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Gene: Erbb3 (erb-b2 receptor tyrosine kinase 3) Rattus norvegicus
Symbol: Erbb3
Name: erb-b2 receptor tyrosine kinase 3
RGD ID: 69323
Description: Exhibits neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including animal organ development; cellular response to insulin stimulus; and positive regulation of glucose import. Localizes to nucleus and postsynaptic membrane. Biomarker of chronic obstructive pulmonary disease and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; angiotensin II signaling pathway via AT2 receptor; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: avian erythroblastosis oncogene B 3; c-erbB-3; c-erbB3; nuc-ErbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine-protein kinase erbB-3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Homo sapiens (human) : ERBB3 (erb-b2 receptor tyrosine kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Erbb3 (erb-b2 receptor tyrosine kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erbb3 (erb-b2 receptor tyrosine kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ERBB3 (erb-b2 receptor tyrosine kinase 3)
Canis lupus familiaris (dog) : ERBB3 (erb-b2 receptor tyrosine kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Erbb3 (erb-b2 receptor tyrosine kinase 3)
Sus scrofa (pig) : ERBB3 (erb-b2 receptor tyrosine kinase 3)
Chlorocebus sabaeus (African green monkey) : ERBB3 (erb-b2 receptor tyrosine kinase 3)
Heterocephalus glaber (naked mole-rat) : Erbb3 (erb-b2 receptor tyrosine kinase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.072,989,202 - 3,010,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,989,340 - 3,010,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,962,964 - 2,984,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,858,057 - 1,877,353 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,858,056 - 1,877,353 (-)NCBI
Celera7866,587 - 885,873 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Erbb3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69323
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.