MMP3 (matrix metallopeptidase 3) - Rat Genome Database

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Gene: MMP3 (matrix metallopeptidase 3) Homo sapiens
Analyze
Symbol: MMP3
Name: matrix metallopeptidase 3
RGD ID: 1345848
HGNC Page HGNC:7173
Description: Enables endopeptidase activity and metallopeptidase activity. Involved in several processes, including cellular response to UV-A; negative regulation of reactive oxygen species metabolic process; and positive regulation of protein-containing complex assembly. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Biomarker of several diseases, including Takayasu's arteritis; arthritis (multiple); autoimmune disease (multiple); conjunctivochalasis; and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CHDS6; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 (stromelysin 1, progelatinase); matrix metalloproteinase-3; MGC126102; MGC126103; MGC126104; MMP-3; proteoglycanase; SL-1; STMY; STMY1; STR1; stromelysin-1; transin-1
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,835,801 - 102,843,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,835,801 - 102,843,609 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,706,532 - 102,714,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,211,738 - 102,219,552 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,211,742 - 102,219,550NCBI
Celera1199,868,135 - 99,875,949 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,634,450 - 98,642,264 (-)NCBIHuRef
CHM1_111102,589,497 - 102,597,317 (-)NCBICHM1_1
T2T-CHM13v2.011102,839,570 - 102,847,378 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Otitis Media  (ISO)
allergic contact dermatitis  (ISO)
Alport syndrome  (IEP)
arteriosclerosis  (IAGP)
asphyxiating thoracic dystrophy  (IAGP)
ataxia telangiectasia  (IAGP)
atrial fibrillation  (IAGP)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (IAGP)
Breast Neoplasms  (EXP)
Carotid Artery Injuries  (ISO)
carotid stenosis  (IAGP)
cartilage disease  (ISO)
cataract  (IEP)
celiac disease  (EXP)
Cerebral Hemorrhage  (EXP)
Chronic Allograft Nephropathy  (IEP)
cognitive disorder  (ISO)
colon cancer  (ISO)
Colorectal Neoplasms  (IAGP)
congestive heart failure  (IEP)
conjunctivochalasis  (IEP)
coronary artery disease  (EXP,IAGP)
Coronary Disease  (EXP,IAGP)
coronary restenosis  (EXP)
crescentic glomerulonephritis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (IEP)
Diabetic Nephropathies  (IEP)
dry eye syndrome  (ISO)
end stage renal disease  (IAGP)
Endotoxemia  (ISO)
esophagus adenocarcinoma  (IAGP)
Experimental Arthritis  (EXP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
gastric ulcer  (ISO)
glomerulonephritis  (IEP,ISO)
Gouty Arthritis  (IEP)
Hyperalgesia  (EXP,ISO)
idiopathic pulmonary fibrosis  (EXP,IEP)
immunoglobulin light chain amyloidosis  (IEP)
intellectual disability  (IAGP)
Knee Osteoarthritis  (ISO)
lung cancer  (IEP)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (IAGP)
malignant astrocytoma  (EXP)
myocardial infarction  (IAGP)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (ISO)
osteoarthritis  (IDA,IEP)
Parkinsonism  (ISO)
Penetrating Wounds  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (EXP)
polymyalgia rheumatica  (IEP)
primary biliary cholangitis  (ISO)
psoriatic arthritis  (IEP)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (EXP)
renal cell carcinoma  (IAGP)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (IEP)
Sjogren's syndrome  (IEP)
Stroke  (ISO)
systemic scleroderma  (IDA,IEP)
Takayasu's arteritis  (IEP)
Tendon Injuries  (ISO)
thrombosis  (IAGP)
Transplant Rejection  (IEP)
type 2 diabetes mellitus  (ISO)
Ulcer  (IEP)
Venous Thrombosis  (ISO)
von Hippel-Lindau disease  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-citrinin  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
3-hydroxypicolinic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
5-iodotubercidin  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alpha-naphthoflavone  (ISO)
aluminium oxide  (EXP)
ammonium chloride  (ISO)
anandamide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
avobenzone  (EXP)
azathioprine  (EXP)
azithromycin  (EXP)
Azoxymethane  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
BQ 123  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (ISO)
C.I. Natural Red 20  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
carvacrol  (ISO)
CGP 52608  (EXP)
chloramphenicol  (EXP)
chlorothalonil  (EXP)
choline  (ISO)
chondroitin sulfate  (EXP)
ciprofloxacin  (EXP)
cisplatin  (EXP)
cobalt atom  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cordycepin  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (EXP)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
DDT  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dieckol  (EXP)
diethyl malate  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disulfiram  (EXP)
diuron  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP,ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (EXP)
enalapril  (ISO)
endosulfan  (EXP,ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
farnesol  (EXP)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fucoidan  (EXP)
galaxolide  (EXP)
gemcitabine  (EXP)
genistein  (ISO)
geraniol  (EXP)
glycitein  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
graphene oxide  (ISO)
HU-308  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
ibuprofen  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
irigenin  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
L-proline betaine  (EXP)
lidocaine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
loliolide  (EXP)
lovastatin  (ISO)
malathion  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
megestrol acetate  (ISO)
melittin  (EXP)
Methanandamide  (EXP)
methotrexate  (EXP)
methyl caffeate  (EXP)
methylisothiazolinone  (EXP)
mibolerone  (EXP)
mifepristone  (EXP,ISO)
minocycline  (ISO)
Morroniside  (ISO)
moxifloxacin  (EXP)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP,ISO)
NSC 23766  (ISO)
ofloxacin  (ISO)
oroxylin A  (EXP)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 168393  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
pravastatin  (EXP)
prinomastat  (EXP)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
raloxifene  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rofecoxib  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (EXP)
serpentine asbestos  (EXP,ISO)
Shikonin  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP)
sodium azide  (EXP)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
sotorasib  (EXP)
streptozocin  (EXP,ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
tetracycline  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
tofacitinib  (EXP)
trametinib  (EXP)
triclosan  (EXP)
tunicamycin  (EXP)
ursodeoxycholic acid  (ISO)
varespladib methyl  (EXP)
zerumbone  (EXP)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Changes in matrix metalloproteinases and their inhibitors in kidney transplant recipients. Ahmed AK, etal., Exp Clin Transplant. 2012 Aug;10(4):332-43.
