioxide inhibits the reaction [TNF protein results in increased secretion of and results in increased activity of MMP2 protein]; Arsenic Trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Arsenic Trioxide results in decreased expression of and results in decreased secretion of MMP2 protein; Berberine promotes the reaction [Arsenic Trioxide results in decreased activity of MMP2 protein]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of MMP2 protein]; GH1 protein promotes the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA]; MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA]; Silybin promotes the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA]PMID:15962302 PMID:18294404 PMID:21078271 PMID:21540248 PMID:21969006 PMID:23253724 PMID:23851143 PMID:24680928 PMID:29274334
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