RGD Reference Report - Expression of RECK gene and MMP-9 in hilar cholangiocarcinoma and its clinical significance. - Rat Genome Database

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Expression of RECK gene and MMP-9 in hilar cholangiocarcinoma and its clinical significance.

Authors: Li, Y  Zhang, Y  Zheng, Q 
Citation: Li Y, etal., J Huazhong Univ Sci Technolog Med Sci. 2005;25(5):552-4.
RGD ID: 2325856
Pubmed: PMID:16463672   (View Abstract at PubMed)

In order to study the expression of transformation suppressor gene RECK and MMP-9 in hilar cholangiocarcinomas and its clinical significance, and explore the roles of RECK gene in metastasis and invasion of hilar cholangiocarcinoma, the expression levels of RECK, and MMP-9 mRNA were detected by using reverse transcription-polymerase reaction in 42 paraffin-embedded samples of hilar cholangiocarcinomas and 10 samples of benign bile duct diseases. The results showed that in hilar cholangiocarcinoma tissues, the expression of RECK gene was 0.235 +/- 0.062, significantly lower than in normal bile duct tissues (0.533 +/- 0.024, P < 0.05). In hilar cholangiocarcinoma tissues, the expression of MMP-9 (0.528 +/- 0.039) was significantly higher than in the normal tissues (0.311 +/- 0.032, P < 0.05). The expression of RECK gene was closely related to the intrahepatic and surrounding organs invasion (P < 0.05). It was concluded that RECK gene could inhibit the expression of MMP-9 in hilar cholangiocarcinomas and closely correlated with the biological behaviors. The abnormal expression of RECK gene might be one of the molecular mechanisms of hilar cholangiocarcinoma metastasis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cholangiocarcinoma  IEP 2325856mRNA:increased expression:bile ductRGD 
cholangiocarcinoma  ISOMMP9 (Homo sapiens)2325856; 2325856mRNA:increased expression:bile ductRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP9  (matrix metallopeptidase 9)


Additional Information