2. Type 2 diabetes impairs tendon repair after injury in a rat model. Ahmed AS, etal., J Appl Physiol (1985). 2012 Dec 1;113(11):1784-91. doi: 10.1152/japplphysiol.00767.2012. Epub 2012 Oct 4.
3. Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. Bousserouel S, etal., Oncol Rep. 2010 Feb;23(2):511-7.
4. Novel phosphoinositide 3-kinase delta,gamma inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. Boyle DL, etal., J Pharmacol Exp Ther. 2014 Feb;348(2):271-80. doi: 10.1124/jpet.113.205955. Epub 2013 Nov 15.
5. Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis. Bradbury PA, etal., Carcinogenesis. 2009 May;30(5):793-8. doi: 10.1093/carcin/bgp065. Epub 2009 Mar 25.
6. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
7. Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjogren's syndrome. Chen WS, etal., J Rheumatol. 2009 May;36(5):989-96. doi: 10.3899/jrheum.080733. Epub 2009 Mar 30.
8. Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model. Chou LW, etal., Arthritis Res Ther. 2011 Jun 16;13(3):R90. doi: 10.1186/ar3365.
9. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. Christianson CA, etal., Neuroscience. 2012 Jan 3;200:199-210. doi: 10.1016/j.neuroscience.2011.10.019. Epub 2011 Oct 20.
10. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. Cozzolino M, etal., Nephrol Dial Transplant. 2009 Jul;24(7):2207-12. doi: 10.1093/ndt/gfp061. Epub 2009 Feb 16.
11. Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve. Gantus MA, etal., Brain Res. 2006 Nov 29;1122(1):36-46. Epub 2006 Oct 6.
12. A multigenic approach to predict breast cancer risk. Gerger A, etal., Breast Cancer Res Treat. 2007 Aug;104(2):159-64. Epub 2006 Oct 21.
13. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. Ghilardi G, etal., Stroke. 2002 Oct;33(10):2408-12.
14. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
15. Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM). Goncharova EA, etal., Sci Transl Med. 2012 Oct 3;4(154):154ra134. doi: 10.1126/scitranslmed.3003840.
16. Gene expression profiling of skin and draining lymph nodes of rats affected with cutaneous contact hypersensitivity. Hartmann B, etal., Inflamm Res. 2006 Aug;55(8):322-34.
17. Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma. Hirata H, etal., Carcinogenesis. 2004 Dec;25(12):2379-84. Epub 2004 Aug 19.
18. Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease. Horne BD, etal., Am Heart J. 2007 Oct;154(4):751-8.
19. Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up. Houseman M, etal., Arthritis Res Ther. 2012 Feb 7;14(1):R30. doi: 10.1186/ar3734.
20. Diagnosis and assessment of Takayasu arteritis by multiple biomarkers. Ishihara T, etal., Circ J. 2013;77(2):477-83. Epub 2012 Oct 26.
21. Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke. Ishrat T, etal., Neurochem Res. 2013 Dec;38(12):2668-77. doi: 10.1007/s11064-013-1185-y. Epub 2013 Nov 6.
22. Myelin loss associated with neuroinflammation in hypertensive rats. Jalal FY, etal., Stroke. 2012 Apr;43(4):1115-22. doi: 10.1161/STROKEAHA.111.643080. Epub 2012 Feb 23.
23. Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat. Jeong WI, etal., Anticancer Res. 2006 Sep-Oct;26(5A):3517-26.
24. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
25. Production and degradation of extracellular matrix in reversible glomerular lesions in rat model of habu snake venom-induced glomerulonephritis. Kawazu T, etal., Med Mol Morphol. 2012 Dec;45(4):190-8. doi: 10.1007/s00795-011-0559-y. Epub 2012 Dec 7.
26. Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
27. Honokiol inhibits the progression of collagen-induced arthritis by reducing levels of pro-inflammatory cytokines and matrix metalloproteinases and blocking oxidative tissue damage. Kim KR, etal., J Pharmacol Sci. 2010;114(1):69-78. Epub 2010 Aug 10.
