Mmp3 (matrix metallopeptidase 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mmp3 (matrix metallopeptidase 3) Mus musculus
Analyze
Symbol: Mmp3
Name: matrix metallopeptidase 3
RGD ID: 733756
MGI Page MGI
Description: Predicted to have metalloendopeptidase activity. Involved in several processes, including cellular response to amino acid stimulus; negative regulation of protein kinase B signaling; and positive regulation of oxidative stress-induced cell death. Localizes to cytosol and mitochondrion. Is expressed in several structures, including axial skeleton thoracic region; genitourinary system; jaw; lung; and oral epithelium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EMS-2; matrix metalloproteinase 3; matrix metalloproteinase-3; MMP-3; progelatinase; S; SL; SL-1; SLN-1; SLN1; St; Stmy; Stmy1; STR; STR-1; Str1; stromelysin 1; stromelysin-1; transin-1
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,445,822 - 7,455,975 (+)NCBIGRCm39mm39
GRCm39 Ensembl97,445,822 - 7,455,975 (+)Ensembl
GRCm3897,445,822 - 7,455,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,445,822 - 7,455,975 (+)NCBIGRCm37mm9NCBIm37
MGSCv3697,445,822 - 7,455,975 (+)NCBImm8
Celera94,846,374 - 4,856,527 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Otitis Media  (IEP)
allergic contact dermatitis  (IMP,ISO)
Alport syndrome  (IEP)
arteriosclerosis  (ISO)
ataxia telangiectasia  (ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Carotid Artery Injuries  (ISO)
carotid stenosis  (ISO)
cartilage disease  (ISO)
cataract  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Allograft Nephropathy  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
conjunctivochalasis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
crescentic glomerulonephritis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dry eye syndrome  (IEP)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Arthritis  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
gastric ulcer  (ISO)
glomerulonephritis  (ISO)
Gouty Arthritis  (ISO)
Hyperalgesia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic pulmonary fibrosis  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
intellectual disability  (ISO)
Knee Osteoarthritis  (ISO)
lung cancer  (ISO)
lymphangioleiomyomatosis  (IEP)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
osteoarthritis  (ISO)
Parkinsonism  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
polymyalgia rheumatica  (ISO)
primary biliary cholangitis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (IMP)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Sjogren's syndrome  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
Takayasu's arteritis  (ISO)
Tendon Injuries  (ISO)
thrombosis  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
Venous Thrombosis  (ISO)
von Hippel-Lindau disease  (ISO)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-citrinin  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-dichloroaniline  (ISO)
3-hydroxypicolinic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-aminolevulinic acid  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-iodotubercidin  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (EXP)
avobenzone  (ISO)
azathioprine  (ISO)
azithromycin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
BQ 123  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chloramphenicol  (ISO)
choline  (EXP)
chondroitin sulfate  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
cobalt atom  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dieckol  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP,ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
enalapril  (EXP)
endosulfan  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fluoranthene  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fucoidan  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
geraniol  (ISO)
glycitein  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (EXP)
hyaluronic acid  (EXP)
hydroquinone  (ISO)
ibuprofen  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
isoprenaline  (EXP,ISO)
L-methionine  (EXP)
L-proline betaine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
megestrol acetate  (ISO)
melittin  (ISO)
Methanandamide  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
mibolerone  (ISO)
mifepristone  (EXP,ISO)
minocycline  (EXP)
moxifloxacin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
NSC 23766  (EXP)
ofloxacin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD 168393  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
prinomastat  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rofecoxib  (ISO)
SB 203580  (ISO)
serpentine asbestos  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
streptozocin  (EXP,ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP)
tofacitinib  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Ahmed AK, etal., Exp Clin Transplant. 2012 Aug;10(4):332-43.
2. Ahmed AS, etal., J Appl Physiol (1985). 2012 Dec 1;113(11):1784-91. doi: 10.1152/japplphysiol.00767.2012. Epub 2012 Oct 4.
