Mmp2 (matrix metallopeptidase 2) - Rat Genome Database

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Gene: Mmp2 (matrix metallopeptidase 2) Chinchilla lanigera
Symbol: Mmp2
Name: matrix metallopeptidase 2
RGD ID: 8804102
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); fibronectin binding (ortholog); metalloendopeptidase activity (ortholog); INVOLVED IN aging (ortholog); angiogenesis (ortholog); blood vessel maturation (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Lung Injury (ortholog); Acute Necrotizing Pancreatitis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 72 kDa type IV collagenase; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543313,024,418 - 13,052,775 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543313,024,844 - 13,050,041 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (ISO)
Acute Necrotizing Pancreatitis  (ISO)
Acute Otitis Media  (ISO)
adrenoleukodystrophy  (ISO)
alcohol use disorder  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aortic disease  (ISO)
Aortic Rupture  (ISO)
aortic valve disease 2  (ISO)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
bone disease  (ISO)
Bone Neoplasms  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chlamydophila Infections  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Periodontitis  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
conjunctivitis  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous leishmaniasis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Embolism  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
glioblastoma  (ISO)
Gouty Arthritis  (ISO)
Graft Occlusion, Vascular  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
high grade glioma  (ISO)
Hydatidiform Mole  (ISO)
Hyperoxia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (ISO)
ischemia  (ISO)
keratoconus  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
Malignant Pleural Effusions  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Mandibular Diseases  (ISO)
Marfan syndrome  (ISO)
Maxillary Diseases  (ISO)
Metabolic Bone Diseases  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
Nose Neoplasms  (ISO)
ocular hypertension  (ISO)
Oral Lichen Planus  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteolysis  (ISO)
Osteolysis Hereditary Multicentric  (ISO)
osteonecrosis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
Pneumococcal Meningitis  (ISO)
polycystic ovary syndrome  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
pseudoxanthoma elasticum  (ISO)
pterygium  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
pyoderma gangrenosum  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sepsis  (ISO)
skin melanoma  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (ISO)
Stroke  (ISO)
Sturge-Weber syndrome  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sweet syndrome  (ISO)
temporal arteritis  (ISO)
Testicular Germ Cell Tumor  (ISO)
thoracic aortic aneurysm  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
tropical spastic paraparesis  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)
Venous Thrombosis  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis  (ISO)
blood vessel maturation  (ISO)
bone trabecula formation  (ISO)
cell migration  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to UV-A  (ISO)
collagen catabolic process  (ISO)
embryo implantation  (ISO)
endodermal cell differentiation  (ISO)
face morphogenesis  (ISO)
female pregnancy  (ISO)
heart development  (ISO)
intramembranous ossification  (ISO)
luteinization  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of vasoconstriction  (ISO)
ovarian follicle development  (ISO)
ovulation from ovarian follicle  (ISO)
parturition  (ISO)
peripheral nervous system axon regeneration  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
prostate gland epithelium morphogenesis  (ISO)
proteolysis  (ISO)
response to activity  (ISO)
response to amyloid-beta  (ISO)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to oxidative stress  (ISO)
response to radiation  (ISO)
response to retinoic acid  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal system morphogenesis  (ISO)
tissue remodeling  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View


Comparative Map Data
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543313,024,418 - 13,052,775 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543313,024,844 - 13,050,041 (+)NCBIChiLan1.0ChiLan1.0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1655,389,700 - 55,506,691 (+)EnsemblGRCh38hg38GRCh38
GRCh381655,478,830 - 55,506,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371655,512,742 - 55,540,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,070,589 - 54,098,104 (+)NCBINCBI36hg18NCBI36
Build 341654,070,603 - 54,097,652NCBI
Celera1640,027,315 - 40,054,814 (+)NCBI
Cytogenetic Map16q12.2NCBI
HuRef1641,400,533 - 41,427,983 (+)NCBIHuRef
CHM1_11656,920,344 - 56,947,845 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39893,553,920 - 93,580,049 (+)NCBIGRCm39mm39
GRCm39 Ensembl893,553,919 - 93,580,048 (+)Ensembl
GRCm38892,827,290 - 92,853,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,827,291 - 92,853,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37895,351,227 - 95,377,319 (+)NCBIGRCm37mm9NCBIm37
MGSCv36895,716,456 - 95,742,548 (+)NCBImm8
Celera897,157,107 - 97,183,318 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.99NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21914,154,657 - 14,182,870 (-)NCBI
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01915,542,771 - 15,570,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01926,629,728 - 26,658,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,246,036 - 15,275,061 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1914,077,766 - 14,105,839 (-)NCBICelera
Cytogenetic Map19p11NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11654,817,228 - 54,844,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1654,812,694 - 54,844,279 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01635,711,866 - 35,738,881 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1260,471,092 - 60,492,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,471,257 - 60,494,113 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,105,772 - 57,130,788 (-)NCBI
ROS_Cfam_1.0261,016,206 - 61,041,216 (-)NCBI
UMICH_Zoey_3.1257,844,808 - 57,869,825 (-)NCBI
UNSW_CanFamBas_1.0258,869,067 - 58,894,067 (-)NCBI
UU_Cfam_GSD_1.0259,747,357 - 59,772,363 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934951,763,246 - 51,787,737 (-)NCBI
SpeTri2.0NW_0049364757,801,356 - 7,825,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl630,058,594 - 30,086,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1630,059,247 - 30,087,031 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2627,526,396 - 27,553,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1541,264,382 - 41,291,657 (+)NCBI
ChlSab1.1 Ensembl541,264,354 - 41,291,004 (+)Ensembl
Vero_WHO_p1.0NW_02366604735,055,095 - 35,082,722 (-)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247571,450,680 - 1,479,160 (-)NCBI



Reference Sequences
RefSeq Acc Id: ENSCLAT00000006302   ⟹   ENSCLAP00000006199
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543313,024,418 - 13,052,775 (+)Ensembl
RefSeq Acc Id: XM_005388317   ⟹   XP_005388374
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543313,024,844 - 13,050,041 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005388374 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005388374   ⟸   XM_005388317
- Sequence:
RefSeq Acc Id: ENSCLAP00000006199   ⟸   ENSCLAT00000006302

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004390 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000006199 ENTREZGENE
Ensembl Transcript ENSCLAT00000006302 ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Mmp2  matrix metallopeptidase 2    matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)  Symbol and/or name change 5135510 APPROVED