28. Pleural fluid analysis of lung cancer vs benign inflammatory disease patients. Kremer R, etal., Br J Cancer. 2010 Mar 30;102(7):1180-4. Epub 2010 Mar 9.
29. The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer. Krippl P, etal., Clin Cancer Res. 2004 May 15;10(10):3518-20.
30. Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Leong DJ, etal., Matrix Biol. 2010 Feb 12.
31. Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats. Liang QQ, etal., J Pharmacol Sci. 2010;113(1):23-31.
32. Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine. Liang QQ, etal., Spine (Phila Pa 1976). 2011 Jan 1;36(1):E14-9. doi: 10.1097/BRS.0b013e3181d2dec2.
33. Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. Lievre A, etal., BMC Cancer. 2006 Nov 24;6:270.
34. Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients. Lin CC, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1805-14. doi: 10.2215/CJN.01500210. Epub 2010 Jul 8.
35. MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation. Lombardi F, etal., J Cardiovasc Med (Hagerstown). 2011 Jan;12(1):37-42. doi: 10.2459/JCM.0b013e3283403366.
36. The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc. MacLean JJ, etal., J Orthop Res. 2005 Sep;23(5):1120-7. Epub 2005 Apr 9.
37. Levels of circulating collagenase, stromelysin-1, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis. Relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation. Manicourt DH, etal., Arthritis Rheum. 1995 Aug;38(8):1031-9.
38. Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. Manicourt DH, etal., Drugs R D. 2005;6(5):261-71.
39. Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Mendes O, etal., Clin Exp Metastasis. 2005;22(3):237-46.
40. Renal expression of the Ets-1 proto-oncogene during progression of rat crescentic glomerulonephritis. Naito T, etal., J Am Soc Nephrol. 2000 Dec;11(12):2243-55.
41. Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats. Ni GX, etal., Arthritis Res Ther. 2011;13(6):R192. doi: 10.1186/ar3521. Epub 2011 Nov 24.
42. Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis. Nishijima C, etal., Clin Exp Immunol. 2004 Nov;138(2):357-63.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease. Park JA, etal., J Korean Med Sci. 2005 Aug;20(4):607-11.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. Pollanen PJ, etal., Atherosclerosis. 2005 May;180(1):73-8. Epub 2004 Dec 18.
47. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. Ribbens C, etal., Ann Rheum Dis. 2002 Feb;61(2):161-6.
51. Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. Ricketts C, etal., PLoS One. 2009 Jun 24;4(6):e6037. doi: 10.1371/journal.pone.0006037.
52. Full and partial peroxisome proliferation-activated receptor-gamma agonists, but not delta agonist, rescue of dopaminergic neurons in the 6-OHDA parkinsonian model is associated with inhibition of microglial activation and MMP expression. Sadeghian M, etal., J Neuroimmunol. 2012 May 15;246(1-2):69-77. doi: 10.1016/j.jneuroim.2012.03.010. Epub 2012 Apr 11.
53. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Saghizadeh M, etal., Am J Pathol. 2001 Feb;158(2):723-34.
54. Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis. Sanders JS, etal., Nephrol Dial Transplant. 2004 Jun;19(6):1412-9. Epub 2004 Mar 19.
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Additional References at PubMed
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Genomics

Comparative Map Data
MMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,835,801 - 102,843,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,835,801 - 102,843,609 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,706,532 - 102,714,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,211,738 - 102,219,552 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,211,742 - 102,219,550NCBI
Celera1199,868,135 - 99,875,949 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,634,450 - 98,642,264 (-)NCBIHuRef
CHM1_111102,589,497 - 102,597,317 (-)NCBICHM1_1
T2T-CHM13v2.011102,839,570 - 102,847,378 (-)NCBIT2T-CHM13v2.0
Mmp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,445,845 - 7,455,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm39 Ensembl
GRCm3897,445,822 - 7,455,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,445,822 - 7,455,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,445,822 - 7,455,975 (+)NCBIMGSCv36mm8
Celera94,846,374 - 4,856,527 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8812,925,267 - 12,938,828 (+)NCBIGRCr8
mRatBN7.284,640,397 - 4,653,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,640,416 - 4,653,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,600,140 - 8,613,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,897,910 - 6,911,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,900,079 - 4,913,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,676,608 - 5,698,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,676,665 - 5,698,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,680,382 - 5,701,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,315,601 - 4,329,146 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,315,600 - 4,329,146 (+)NCBI
