Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PFDN1 mRNA | CTD | PMID:36331819 | (S)-nicotine | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | 1,2-dimethylhydrazine | increases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PFDN1 mRNA | CTD | PMID:22206623 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | increases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | 17alpha-ethynylestradiol | increases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PFDN1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PFDN1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of PFDN1 mRNA | CTD | PMID:26496021 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Pfdn1 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PFDN1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PFDN1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PFDN1 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pfdn1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PFDN1 mRNA | CTD | PMID:21570461 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of PFDN1 mRNA | CTD | PMID:18648102 | acrolein | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PFDN1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PFDN1 mRNA | CTD | PMID:32699268 | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of PFDN1 gene | CTD | PMID:27153756 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of PFDN1 intron | CTD | PMID:30157460 | alpha-pinene | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PFDN1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PFDN1 mRNA | CTD | PMID:32699268 | aristolochic acid A | increases expression | EXP | | 6480464 | aristolochic acid I results in increased expression of PFDN1 mRNA | CTD | PMID:33212167 | bisphenol A | multiple interactions | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of PFDN1 mRNA | CTD | PMID:26496021 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PFDN1 protein | CTD | PMID:37567409 | bisphenol A | decreases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of PFDN1 mRNA | CTD | PMID:33296240 | bisphenol A | increases methylation | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of PFDN1 gene | CTD | PMID:28505145 | bisphenol A | increases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PFDN1 mRNA | CTD | PMID:25181051 | Brodifacoum | decreases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | bromfenacoum results in decreased expression of PFDN1 protein | CTD | PMID:28903499 | cadmium atom | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PFDN1 mRNA | CTD | PMID:37325564 | cadmium dichloride | increases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of PFDN1 protein | CTD | PMID:21699967 | cadmium dichloride | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PFDN1 mRNA | CTD | PMID:37325564 | caffeine | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PFDN1 gene] | CTD | PMID:28238834 | crocidolite asbestos | decreases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of PFDN1 mRNA | CTD | PMID:29279043 | cylindrospermopsin | increases expression | EXP | | 6480464 | cylindrospermopsin results in increased expression of PFDN1 mRNA | CTD | PMID:24921660 | dibutyl phthalate | decreases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of PFDN1 mRNA | CTD | PMID:17361019 | diuron | decreases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | Diuron results in decreased expression of PFDN1 mRNA | CTD | PMID:21551480 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PFDN1 mRNA | CTD | PMID:35967413 | epoxiconazole | increases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of PFDN1 mRNA | CTD | PMID:35436446 | ethanol | affects expression | ISO | Pfdn1 (Mus musculus) | 6480464 | Ethanol affects the expression of PFDN1 mRNA | CTD | PMID:30319688 | finasteride | increases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | Finasteride results in increased expression of PFDN1 mRNA | CTD | PMID:24136188 | flutamide | increases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of PFDN1 mRNA | CTD | PMID:24136188 | gentamycin | increases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of PFDN1 mRNA | CTD | PMID:22061828 | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of PFDN1 protein | CTD | PMID:32959892 | methidathion | decreases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | methidathion results in decreased expression of PFDN1 mRNA | CTD | PMID:34813904 | miconazole | increases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | Miconazole results in increased expression of PFDN1 mRNA | CTD | PMID:27462272 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of PFDN1 gene | CTD | PMID:33148267 | nicotine | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | ozone | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PFDN1 mRNA more ... | CTD | PMID:32699268 | ozone | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of PFDN1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of PFDN1 mRNA | CTD | PMID:34911549 | paracetamol | affects response to substance | EXP | | 6480464 | PFDN1 gene polymorphism affects the susceptibility to Acetaminophen | CTD | PMID:26104854 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Pfdn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PFDN1 mRNA | CTD | PMID:36331819 | permethrin | multiple interactions | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of PFDN1 gene | CTD | PMID:33148267 | pyrogallol | increases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | Pyrogallol results in increased expression of PFDN1 mRNA | CTD | PMID:20362636 | SB 431542 | multiple interactions | EXP | | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of PFDN1 protein | CTD | PMID:37664457 | sunitinib | decreases expression | EXP | | 6480464 | Sunitinib results in decreased expression of PFDN1 mRNA | CTD | PMID:31533062 | tetrachloromethane | increases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of PFDN1 mRNA | CTD | PMID:31919559 | tolcapone | decreases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | tolcapone results in decreased expression of PFDN1 mRNA | CTD | PMID:24136188 | toluene | decreases expression | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | Toluene results in decreased expression of PFDN1 mRNA | CTD | PMID:22967744 | tungsten | increases expression | ISO | Pfdn1 (Mus musculus) | 6480464 | Tungsten results in increased expression of PFDN1 mRNA | CTD | PMID:30912803 | vinclozolin | increases methylation | ISO | Pfdn1 (Rattus norvegicus) | 6480464 | vinclozolin results in increased methylation of PFDN1 gene | CTD | PMID:31682807 | |