MMP3 (matrix metallopeptidase 3) - Rat Genome Database

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Gene: MMP3 (matrix metallopeptidase 3) Homo sapiens
Analyze
Symbol: MMP3
Name: matrix metallopeptidase 3
RGD ID: 1345848
HGNC Page HGNC:7173
Description: Enables endopeptidase activity and metallopeptidase activity. Involved in several processes, including cellular response to UV-A; negative regulation of reactive oxygen species metabolic process; and positive regulation of protein-containing complex assembly. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Biomarker of several diseases, including Takayasu's arteritis; arthritis (multiple); autoimmune disease (multiple); conjunctivochalasis; and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CHDS6; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 (stromelysin 1, progelatinase); matrix metalloproteinase-3; MGC126102; MGC126103; MGC126104; MMP-3; proteoglycanase; SL-1; STMY; STMY1; STR1; stromelysin-1; transin-1
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,835,801 - 102,843,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,835,801 - 102,843,609 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,706,532 - 102,714,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,211,738 - 102,219,552 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,211,742 - 102,219,550NCBI
Celera1199,868,135 - 99,875,949 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,634,450 - 98,642,264 (-)NCBIHuRef
CHM1_111102,589,497 - 102,597,317 (-)NCBICHM1_1
T2T-CHM13v2.011102,839,570 - 102,847,378 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Otitis Media  (ISO)
allergic contact dermatitis  (ISO)
Alport syndrome  (IEP)
arteriosclerosis  (IAGP)
asphyxiating thoracic dystrophy  (IAGP)
ataxia telangiectasia  (IAGP)
atrial fibrillation  (IAGP)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (IAGP)
Breast Neoplasms  (EXP)
Carotid Artery Injuries  (ISO)
carotid stenosis  (IAGP)
cartilage disease  (ISO)
cataract  (IEP)
celiac disease  (EXP)
Cerebral Hemorrhage  (EXP)
Chronic Allograft Nephropathy  (IEP)
cognitive disorder  (ISO)
colon cancer  (ISO)
Colorectal Neoplasms  (IAGP)
congestive heart failure  (IEP)
conjunctivochalasis  (IEP)
coronary artery disease  (EXP,IAGP)
Coronary Disease  (EXP,IAGP)
coronary restenosis  (EXP)
crescentic glomerulonephritis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (IEP)
Diabetic Nephropathies  (IEP)
dry eye syndrome  (ISO)
end stage renal disease  (IAGP)
Endotoxemia  (ISO)
esophagus adenocarcinoma  (IAGP)
Experimental Arthritis  (EXP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
gastric ulcer  (ISO)
glomerulonephritis  (IEP,ISO)
Gouty Arthritis  (IEP)
Hyperalgesia  (EXP,ISO)
idiopathic pulmonary fibrosis  (EXP,IEP)
immunoglobulin light chain amyloidosis  (IEP)
intellectual disability  (IAGP)
Knee Osteoarthritis  (ISO)
lung cancer  (IEP)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (IAGP)
malignant astrocytoma  (EXP)
myocardial infarction  (IAGP)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (ISO)
osteoarthritis  (IDA,IEP)
Parkinsonism  (ISO)
Penetrating Wounds  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (EXP)
polymyalgia rheumatica  (IEP)
primary biliary cholangitis  (ISO)
psoriatic arthritis  (IEP)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (EXP)
renal cell carcinoma  (IAGP)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (IEP)
Sjogren's syndrome  (IEP)
Stroke  (ISO)
systemic scleroderma  (IDA,IEP)
Takayasu's arteritis  (IEP)
Tendon Injuries  (ISO)
thrombosis  (IAGP)
Transplant Rejection  (IEP)
type 2 diabetes mellitus  (ISO)
Ulcer  (IEP)
Venous Thrombosis  (ISO)
von Hippel-Lindau disease  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-citrinin  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
3-hydroxypicolinic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
5-iodotubercidin  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alpha-naphthoflavone  (ISO)
aluminium oxide  (EXP)
ammonium chloride  (ISO)
anandamide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
avobenzone  (EXP)
azathioprine  (EXP)
azithromycin  (EXP)
Azoxymethane  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
BQ 123  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (ISO)
C.I. Natural Red 20  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
carvacrol  (ISO)
CGP 52608  (EXP)
chloramphenicol  (EXP)
chlorothalonil  (EXP)
choline  (ISO)
chondroitin sulfate  (EXP)
ciprofloxacin  (EXP)
cisplatin  (EXP)
cobalt atom  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cordycepin  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (EXP)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
DDT  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dieckol  (EXP)
diethyl malate  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disulfiram  (EXP)
diuron  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP,ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (EXP)
enalapril  (ISO)
endosulfan  (EXP,ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
farnesol  (EXP)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fucoidan  (EXP)
galaxolide  (EXP)
gemcitabine  (EXP)
genistein  (ISO)
geraniol  (EXP)
glycitein  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
graphene oxide  (ISO)
HU-308  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
ibuprofen  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
irigenin  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
L-proline betaine  (EXP)
lidocaine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
loliolide  (EXP)
lovastatin  (ISO)
malathion  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
megestrol acetate  (ISO)
melittin  (EXP)
Methanandamide  (EXP)
methotrexate  (EXP)
methyl caffeate  (EXP)
methylisothiazolinone  (EXP)
mibolerone  (EXP)
mifepristone  (EXP,ISO)
minocycline  (ISO)
Morroniside  (ISO)
moxifloxacin  (EXP)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP,ISO)
NSC 23766  (ISO)
ofloxacin  (ISO)
oroxylin A  (EXP)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 168393  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
pravastatin  (EXP)
prinomastat  (EXP)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
raloxifene  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rofecoxib  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (EXP)
serpentine asbestos  (EXP,ISO)
Shikonin  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP)
sodium azide  (EXP)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
sotorasib  (EXP)
streptozocin  (EXP,ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
tetracycline  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
tofacitinib  (EXP)
trametinib  (EXP)
triclosan  (EXP)
tunicamycin  (EXP)
ursodeoxycholic acid  (ISO)
varespladib methyl  (EXP)
zerumbone  (EXP)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Changes in matrix metalloproteinases and their inhibitors in kidney transplant recipients. Ahmed AK, etal., Exp Clin Transplant. 2012 Aug;10(4):332-43.
2. Type 2 diabetes impairs tendon repair after injury in a rat model. Ahmed AS, etal., J Appl Physiol (1985). 2012 Dec 1;113(11):1784-91. doi: 10.1152/japplphysiol.00767.2012. Epub 2012 Oct 4.
3. Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. Bousserouel S, etal., Oncol Rep. 2010 Feb;23(2):511-7.
4. Novel phosphoinositide 3-kinase delta,gamma inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. Boyle DL, etal., J Pharmacol Exp Ther. 2014 Feb;348(2):271-80. doi: 10.1124/jpet.113.205955. Epub 2013 Nov 15.
5. Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis. Bradbury PA, etal., Carcinogenesis. 2009 May;30(5):793-8. doi: 10.1093/carcin/bgp065. Epub 2009 Mar 25.
6. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
7. Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjogren's syndrome. Chen WS, etal., J Rheumatol. 2009 May;36(5):989-96. doi: 10.3899/jrheum.080733. Epub 2009 Mar 30.
8. Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model. Chou LW, etal., Arthritis Res Ther. 2011 Jun 16;13(3):R90. doi: 10.1186/ar3365.
9. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. Christianson CA, etal., Neuroscience. 2012 Jan 3;200:199-210. doi: 10.1016/j.neuroscience.2011.10.019. Epub 2011 Oct 20.
10. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. Cozzolino M, etal., Nephrol Dial Transplant. 2009 Jul;24(7):2207-12. doi: 10.1093/ndt/gfp061. Epub 2009 Feb 16.
11. Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve. Gantus MA, etal., Brain Res. 2006 Nov 29;1122(1):36-46. Epub 2006 Oct 6.
12. A multigenic approach to predict breast cancer risk. Gerger A, etal., Breast Cancer Res Treat. 2007 Aug;104(2):159-64. Epub 2006 Oct 21.
13. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. Ghilardi G, etal., Stroke. 2002 Oct;33(10):2408-12.
14. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
15. Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM). Goncharova EA, etal., Sci Transl Med. 2012 Oct 3;4(154):154ra134. doi: 10.1126/scitranslmed.3003840.
16. Gene expression profiling of skin and draining lymph nodes of rats affected with cutaneous contact hypersensitivity. Hartmann B, etal., Inflamm Res. 2006 Aug;55(8):322-34.
17. Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma. Hirata H, etal., Carcinogenesis. 2004 Dec;25(12):2379-84. Epub 2004 Aug 19.
18. Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease. Horne BD, etal., Am Heart J. 2007 Oct;154(4):751-8.
19. Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up. Houseman M, etal., Arthritis Res Ther. 2012 Feb 7;14(1):R30. doi: 10.1186/ar3734.
20. Diagnosis and assessment of Takayasu arteritis by multiple biomarkers. Ishihara T, etal., Circ J. 2013;77(2):477-83. Epub 2012 Oct 26.
21. Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke. Ishrat T, etal., Neurochem Res. 2013 Dec;38(12):2668-77. doi: 10.1007/s11064-013-1185-y. Epub 2013 Nov 6.
22. Myelin loss associated with neuroinflammation in hypertensive rats. Jalal FY, etal., Stroke. 2012 Apr;43(4):1115-22. doi: 10.1161/STROKEAHA.111.643080. Epub 2012 Feb 23.
23. Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat. Jeong WI, etal., Anticancer Res. 2006 Sep-Oct;26(5A):3517-26.
24. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
25. Production and degradation of extracellular matrix in reversible glomerular lesions in rat model of habu snake venom-induced glomerulonephritis. Kawazu T, etal., Med Mol Morphol. 2012 Dec;45(4):190-8. doi: 10.1007/s00795-011-0559-y. Epub 2012 Dec 7.
26. Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
27. Honokiol inhibits the progression of collagen-induced arthritis by reducing levels of pro-inflammatory cytokines and matrix metalloproteinases and blocking oxidative tissue damage. Kim KR, etal., J Pharmacol Sci. 2010;114(1):69-78. Epub 2010 Aug 10.
28. Pleural fluid analysis of lung cancer vs benign inflammatory disease patients. Kremer R, etal., Br J Cancer. 2010 Mar 30;102(7):1180-4. Epub 2010 Mar 9.
29. The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer. Krippl P, etal., Clin Cancer Res. 2004 May 15;10(10):3518-20.
30. Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Leong DJ, etal., Matrix Biol. 2010 Feb 12.
31. Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats. Liang QQ, etal., J Pharmacol Sci. 2010;113(1):23-31.
32. Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine. Liang QQ, etal., Spine (Phila Pa 1976). 2011 Jan 1;36(1):E14-9. doi: 10.1097/BRS.0b013e3181d2dec2.
33. Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. Lievre A, etal., BMC Cancer. 2006 Nov 24;6:270.
34. Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients. Lin CC, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1805-14. doi: 10.2215/CJN.01500210. Epub 2010 Jul 8.
35. MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation. Lombardi F, etal., J Cardiovasc Med (Hagerstown). 2011 Jan;12(1):37-42. doi: 10.2459/JCM.0b013e3283403366.
36. The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc. MacLean JJ, etal., J Orthop Res. 2005 Sep;23(5):1120-7. Epub 2005 Apr 9.
37. Levels of circulating collagenase, stromelysin-1, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis. Relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation. Manicourt DH, etal., Arthritis Rheum. 1995 Aug;38(8):1031-9.
38. Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. Manicourt DH, etal., Drugs R D. 2005;6(5):261-71.
39. Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Mendes O, etal., Clin Exp Metastasis. 2005;22(3):237-46.
40. Renal expression of the Ets-1 proto-oncogene during progression of rat crescentic glomerulonephritis. Naito T, etal., J Am Soc Nephrol. 2000 Dec;11(12):2243-55.
41. Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats. Ni GX, etal., Arthritis Res Ther. 2011;13(6):R192. doi: 10.1186/ar3521. Epub 2011 Nov 24.
42. Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis. Nishijima C, etal., Clin Exp Immunol. 2004 Nov;138(2):357-63.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease. Park JA, etal., J Korean Med Sci. 2005 Aug;20(4):607-11.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. Pollanen PJ, etal., Atherosclerosis. 2005 May;180(1):73-8. Epub 2004 Dec 18.
47. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. Ribbens C, etal., Ann Rheum Dis. 2002 Feb;61(2):161-6.
51. Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. Ricketts C, etal., PLoS One. 2009 Jun 24;4(6):e6037. doi: 10.1371/journal.pone.0006037.
52. Full and partial peroxisome proliferation-activated receptor-gamma agonists, but not delta agonist, rescue of dopaminergic neurons in the 6-OHDA parkinsonian model is associated with inhibition of microglial activation and MMP expression. Sadeghian M, etal., J Neuroimmunol. 2012 May 15;246(1-2):69-77. doi: 10.1016/j.jneuroim.2012.03.010. Epub 2012 Apr 11.
53. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Saghizadeh M, etal., Am J Pathol. 2001 Feb;158(2):723-34.
54. Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis. Sanders JS, etal., Nephrol Dial Transplant. 2004 Jun;19(6):1412-9. Epub 2004 Mar 19.
55. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
56. Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity. Slavkovsky R, etal., Wound Repair Regen. 2011 Jul-Aug;19(4):515-25. doi: 10.1111/j.1524-475X.2011.00703.x. Epub 2011 Jun 7.
57. Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion. Sole S, etal., J Neuropathol Exp Neurol. 2004 Apr;63(4):338-49.
58. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Sternlicht MD, etal., Cell. 1999 Jul 23;98(2):137-46.
59. In situ hybridization studies of matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-1 and type IV collagen in diabetic nephropathy. Suzuki D, etal., Kidney Int. 1997 Jul;52(1):111-9.
60. [Effects of matrix metalloproteinase-3, osteopontin, and tissue inhibitor of metalloproteinase-1 in the formation of cataract]. Tan Q, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Oct;31(5):737-41.
61. Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in patients with malignant melanoma. Tas F, etal., Med Oncol. 2005;22(1):39-44.
62. MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Tchetverikov I, etal., Ann Rheum Dis. 2004 Jul;63(7):881-3.
63. The association of serum matrix metalloproteinases and their tissue inhibitor levels with scleroderma disease severity. Toubi E, etal., Clin Exp Rheumatol. 2002 Mar-Apr;20(2):221-4.
64. Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa/fa obese rats after treatment with swertiamarin. Vaidya H, etal., Exp Clin Cardiol. 2012 Spring;17(1):12-6.
65. [Effects of glutamine on matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-3 expressions in myocardium of rats with sepsis] Wang H, etal., Zhonghua Er Ke Za Zhi. 2006 Aug;44(8):587-91.
66. Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Wang M, etal., Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6885-9.
67. Therapeutic effects of p75 tumor necrosis factor receptor monoclonal antibody on a rat model of traumatic arthritis. Wang YX, etal., J Surg Res. 2014 Jan;186(1):234-9. doi: 10.1016/j.jss.2013.07.047. Epub 2013 Aug 20.
