Mmp9 (matrix metallopeptidase 9) - Rat Genome Database

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Gene: Mmp9 (matrix metallopeptidase 9) Chinchilla lanigera
Symbol: Mmp9
Name: matrix metallopeptidase 9
RGD ID: 8885064
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); fibronectin binding (ortholog); identical protein binding (ortholog); INVOLVED IN aging (ortholog); cellular response to cadmium ion (ortholog); cellular response to cell-matrix adhesion (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; syndecan signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Coronary Syndrome (ortholog); Acute Lung Injury (ortholog); FOUND IN extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase-9
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544511,295,448 - 11,303,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,295,500 - 11,303,322 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
Acute Lung Injury  (ISO)
Acute Otitis Media  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
alcohol use disorder  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Angina, Stable  (ISO)
angle-closure glaucoma  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
anodontia  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aortic aneurysm  (ISO)
aortic disease  (ISO)
Aortic Rupture  (ISO)
Arterial Injury  (ISO)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (ISO)
arteriovenous malformation  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
bacterial meningitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Bone Neoplasms  (ISO)
brain edema  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
bronchiolitis obliterans  (ISO)
Bronchopulmonary Dysplasia  (ISO)
bullous pemphigoid  (ISO)
Burns  (ISO)
calcinosis  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
childhood absence epilepsy  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Choroidal Neovascularization  (ISO)
chronic inflammatory demyelinating polyradiculoneuropathy  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Periodontitis  (ISO)
chronic ulcer of skin  (ISO)
Cicatrix  (ISO)
cognitive disorder  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
conjunctivochalasis  (ISO)
coronary artery disease  (ISO)
crescentic glomerulonephritis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Down syndrome  (ISO)
Duchenne muscular dystrophy  (ISO)
ductal carcinoma in situ  (ISO)
Embolism  (ISO)
Emphysema  (ISO)
endometrial carcinoma  (ISO)
endometriosis  (ISO)
epidermolysis bullosa simplex  (ISO)
epilepsy  (ISO)
esophagus adenocarcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
facial paralysis  (ISO)
familial hyperlipidemia  (ISO)
Febrile Seizures  (ISO)
Fibrosis  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
focal epilepsy  (ISO)
focal segmental glomerulosclerosis  (ISO)
fragile X syndrome  (ISO)
gastric ulcer  (ISO)
glaucoma  (ISO)
glioblastoma  (ISO)
glomerulosclerosis  (ISO)
Gouty Arthritis  (ISO)
heart valve disease  (ISO)
hepatic veno-occlusive disease  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
Hyperoxia  (ISO)
Hyperoxic Lung Injury  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
ileus  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
intracranial aneurysm  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
Laryngeal Neoplasms  (ISO)
Lead Poisoning  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lupus nephritis  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
malignant astrocytoma  (ISO)
Malignant Pleural Effusions  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Mandibuloacral Dysplasia with Type A Lipodystrophy  (ISO)
Marfan syndrome  (ISO)
membranous glomerulonephritis  (ISO)
meningococcal meningitis  (ISO)
Metaphyseal Anadysplasia  (ISO)
Metaphyseal Anadysplasia 2  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
Mycoplasma Infections  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
neuromyelitis optica  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
ocular hypertension  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
paracoccidioidomycosis  (ISO)
Parkinsonism  (ISO)
Pathologic Constriction  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
pre-eclampsia  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
primary progressive multiple sclerosis  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
pterygium  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
pyoderma gangrenosum  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respirovirus Infections  (ISO)
retinal disease  (ISO)
retinal ischemia  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (ISO)
rosacea  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
Sjogren's syndrome  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
stomach carcinoma  (ISO)
Stroke  (ISO)
Sturge-Weber syndrome  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sunburn  (ISO)
Sweet syndrome  (ISO)
systemic scleroderma  (ISO)
Tachycardia, Atrioventricular Nodal Reentry  (ISO)
Takayasu's arteritis  (ISO)
temporal arteritis  (ISO)
temporal lobe epilepsy  (ISO)
thoracic aortic aneurysm  (ISO)
thrombosis  (ISO)
transient cerebral ischemia  (ISO)
tuberous sclerosis  (ISO)
tularemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
varicose veins  (ISO)
Venous Thrombosis  (ISO)
ventricular septal defect  (ISO)
viral encephalitis  (ISO)
visual epilepsy  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cell-matrix adhesion  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to iron(III) ion  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to UV-A  (ISO)
collagen catabolic process  (ISO)
embryo implantation  (ISO)
endodermal cell differentiation  (ISO)
extracellular matrix organization  (ISO)
heart development  (ISO)
kidney development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cation channel activity  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
negative regulation of epithelial cell differentiation involved in kidney development  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
ossification  (ISO)
parturition  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of keratinocyte migration  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
proteolysis  (ISO)
response to amyloid-beta  (ISO)
response to drug  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to high light intensity  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to oxidative stress  (ISO)
response to radiation  (ISO)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to vitamin A  (ISO)
skeletal system development  (ISO)
tissue remodeling  (ISO)
transformation of host cell by virus  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View