3. Bousserouel S, etal., Oncol Rep. 2010 Feb;23(2):511-7.
4. Boyle DL, etal., J Pharmacol Exp Ther. 2014 Feb;348(2):271-80. doi: 10.1124/jpet.113.205955. Epub 2013 Nov 15.
5. Bradbury PA, etal., Carcinogenesis. 2009 May;30(5):793-8. doi: 10.1093/carcin/bgp065. Epub 2009 Mar 25.
6. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
7. Chen WS, etal., J Rheumatol. 2009 May;36(5):989-96. doi: 10.3899/jrheum.080733. Epub 2009 Mar 30.
8. Chou LW, etal., Arthritis Res Ther. 2011 Jun 16;13(3):R90. doi: 10.1186/ar3365.
9. Christianson CA, etal., Neuroscience. 2012 Jan 3;200:199-210. doi: 10.1016/j.neuroscience.2011.10.019. Epub 2011 Oct 20.
10. Cozzolino M, etal., Nephrol Dial Transplant. 2009 Jul;24(7):2207-12. doi: 10.1093/ndt/gfp061. Epub 2009 Feb 16.
11. Gantus MA, etal., Brain Res. 2006 Nov 29;1122(1):36-46. Epub 2006 Oct 6.
12. Gerger A, etal., Breast Cancer Res Treat. 2007 Aug;104(2):159-64. Epub 2006 Oct 21.
13. Ghilardi G, etal., Stroke. 2002 Oct;33(10):2408-12.
14. Goncharova EA, etal., Sci Transl Med. 2012 Oct 3;4(154):154ra134. doi: 10.1126/scitranslmed.3003840.
15. Hartmann B, etal., Inflamm Res. 2006 Aug;55(8):322-34.
16. Hirata H, etal., Carcinogenesis. 2004 Dec;25(12):2379-84. Epub 2004 Aug 19.
17. Horne BD, etal., Am Heart J. 2007 Oct;154(4):751-8.
18. Houseman M, etal., Arthritis Res Ther. 2012 Feb 7;14(1):R30. doi: 10.1186/ar3734.
19. Ishihara T, etal., Circ J. 2013;77(2):477-83. Epub 2012 Oct 26.
20. Ishrat T, etal., Neurochem Res. 2013 Dec;38(12):2668-77. doi: 10.1007/s11064-013-1185-y. Epub 2013 Nov 6.
21. Jalal FY, etal., Stroke. 2012 Apr;43(4):1115-22. doi: 10.1161/STROKEAHA.111.643080. Epub 2012 Feb 23.
22. Jeong WI, etal., Anticancer Res. 2006 Sep-Oct;26(5A):3517-26.
23. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
24. Kawazu T, etal., Med Mol Morphol. 2012 Dec;45(4):190-8. doi: 10.1007/s00795-011-0559-y. Epub 2012 Dec 7.
25. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
26. Kim KR, etal., J Pharmacol Sci. 2010;114(1):69-78. Epub 2010 Aug 10.
27. Kremer R, etal., Br J Cancer. 2010 Mar 30;102(7):1180-4. Epub 2010 Mar 9.
28. Krippl P, etal., Clin Cancer Res. 2004 May 15;10(10):3518-20.
29. Leong DJ, etal., Matrix Biol. 2010 Feb 12.
30. Liang QQ, etal., J Pharmacol Sci. 2010;113(1):23-31.
31. Liang QQ, etal., Spine (Phila Pa 1976). 2011 Jan 1;36(1):E14-9. doi: 10.1097/BRS.0b013e3181d2dec2.
32. Lievre A, etal., BMC Cancer. 2006 Nov 24;6:270.
33. Lin CC, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1805-14. doi: 10.2215/CJN.01500210. Epub 2010 Jul 8.
34. Lombardi F, etal., J Cardiovasc Med (Hagerstown). 2011 Jan;12(1):37-42. doi: 10.2459/JCM.0b013e3283403366.
35. Manicourt DH, etal., Arthritis Rheum. 1995 Aug;38(8):1031-9.
36. Manicourt DH, etal., Drugs R D. 2005;6(5):261-71.
37. Mendes O, etal., Clin Exp Metastasis. 2005;22(3):237-46.
38. MGD data from the GO Consortium
39. MGD IEA
40. Naito T, etal., J Am Soc Nephrol. 2000 Dec;11(12):2243-55.
41. Ni GX, etal., Arthritis Res Ther. 2011;13(6):R192. doi: 10.1186/ar3521. Epub 2011 Nov 24.
42. Nishijima C, etal., Clin Exp Immunol. 2004 Nov;138(2):357-63.
43. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
44. OMIM Disease Annotation Pipeline
45. Park JA, etal., J Korean Med Sci. 2005 Aug;20(4):607-11.
46. Pipeline to import KEGG annotations from KEGG into RGD
47. Pollanen PJ, etal., Atherosclerosis. 2005 May;180(1):73-8. Epub 2004 Dec 18.
48. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
49. RGD automated import pipeline
50. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. RGD automated import pipeline for gene-chemical interactions
52. Ribbens C, etal., Ann Rheum Dis. 2002 Feb;61(2):161-6.
53. Ricketts C, etal., PLoS One. 2009 Jun 24;4(6):e6037. doi: 10.1371/journal.pone.0006037.
54. Sadeghian M, etal., J Neuroimmunol. 2012 May 15;246(1-2):69-77. doi: 10.1016/j.jneuroim.2012.03.010. Epub 2012 Apr 11.
55. Saghizadeh M, etal., Am J Pathol. 2001 Feb;158(2):723-34.
56. Sanders JS, etal., Nephrol Dial Transplant. 2004 Jun;19(6):1412-9. Epub 2004 Mar 19.
57. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
58. Slavkovsky R, etal., Wound Repair Regen. 2011 Jul-Aug;19(4):515-25. doi: 10.1111/j.1524-475X.2011.00703.x. Epub 2011 Jun 7.