68. The role of oxidative stress and inflammation in conjunctivochalasis. Ward SK, etal., Invest Ophthalmol Vis Sci. 2010 Apr;51(4):1994-2002. doi: 10.1167/iovs.09-4130. Epub 2009 Dec 17.
69. Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury. Webb KE, etal., Arterioscler Thromb Vasc Biol. 1997 Sep;17(9):1837-44.
70. [Effect of progesterone on MMP-3 expression in neonatal rat brain after hypoxic-ischemia]. Xu CY, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Aug;26(3):370-3.
71. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Yamashita CM, etal., Am J Pathol. 2011 Oct;179(4):1733-45. doi: 10.1016/j.ajpath.2011.06.041. Epub 2011 Aug 24.
72. Imbalance of matrix metalloproteinases/tissue inhibitor of metalloproteinase-1 and loss of fibronectin expression in patients with congestive heart failure. Yang DC, etal., Cardiology. 2010;116(2):133-41. doi: 10.1159/000317245. Epub 2010 Jul 1.
73. Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. Zeisberg M, etal., PLoS Med. 2006 Apr;3(4):e100. Epub 2006 Mar 7.
74. NK cells promote Th-17 mediated corneal barrier disruption in dry eye. Zhang X, etal., PLoS One. 2012;7(5):e36822. doi: 10.1371/journal.pone.0036822. Epub 2012 May 8.
75. Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis. Zhang YB, etal., Chin J Traumatol. 2010 Jun 1;13(3):188-92.
76. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology Zhong LJ, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2009 Aug;44(8):464-8.
77. Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study. Zhou X, etal., Thromb Haemost. 2004 Oct;92(4):867-73.
Additional References at PubMed
PMID:2383557   PMID:2605216   PMID:2785989   PMID:3030290   PMID:3360803   PMID:3477804   PMID:7523391   PMID:7656014   PMID:7694569   PMID:7998967   PMID:8125298   PMID:8216228  
PMID:8486377   PMID:8535233   PMID:8662692   PMID:8740360   PMID:8804434   PMID:8921407   PMID:8957070   PMID:9083493   PMID:9148753   PMID:9288970   PMID:9548733   PMID:9558113  
PMID:9573338   PMID:9733482   PMID:9737711   PMID:9760240   PMID:9792098   PMID:9827994   PMID:9873489   PMID:9888835   PMID:10419448   PMID:10422833   PMID:10543949   PMID:10639284  
PMID:10669564   PMID:10877850   PMID:10922468   PMID:10947989   PMID:10967118   PMID:10986281   PMID:11116068   PMID:11297453   PMID:11327577   PMID:11375993   PMID:11380116   PMID:11438501  
PMID:11485914   PMID:11546917   PMID:11751414   PMID:11827795   PMID:11836255   PMID:11841344   PMID:11841844   PMID:11977998   PMID:11982752   PMID:11988625   PMID:12009331   PMID:12034345  
PMID:12034715   PMID:12054564   PMID:12054629   PMID:12071839   PMID:12103254   PMID:12124858   PMID:12149192   PMID:12204805   PMID:12205736   PMID:12229968   PMID:12230559   PMID:12385578  
PMID:12432557   PMID:12473595   PMID:12477932   PMID:12477941   PMID:12485468   PMID:12572877   PMID:12634064   PMID:12651627   PMID:12727228   PMID:12736398   PMID:12750310   PMID:12761889  
PMID:12784383   PMID:12810672   PMID:12821236   PMID:12832381   PMID:12834347   PMID:12837283   PMID:12866026   PMID:12867428   PMID:12876636   PMID:12880418   PMID:12952836   PMID:13129650  
PMID:14712311   PMID:14715248   PMID:14718574   PMID:14984923   PMID:14998290   PMID:15009479   PMID:15033492   PMID:15070833   PMID:15084374   PMID:15094779   PMID:15102660   PMID:15142265  
PMID:15172469   PMID:15194213   PMID:15203551   PMID:15234427   PMID:15274394   PMID:15288468   PMID:15290728   PMID:15308783   PMID:15312099   PMID:15319302   PMID:15337261   PMID:15342709  
PMID:15355616   PMID:15383690   PMID:15389640   PMID:15474069   PMID:15489334   PMID:15528217   PMID:15529384   PMID:15546966   PMID:15610507   PMID:15640153   PMID:15665388   PMID:15667946  
PMID:15701845   PMID:15716694   PMID:15748780   PMID:15757531   PMID:15763339   PMID:15863497   PMID:15879464   PMID:15894268   PMID:15944607   PMID:15955221   PMID:15972662   PMID:15993717  
PMID:16080875   PMID:16082623   PMID:16088212   PMID:16102106   PMID:16202315   PMID:16238676   PMID:16278009   PMID:16302209   PMID:16311244   PMID:16323393   PMID:16344560   PMID:16356191  
PMID:16405530   PMID:16424284   PMID:16430740   PMID:16516860   PMID:16532917   PMID:16615041   PMID:16629857   PMID:16677108   PMID:16739355   PMID:16802342   PMID:16822591   PMID:16871440  
PMID:16899023   PMID:16904077   PMID:16905683   PMID:16919028   PMID:16935611   PMID:16937230   PMID:16972019   PMID:16972255   PMID:16972994   PMID:16984617   PMID:16998253   PMID:17000679  
PMID:17000887   PMID:17003494   PMID:17024375   PMID:17027562   PMID:17033924   PMID:17065356   PMID:17077200   PMID:17137622   PMID:17145822   PMID:17151781   PMID:17178858   PMID:17181997  
PMID:17182940   PMID:17198194   PMID:17207965   PMID:17316652   PMID:17316907   PMID:17319946   PMID:17320799   PMID:17373931   PMID:17381556   PMID:17383306   PMID:17434489   PMID:17436000  
PMID:17471097   PMID:17473191   PMID:17502998   PMID:17530713   PMID:17537400   PMID:17543900   PMID:17559909   PMID:17564313   PMID:17589947   PMID:17607721   PMID:17617834   PMID:17617837  
PMID:17664256   PMID:17669621   PMID:17672933   PMID:17703334   PMID:17710450   PMID:17719307   PMID:17763214   PMID:17763953   PMID:17765638   PMID:17875574   PMID:17901377   PMID:17911432  
PMID:17919326   PMID:17922906   PMID:17929133   PMID:17942123   PMID:17958893   PMID:17975717   PMID:18006768   PMID:18007247   PMID:18028894   PMID:18029348   PMID:18035073   PMID:18063811  
PMID:18076359   PMID:18077489   PMID:18091353   PMID:18172013   PMID:18212480   PMID:18220784   PMID:18225577   PMID:18234553   PMID:18237197   PMID:18262287   PMID:18275497   PMID:18303200  
PMID:18308831   PMID:18342317   PMID:18363112   PMID:18426080   PMID:18445105   PMID:18469698   PMID:18485900   PMID:18496696   PMID:18513389   PMID:18541955   PMID:18566588   PMID:18571835  
PMID:18573993   PMID:18606478   PMID:18609140   PMID:18619594   PMID:18634015   PMID:18636124   PMID:18674944   PMID:18674955   PMID:18760468   PMID:18801353   PMID:18810583   PMID:18818437  
PMID:18818748   PMID:18830194   PMID:18974705   PMID:19005290   PMID:19008710   PMID:19019335   PMID:19019896   PMID:19022250   PMID:19042922   PMID:19056482   PMID:19064570   PMID:19065524  
PMID:19100060   PMID:19131662   PMID:19132754   PMID:19155066   PMID:19159011   PMID:19165649   PMID:19180518   PMID:19212832   PMID:19238444   PMID:19245826   PMID:19263529   PMID:19268777  
PMID:19275880   PMID:19279308   PMID:19293200   PMID:19318431   PMID:19336475   PMID:19337798   PMID:19376102   PMID:19381070   PMID:19432148   PMID:19435861   PMID:19438845   PMID:19479237  
PMID:19504098   PMID:19507017   PMID:19507256   PMID:19508478   PMID:19522160   PMID:19527514   PMID:19559392   PMID:19576586   PMID:19578796   PMID:19585142   PMID:19614693   PMID:19628284  
PMID:19643940   PMID:19664242   PMID:19678938   PMID:19690958   PMID:19729601   PMID:19731200   PMID:19762026   PMID:19770597   PMID:19778329   PMID:19786072   PMID:19789190   PMID:19834535  