Comparative Map Data
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544511,295,448 - 11,303,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,295,500 - 11,303,322 (-)NCBIChiLan1.0ChiLan1.0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2046,008,908 - 46,016,561 (+)EnsemblGRCh38hg38GRCh38
GRCh382046,008,908 - 46,016,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372044,637,547 - 44,645,200 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,070,954 - 44,078,607 (+)NCBINCBI36hg18NCBI36
Build 342044,070,953 - 44,078,606NCBI
Celera2041,348,998 - 41,356,660 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2041,378,970 - 41,386,505 (+)NCBIHuRef
CHM1_12044,540,180 - 44,547,844 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392164,782,246 - 164,797,770 (+)NCBIGRCm39mm39
GRCm39 Ensembl2164,782,700 - 164,797,770 (+)Ensembl
GRCm382164,940,326 - 164,955,850 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,940,780 - 164,955,850 (+)EnsemblGRCm38mm10GRCm38
MGSCv372164,773,751 - 164,781,346 (+)NCBIGRCm37mm9NCBIm37
MGSCv362164,639,456 - 164,647,051 (+)NCBImm8
Celera2170,885,579 - 170,893,176 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.27NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23153,684,158 - 153,692,118 (+)NCBI
Rnor_6.0 Ensembl3161,413,298 - 161,421,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03161,413,410 - 161,421,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03167,578,904 - 167,605,890 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,985,473 - 155,993,433 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13155,891,508 - 155,899,467 (+)NCBI
Celera3152,289,466 - 152,297,426 (+)NCBICelera
Cytogenetic Map3q42NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12043,432,389 - 43,440,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,432,389 - 43,440,129 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02042,346,305 - 42,354,018 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12433,274,260 - 33,281,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2433,274,268 - 33,281,293 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,801,110 - 32,807,958 (+)NCBI
ROS_Cfam_1.02433,984,592 - 33,991,450 (+)NCBI
UMICH_Zoey_3.12433,242,837 - 33,249,697 (+)NCBI
UNSW_CanFamBas_1.02433,358,136 - 33,364,990 (+)NCBI
UU_Cfam_GSD_1.02433,897,331 - 33,904,192 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640191,584,597 - 191,592,230 (-)NCBI
SpeTri2.0NW_0049365147,038,240 - 7,045,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1748,175,056 - 48,188,264 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,179,690 - 48,186,782 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,819,971 - 53,827,064 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1217,867,267 - 17,874,757 (-)NCBI
ChlSab1.1 Ensembl217,867,177 - 17,874,712 (-)Ensembl
Vero_WHO_p1.0NW_02366605066,502,195 - 66,509,744 (-)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247908,584,399 - 8,591,763 (-)NCBI



Reference Sequences
RefSeq Acc Id: ENSCLAT00000020649   ⟹   ENSCLAP00000020451
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544511,295,448 - 11,303,288 (-)Ensembl
RefSeq Acc Id: XM_005392393   ⟹   XP_005392450
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544511,295,500 - 11,303,322 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005392450 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005392450   ⟸   XM_005392393
- Sequence:
RefSeq Acc Id: ENSCLAP00000020451   ⟸   ENSCLAT00000020649

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014014 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000020451 ENTREZGENE
Ensembl Transcript ENSCLAT00000020649 ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Mmp9  matrix metallopeptidase 9    matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)  Symbol and/or name change 5135510 APPROVED