RGD Reference Report - [Modulative effect of zhenqing recipe on expressions of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in experimental type 2 diabetic rats]

General

[Modulative effect of zhenqing recipe on expressions of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in experimental type 2 diabetic rats]
Authors:	Zheng, LY Wen, XY Xu, MW
Citation:	Zheng LY, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:72-6.
RGD ID:	2290354
Pubmed:	PMID:17569353 (View Abstract at PubMed)
OBJECTIVE: To explore the effect of Zhenqing Recipe (ZQR) on renal structure and expressions of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in experimental type 2 diabetic rats. METHODS: The rat models of type 2 diabetic were set up by intraperitoneally giving small-dose streptozotocin (STZ) after fed with high carbohydrate and high fat diets for one month. The model rats were randomly divided into the model group,the high and low dose ZQR-treated groups,and the enalapril-treated group; a normal control group was also established. The course of treatment continued 8 weeks. The expressions of MMP-9, TIMP-1, and fibronectin (FN) in renal tissues were detected by immunohistochemistry. The morphological changes of glomeruli and renal tubules were checked by microscopy. RESULTS: Compared with the normal control group, the expression of TIMP-1 and FN increased and MMP-9 decreased in the model group; the treated groups could decrease the expressions of TIMP-1 and FN, and increase the expression of MMP-9, especially the high-dose ZQR group had the best effect. The morphological changes of renal tubules and glomerulus in the treated groups were improved better as compared with the model group. CONCLUSION: be achieved by modulating the expressions of MMP-1 and TIMP-1.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Experimental Diabetes Mellitus		ISO	Mmp9 (Rattus norvegicus)	2290354; 2290354	protein:increased expression:kidney	RGD
Experimental Diabetes Mellitus		IEP		2290354; 2290354	protein:increased expression:kidney	RGD
Experimental Diabetes Mellitus		ISO	Timp1 (Rattus norvegicus)	2290354; 2290354	protein:increased expression:kidney	RGD

Objects Annotated

Genes (Rattus norvegicus)

Mmp9 (matrix metallopeptidase 9)

Timp1 (TIMP metallopeptidase inhibitor 1)

Genes (Mus musculus)

Mmp9 (matrix metallopeptidase 9)

Timp1 (tissue inhibitor of metalloproteinase 1)

Genes (Homo sapiens)

MMP9 (matrix metallopeptidase 9)

TIMP1 (TIMP metallopeptidase inhibitor 1)

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[Modulative effect of zhenqing recipe on expressions of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in experimental type 2 diabetic rats]