PMID:19836620   PMID:19843588   PMID:19892918   PMID:19906289   PMID:19913121   PMID:19923455   PMID:19948975   PMID:19949639   PMID:20009418   PMID:20031604   PMID:20038976   PMID:20082876  
PMID:20092902   PMID:20113256   PMID:20142115   PMID:20204402   PMID:20211321   PMID:20215736   PMID:20302034   PMID:20346360   PMID:20359947   PMID:20360864   PMID:20374310   PMID:20385826  
PMID:20435584   PMID:20436380   PMID:20437586   PMID:20452482   PMID:20453000   PMID:20455995   PMID:20467172   PMID:20472558   PMID:20483790   PMID:20484597   PMID:20485444   PMID:20538124  
PMID:20541269   PMID:20574775   PMID:20584750   PMID:20587546   PMID:20609072   PMID:20609440   PMID:20616708   PMID:20622166   PMID:20628086   PMID:20628624   PMID:20630073   PMID:20640910  
PMID:20654099   PMID:20655856   PMID:20672350   PMID:20673868   PMID:20707923   PMID:20708412   PMID:20731042   PMID:20740392   PMID:20802378   PMID:20822909   PMID:20827277   PMID:20832538  
PMID:20853681   PMID:20873121   PMID:20936527   PMID:20942234   PMID:20948207   PMID:20959880   PMID:20969476   PMID:21037509   PMID:21044079   PMID:21048031   PMID:21103065   PMID:21108787  
PMID:21111627   PMID:21113741   PMID:21134112   PMID:21150162   PMID:21183746   PMID:21187770   PMID:21190865   PMID:21206012   PMID:21212676   PMID:21219546   PMID:21227015   PMID:21228692  
PMID:21232745   PMID:21244504   PMID:21247370   PMID:21277817   PMID:21321996   PMID:21330369   PMID:21336947   PMID:21345293   PMID:21357403   PMID:21410539   PMID:21431945   PMID:21443102  
PMID:21451793   PMID:21454617   PMID:21454822   PMID:21481333   PMID:21601886   PMID:21667159   PMID:21707906   PMID:21753786   PMID:21770773   PMID:21782982   PMID:21802713   PMID:21853476  
PMID:21867693   PMID:21872914   PMID:21873635   PMID:21900582   PMID:21917825   PMID:21925226   PMID:21935932   PMID:21948134   PMID:22027013   PMID:22057989   PMID:22089392   PMID:22092736  
PMID:22114952   PMID:22121090   PMID:22122951   PMID:22134873   PMID:22175304   PMID:22184093   PMID:22204652   PMID:22207289   PMID:22210296   PMID:22222271   PMID:22241750   PMID:22265821  
PMID:22278305   PMID:22323068   PMID:22441965   PMID:22455335   PMID:22457004   PMID:22515887   PMID:22531699   PMID:22587600   PMID:22628530   PMID:22671570   PMID:22730240   PMID:22776467  
PMID:22786680   PMID:22819245   PMID:22832961   PMID:22836729   PMID:22862420   PMID:22868188   PMID:22888638   PMID:22890115   PMID:22922035   PMID:22927007   PMID:22965799   PMID:22975753  
PMID:23043898   PMID:23108733   PMID:23123160   PMID:23128460   PMID:23328930   PMID:23343931   PMID:23357697   PMID:23377317   PMID:23409137   PMID:23412981   PMID:23483952   PMID:23509928  
PMID:23522322   PMID:23548063   PMID:23564449   PMID:23575435   PMID:23608488   PMID:23637955   PMID:23696797   PMID:23705892   PMID:23707809   PMID:23744166   PMID:23744893   PMID:23752352  
PMID:23769926   PMID:23794948   PMID:23845380   PMID:23872201   PMID:23922934   PMID:23926017   PMID:23934131   PMID:23936524   PMID:23941979   PMID:23967200   PMID:23975061   PMID:23978194  
PMID:24043512   PMID:24079541   PMID:24101259   PMID:24111521   PMID:24146820   PMID:24168165   PMID:24338609   PMID:24349530   PMID:24374826   PMID:24414606   PMID:24416274   PMID:24464212  
PMID:24489939   PMID:24507680   PMID:24577893   PMID:24583398   PMID:24667918   PMID:24670135   PMID:24799419   PMID:24804215   PMID:24850902   PMID:24939159   PMID:24999605   PMID:25049354  
PMID:25135219   PMID:25135220   PMID:25147433   PMID:25168209   PMID:25177880   PMID:25217476   PMID:25263962   PMID:25291965   PMID:25292126   PMID:25292349   PMID:25340798   PMID:25351421  
PMID:25391977   PMID:25403368   PMID:25416956   PMID:25463899   PMID:25482733   PMID:25564266   PMID:25599395   PMID:25605062   PMID:25611261   PMID:25711032   PMID:25742789   PMID:25807652  
PMID:25818544   PMID:25854159   PMID:25912212   PMID:25933064   PMID:25993872   PMID:26087627   PMID:26109466   PMID:26123623   PMID:26125893   PMID:26156043   PMID:26186194   PMID:26191285  
PMID:26206176   PMID:26260627   PMID:26314579   PMID:26437765   PMID:26510114   PMID:26526578   PMID:26528997   PMID:26634533   PMID:26681054   PMID:26712881   PMID:26713439   PMID:26754027  
PMID:26805660   PMID:26850593   PMID:26853425   PMID:26863055   PMID:27013197   PMID:27043485   PMID:27051023   PMID:27061553   PMID:27072559   PMID:27089651   PMID:27108649   PMID:27129069  
PMID:27145630   PMID:27161754   PMID:27173221   PMID:27176648   PMID:27177702   PMID:27206651   PMID:27211292   PMID:27268637   PMID:27389714   PMID:27391467   PMID:27423606   PMID:27438616  
PMID:27611862   PMID:27659327   PMID:27659332   PMID:27706715   PMID:27733582   PMID:27771306   PMID:27793533   PMID:27797337   PMID:27837634   PMID:27911281   PMID:27975070   PMID:28002595  
PMID:28024290   PMID:28158775   PMID:28160256   PMID:28337851   PMID:28365812   PMID:28396463   PMID:28432524   PMID:28445942   PMID:28447732   PMID:28461705   PMID:28497435   PMID:28514442  
PMID:28521653   PMID:28676856   PMID:28718374   PMID:28781337   PMID:28798935   PMID:28819304   PMID:28831065   PMID:28843428   PMID:28850021   PMID:28912710   PMID:28914997   PMID:28944430  
PMID:28961241   PMID:29044936   PMID:29070037   PMID:29120572   PMID:29141665   PMID:29164307   PMID:29165854   PMID:29276151   PMID:29304854   PMID:29317790   PMID:29358561   PMID:29390034  
PMID:29421776   PMID:29442475   PMID:29458338   PMID:29462373   PMID:29483840   PMID:29670668   PMID:29738289   PMID:29883760   PMID:30031401   PMID:30036111   PMID:30117779   PMID:30138480  
PMID:30187662   PMID:30288688   PMID:30297859   PMID:30406565   PMID:30422384   PMID:30509760   PMID:30732526   PMID:30755371   PMID:30856693   PMID:31055827   PMID:31081124   PMID:31124320  
PMID:31208828   PMID:31218540   PMID:31355596   PMID:31356534   PMID:31377584   PMID:31380578   PMID:31396295   PMID:31467432   PMID:31525531   PMID:31652448   PMID:31808123   PMID:31827179  
PMID:31833734   PMID:31882488   PMID:31887330   PMID:31894328   PMID:31955640   PMID:32093874   PMID:32157746   PMID:32272349   PMID:32325785   PMID:32417757   PMID:32421262   PMID:32450244  
PMID:32603484   PMID:32610117   PMID:32748631   PMID:32945390   PMID:33130223   PMID:33139684   PMID:33157227   PMID:33170424   PMID:33243974   PMID:33319933   PMID:33337838   PMID:33404658  
PMID:33531109   PMID:33664330   PMID:33961781   PMID:33986628   PMID:34198485   PMID:34222497   PMID:34257518   PMID:34367126   PMID:34445715   PMID:34608503   PMID:34693500   PMID:34801997  
PMID:34857952   PMID:34860335   PMID:34980041   PMID:35023695   PMID:35176662   PMID:35256949   PMID:35329213   PMID:35708757   PMID:35912721   PMID:35960412   PMID:35967336   PMID:36231910  
PMID:36319784   PMID:36362386   PMID:36370803   PMID:36389698   PMID:36640492   PMID:36724073   PMID:36739977   PMID:36808352   PMID:37176106   PMID:37442641   PMID:37471217   PMID:37551683  
PMID:37859283   PMID:37986083   PMID:38004080   PMID:38454645   PMID:39000435   PMID:39238192  


