RGD Reference Report - Neutrophil adsorption by polymyxin B-immobilized fiber column for acute exacerbation in patients with interstitial pneumonia: a pilot study. - Rat Genome Database

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Neutrophil adsorption by polymyxin B-immobilized fiber column for acute exacerbation in patients with interstitial pneumonia: a pilot study.

Authors: Abe, S  Seo, Y  Hayashi, H  Matsuda, K  Usuki, J  Azuma, A  Kudoh, S  Gemma, A 
Citation: Abe S, etal., Blood Purif. 2010;29(4):321-6. Epub 2010 Feb 24.
RGD ID: 5130857
Pubmed: PMID:20185904   (View Abstract at PubMed)
DOI: DOI:10.1159/000287232   (Journal Full-text)

BACKGROUND/AIMS: Polymyxin B-immobilized fiber (PMX) treatment has beneficial effects in patients with acute lung injury/acute respiratory distress syndrome or acute exacerbation of idiopathic pulmonary fibrosis. This study was aimed to clarify the mechanism of PMX treatment for acute exacerbation of interstitial pneumonia (IP). MATERIALS AND METHODS: Sixteen consecutive IP patients with acute exacerbation were included. The patients were treated with PMX once daily for 2 successive days at a flow rate of 80-100 ml/min for 6 h. Cells adsorbed by PMX were analyzed morphologically by electron microscopy. Surface markers of these cells were determined by flow cytometry. Serum matrix metalloproteinase (MMP)-9 was measured before and after PMX treatment. RESULTS: Cells adsorbed by PMX were neutrophils and highly expressed HLA-DR, CD14, CD62L and CD114. Serum MMP-9 levels were significantly decreased after PMX treatment. CONCLUSION: This pilot study demonstrated neutrophil adsorption by PMX and its possible clinical application for acute exacerbation of IP.




  
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Evidence
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Original Reference(s)
MMP9Humaninterstitial lung disease  IDA  RGD 
Mmp9Ratinterstitial lung disease  ISOMMP9 (Homo sapiens) RGD 
Mmp9Mouseinterstitial lung disease  ISOMMP9 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP9  (matrix metallopeptidase 9)