Celera86,200,234 - 6,213,783 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,629,536 - 103,637,408 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,717,742 - 104,725,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,776,729 - 97,784,549 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,267,561 - 101,275,432 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,267,566 - 101,275,354 (-)Ensemblpanpan1.1panPan2
MMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,949,631 - 28,957,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,949,631 - 28,958,222 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,898,123 - 28,906,399 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,000,797 - 29,009,079 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,000,797 - 29,009,386 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,035,847 - 29,044,131 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0528,915,267 - 28,923,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,090,249 - 29,098,533 (+)NCBIUU_Cfam_GSD_1.0
MMP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,446,836 - 33,454,000 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,446,969 - 33,453,995 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,394,116 - 37,401,146 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,216,156 - 94,224,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,216,173 - 94,224,264 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,654,560 - 31,662,871 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462487839,358 - 47,075 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462487839,282 - 47,386 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MMP3
69 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NC_000011.10:g.102845221dup duplication Coronary heart disease, susceptibility to, 6 [RCV000013637] Chr11:102845216..102845217 [GRCh38]
Chr11:102715947..102715948 [GRCh37]
Chr11:11q22.2		 risk factor
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3		 pathogenic
GRCh38/hg38 11q14.1-22.2(chr11:85242847-102920097)x1 copy number loss See cases [RCV000052711] Chr11:85242847..102920097 [GRCh38]
Chr11:84953891..102738968 [GRCh37]
Chr11:84631539..102296037 [NCBI36]
Chr11:11q14.1-22.2		 pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25		 pathogenic
NM_002422.3(MMP3):c.921G>T (p.Leu307=) single nucleotide variant Malignant melanoma [RCV000069136] Chr11:102840122 [GRCh38]
Chr11:102710853 [GRCh37]
Chr11:102216063 [NCBI36]
Chr11:11q22.2		 not provided
NM_002422.3(MMP3):c.558C>T (p.Ala186=) single nucleotide variant Malignant melanoma [RCV000069137] Chr11:102842221 [GRCh38]
Chr11:102712952 [GRCh37]
Chr11:102218162 [NCBI36]
Chr11:11q22.2		 not provided
NM_002422.3(MMP3):c.165G>A (p.Lys55=) single nucleotide variant Malignant melanoma [RCV000069138] Chr11:102842857 [GRCh38]
Chr11:102713588 [GRCh37]
Chr11:102218798 [NCBI36]
Chr11:11q22.2		 not provided
GRCh38/hg38 11q22.1-22.3(chr11:98357901-106059146)x1 copy number loss See cases [RCV000136574] Chr11:98357901..106059146 [GRCh38]
Chr11:98228629..105929873 [GRCh37]
Chr11:97733839..105435083 [NCBI36]
Chr11:11q22.1-22.3		 pathogenic
GRCh38/hg38 11q22.1-22.3(chr11:101452984-104044105)x3 copy number gain See cases [RCV000136846] Chr11:101452984..104044105 [GRCh38]
Chr11:101323715..103914833 [GRCh37]
Chr11:100828925..103420043 [NCBI36]
Chr11:11q22.1-22.3		 pathogenic
GRCh38/hg38 11q14.3-22.3(chr11:91086659-109595582)x1 copy number loss See cases [RCV000138038] Chr11:91086659..109595582 [GRCh38]
Chr11:90819827..109466308 [GRCh37]
Chr11:90459475..108971518 [NCBI36]
Chr11:11q14.3-22.3		 pathogenic
GRCh37/hg19 11q22.2(chr11:102642841-102826187)x1 copy number loss See cases [RCV000448411] Chr11:102642841..102826187 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.626-14A>G single nucleotide variant not provided [RCV001653800]|not specified [RCV000454459] Chr11:102840607 [GRCh38]
Chr11:102711338 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.133A>G (p.Lys45Glu) single nucleotide variant not provided [RCV001598670]|not specified [RCV000454524] Chr11:102842889 [GRCh38]
Chr11:102842889..102842890 [GRCh38]
Chr11:102713620 [GRCh37]
Chr11:102713620..102713621 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.306C>G (p.Thr102=) single nucleotide variant not provided [RCV001707693]|not specified [RCV000454940] Chr11:102842716 [GRCh38]
Chr11:102713447 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.1086T>C (p.Ala362=) single nucleotide variant not provided [RCV001683493]|not specified [RCV000455579] Chr11:102838694 [GRCh38]
Chr11:102838694..102838695 [GRCh38]
Chr11:102709425 [GRCh37]
Chr11:102709425..102709426 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.288T>C (p.Asp96=) single nucleotide variant not provided [RCV001712410]|not specified [RCV000455590] Chr11:102842734 [GRCh38]
Chr11:102713465 [GRCh37]
Chr11:11q22.2		 benign
GRCh37/hg19 11q14.2-22.3(chr11:88152458-109414650)x1 copy number loss See cases [RCV000510457] Chr11:88152458..109414650 [GRCh37]
Chr11:11q14.2-22.3		 pathogenic
GRCh37/hg19 11q22.1-22.3(chr11:98515900-104970876)x1 copy number loss See cases [RCV000511844] Chr11:98515900..104970876 [GRCh37]
Chr11:11q22.1-22.3		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q22.2-22.3(chr11:102578709-107230611)x1 copy number loss not provided [RCV000683366] Chr11:102578709..107230611 [GRCh37]