Genomics

Comparative Map Data
MMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,835,801 - 102,843,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,835,801 - 102,843,609 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,706,532 - 102,714,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,211,738 - 102,219,552 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,211,742 - 102,219,550NCBI
Celera1199,868,135 - 99,875,949 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,634,450 - 98,642,264 (-)NCBIHuRef
CHM1_111102,589,497 - 102,597,317 (-)NCBICHM1_1
T2T-CHM13v2.011102,839,570 - 102,847,378 (-)NCBIT2T-CHM13v2.0
Mmp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,445,845 - 7,455,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm39 Ensembl
GRCm3897,445,822 - 7,455,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,445,822 - 7,455,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,445,822 - 7,455,975 (+)NCBIMGSCv36mm8
Celera94,846,374 - 4,856,527 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8812,925,267 - 12,938,828 (+)NCBIGRCr8
mRatBN7.284,640,397 - 4,653,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,640,416 - 4,653,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,600,140 - 8,613,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,897,910 - 6,911,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,900,079 - 4,913,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,676,608 - 5,698,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,676,665 - 5,698,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,680,382 - 5,701,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,315,601 - 4,329,146 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,315,600 - 4,329,146 (+)NCBI
Celera86,200,234 - 6,213,783 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,629,536 - 103,637,408 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,717,742 - 104,725,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,776,729 - 97,784,549 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,267,561 - 101,275,432 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,267,566 - 101,275,354 (-)Ensemblpanpan1.1panPan2
MMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,949,631 - 28,957,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,949,631 - 28,958,222 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,898,123 - 28,906,399 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,000,797 - 29,009,079 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,000,797 - 29,009,386 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,035,847 - 29,044,131 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0528,915,267 - 28,923,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,090,249 - 29,098,533 (+)NCBIUU_Cfam_GSD_1.0
MMP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,446,836 - 33,454,000 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,446,969 - 33,453,995 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,394,116 - 37,401,146 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,216,156 - 94,224,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,216,173 - 94,224,264 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,654,560 - 31,662,871 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462487839,358 - 47,075 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462487839,282 - 47,386 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MMP3
69 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NC_000011.10:g.102845221dup duplication Coronary heart disease, susceptibility to, 6 [RCV000013637] Chr11:102845216..102845217 [GRCh38]
Chr11:102715947..102715948 [GRCh37]
Chr11:11q22.2
risk factor
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3
pathogenic
GRCh38/hg38 11q14.1-22.2(chr11:85242847-102920097)x1 copy number loss See cases [RCV000052711] Chr11:85242847..102920097 [GRCh38]
Chr11:84953891..102738968 [GRCh37]
Chr11:84631539..102296037 [NCBI36]
Chr11:11q14.1-22.2
pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
NM_002422.3(MMP3):c.921G>T (p.Leu307=) single nucleotide variant Malignant melanoma [RCV000069136] Chr11:102840122 [GRCh38]
Chr11:102710853 [GRCh37]
Chr11:102216063 [NCBI36]
Chr11:11q22.2
not provided
NM_002422.3(MMP3):c.558C>T (p.Ala186=) single nucleotide variant Malignant melanoma [RCV000069137] Chr11:102842221 [GRCh38]
Chr11:102712952 [GRCh37]
Chr11:102218162 [NCBI36]
Chr11:11q22.2
not provided
NM_002422.3(MMP3):c.165G>A (p.Lys55=) single nucleotide variant Malignant melanoma [RCV000069138] Chr11:102842857 [GRCh38]
Chr11:102713588 [GRCh37]
Chr11:102218798 [NCBI36]
Chr11:11q22.2
not provided
GRCh38/hg38 11q22.1-22.3(chr11:98357901-106059146)x1 copy number loss See cases [RCV000136574] Chr11:98357901..106059146 [GRCh38]
Chr11:98228629..105929873 [GRCh37]
Chr11:97733839..105435083 [NCBI36]
Chr11:11q22.1-22.3
pathogenic
GRCh38/hg38 11q22.1-22.3(chr11:101452984-104044105)x3 copy number gain See cases [RCV000136846] Chr11:101452984..104044105 [GRCh38]
Chr11:101323715..103914833 [GRCh37]
Chr11:100828925..103420043 [NCBI36]
Chr11:11q22.1-22.3
pathogenic
GRCh38/hg38 11q14.3-22.3(chr11:91086659-109595582)x1 copy number loss See cases [RCV000138038] Chr11:91086659..109595582 [GRCh38]
Chr11:90819827..109466308 [GRCh37]
Chr11:90459475..108971518 [NCBI36]
Chr11:11q14.3-22.3
pathogenic
GRCh37/hg19 11q22.2(chr11:102642841-102826187)x1 copy number loss See cases [RCV000448411] Chr11:102642841..102826187 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.626-14A>G single nucleotide variant not provided [RCV001653800]|not specified [RCV000454459] Chr11:102840607 [GRCh38]
Chr11:102711338 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.133A>G (p.Lys45Glu) single nucleotide variant not provided [RCV001598670]|not specified [RCV000454524] Chr11:102842889 [GRCh38]
Chr11:102842889..102842890 [GRCh38]
Chr11:102713620 [GRCh37]
Chr11:102713620..102713621 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.306C>G (p.Thr102=) single nucleotide variant not provided [RCV001707693]|not specified [RCV000454940] Chr11:102842716 [GRCh38]
Chr11:102713447 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.1086T>C (p.Ala362=) single nucleotide variant not provided [RCV001683493]|not specified [RCV000455579] Chr11:102838694 [GRCh38]
Chr11:102838694..102838695 [GRCh38]
Chr11:102709425 [GRCh37]
Chr11:102709425..102709426 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.288T>C (p.Asp96=) single nucleotide variant not provided [RCV001712410]|not specified [RCV000455590] Chr11:102842734 [GRCh38]
Chr11:102713465 [GRCh37]
Chr11:11q22.2
benign
GRCh37/hg19 11q14.2-22.3(chr11:88152458-109414650)x1 copy number loss See cases [RCV000510457] Chr11:88152458..109414650 [GRCh37]
Chr11:11q14.2-22.3
pathogenic
GRCh37/hg19 11q22.1-22.3(chr11:98515900-104970876)x1 copy number loss See cases [RCV000511844] Chr11:98515900..104970876 [GRCh37]
Chr11:11q22.1-22.3
