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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:2567
Term: alendronic acid
Definition: A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Chemical ID: MESH:D019386
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2affects expressionEXP 6480464CTDAlendronate affects the expression of MMP2 mRNAPMID:16079270
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDAlendronate results in decreased expression of MMP2 mRNAPMID:15049011
Mmp2decreases secretionISOMMP2 (Homo sapiens)6480464CTDAlendronate results in decreased secretion of MMP2 proteinPMID:15049011
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