Chr11:11q22.2-22.3		 likely pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2		 pathogenic
NM_002422.5(MMP3):c.106-188del deletion not provided [RCV001707091] Chr11:102843104 [GRCh38]
Chr11:102713835 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.126C>T (p.Tyr42=) single nucleotide variant not provided [RCV000936548] Chr11:102842896 [GRCh38]
Chr11:102713627 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002422.5(MMP3):c.792A>G (p.Gly264=) single nucleotide variant MMP3-related disorder [RCV003925926]|not provided [RCV000950210] Chr11:102840251 [GRCh38]
Chr11:102710982 [GRCh37]
Chr11:11q22.2		 benign|likely benign
NM_002422.5(MMP3):c.12T>A (p.Leu4=) single nucleotide variant not provided [RCV000886546] Chr11:102843535 [GRCh38]
Chr11:102714266 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002422.5(MMP3):c.249T>C (p.Thr83=) single nucleotide variant not provided [RCV000881514] Chr11:102842773 [GRCh38]
Chr11:102713504 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.1131C>T (p.His377=) single nucleotide variant not provided [RCV000962222] Chr11:102838649 [GRCh38]
Chr11:102709380 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.457T>C (p.Tyr153His) single nucleotide variant not provided [RCV000960056] Chr11:102842473 [GRCh38]
Chr11:102713204 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002422.5(MMP3):c.58T>C (p.Leu20=) single nucleotide variant not provided [RCV000960121] Chr11:102843489 [GRCh38]
Chr11:102714220 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.583G>T (p.Ala195Ser) single nucleotide variant Mendelian syndromes with cleft lip/palate [RCV003315092] Chr11:102842196 [GRCh38]
Chr11:102712927 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.970C>T (p.Pro324Ser) single nucleotide variant not specified [RCV004320996] Chr11:102839209 [GRCh38]
Chr11:102709940 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.499+2T>A single nucleotide variant not provided [RCV001596794] Chr11:102842429 [GRCh38]
Chr11:102713160 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.106-130C>G single nucleotide variant not provided [RCV001667385] Chr11:102843046 [GRCh38]
Chr11:102713777 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.1334-348C>T single nucleotide variant not provided [RCV001674814] Chr11:102836574 [GRCh38]
Chr11:102707305 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.499+37A>G single nucleotide variant not provided [RCV001595601] Chr11:102842394 [GRCh38]
Chr11:102713125 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.1305A>G (p.Ser435=) single nucleotide variant not provided [RCV000910672] Chr11:102837326 [GRCh38]
Chr11:102708057 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002422.5(MMP3):c.228G>A (p.Thr76=) single nucleotide variant not provided [RCV000908648] Chr11:102842794 [GRCh38]
Chr11:102713525 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.858G>T (p.Thr286=) single nucleotide variant not provided [RCV000962223] Chr11:102840185 [GRCh38]
Chr11:102710916 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.480G>T (p.Met160Ile) single nucleotide variant not provided [RCV000930687] Chr11:102842450 [GRCh38]
Chr11:102713181 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002422.5(MMP3):c.478A>T (p.Met160Leu) single nucleotide variant not provided [RCV000971018] Chr11:102842452 [GRCh38]
Chr11:102713183 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002422.5(MMP3):c.711C>T (p.Tyr237=) single nucleotide variant MMP3-related disorder [RCV003903108]|not provided [RCV000934455] Chr11:102840508 [GRCh38]
Chr11:102711239 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002422.5(MMP3):c.106-197dup duplication not provided [RCV001637170] Chr11:102843103..102843104 [GRCh38]
Chr11:102713834..102713835 [GRCh37]
Chr11:11q22.2		 benign
GRCh37/hg19 11q22.1-22.3(chr11:99059204-103281943)x3 copy number gain not provided [RCV002472738] Chr11:99059204..103281943 [GRCh37]
Chr11:11q22.1-22.3		 uncertain significance
NM_002422.5(MMP3):c.499+28CAAAA[2] microsatellite not provided [RCV001688107] Chr11:102842384..102842393 [GRCh38]
Chr11:102713115..102713124 [GRCh37]
Chr11:11q22.2		 benign
NC_000011.10:g.102843985C>G single nucleotide variant not provided [RCV001598232] Chr11:102843985 [GRCh38]
Chr11:102714716 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.936-109C>T single nucleotide variant not provided [RCV001596308] Chr11:102839352 [GRCh38]
Chr11:102710083 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.1070-81A>T single nucleotide variant not provided [RCV001685184] Chr11:102838791 [GRCh38]
Chr11:102709522 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.1333+115T>C single nucleotide variant not provided [RCV001708603] Chr11:102837183 [GRCh38]
Chr11:102837183..102837184 [GRCh38]
Chr11:102707914 [GRCh37]
Chr11:102707914..102707915 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.935+132A>T single nucleotide variant not provided [RCV001710130] Chr11:102839976 [GRCh38]
Chr11:102710707 [GRCh37]
Chr11:11q22.2		 benign
NC_000011.10:g.102847936G>C single nucleotide variant not provided [RCV001358154] Chr11:102847936 [GRCh38]
Chr11:102718667 [GRCh37]
Chr11:11q22.2		 uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
