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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionEXP 6480464CTDGlucose results in decreased expression of MMP2 mRNA; Glucose results in decreased expression of MMP2 proteinPMID:31838053
Mmp2increases expressionEXP 6480464CTDGlucose results in increased expression of MMP2 mRNA; Glucose results in increased expression of MMP2 proteinPMID:18665442
Mmp2multiple interactionsEXP 6480464CTDfarrerol inhibits the reaction [Glucose results in decreased expression of MMP2 mRNA]; farrerol inhibits the reaction [Glucose results in decreased expression of MMP2 protein]; Rosiglitazone inhibits the reaction [Glucose results in increased expression of MMP2 mRNA]; Rosiglitazone inhibits the reaction [Glucose results in increased expression of MMP2 protein]PMID:18665442 PMID:31838053
Mmp2increases activityISOMmp2 (Mus musculus)6480464CTDGlucose results in increased activity of MMP2 proteinPMID:24659233
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDGlucose promotes the reaction [Air Pollutants results in increased activity of MMP2 protein]; Glucose promotes the reaction [Air Pollutants results in increased expression of MMP2 mRNA]; Glucose promotes the reaction [Particulate Matter results in increased activity of MMP2 protein]; Glucose promotes the reaction [Particulate Matter results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Glucose promotes the reaction [Air Pollutants results in increased activity of MMP2 protein]]; SB 203580 inhibits the reaction [Glucose promotes the reaction [Particulate Matter results in increased activity of MMP2 protein]]PMID:26179980
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTDCEBPB protein inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of MMP2 protein]; Glucose results in decreased expression of and results in decreased activity of MMP2 protein; Resveratrol inhibits the reaction [Glucose results in increased activity of MMP2 protein]; Valsartan inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of MMP2 protein]PMID:24659233 PMID:29266779
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