Erbb3 (erb-b2 receptor tyrosine kinase 3) - Rat Genome Database

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Gene: Erbb3 (erb-b2 receptor tyrosine kinase 3) Rattus norvegicus
Symbol: Erbb3
Name: erb-b2 receptor tyrosine kinase 3
RGD ID: 69323
Description: Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including cellular response to insulin stimulus; mammary gland involution; and positive regulation of glucose import. Located in postsynaptic membrane. Biomarker of chronic obstructive pulmonary disease and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; angiotensin II signaling pathway via AT2 receptor; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: avian erythroblastosis oncogene B 3; c-erbB-3; c-erbB3; nuc-ErbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine-protein kinase erbB-3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27994,549 - 1,015,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,758,331 - 3,777,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,634,321 - 5,653,694 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,932,064 - 5,951,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,989,202 - 3,010,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,989,340 - 3,010,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,962,964 - 2,984,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,858,057 - 1,877,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,858,056 - 1,877,353 (-)NCBI
Celera7866,587 - 885,873 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylparaben  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
capecitabine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
casticin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (EXP)
daunorubicin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichromium trioxide  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
fisetin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glycidol  (EXP)
hydrogen sulfide  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
lead diacetate  (ISO)
linuron  (EXP)
lithium chloride  (ISO)
LY294002  (ISO)
menadione  (ISO)
metformin  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-acetylcysteamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
pyrethrins  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tephrosin  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
axonogenesis  (IEP)
cellular response to insulin stimulus  (IEP)
circadian rhythm  (IEP)
cranial nerve development  (IEA,ISO)
endocardial cushion development  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IMP)
ERBB signaling pathway  (IEA)
ERBB2-ERBB3 signaling pathway  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
mammary gland involution  (IEP)
motor neuron apoptotic process  (IEA,ISO)
myelination  (IEA,ISO)
negative regulation of apoptotic process  (IBA)
negative regulation of cell adhesion  (IEA,ISO)
negative regulation of motor neuron apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of secretion  (IEA,ISO)
negative regulation of signal transduction  (IEA,ISO)
nervous system development  (IEA)
neurogenesis  (IBA)
neuron apoptotic process  (ISO)
peripheral nervous system development  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
phosphorylation  (IEA)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cardiac muscle tissue development  (IEA,ISO)
positive regulation of cell population proliferation  (IBA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glucose import  (IMP)
regulation of cell population proliferation  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
Schwann cell development  (IEA,ISO)
Schwann cell differentiation  (ISO)
signal transduction  (ISO)
skeletal muscle tissue development  (IEP)
tongue development  (IEP)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,ISO,TAS)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. Amsellem-Ouazana D, etal., J Urol. 2006 Mar;175(3 Pt 1):1127-32.
2. ErbB receptors modulation in different types of peripheral nerve regeneration. Audisio C, etal., Neuroreport. 2008 Oct 29;19(16):1605-9. doi: 10.1097/WNR.0b013e32831313ef.
3. Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome. Begnami MD, etal., J Clin Oncol. 2011 Aug 1;29(22):3030-6. doi: 10.1200/JCO.2010.33.6313. Epub 2011 Jun 27.
4. c-erbB-3 protein expression in ductal carcinoma in situ of the breast. Bobrow LG, etal., Eur J Cancer. 1997 Oct;33(11):1846-50.
5. Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas: antioncogenic significance of the HER4 protein in laryngeal squamous cell carcinoma. Bussu F, etal., Laryngoscope. 2012 Aug;122(8):1724-33. doi: 10.1002/lary.23311. Epub 2012 May 1.
6. Neuregulin signaling on glucose transport in muscle cells. Canto C, etal., J Biol Chem. 2004 Mar 26;279(13):12260-8. Epub 2004 Jan 6.
7. Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. Carroll SL, etal., J Neurosci 1997 Mar 1;17(5):1642-59.
8. Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors. Carver RS, etal., Endocrinology. 1997 Dec;138(12):5195-201.
9. Diverse expression of ErbB receptor proteins during rat liver development and regeneration. Carver RS, etal., Gastroenterology. 2002 Dec;123(6):2017-27.
10. EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma. Chen HY, etal., Oncotarget. 2016 Feb 23;7(8):9017-25. doi: 10.18632/oncotarget.7029.
11. Bone microenvironment and androgen status modulate subcellular localization of ErbB3 in prostate cancer cells. Cheng CJ, etal., Mol Cancer Res. 2007 Jul;5(7):675-84.
12. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
13. Unique properties of lamp2a compared to other lamp2 isoforms. Cuervo AM and Dice JF, J Cell Sci. 2000 Dec;113 Pt 24:4441-50.
14. Protein levels and gene expressions of the epidermal growth factor receptors, HER1, HER2, HER3 and HER4 in benign and malignant ovarian tumors. Dahl Steffensen K, etal., Int J Oncol. 2008 Jul;33(1):195-204.
15. Changes in ErbB2 (her-2/neu), ErbB3, and ErbB4 during growth, differentiation, and apoptosis of normal rat mammary epithelial cells. Darcy KM, etal., J Histochem Cytochem. 2000 Jan;48(1):63-80.
16. HER family receptors expression in squamous cell carcinoma of the tongue: study of the possible prognostic and biological significance. Del Sordo R, etal., J Oral Pathol Med. 2010 Jan;39(1):79-86. doi: 10.1111/j.1600-0714.2009.00815.x. Epub 2009 Aug 18.
17. Expression of the epidermal growth factor system in endometrioid endometrial cancer. Ejskjaer K, etal., Gynecol Oncol. 2007 Jan;104(1):158-67. Epub 2006 Sep 7.
18. Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development. Fried K, etal., Dev Dyn 2002 Jul;224(3):356-60.
19. Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line. Frohnert PW, etal., Glia. 2003 Aug;43(2):104-18.
20. The prognostic significance of human epidermal growth factor receptor correlations in squamous cell cervical carcinoma. Fuchs I, etal., Anticancer Res. 2007 Mar-Apr;27(2):959-63.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein. Hellyer NJ, etal., Gene 1995 Nov 20;165(2):279-84.
24. A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4. Higashiyama S, etal., J Biochem (Tokyo) 1997 Sep;122(3):675-80.
25. Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. Ito Y, etal., Br J Cancer. 2001 May 18;84(10):1377-83. doi: 10.1054/bjoc.2000.1580.
26. Expressions of tumor necrosis factor-converting enzyme and ErbB3 in rats with chronic obstructive pulmonary disease. Ju CR, etal., Chin Med J (Engl). 2007 Sep 5;120(17):1505-10.
27. Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients. Junttila TT, etal., Clin Cancer Res. 2003 Nov 1;9(14):5346-57.
28. Expression of the HER family mRNA in breast cancer tissue and association with cell cycle inhibitors p21(waf1) and p27(kip1). Kalemi TG, etal., Anticancer Res. 2007 Mar-Apr;27(2):913-20.
29. Low nuclear ErbB3 predicts biochemical recurrence in patients with prostate cancer. Koumakpayi IH, etal., BJU Int. 2007 Aug;100(2):303-9. Epub 2007 May 26.
30. Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas. Kountourakis P, etal., BMC Cancer. 2006 Feb 28;6:46. doi: 10.1186/1471-2407-6-46.
31. Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer. Lai WW, etal., Ann Thorac Surg. 2001 Dec;72(6):1868-76. doi: 10.1016/s0003-4975(01)03207-6.
32. Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle. Lebrasseur NK, etal., Am J Physiol Cell Physiol. 2003 May;284(5):C1149-55. Epub 2003 Jan 2.
33. Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway. Li M, etal., Nat Genet. 2014 Aug;46(8):872-6. doi: 10.1038/ng.3030. Epub 2014 Jul 6.
34. Soluble ErbB3 Levels in Bone Marrow and Plasma of Men with Prostate Cancer. Lin SH, etal., Clin Cancer Res. 2008 Jun 15;14(12):3729-36.
35. Expression of neuregulin and ErbB3 and ErbB4 after a traumatic lesion in the ventral funiculus of the spinal cord and in the intact primary olfactory system. Lindholm T, etal., Exp Brain Res. 2002 Jan;142(1):81-90. Epub 2001 Nov 9.
