RGD Reference Report - Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China. - Rat Genome Database

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Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China.

Authors: Peihong, S  Perry, F 
Citation: Peihong S and Perry F, Ethiop Med J. 2007 Jan;45(1):79-83.
RGD ID: 2290392
Pubmed: PMID:17642161   (View Abstract at PubMed)

BACKGROUND: In recent years, the carcinoma of the breast threatens to women's health heavily. Invasion and metastasis is the main reason that results in the patients death. OBJECTIVE: A prospective study is made in the center hospital of zhengzhou, in order to approach the expression of nm23, MMP-2 (Matrix metallo-proteinase-2), TIMP-2 (it's tissue-inhibitor of the metalloproteinase-2) in the breast neoplasm and the relationship with invasion and metastasis. METHODOLOGY: This study applied the immunohistochemistry technique SP method RESULTS: In fibroadenoma, ductal carcinoma in situ and invasive ductal carcinoma of the breast 4 groups, the positive immunostaining rate of nm23, MMP-2 and TIMP-2 have significant difference among 4 groups (p < 0.05). In the breast invasive ductal carcinoma, the expression of nm23 and TIMP-2 decreased or the expression of MMP-2 increased CONCLUSION: This suggested that invasion and metastasis is ability of the neoplasm. MMP-2 in the breast ductal carcinoma in situ appears of high expression and this suggested that the positive expression of this onco-proteins was the early incident in the genetic course of the breast cancer The unite detection of nm23, MMP-2 and TIMP-2 expression would contribute to the early diagnosis and prognostic assessment of the carcinoma of the breast.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Breast Neoplasms  IEP 2290392protein:increased expression:breastRGD 
Breast Neoplasms  ISOMMP2 (Homo sapiens)2290392; 2290392protein:increased expression:breastRGD 
Breast Neoplasms  IEP 2290392protein:decreased expression:breastRGD 
Breast Neoplasms  ISOTIMP2 (Homo sapiens)2290392; 2290392protein:decreased expression:breastRGD 
ductal carcinoma in situ  IEP 2290392protein:increased expression:breastRGD 
ductal carcinoma in situ  ISOMMP2 (Homo sapiens)2290392; 2290392protein:increased expression:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp2  (matrix metallopeptidase 2)
Timp2  (TIMP metallopeptidase inhibitor 2)

Genes (Mus musculus)
Mmp2  (matrix metallopeptidase 2)
Timp2  (tissue inhibitor of metalloproteinase 2)

Genes (Homo sapiens)
MMP2  (matrix metallopeptidase 2)
TIMP2  (TIMP metallopeptidase inhibitor 2)


Additional Information