Rbl1 (RB transcriptional corepressor like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rbl1 (RB transcriptional corepressor like 1) Rattus norvegicus
Analyze
Symbol: Rbl1
Name: RB transcriptional corepressor like 1
RGD ID: 1595511
Description: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cellular senescence; and regulation of lipid kinase activity. Predicted to act upstream of or within negative regulation of gene expression and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin. Orthologous to human RBL1 (RB transcriptional corepressor like 1); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC680111; p107; pRb1; retinoblastoma-like 1; retinoblastoma-like 1 (p107); retinoblastoma-like protein 1; similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,226,187 - 166,289,862 (-)NCBIGRCr8
mRatBN7.23145,806,160 - 145,869,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,807,095 - 145,869,330 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,633,152 - 149,694,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,130,942 - 158,195,584 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,871,986 - 155,936,707 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,263,692 - 153,321,351 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,263,692 - 153,321,352 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,398,177 - 158,452,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43147,734,622 - 147,796,630 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3144,513,506 - 144,575,032 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calyculin a  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
D-mannitol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
GW 3965  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
lamivudine  (ISO)
Lasiocarpine  (ISO)
lidocaine  (EXP,ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (ISO)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
riddelliine  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
transcription regulator complex  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGF. Kolupaeva V, etal., PLoS One. 2008;3(10):e3447. doi: 10.1371/journal.pone.0003447. Epub 2008 Oct 17.
3. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7797074   PMID:8245034   PMID:10082561   PMID:12853964   PMID:15701640   PMID:16286473   PMID:16360038   PMID:18818403   PMID:23716589   PMID:23775125   PMID:25100735   PMID:28595801  


Genomics

Comparative Map Data
Rbl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,226,187 - 166,289,862 (-)NCBIGRCr8
mRatBN7.23145,806,160 - 145,869,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,807,095 - 145,869,330 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,633,152 - 149,694,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,130,942 - 158,195,584 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,871,986 - 155,936,707 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,263,692 - 153,321,351 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,263,692 - 153,321,352 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,398,177 - 158,452,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43147,734,622 - 147,796,630 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3144,513,506 - 144,575,032 (-)NCBICelera
Cytogenetic Map3q42NCBI
RBL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382036,996,349 - 37,095,997 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2036,996,349 - 37,095,997 (-)EnsemblGRCh38hg38GRCh38
GRCh372035,624,752 - 35,724,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,059,592 - 35,157,824 (-)NCBINCBI36Build 36hg18NCBI36
Build 342035,065,390 - 35,157,824NCBI
Celera2032,333,780 - 32,432,015 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,360,436 - 32,458,763 (-)NCBIHuRef
CHM1_12035,527,068 - 35,627,333 (-)NCBICHM1_1
T2T-CHM13v2.02038,720,692 - 38,820,363 (-)NCBIT2T-CHM13v2.0
Rbl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,987,813 - 157,046,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,987,813 - 157,046,454 (-)EnsemblGRCm39 Ensembl
GRCm382157,145,893 - 157,204,534 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,145,893 - 157,204,534 (-)EnsemblGRCm38mm10GRCm38
MGSCv372156,971,629 - 157,030,270 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362156,837,339 - 156,895,960 (-)NCBIMGSCv36mm8
Celera2163,079,752 - 163,138,173 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.05NCBI
Rbl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,620,078 - 24,695,229 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542224,620,068 - 24,695,203 (+)NCBIChiLan1.0ChiLan1.0
RBL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,730,094 - 42,825,356 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,722,411 - 42,818,447 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,324,663 - 33,419,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,442,865 - 34,535,248 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,443,203 - 34,534,109 (-)Ensemblpanpan1.1panPan2
RBL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,698,313 - 25,757,358 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,699,638 - 25,757,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,346,666 - 25,405,658 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,395,755 - 26,454,244 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,395,763 - 26,454,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,673,462 - 25,732,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,777,693 - 25,836,916 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,267,110 - 26,325,939 (-)NCBIUU_Cfam_GSD_1.0
