RGD Reference Report - Pleural fluid analysis of lung cancer vs benign inflammatory disease patients. - Rat Genome Database

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Pleural fluid analysis of lung cancer vs benign inflammatory disease patients.

Authors: Kremer, R  Best, LA  Savulescu, D  Gavish, M  Nagler, RM 
Citation: Kremer R, etal., Br J Cancer. 2010 Mar 30;102(7):1180-4. Epub 2010 Mar 9.
RGD ID: 5129491
Pubmed: PMID:20216542   (View Abstract at PubMed)
PMCID: PMC2853096   (View Article at PubMed Central)
DOI: DOI:10.1038/sj.bjc.6605607   (Journal Full-text)

BACKGROUND: Correct diagnosis of pleural effusion (PE) as either benign or malignant is crucial, although conventional cytological evaluation is of limited diagnostic accuracy, with relatively low sensitivity rates. METHODS: We identified biological markers accurately detected in a simple PE examination. We analysed data from 19 patients diagnosed with lung cancer (nine adeno-Ca, five non-small-cell Ca (not specified), four squamous-cell Ca, one large-cell Ca) and 22 patients with benign inflammatory pathologies: secondary to trauma, pneumonia or TB. RESULTS: Pleural effusion concentrations of seven analysed biological markers were significantly lower in lung cancer patients than in benign inflammatory patients, especially in matrix metalloproteinase (MMP)-9, MMP-3 and CycD1 (lower by 65% (P<0.000003), 40% (P<0.0007) and 34% (P<0.0001), respectively), and in Ki67, ImAnOx, carbonyls and p27. High rates of sensitivity and specificity values were found for MMP-9, MMP-3 and CycD1: 80 and 100%; 87 and 73%; and 87 and 82%, respectively. CONCLUSION: Although our results are of significant merit in both the clinical and pathogenetic aspects of lung cancer, further research aimed at defining the best combination for marker analysis is warranted. The relative simplicity in analysing these markers in any routine hospital laboratory may result in its acceptance as a new diagnostic tool.




  
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Original Reference(s)
MMP3Humanlung cancer  IEP protein:decreased expression:pleural fluidRGD 
Mmp3Ratlung cancer  ISOMMP3 (Homo sapiens)protein:decreased expression:pleural fluidRGD 
Mmp3Mouselung cancer  ISOMMP3 (Homo sapiens)protein:decreased expression:pleural fluidRGD 
MMP9HumanLung Neoplasms  IEP associated with lung disease and protein:decreased expression:pleural fluidRGD 
Mmp9RatLung Neoplasms  ISOMMP9 (Homo sapiens)associated with lung disease and protein:decreased expression:pleural fluidRGD 
Mmp9MouseLung Neoplasms  ISOMMP9 (Homo sapiens)associated with lung disease and protein:decreased expression:pleural fluidRGD 


Genes (Rattus norvegicus)
Mmp3  (matrix metallopeptidase 3) Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp3  (matrix metallopeptidase 3) Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP3  (matrix metallopeptidase 3) MMP9  (matrix metallopeptidase 9)