NC_000011.9:g.(?_94153285)_(111965700_?)del deletion Ataxia-telangiectasia syndrome [RCV001389105] Chr11:94153285..111965700 [GRCh37]
Chr11:11q21-23.1		 pathogenic
NM_002422.5(MMP3):c.500-36G>A single nucleotide variant not provided [RCV001655275] Chr11:102842315 [GRCh38]
Chr11:102713046 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.626-257G>C single nucleotide variant not provided [RCV001651687] Chr11:102840850 [GRCh38]
Chr11:102711581 [GRCh37]
Chr11:11q22.2		 benign
NM_002422.5(MMP3):c.1070-22_1070-21del microsatellite not provided [RCV001654375] Chr11:102838731..102838732 [GRCh38]
Chr11:102709462..102709463 [GRCh37]
Chr11:11q22.2		 benign
GRCh37/hg19 11q14.1-23.3(chr11:85422071-118022671)x1 copy number loss not provided [RCV001832892] Chr11:85422071..118022671 [GRCh37]
Chr11:11q14.1-23.3		 uncertain significance
NC_000011.9:g.(?_101323686)_(103349981_?)del deletion Jeune thoracic dystrophy [RCV001942288]|not provided [RCV001942287] Chr11:101323686..103349981 [GRCh37]
Chr11:11q22.1-22.3		 pathogenic|no classifications from unflagged records
NC_000011.9:g.(?_101374735)_(103349981_?)dup duplication not provided [RCV003122918] Chr11:101374735..103349981 [GRCh37]
Chr11:11q22.1-22.3		 uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_002422.5(MMP3):c.527G>A (p.Gly176Glu) single nucleotide variant not specified [RCV004309000] Chr11:102842252 [GRCh38]
Chr11:102712983 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.989C>A (p.Ser330Tyr) single nucleotide variant not specified [RCV004316115] Chr11:102839190 [GRCh38]
Chr11:102709921 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.244G>A (p.Asp82Asn) single nucleotide variant not specified [RCV004240327] Chr11:102842778 [GRCh38]
Chr11:102713509 [GRCh37]
Chr11:11q22.2		 uncertain significance
GRCh37/hg19 11q22.1-22.3(chr11:98770072-104602846)x1 copy number loss not provided [RCV002472602] Chr11:98770072..104602846 [GRCh37]
Chr11:11q22.1-22.3		 likely pathogenic
GRCh37/hg19 11q22.1-22.3(chr11:101371503-109306519)x1 copy number loss not provided [RCV002472494] Chr11:101371503..109306519 [GRCh37]
Chr11:11q22.1-22.3		 pathogenic
GRCh37/hg19 11q14.1-22.3(chr11:81478509-104667040)x1 copy number loss not provided [RCV002475722] Chr11:81478509..104667040 [GRCh37]
Chr11:11q14.1-22.3		 pathogenic
NM_002422.5(MMP3):c.211C>G (p.Leu71Val) single nucleotide variant not specified [RCV004139287] Chr11:102842811 [GRCh38]
Chr11:102713542 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.476T>C (p.Ile159Thr) single nucleotide variant not specified [RCV004182361] Chr11:102842454 [GRCh38]
Chr11:102713185 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.1126A>T (p.Ile376Phe) single nucleotide variant not specified [RCV004154406] Chr11:102838654 [GRCh38]
Chr11:102709385 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.788A>G (p.Tyr263Cys) single nucleotide variant not specified [RCV004213340] Chr11:102840431 [GRCh38]
Chr11:102711162 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.755C>A (p.Ser252Tyr) single nucleotide variant not specified [RCV004138360] Chr11:102840464 [GRCh38]
Chr11:102711195 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.526G>A (p.Gly176Arg) single nucleotide variant not specified [RCV004124707] Chr11:102842253 [GRCh38]
Chr11:102712984 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.1169C>T (p.Ala390Val) single nucleotide variant not specified [RCV004229331] Chr11:102838611 [GRCh38]
Chr11:102709342 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.1319T>C (p.Val440Ala) single nucleotide variant not specified [RCV004140893] Chr11:102837312 [GRCh38]
Chr11:102708043 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.830C>T (p.Thr277Met) single nucleotide variant not specified [RCV004085816] Chr11:102840213 [GRCh38]
Chr11:102710944 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.23T>C (p.Leu8Pro) single nucleotide variant not specified [RCV004099423] Chr11:102843524 [GRCh38]
Chr11:102714255 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.289G>A (p.Val97Ile) single nucleotide variant not specified [RCV004181878] Chr11:102842733 [GRCh38]
Chr11:102713464 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.1385C>G (p.Ala462Gly) single nucleotide variant not specified [RCV004136585] Chr11:102836175 [GRCh38]
Chr11:102706906 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.1300G>T (p.Asp434Tyr) single nucleotide variant not specified [RCV004123590] Chr11:102837331 [GRCh38]
Chr11:102708062 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.290T>C (p.Val97Ala) single nucleotide variant not specified [RCV004163091] Chr11:102842732 [GRCh38]
Chr11:102713463 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.963G>T (p.Lys321Asn) single nucleotide variant not specified [RCV004222627] Chr11:102839216 [GRCh38]
Chr11:102709947 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.809C>T (p.Pro270Leu) single nucleotide variant not specified [RCV004253384] Chr11:102840234 [GRCh38]
Chr11:102710965 [GRCh37]
Chr11:11q22.2		 uncertain significance
Single allele duplication not provided [RCV003448710] Chr11:102134973..134945611 [GRCh37]
Chr11:11q22.2-25		 pathogenic
