RGD Reference Report - Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease. - Rat Genome Database

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Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease.

Authors: Park, JA  Shin, KS  Kim, YW 
Citation: Park JA, etal., J Korean Med Sci. 2005 Aug;20(4):607-11.
RGD ID: 8693322
Pubmed: PMID:16100452   (View Abstract at PubMed)
PMCID: PMC2782156   (View Article at PubMed Central)
DOI: DOI:10.3346/jkms.2005.20.4.607   (Journal Full-text)

Kawasaki disease (KD) is a major cause of acquired coronary artery diseases in childhood. The serum levels of matrix metalloproteinase (MMP)-3 and MMP-9 in KD have been reported to be significantly higher than other diseases. Several studies have demonstrated that MMP-3 5A/6A polymorphism and MMP-9 C-1562T polymorphism modify each transcriptional activity in allele specific manner. We hypothesized that these polymorphisms may play a role as a risk factor for development of coronary artery lesions (CAL) in KD. Eighty-three patients, diagnosed with KD in Cheju National University Hospital from January 2000 to February 2004, were divided into two groups according to the presence of CAL. Genotyping of MMP-3 and MMP-9 gene polymorphisms were determined by restriction fragment length polymorphism. With regard to MMP-3 gene polymorphism, the KD with CAL group had a higher frequency of 6A/6A genotype than control group (p=0.0127) and the KD without CAL group (p=0.0036). However, no significant differences in the allele and genotype distributions of the MMP-9 polymorphism were observed. These findings suggest that MMP-3 6A/6A genotype may be an independent risk factor for CAL formation in KD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
coronary artery disease  IAGP 8693322associated with Mucocutaneous Lymph Node SyndromeRGD 
coronary artery disease  ISOMMP3 (Homo sapiens)8693322; 8693322associated with Mucocutaneous Lymph Node SyndromeRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp3  (matrix metallopeptidase 3)

Genes (Mus musculus)
Mmp3  (matrix metallopeptidase 3)

Genes (Homo sapiens)
MMP3  (matrix metallopeptidase 3)

Objects referenced in this article
Gene MMP9 matrix metallopeptidase 9 Homo sapiens
Gene Mmp9 matrix metallopeptidase 9 Mus musculus
Gene Mmp9 matrix metallopeptidase 9 Rattus norvegicus

Additional Information