Rbl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,589,725 - 174,641,443 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365614,107,861 - 4,157,647 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365614,108,393 - 4,157,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,194,950 - 40,279,156 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,201,214 - 40,279,318 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,641,172 - 45,716,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103246453
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,593,657 - 26,601,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666054222,711 - 309,667 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,494,911 - 2,563,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,495,015 - 2,565,220 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbl1
515 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:83
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000064824
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
D3Uwm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83166,284,097 - 166,284,258 (+)Marker Load Pipeline
mRatBN7.23145,864,084 - 145,864,245 (+)MAPPERmRatBN7.2
Rnor_6.03153,320,686 - 153,320,846NCBIRnor6.0
Rnor_5.03158,398,682 - 158,398,842UniSTSRnor5.0
RGSC_v3.43147,791,421 - 147,791,581UniSTSRGSC3.4
RGSC_v3.13147,697,329 - 147,697,490RGD
Celera3144,569,830 - 144,569,990UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000064824   ⟹   ENSRNOP00000063017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3145,807,095 - 145,869,330 (-)Ensembl
Rnor_6.0 Ensembl3153,263,692 - 153,321,352 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100752   ⟹   ENSRNOP00000093339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3145,807,095 - 145,869,330 (-)Ensembl
RefSeq Acc Id: NM_001191066   ⟹   NP_001177995
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,226,187 - 166,289,376 (-)NCBI
mRatBN7.23145,806,160 - 145,869,363 (-)NCBI
Rnor_6.03153,263,692 - 153,321,351 (-)NCBI
Rnor_5.03158,398,177 - 158,452,482 (+)NCBI
Celera3144,513,506 - 144,575,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105840   ⟹   XP_038961768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,226,187 - 166,289,862 (-)NCBI
mRatBN7.23145,806,160 - 145,869,434 (-)NCBI
RefSeq Acc Id: XM_039105841   ⟹   XP_038961769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,226,187 - 166,274,917 (-)NCBI
mRatBN7.23145,806,160 - 145,854,904 (-)NCBI
RefSeq Acc Id: XR_010064693
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,246,449 - 166,289,862 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001177995 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961768 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961769 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZS28 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063017
  ENSRNOP00000063017.4
  ENSRNOP00000093339
  ENSRNOP00000093339.1
RefSeq Acc Id: NP_001177995   ⟸   NM_001191066
- UniProtKB: D3ZS28 (UniProtKB/Swiss-Prot),   A0A573VVF2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063017   ⟸   ENSRNOT00000064824
RefSeq Acc Id: XP_038961768   ⟸   XM_039105840
- Peptide Label: isoform X1
- UniProtKB: D3ZS28 (UniProtKB/Swiss-Prot),   A0A8I6AK71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961769   ⟸   XM_039105841
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000093339   ⟸   ENSRNOT00000100752
Protein Domains
Cyclin-like   Retinoblastoma-associated protein A-box   Retinoblastoma-associated protein C-terminal   Retinoblastoma-associated protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS28-F1-model_v2 AlphaFold D3ZS28 1-1049 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595511 AgrOrtholog
BioCyc Gene G2FUF-47064 BioCyc
Ensembl Genes ENSRNOG00000006921 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064824 ENTREZGENE
  ENSRNOT00000064824.4 UniProtKB/TrEMBL
  ENSRNOT00000100752 ENTREZGENE
  ENSRNOT00000100752.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.472.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:680111 UniProtKB/Swiss-Prot
NCBI Gene 680111 ENTREZGENE
PANTHER PTHR13742 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13742:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rb_C UniProtKB/TrEMBL
PhenoGen Rbl1 PhenoGen
RatGTEx ENSRNOG00000006921 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rb_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A573VVF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK71 ENTREZGENE, UniProtKB/TrEMBL
  D3ZS28 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Rbl1  RB transcriptional corepressor like 1  Rbl1  retinoblastoma-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-03-24 Rbl1  retinoblastoma-like 1  Rbl1  retinoblastoma-like 1 (p107)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Rbl1  retinoblastoma-like 1 (p107)  LOC680111  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680111  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)  LOC683869  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)  Data merged from RGD:1597810 1643240 APPROVED
2006-11-20 LOC680111  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC683869  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)      Symbol and Name status set to provisional 70820 PROVISIONAL