59. Sole S, etal., J Neuropathol Exp Neurol. 2004 Apr;63(4):338-49.
60. Sternlicht MD, etal., Cell. 1999 Jul 23;98(2):137-46.
61. Suzuki D, etal., Kidney Int. 1997 Jul;52(1):111-9.
62. Tan Q, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Oct;31(5):737-41.
63. Tas F, etal., Med Oncol. 2005;22(1):39-44.
64. Tchetverikov I, etal., Ann Rheum Dis. 2004 Jul;63(7):881-3.
65. Toubi E, etal., Clin Exp Rheumatol. 2002 Mar-Apr;20(2):221-4.
66. Vaidya H, etal., Exp Clin Cardiol. 2012 Spring;17(1):12-6.
67. Wang H, etal., Zhonghua Er Ke Za Zhi. 2006 Aug;44(8):587-91.
68. Wang M, etal., Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6885-9.
69. Wang YX, etal., J Surg Res. 2014 Jan;186(1):234-9. doi: 10.1016/j.jss.2013.07.047. Epub 2013 Aug 20.
70. Ward SK, etal., Invest Ophthalmol Vis Sci. 2010 Apr;51(4):1994-2002. doi: 10.1167/iovs.09-4130. Epub 2009 Dec 17.
71. Webb KE, etal., Arterioscler Thromb Vasc Biol. 1997 Sep;17(9):1837-44.
72. Xu CY, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Aug;26(3):370-3.
73. Yamashita CM, etal., Am J Pathol. 2011 Oct;179(4):1733-45. doi: 10.1016/j.ajpath.2011.06.041. Epub 2011 Aug 24.
74. Yang DC, etal., Cardiology. 2010;116(2):133-41. doi: 10.1159/000317245. Epub 2010 Jul 1.
75. Zeisberg M, etal., PLoS Med. 2006 Apr;3(4):e100. Epub 2006 Mar 7.
76. Zhang X, etal., PLoS One. 2012;7(5):e36822. doi: 10.1371/journal.pone.0036822. Epub 2012 May 8.
77. Zhang YB, etal., Chin J Traumatol. 2010 Jun 1;13(3):188-92.
78. Zhong LJ, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2009 Aug;44(8):464-8.
79. Zhou X, etal., Thromb Haemost. 2004 Oct;92(4):867-73.
Additional References at PubMed
PMID:1398148   PMID:2744464   PMID:7669731   PMID:7760812   PMID:7960227   PMID:8144618   PMID:8175886   PMID:8573787   PMID:8672141   PMID:8674412   PMID:8872958   PMID:9006971  
PMID:9030563   PMID:9108368   PMID:9291579   PMID:9348221   PMID:9398846   PMID:9433876   PMID:9490689   PMID:9708806   PMID:10048576   PMID:10349636   PMID:10419448   PMID:10433819  
PMID:10450741   PMID:10502816   PMID:10531025   PMID:10553093   PMID:10642592   PMID:10657574   PMID:10713697   PMID:10731089   PMID:10949577   PMID:10985432   PMID:11042159   PMID:11076861  
PMID:11113146   PMID:11217851   PMID:11350822   PMID:11359935   PMID:11566859   PMID:11689884   PMID:11830584   PMID:11865039   PMID:11869290   PMID:12060661   PMID:12097550   PMID:12477932  
PMID:12669125   PMID:12815621   PMID:12975354   PMID:14673996   PMID:14720510   PMID:14726605   PMID:15044844   PMID:15063736   PMID:15466188   PMID:15470062   PMID:15536133   PMID:15550552  
PMID:15618213   PMID:15734845   PMID:15841177   PMID:15893322   PMID:15894268   PMID:15921521   PMID:16141072   PMID:16141073   PMID:16221765   PMID:16624562   PMID:16678100   PMID:17021275  
PMID:17116747   PMID:17235437   PMID:17307908   PMID:17376075   PMID:17540368   PMID:17596135   PMID:18036345   PMID:18050203   PMID:18172013   PMID:18267097   PMID:18337830   PMID:18397366  
PMID:18639653   PMID:18641052   PMID:18802027   PMID:18818437   PMID:18923335   PMID:19058297   PMID:19111539   PMID:19138802   PMID:19139395   PMID:19608750   PMID:19799610   PMID:19815046  
PMID:19844242   PMID:19853894   PMID:19913533   PMID:20165883   PMID:20360864   PMID:20368330   PMID:20472558   PMID:20495570   PMID:20513444   PMID:20534975   PMID:20548288   PMID:20609072  
