Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Mmp3 (matrix metallopeptidase 3) Mus musculus
Symbol: Mmp3
Name: matrix metallopeptidase 3
Description: Predicted to have metalloendopeptidase activity. Involved in several processes, including cellular response to amino acid stimulus; negative regulation of protein kinase B signaling; and positive regulation of oxidative stress-induced cell death. Localizes to the cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal failure; esophagus adenocarcinoma; osteoarthritis; and von Hippel-Lindau disease. Is expressed in several structures, including axial skeleton thoracic region; genitourinary system; jaw; lung; and oral epithelium. Orthologous to human MMP3 (matrix metallopeptidase 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EMS-2; matrix metalloproteinase 3; matrix metalloproteinase-3; MMP-3; progelatinase; SL-1; SLN-1; SLN1; Stmy1; STR-1; Str1; stromelysin 1; stromelysin-1; transin-1
Homo sapiens (human) : MMP3 (matrix metallopeptidase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mmp3 (matrix metallopeptidase 3)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : MMP3 (matrix metallopeptidase 3)
Canis lupus familiaris (dog) : MMP3 (matrix metallopeptidase 3 (stromelysin 1, progelatinase))
Sus scrofa (pig) : MMP3 (matrix metallopeptidase 3)
Chlorocebus sabaeus (African green monkey) : MMP3 (matrix metallopeptidase 3)
Heterocephalus glaber (naked mole-rat) : Mmp3 (matrix metallopeptidase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl97,445,822 - 7,455,975 (+)Ensembl
GRCm3897,445,822 - 7,455,975 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3797,445,822 - 7,455,975 (+)NCBIGRCm37mm9NCBIm37
MGSCv3697,445,822 - 7,455,975 (+)NCBImm8
Celera94,846,374 - 4,856,527 (+)NCBICelera
Cytogenetic Map9 A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mmp3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733756
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.