RGD Reference Report - Expression of metalloproteinase-2 (gelatinase A) in labial salivary glands of patients with Sjogren's syndrome with HTLV-I infection. - Rat Genome Database

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Expression of metalloproteinase-2 (gelatinase A) in labial salivary glands of patients with Sjogren's syndrome with HTLV-I infection.

Authors: Tominaga, M  Migita, K  Nakamura, H  Ichinose, Y  Furuya, T  Origuchi, T  Kawabe, Y  Hida, A  Nakamura, T  Eguchi, K 
Citation: Tominaga M, etal., Clin Exp Rheumatol. 1999 Jul-Aug;17(4):463-6.
RGD ID: 8657078
Pubmed: PMID:10464559   (View Abstract at PubMed)

OBJECTIVE: To determine whether gelatinase A (MMP-2) plays a significant role in the pathogenesis of Sjogren's syndrome (SS) with or without HTLV-I infection. METHODS: We examined 24 patients with SS (14 HTLV-I-seropositive and 8 HTLV-I-seronegative). Labial salivary gland tissue samples were analysed immunohistochemically using anti-MMP-2 monoclonal antibodies. RESULTS: In normal salivary glands, MMP-2 expression was not detected. All biopsy samples of 8 SS patients with HTLV-I-associated myelopathy (HAM) and 3 of 6 HTLV-I-seropositive SS patients without manifestation of HAM stained positively for MMP-2. However, the other samples were negative for MMP-2. CONCLUSION: Our study showed the MMP-2 expression in labial salivary glands of HTLV-I seropositive SS patients, especially in all SS patients with HAM. The presence of MMP-2 in the salivary glands of these patients suggests that it may play a role in cellular infiltration and destruction in salivary glands of SS.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MMP2Humantropical spastic paraparesis  IEP associated with Sjogren's SyndromeRGD 
Mmp2Rattropical spastic paraparesis  ISOMMP2 (Homo sapiens)associated with Sjogren's SyndromeRGD 
Mmp2Mousetropical spastic paraparesis  ISOMMP2 (Homo sapiens)associated with Sjogren's SyndromeRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp2  (matrix metallopeptidase 2)

Genes (Mus musculus)
Mmp2  (matrix metallopeptidase 2)

Genes (Homo sapiens)
MMP2  (matrix metallopeptidase 2)


Additional Information