GRCh37/hg19 11q21-22.3(chr11:97147292-102979905)x3 copy number gain not provided [RCV003484850] Chr11:97147292..102979905 [GRCh37]
Chr11:11q21-22.3		 uncertain significance
NM_002422.5(MMP3):c.626-3T>C single nucleotide variant MMP3-related disorder [RCV003981801] Chr11:102840596 [GRCh38]
Chr11:102711327 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002422.5(MMP3):c.-7A>C single nucleotide variant MMP3-related disorder [RCV003934497] Chr11:102843553 [GRCh38]
Chr11:102714284 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002422.5(MMP3):c.191T>A (p.Ile64Asn) single nucleotide variant not specified [RCV004464842] Chr11:102842831 [GRCh38]
Chr11:102713562 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.1274A>G (p.Gln425Arg) single nucleotide variant not specified [RCV004464708] Chr11:102837357 [GRCh38]
Chr11:102708088 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.557C>A (p.Ala186Asp) single nucleotide variant not specified [RCV004457601] Chr11:102842222 [GRCh38]
Chr11:102712953 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.1165G>A (p.Asp389Asn) single nucleotide variant not specified [RCV004464637] Chr11:102838615 [GRCh38]
Chr11:102709346 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.148C>A (p.Gln50Lys) single nucleotide variant not specified [RCV004464827] Chr11:102842874 [GRCh38]
Chr11:102713605 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.262C>T (p.Arg88Cys) single nucleotide variant not specified [RCV004457433] Chr11:102842760 [GRCh38]
Chr11:102713491 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.626G>C (p.Gly209Ala) single nucleotide variant not specified [RCV004457632] Chr11:102840593 [GRCh38]
Chr11:102711324 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.815C>A (p.Thr272Asn) single nucleotide variant not specified [RCV004457743] Chr11:102840228 [GRCh38]
Chr11:102710959 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002422.5(MMP3):c.1025C>A (p.Ala342Asp) single nucleotide variant not specified [RCV004629012] Chr11:102839154 [GRCh38]
Chr11:102709885 [GRCh37]
Chr11:11q22.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:321
Count of miRNA genes:286
Interacting mature miRNAs:300
Transcripts:ENST00000299855, ENST00000434103, ENST00000524478
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407061921GWAS710897_Hblood protein measurement QTL GWAS710897 (human)2e-33blood protein measurementblood protein measurement (CMO:0000028)11102837183102837184Human
407169510GWAS818486_HFEV/FVC ratio, response to bronchodilator QTL GWAS818486 (human)0.0000007FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102839976102839977Human
407200614GWAS849590_Hblood protein measurement QTL GWAS849590 (human)2e-54blood protein measurementblood protein measurement (CMO:0000028)11102838694102838695Human
407229600GWAS878576_Hblood protein measurement QTL GWAS878576 (human)3e-2093blood protein measurementblood protein measurement (CMO:0000028)11102842889102842890Human
407161186GWAS810162_HFEV/FVC ratio, response to bronchodilator QTL GWAS810162 (human)0.0000002FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102839976102839977Human
407171820GWAS820796_HFEV/FVC ratio, response to bronchodilator QTL GWAS820796 (human)0.0000006FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102837776102837777Human
407170796GWAS819772_HFEV/FVC ratio, response to bronchodilator QTL GWAS819772 (human)0.000001FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102839740102839741Human
407165768GWAS814744_HFEV/FVC ratio, response to bronchodilator QTL GWAS814744 (human)0.0000007FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102840850102840851Human
407095095GWAS744071_Hperipheral arterial disease QTL GWAS744071 (human)4e-09peripheral arterial disease11102839740102839741Human
407107991GWAS756967_HFEV/FVC ratio, response to bronchodilator QTL GWAS756967 (human)0.0000002FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102840850102840851Human
407161746GWAS810722_HFEV/FVC ratio, response to bronchodilator QTL GWAS810722 (human)0.0000003FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102838791102838792Human
407161747GWAS810723_HFEV/FVC ratio, response to bronchodilator QTL GWAS810723 (human)0.0000003FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102837776102837777Human
407268063GWAS917039_Hperipheral arterial disease QTL GWAS917039 (human)0.0000003peripheral arterial disease11102839740102839741Human
407169503GWAS818479_HFEV/FVC ratio, response to bronchodilator QTL GWAS818479 (human)0.0000006FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102838791102838792Human
1559115SCL20_HSerum cholesterol level QTL 20 (human)3.220.001213Lipid levelLDL cholesterol11100442501126442501Human
407161400GWAS810376_HFEV/FVC ratio, response to bronchodilator QTL GWAS810376 (human)0.0000002FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102839740102839741Human
406995645GWAS644621_Hlevel of stromelysin-1 in blood serum QTL GWAS644621 (human)3e-16level of stromelysin-1 in blood serum11102842889102842890Human

Markers in Region
D14S1188  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,706,653 - 102,706,848UniSTSGRCh37
Build 3611102,211,863 - 102,212,058RGDNCBI36
Celera1199,868,260 - 99,868,455RGD
Cytogenetic Map11q22.2UniSTS
Cytogenetic Map11q22.3UniSTS