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q22.2-22.3(chr11:102578709-107230611)x1 copy number loss not provided [RCV000683366] Chr11:102578709..107230611 [GRCh37]
Chr11:11q22.2-22.3
likely pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2
pathogenic
NM_002422.5(MMP3):c.106-188del deletion not provided [RCV001707091] Chr11:102843104 [GRCh38]
Chr11:102713835 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.126C>T (p.Tyr42=) single nucleotide variant not provided [RCV000936548] Chr11:102842896 [GRCh38]
Chr11:102713627 [GRCh37]
Chr11:11q22.2
likely benign
NM_002422.5(MMP3):c.792A>G (p.Gly264=) single nucleotide variant MMP3-related disorder [RCV003925926]|not provided [RCV000950210] Chr11:102840251 [GRCh38]
Chr11:102710982 [GRCh37]
Chr11:11q22.2
benign|likely benign
NM_002422.5(MMP3):c.12T>A (p.Leu4=) single nucleotide variant not provided [RCV000886546] Chr11:102843535 [GRCh38]
Chr11:102714266 [GRCh37]
Chr11:11q22.2
likely benign
NM_002422.5(MMP3):c.249T>C (p.Thr83=) single nucleotide variant not provided [RCV000881514] Chr11:102842773 [GRCh38]
Chr11:102713504 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.1131C>T (p.His377=) single nucleotide variant not provided [RCV000962222] Chr11:102838649 [GRCh38]
Chr11:102709380 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.457T>C (p.Tyr153His) single nucleotide variant not provided [RCV000960056] Chr11:102842473 [GRCh38]
Chr11:102713204 [GRCh37]
Chr11:11q22.2
likely benign
NM_002422.5(MMP3):c.58T>C (p.Leu20=) single nucleotide variant not provided [RCV000960121] Chr11:102843489 [GRCh38]
Chr11:102714220 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.583G>T (p.Ala195Ser) single nucleotide variant Mendelian syndromes with cleft lip/palate [RCV003315092] Chr11:102842196 [GRCh38]
Chr11:102712927 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.970C>T (p.Pro324Ser) single nucleotide variant not specified [RCV004320996] Chr11:102839209 [GRCh38]
Chr11:102709940 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.499+2T>A single nucleotide variant not provided [RCV001596794] Chr11:102842429 [GRCh38]
Chr11:102713160 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.106-130C>G single nucleotide variant not provided [RCV001667385] Chr11:102843046 [GRCh38]
Chr11:102713777 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.1334-348C>T single nucleotide variant not provided [RCV001674814] Chr11:102836574 [GRCh38]
Chr11:102707305 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.499+37A>G single nucleotide variant not provided [RCV001595601] Chr11:102842394 [GRCh38]
Chr11:102713125 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.1305A>G (p.Ser435=) single nucleotide variant not provided [RCV000910672] Chr11:102837326 [GRCh38]
Chr11:102708057 [GRCh37]
Chr11:11q22.2
likely benign
NM_002422.5(MMP3):c.228G>A (p.Thr76=) single nucleotide variant not provided [RCV000908648] Chr11:102842794 [GRCh38]
Chr11:102713525 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.858G>T (p.Thr286=) single nucleotide variant not provided [RCV000962223] Chr11:102840185 [GRCh38]
Chr11:102710916 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.480G>T (p.Met160Ile) single nucleotide variant not provided [RCV000930687] Chr11:102842450 [GRCh38]
Chr11:102713181 [GRCh37]
Chr11:11q22.2
likely benign
NM_002422.5(MMP3):c.478A>T (p.Met160Leu) single nucleotide variant not provided [RCV000971018] Chr11:102842452 [GRCh38]
Chr11:102713183 [GRCh37]
Chr11:11q22.2
likely benign
NM_002422.5(MMP3):c.711C>T (p.Tyr237=) single nucleotide variant MMP3-related disorder [RCV003903108]|not provided [RCV000934455] Chr11:102840508 [GRCh38]
Chr11:102711239 [GRCh37]
Chr11:11q22.2
likely benign
NM_002422.5(MMP3):c.106-197dup duplication not provided [RCV001637170] Chr11:102843103..102843104 [GRCh38]
Chr11:102713834..102713835 [GRCh37]
Chr11:11q22.2
benign
GRCh37/hg19 11q22.1-22.3(chr11:99059204-103281943)x3 copy number gain not provided [RCV002472738] Chr11:99059204..103281943 [GRCh37]
Chr11:11q22.1-22.3
uncertain significance
NM_002422.5(MMP3):c.499+28CAAAA[2] microsatellite not provided [RCV001688107] Chr11:102842384..102842393 [GRCh38]
Chr11:102713115..102713124 [GRCh37]
Chr11:11q22.2
benign
NC_000011.10:g.102843985C>G single nucleotide variant not provided [RCV001598232] Chr11:102843985 [GRCh38]
Chr11:102714716 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.936-109C>T single nucleotide variant not provided [RCV001596308] Chr11:102839352 [GRCh38]
Chr11:102710083 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.1070-81A>T single nucleotide variant not provided [RCV001685184] Chr11:102838791 [GRCh38]
Chr11:102709522 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.1333+115T>C single nucleotide variant not provided [RCV001708603] Chr11:102837183 [GRCh38]
Chr11:102837183..102837184 [GRCh38]
Chr11:102707914 [GRCh37]
Chr11:102707914..102707915 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.935+132A>T single nucleotide variant not provided [RCV001710130] Chr11:102839976 [GRCh38]
Chr11:102710707 [GRCh37]
Chr11:11q22.2
benign
NC_000011.10:g.102847936G>C single nucleotide variant not provided [RCV001358154] Chr11:102847936 [GRCh38]
Chr11:102718667 [GRCh37]
Chr11:11q22.2
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
NC_000011.9:g.(?_94153285)_(111965700_?)del deletion Ataxia-telangiectasia syndrome [RCV001389105] Chr11:94153285..111965700 [GRCh37]
Chr11:11q21-23.1
pathogenic
NM_002422.5(MMP3):c.500-36G>A single nucleotide variant not provided [RCV001655275] Chr11:102842315 [GRCh38]
Chr11:102713046 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.626-257G>C single nucleotide variant not provided [RCV001651687] Chr11:102840850 [GRCh38]
Chr11:102711581 [GRCh37]
Chr11:11q22.2
benign
NM_002422.5(MMP3):c.1070-22_1070-21del microsatellite not provided [RCV001654375] Chr11:102838731..102838732 [GRCh38]
Chr11:102709462..102709463 [GRCh37]
Chr11:11q22.2
benign
GRCh37/hg19 11q14.1-23.3(chr11:85422071-118022671)x1 copy number loss not provided [RCV001832892] Chr11:85422071..118022671 [GRCh37]
Chr11:11q14.1-23.3
uncertain significance
NC_000011.9:g.(?_101323686)_(103349981_?)del deletion Jeune thoracic dystrophy [RCV001942288]|not provided [RCV001942287] Chr11:101323686..103349981 [GRCh37]
Chr11:11q22.1-22.3
pathogenic|no classifications from unflagged records
NC_000011.9:g.(?_101374735)_(103349981_?)dup duplication not provided [RCV003122918] Chr11:101374735..103349981 [GRCh37]
Chr11:11q22.1-22.3
uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25
pathogenic
NM_002422.5(MMP3):c.527G>A (p.Gly176Glu) single nucleotide variant not specified [RCV004309000] Chr11:102842252 [GRCh38]
Chr11:102712983 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.989C>A (p.Ser330Tyr) single nucleotide variant not specified [RCV004316115] Chr11:102839190 [GRCh38]
Chr11:102709921 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.244G>A (p.Asp82Asn) single nucleotide variant not specified [RCV004240327] Chr11:102842778 [GRCh38]