PMID:20864640   PMID:20930145   PMID:20969476   PMID:21719762   PMID:21750040   PMID:21800363   PMID:21858843   PMID:21873635   PMID:21928379   PMID:22014525   PMID:22108898   PMID:22171010  
PMID:22201681   PMID:22345078   PMID:22398316   PMID:22484054   PMID:22682244   PMID:22786680   PMID:22862420   PMID:22927007   PMID:22951731   PMID:22959068   PMID:23145787   PMID:23281061  
PMID:23404611   PMID:23421805   PMID:23554135   PMID:23564449   PMID:23592797   PMID:23658188   PMID:23853428   PMID:23871604   PMID:23934123   PMID:24006456   PMID:24416274   PMID:24957860  
PMID:25194508   PMID:25285627   PMID:25325922   PMID:25344368   PMID:25536219   PMID:25652596   PMID:25662160   PMID:25664857   PMID:25693634   PMID:25742789   PMID:25743255   PMID:25848906  
PMID:25891852   PMID:25940877   PMID:26008967   PMID:26079709   PMID:26135838   PMID:26163370   PMID:26203177   PMID:26358260   PMID:26378628   PMID:26445891   PMID:27033979   PMID:27096327  
PMID:27398409   PMID:27461525   PMID:27633994   PMID:27676418   PMID:27809288   PMID:27879248   PMID:28069922   PMID:28158775   PMID:29247173   PMID:29276151   PMID:29377313   PMID:29761931  
PMID:30054581   PMID:30269950   PMID:30295685   PMID:30479344   PMID:31470007   PMID:31652545   PMID:32109382   PMID:32959071   PMID:32987131  


Genomics

Comparative Map Data
Mmp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,445,822 - 7,455,975 (+)NCBIGRCm39mm39
GRCm39 Ensembl97,445,822 - 7,455,975 (+)Ensembl
GRCm3897,445,822 - 7,455,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,445,822 - 7,455,975 (+)NCBIGRCm37mm9NCBIm37
MGSCv3697,445,822 - 7,455,975 (+)NCBImm8
Celera94,846,374 - 4,856,527 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
MMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11102,835,801 - 102,843,609 (-)EnsemblGRCh38hg38GRCh38
GRCh3811102,835,801 - 102,843,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711102,706,532 - 102,714,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,211,738 - 102,219,552 (-)NCBINCBI36hg18NCBI36
Build 3411102,211,742 - 102,219,550NCBI
Celera1199,868,135 - 99,875,949 (-)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,634,450 - 98,642,264 (-)NCBIHuRef
CHM1_111102,589,497 - 102,597,395 (-)NCBICHM1_1
Mmp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.284,640,397 - 4,653,963 (+)NCBI
Rnor_6.0 Ensembl85,676,665 - 5,698,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.085,676,608 - 5,698,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.085,680,382 - 5,701,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,315,601 - 4,329,146 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,315,600 - 4,329,146 (+)NCBI
Celera86,200,234 - 6,213,783 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111101,267,561 - 101,275,432 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,267,566 - 101,275,354 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01197,776,729 - 97,784,549 (-)NCBIMhudiblu_PPA_v0panPan3
MMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,949,631 - 28,957,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,949,631 - 28,958,222 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,898,123 - 28,906,399 (+)NCBI
ROS_Cfam_1.0529,000,797 - 29,009,079 (+)NCBI
UMICH_Zoey_3.1529,035,847 - 29,044,131 (+)NCBI
UNSW_CanFamBas_1.0528,915,267 - 28,923,546 (+)NCBI
UU_Cfam_GSD_1.0529,090,249 - 29,098,533 (+)NCBI