HuRef1198,634,575 - 98,634,770UniSTS
Stanford-G3 RH Map114507.0UniSTS
NCBI RH Map11891.8UniSTS
GeneMap99-G3 RH Map114507.0UniSTS
PMC85083P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,706,594 - 102,706,896UniSTSGRCh37
Build 3611102,211,804 - 102,212,106RGDNCBI36
Celera1199,868,201 - 99,868,503RGD
Cytogenetic Map11q22.2UniSTS
Cytogenetic Map11q22.3UniSTS
HuRef1198,634,516 - 98,634,818UniSTS
STS-X05232  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,706,659 - 102,706,930UniSTSGRCh37
Build 3611102,211,869 - 102,212,140RGDNCBI36
Celera1199,868,266 - 99,868,537RGD
Cytogenetic Map11q22.2UniSTS
Cytogenetic Map11q22.3UniSTS
HuRef1198,634,581 - 98,634,852UniSTS
GeneMap99-GB4 RH Map11352.42UniSTS
MMP3_2663  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,706,338 - 102,706,986UniSTSGRCh37
Build 3611102,211,548 - 102,212,196RGDNCBI36
Celera1199,867,945 - 99,868,593RGD
HuRef1198,634,260 - 98,634,908UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1114 2336 2751 1881 3855 1254 1782 2 397 950 234 2143 5391 4956 40 2778 1 629 1479 1292 172 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF405705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI628953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA982602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ399598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT355692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT355693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S52369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000299855   ⟹   ENSP00000299855
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,835,801 - 102,843,609 (-)Ensembl
Ensembl Acc Id: ENST00000434103   ⟹   ENSP00000398346
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,836,497 - 102,838,710 (-)Ensembl
Ensembl Acc Id: ENST00000524478   ⟹   ENSP00000435255
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,842,252 - 102,843,607 (-)Ensembl
RefSeq Acc Id: NM_002422   ⟹   NP_002413
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,835,801 - 102,843,609 (-)NCBI
GRCh3711102,706,528 - 102,714,342 (-)ENTREZGENE
Build 3611102,211,738 - 102,219,552 (-)NCBI Archive
HuRef1198,634,450 - 98,642,264 (-)ENTREZGENE
CHM1_111102,589,497 - 102,597,395 (-)NCBI
T2T-CHM13v2.011102,839,570 - 102,847,378 (-)NCBI
Sequence:
RefSeq Acc Id: NP_002413   ⟸   NM_002422
- Peptide Label: preproprotein
- UniProtKB: Q3B7S0 (UniProtKB/Swiss-Prot),   B2R8B8 (UniProtKB/Swiss-Prot),   Q6GRF8 (UniProtKB/Swiss-Prot),   P08254 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000299855   ⟸   ENST00000299855
Ensembl Acc Id: ENSP00000435255   ⟸   ENST00000524478
Ensembl Acc Id: ENSP00000398346   ⟸   ENST00000434103
Protein Domains
Peptidoglycan binding-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08254-F1-model_v2 AlphaFold P08254 1-477 view protein structure

Promoters
RGD ID:6849896
Promoter ID:EP30051
Type:single initiation site
Name:HS_MMP3
Description:Stromelysin, MMP3 or STMY1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 173; Mammalian transin/stromelysin.
Experiment Methods:Primer extension with homologous sequence ladder; Nuclease protection; experiments performed with closely related; gene
Regulation:fibroblasts; (induced by or strongly expressed in) IL (repressed by or weakly expressed in) 1b', (repressed by or weakly expressed in) glucocorticoid
Position:
Human AssemblyChrPosition (strand)Source
Build 3611102,219,550 - 102,219,610EPD
RGD ID:7221927
Promoter ID:EPDNEW_H16709
Type:initiation region
Name:MMP3_1
Description:matrix metallopeptidase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,843,607 - 102,843,667EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7173 AgrOrtholog
COSMIC MMP3 COSMIC
Ensembl Genes ENSG00000149968 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000299855 ENTREZGENE
  ENST00000299855.10 UniProtKB/Swiss-Prot
  ENST00000434103.1 UniProtKB/TrEMBL
  ENST00000524478.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.101.10 UniProtKB/TrEMBL
  2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot
GTEx ENSG00000149968 GTEx
HGNC ID HGNC:7173 ENTREZGENE
Human Proteome Map MMP3 Human Proteome Map
InterPro Heme_transport/Cell_adhesion UniProtKB/TrEMBL
  Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBDSf UniProtKB/TrEMBL
KEGG Report hsa:4314 UniProtKB/Swiss-Prot
NCBI Gene 4314 ENTREZGENE
OMIM 185250 OMIM
PANTHER EG:8D8.2 PROTEIN-RELATED UniProtKB/TrEMBL
  HEMOPEXIN DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
  STROMELYSIN-1 UniProtKB/Swiss-Prot
Pfam Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MMP3 RGD, PharmGKB
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot
  HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U3J4I2_HUMAN UniProtKB/TrEMBL
  A5GZ70_HUMAN UniProtKB/TrEMBL
  B2R8B8 ENTREZGENE
  E9PKX2_HUMAN UniProtKB/TrEMBL
  H7C139_HUMAN UniProtKB/TrEMBL
  MMP3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q3B7S0 ENTREZGENE
  Q6GRF8 ENTREZGENE
UniProt Secondary B2R8B8 UniProtKB/Swiss-Prot
  Q3B7S0 UniProtKB/Swiss-Prot
  Q6GRF8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-03 MMP3  matrix metallopeptidase 3  MMP3  matrix metallopeptidase 3 (stromelysin 1, progelatinase)  Symbol and/or name change 5135510 APPROVED