Chr11:102713509 [GRCh37]
Chr11:11q22.2
uncertain significance
GRCh37/hg19 11q22.1-22.3(chr11:98770072-104602846)x1 copy number loss not provided [RCV002472602] Chr11:98770072..104602846 [GRCh37]
Chr11:11q22.1-22.3
likely pathogenic
GRCh37/hg19 11q22.1-22.3(chr11:101371503-109306519)x1 copy number loss not provided [RCV002472494] Chr11:101371503..109306519 [GRCh37]
Chr11:11q22.1-22.3
pathogenic
GRCh37/hg19 11q14.1-22.3(chr11:81478509-104667040)x1 copy number loss not provided [RCV002475722] Chr11:81478509..104667040 [GRCh37]
Chr11:11q14.1-22.3
pathogenic
NM_002422.5(MMP3):c.211C>G (p.Leu71Val) single nucleotide variant not specified [RCV004139287] Chr11:102842811 [GRCh38]
Chr11:102713542 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.476T>C (p.Ile159Thr) single nucleotide variant not specified [RCV004182361] Chr11:102842454 [GRCh38]
Chr11:102713185 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.1126A>T (p.Ile376Phe) single nucleotide variant not specified [RCV004154406] Chr11:102838654 [GRCh38]
Chr11:102709385 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.788A>G (p.Tyr263Cys) single nucleotide variant not specified [RCV004213340] Chr11:102840431 [GRCh38]
Chr11:102711162 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.755C>A (p.Ser252Tyr) single nucleotide variant not specified [RCV004138360] Chr11:102840464 [GRCh38]
Chr11:102711195 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.526G>A (p.Gly176Arg) single nucleotide variant not specified [RCV004124707] Chr11:102842253 [GRCh38]
Chr11:102712984 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.1169C>T (p.Ala390Val) single nucleotide variant not specified [RCV004229331] Chr11:102838611 [GRCh38]
Chr11:102709342 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.1319T>C (p.Val440Ala) single nucleotide variant not specified [RCV004140893] Chr11:102837312 [GRCh38]
Chr11:102708043 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.830C>T (p.Thr277Met) single nucleotide variant not specified [RCV004085816] Chr11:102840213 [GRCh38]
Chr11:102710944 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.23T>C (p.Leu8Pro) single nucleotide variant not specified [RCV004099423] Chr11:102843524 [GRCh38]
Chr11:102714255 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.289G>A (p.Val97Ile) single nucleotide variant not specified [RCV004181878] Chr11:102842733 [GRCh38]
Chr11:102713464 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.1385C>G (p.Ala462Gly) single nucleotide variant not specified [RCV004136585] Chr11:102836175 [GRCh38]
Chr11:102706906 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.1300G>T (p.Asp434Tyr) single nucleotide variant not specified [RCV004123590] Chr11:102837331 [GRCh38]
Chr11:102708062 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.290T>C (p.Val97Ala) single nucleotide variant not specified [RCV004163091] Chr11:102842732 [GRCh38]
Chr11:102713463 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.963G>T (p.Lys321Asn) single nucleotide variant not specified [RCV004222627] Chr11:102839216 [GRCh38]
Chr11:102709947 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.809C>T (p.Pro270Leu) single nucleotide variant not specified [RCV004253384] Chr11:102840234 [GRCh38]
Chr11:102710965 [GRCh37]
Chr11:11q22.2
uncertain significance
Single allele duplication not provided [RCV003448710] Chr11:102134973..134945611 [GRCh37]
Chr11:11q22.2-25
pathogenic
GRCh37/hg19 11q21-22.3(chr11:97147292-102979905)x3 copy number gain not provided [RCV003484850] Chr11:97147292..102979905 [GRCh37]
Chr11:11q21-22.3
uncertain significance
NM_002422.5(MMP3):c.626-3T>C single nucleotide variant MMP3-related disorder [RCV003981801] Chr11:102840596 [GRCh38]
Chr11:102711327 [GRCh37]
Chr11:11q22.2
likely benign
NM_002422.5(MMP3):c.-7A>C single nucleotide variant MMP3-related disorder [RCV003934497] Chr11:102843553 [GRCh38]
Chr11:102714284 [GRCh37]
Chr11:11q22.2
likely benign
NM_002422.5(MMP3):c.191T>A (p.Ile64Asn) single nucleotide variant not specified [RCV004464842] Chr11:102842831 [GRCh38]
Chr11:102713562 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.1274A>G (p.Gln425Arg) single nucleotide variant not specified [RCV004464708] Chr11:102837357 [GRCh38]
Chr11:102708088 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.557C>A (p.Ala186Asp) single nucleotide variant not specified [RCV004457601] Chr11:102842222 [GRCh38]
Chr11:102712953 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.1165G>A (p.Asp389Asn) single nucleotide variant not specified [RCV004464637] Chr11:102838615 [GRCh38]
Chr11:102709346 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.148C>A (p.Gln50Lys) single nucleotide variant not specified [RCV004464827] Chr11:102842874 [GRCh38]
Chr11:102713605 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.262C>T (p.Arg88Cys) single nucleotide variant not specified [RCV004457433] Chr11:102842760 [GRCh38]
Chr11:102713491 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.626G>C (p.Gly209Ala) single nucleotide variant not specified [RCV004457632] Chr11:102840593 [GRCh38]
Chr11:102711324 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.815C>A (p.Thr272Asn) single nucleotide variant not specified [RCV004457743] Chr11:102840228 [GRCh38]
Chr11:102710959 [GRCh37]
Chr11:11q22.2
uncertain significance
NM_002422.5(MMP3):c.1025C>A (p.Ala342Asp) single nucleotide variant not specified [RCV004629012] Chr11:102839154 [GRCh38]
Chr11:102709885 [GRCh37]
Chr11:11q22.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:321
Count of miRNA genes:286
Interacting mature miRNAs:300
Transcripts:ENST00000299855, ENST00000434103, ENST00000524478
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407061921GWAS710897_Hblood protein measurement QTL GWAS710897 (human)2e-33blood protein measurementblood protein measurement (CMO:0000028)11102837183102837184Human
407169510GWAS818486_HFEV/FVC ratio, response to bronchodilator QTL GWAS818486 (human)0.0000007FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102839976102839977Human
407200614GWAS849590_Hblood protein measurement QTL GWAS849590 (human)2e-54blood protein measurementblood protein measurement (CMO:0000028)11102838694102838695Human
407229600GWAS878576_Hblood protein measurement QTL GWAS878576 (human)3e-2093blood protein measurementblood protein measurement (CMO:0000028)11102842889102842890Human
407161186GWAS810162_HFEV/FVC ratio, response to bronchodilator QTL GWAS810162 (human)0.0000002FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102839976102839977Human
407171820GWAS820796_HFEV/FVC ratio, response to bronchodilator QTL GWAS820796 (human)0.0000006FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102837776102837777Human
407170796GWAS819772_HFEV/FVC ratio, response to bronchodilator QTL GWAS819772 (human)0.000001FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102839740102839741Human
407165768GWAS814744_HFEV/FVC ratio, response to bronchodilator QTL GWAS814744 (human)0.0000007FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102840850102840851Human