MMP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,411,065 - 33,454,000 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,446,969 - 33,453,995 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,394,116 - 37,401,146 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,216,156 - 94,224,437 (-)NCBI
ChlSab1.1 Ensembl194,216,173 - 94,224,264 (-)Ensembl
Vero_WHO_p1.0NW_02366604331,654,560 - 31,662,871 (+)NCBI
Mmp3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462487839,282 - 47,386 (+)NCBI

Position Markers
BB224515  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3897,455,691 - 7,455,786UniSTSGRCm38
GRCm381519,988,941 - 19,989,036UniSTSGRCm38
MGSCv3797,455,691 - 7,455,786UniSTSGRCm37
MGSCv371519,918,696 - 19,918,791UniSTSGRCm37
Celera94,856,243 - 4,856,338UniSTS
Celera1520,801,597 - 20,801,692UniSTS
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
Whitehead/MRC_RH991.01UniSTS
Mmp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3797,449,798 - 7,450,123UniSTSGRCm37
MGSCv37X157,151,832 - 157,152,033UniSTSGRCm37
Celera94,850,350 - 4,850,675UniSTS
CeleraX143,954,782 - 143,954,983UniSTS
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
Mmp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X160,713,900 - 160,714,101UniSTSGRCm38
MGSCv37X157,151,832 - 157,152,033UniSTSGRCm37
CeleraX143,954,782 - 143,954,983UniSTS
Cytogenetic MapXF4UniSTS
Cytogenetic Map9A1UniSTS
Mmp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3897,449,798 - 7,450,123UniSTSGRCm38
MGSCv3797,449,798 - 7,450,123UniSTSGRCm37
Celera94,850,350 - 4,850,675UniSTS
Cytogenetic Map9A1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902908Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130430544Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:84
Interacting mature miRNAs:97
Transcripts:ENSMUST00000034497
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034497   ⟹   ENSMUSP00000034497
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl97,445,822 - 7,455,975 (+)Ensembl
RefSeq Acc Id: NM_010809   ⟹   NP_034939
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,445,822 - 7,455,975 (+)NCBI
GRCm3897,445,822 - 7,455,975 (+)ENTREZGENE
MGSCv3797,445,822 - 7,455,975 (+)RGD
Celera94,846,374 - 4,856,527 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034939   ⟸   NM_010809
- Peptide Label: preproprotein
- UniProtKB: P28862 (UniProtKB/Swiss-Prot),   Q3UFJ0 (UniProtKB/TrEMBL),   Q922W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034497   ⟸   ENSMUST00000034497
Protein Domains
ZnMc

Promoters
RGD ID:8668748
Promoter ID:EPDNEW_M12405
Type:multiple initiation site
Name:Mmp3_1
Description:Mus musculus matrix metallopeptidase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3897,445,845 - 7,445,905EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97010 AgrOrtholog
Ensembl Genes ENSMUSG00000043613 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034497 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034497 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.101.10 UniProtKB/Swiss-Prot
  2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBDSf UniProtKB/Swiss-Prot
KEGG Report mmu:17392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97010 ENTREZGENE
NCBI Gene 17392 ENTREZGENE
Pfam Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MMP3 RGD
PhenoGen Mmp3 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MMP3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UFJ0 ENTREZGENE, UniProtKB/TrEMBL
  Q6GXA4_MOUSE UniProtKB/TrEMBL
  Q922W6 ENTREZGENE, UniProtKB/TrEMBL