407095095GWAS744071_Hperipheral arterial disease QTL GWAS744071 (human)4e-09peripheral arterial disease11102839740102839741Human
407107991GWAS756967_HFEV/FVC ratio, response to bronchodilator QTL GWAS756967 (human)0.0000002FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102840850102840851Human
407161746GWAS810722_HFEV/FVC ratio, response to bronchodilator QTL GWAS810722 (human)0.0000003FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102838791102838792Human
407161747GWAS810723_HFEV/FVC ratio, response to bronchodilator QTL GWAS810723 (human)0.0000003FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102837776102837777Human
407268063GWAS917039_Hperipheral arterial disease QTL GWAS917039 (human)0.0000003peripheral arterial disease11102839740102839741Human
407169503GWAS818479_HFEV/FVC ratio, response to bronchodilator QTL GWAS818479 (human)0.0000006FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102838791102838792Human
1559115SCL20_HSerum cholesterol level QTL 20 (human)3.220.001213Lipid levelLDL cholesterol11100442501126442501Human
407161400GWAS810376_HFEV/FVC ratio, response to bronchodilator QTL GWAS810376 (human)0.0000002FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)11102839740102839741Human
406995645GWAS644621_Hlevel of stromelysin-1 in blood serum QTL GWAS644621 (human)3e-16level of stromelysin-1 in blood serum11102842889102842890Human

Markers in Region
D14S1188  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,706,653 - 102,706,848UniSTSGRCh37
Build 3611102,211,863 - 102,212,058RGDNCBI36
Celera1199,868,260 - 99,868,455RGD
Cytogenetic Map11q22.2UniSTS
Cytogenetic Map11q22.3UniSTS
HuRef1198,634,575 - 98,634,770UniSTS
Stanford-G3 RH Map114507.0UniSTS
NCBI RH Map11891.8UniSTS
GeneMap99-G3 RH Map114507.0UniSTS
PMC85083P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,706,594 - 102,706,896UniSTSGRCh37
Build 3611102,211,804 - 102,212,106RGDNCBI36
Celera1199,868,201 - 99,868,503RGD
Cytogenetic Map11q22.2UniSTS
Cytogenetic Map11q22.3UniSTS
HuRef1198,634,516 - 98,634,818UniSTS
STS-X05232  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,706,659 - 102,706,930UniSTSGRCh37
Build 3611102,211,869 - 102,212,140RGDNCBI36
Celera1199,868,266 - 99,868,537RGD
Cytogenetic Map11q22.2UniSTS
Cytogenetic Map11q22.3UniSTS
HuRef1198,634,581 - 98,634,852UniSTS
GeneMap99-GB4 RH Map11352.42UniSTS
MMP3_2663  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,706,338 - 102,706,986UniSTSGRCh37
Build 3611102,211,548 - 102,212,196RGDNCBI36
Celera1199,867,945 - 99,868,593RGD
HuRef1198,634,260 - 98,634,908UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1114 2336 2751 1881 3855 1254 1782 2 397 950 234 2143 5391 4956 40 2778 1 629 1479 1292 172 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF405705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI628953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA982602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ399598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT355692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT355693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S52369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000299855   ⟹   ENSP00000299855
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,835,801 - 102,843,609 (-)Ensembl
Ensembl Acc Id: ENST00000434103   ⟹   ENSP00000398346
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,836,497 - 102,838,710 (-)Ensembl
Ensembl Acc Id: ENST00000524478   ⟹   ENSP00000435255
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,842,252 - 102,843,607 (-)Ensembl
RefSeq Acc Id: NM_002422   ⟹   NP_002413
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,835,801 - 102,843,609 (-)NCBI
GRCh3711102,706,528 - 102,714,342 (-)ENTREZGENE
Build 3611102,211,738 - 102,219,552 (-)NCBI Archive
HuRef1198,634,450 - 98,642,264 (-)ENTREZGENE
CHM1_111102,589,497 - 102,597,395 (-)NCBI
T2T-CHM13v2.011102,839,570 - 102,847,378 (-)NCBI
Sequence:
RefSeq Acc Id: NP_002413   ⟸   NM_002422
- Peptide Label: preproprotein
- UniProtKB: Q3B7S0 (UniProtKB/Swiss-Prot),   B2R8B8 (UniProtKB/Swiss-Prot),   Q6GRF8 (UniProtKB/Swiss-Prot),   P08254 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000299855   ⟸   ENST00000299855
Ensembl Acc Id: ENSP00000435255   ⟸   ENST00000524478
Ensembl Acc Id: ENSP00000398346   ⟸   ENST00000434103
Protein Domains
Peptidoglycan binding-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08254-F1-model_v2 AlphaFold P08254 1-477 view protein structure

Promoters
RGD ID:6849896
Promoter ID:EP30051
Type:single initiation site
Name:HS_MMP3
Description:Stromelysin, MMP3 or STMY1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 173; Mammalian transin/stromelysin.
Experiment Methods:Primer extension with homologous sequence ladder; Nuclease protection; experiments performed with closely related; gene
Regulation:fibroblasts; (induced by or strongly expressed in) IL (repressed by or weakly expressed in) 1b', (repressed by or weakly expressed in) glucocorticoid
Position:
Human AssemblyChrPosition (strand)Source
Build 3611102,219,550 - 102,219,610EPD
RGD ID:7221927
Promoter ID:EPDNEW_H16709
Type:initiation region
Name:MMP3_1
Description:matrix metallopeptidase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,843,607 - 102,843,667EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7173 AgrOrtholog
COSMIC MMP3 COSMIC
Ensembl Genes ENSG00000149968 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000299855 ENTREZGENE
  ENST00000299855.10 UniProtKB/Swiss-Prot
  ENST00000434103.1 UniProtKB/TrEMBL
  ENST00000524478.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.101.10 UniProtKB/TrEMBL
  2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot
GTEx ENSG00000149968 GTEx
HGNC ID HGNC:7173 ENTREZGENE
Human Proteome Map MMP3 Human Proteome Map
InterPro Heme_transport/Cell_adhesion UniProtKB/TrEMBL
  Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBDSf UniProtKB/TrEMBL
KEGG Report hsa:4314 UniProtKB/Swiss-Prot
NCBI Gene 4314 ENTREZGENE
OMIM 185250 OMIM
PANTHER EG:8D8.2 PROTEIN-RELATED UniProtKB/TrEMBL
  HEMOPEXIN DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
  STROMELYSIN-1 UniProtKB/Swiss-Prot
Pfam Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MMP3 RGD, PharmGKB
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot
  HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U3J4I2_HUMAN UniProtKB/TrEMBL
  A5GZ70_HUMAN UniProtKB/TrEMBL
  B2R8B8 ENTREZGENE
  E9PKX2_HUMAN UniProtKB/TrEMBL
  H7C139_HUMAN UniProtKB/TrEMBL
  MMP3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q3B7S0 ENTREZGENE
  Q6GRF8 ENTREZGENE
UniProt Secondary B2R8B8 UniProtKB/Swiss-Prot
  Q3B7S0 UniProtKB/Swiss-Prot
  Q6GRF8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-03 MMP3  matrix metallopeptidase 3  MMP3  matrix metallopeptidase 3 (stromelysin 1, progelatinase)  Symbol and/or name change 5135510 APPROVED