36. The ErbB4 receptor in fetal rat lung fibroblasts and epithelial type II cells. Liu W, etal., Biochim Biophys Acta. 2007 Jul;1772(7):737-47. Epub 2007 May 5.
37. Prognostic significance of serum ERBB3 and ERBB4 mRNA in lung adenocarcinoma patients. Masroor M, etal., Tumour Biol. 2016 Jan;37(1):857-63. doi: 10.1007/s13277-015-3859-3. Epub 2015 Aug 9.
38. Gene-specific inhibition of breast carcinoma in BALB-neuT mice by active immunization with rat Neu or human ErbB receptors. Masuelli L, etal., Int J Oncol. 2007 Feb;30(2):381-92.
39. Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. McConkey M, etal., J Biol Chem. 2004 May 14;279(20):20882-8. Epub 2004 Mar 8.
40. Erb and c-Kit receptors have distinctive patterns of expression in adult and developing taste papillae and taste buds. McLaughlin SK J Neurosci. 2000 Aug 1;20(15):5679-88.
41. The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients. Memon AA, etal., Br J Cancer. 2006 Jun 5;94(11):1703-9.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Neuregulins and cancer. Montero JC, etal., Clin Cancer Res. 2008 Jun 1;14(11):3237-41. doi: 10.1158/1078-0432.CCR-07-5133.
44. Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. Moscoso LM, etal., Dev Biol. 1995 Nov;172(1):158-69.
45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. Denervation and reinnervation of adult skeletal muscle modulate mRNA expression of neuregulin-1 and ErbB receptors. Nicolino S, etal., Microsurgery. 2009;29(6):464-72. doi: 10.1002/micr.20636.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
50. GOA pipeline RGD automated data pipeline
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Rodrigues-Ferreira S and Nahmias C, Trends Endocrinol Metab. 2010 Nov;21(11):684-90.
54. Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. Sassen A, etal., Breast Cancer Res. 2008 Jan 8;10(1):R2.
55. ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. Silva SD, etal., Oral Dis. 2010 Nov;16(8):774-80. doi: 10.1111/j.1601-0825.2010.01687.x.
56. Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer. Srinivasan R, etal., Clin Cancer Res. 1999 Oct;5(10):2877-83.
57. Phyllodes tumor of the breast: EGFR family expression and relation to clinicopathological features. Suo Z and Nesland JM, Ultrastruct Pathol. 2000 Nov-Dec;24(6):371-81.
58. ErbB-3 predicts survival in ovarian cancer. Tanner B, etal., J Clin Oncol. 2006 Sep 10;24(26):4317-23. Epub 2006 Aug 8.
59. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
60. ERBB3 as an independent prognostic marker for nasopharyngeal carcinoma. Tulalamba W, etal., J Clin Pathol. 2014 Aug;67(8):667-72. doi: 10.1136/jclinpath-2013-202154. Epub 2014 May 13.
61. Enhancement of erbB2 and erbB3 expression during oral oncogenesis in diabetic rats. Vairaktaris E, etal., J Cancer Res Clin Oncol. 2008 Mar;134(3):337-44. Epub 2007 Aug 18.
62. Chronic antipsychotic drug administration alters the expression of neuregulin 1beta, ErbB2, ErbB3, and ErbB4 in the rat prefrontal cortex and hippocampus. Wang XD, etal., Int J Neuropsychopharmacol. 2008 Jan 10;:1-9.
63. A peptide antagonist of the ErbB1 receptor inhibits receptor activation, tumor cell growth and migration in vitro and xenograft tumor growth in vivo. Xu R, etal., Cell Oncol. 2010 Jan 1;32(4):259-74. doi: 10.3233/CLO-2010-0515.
64. Neuregulin receptors, erbB3 and erbB4, are localized at neuromuscular synapses. Zhu X, etal., EMBO J. 1995 Dec 1;14(23):5842-8.
Additional References at PubMed
PMID:7556068   PMID:9338783   PMID:9362461   PMID:9791008   PMID:10095121   PMID:10559227   PMID:10572067   PMID:11389077   PMID:12000754   PMID:12646923   PMID:15306553   PMID:17585012  
PMID:17701904   PMID:18056992   PMID:19179536   PMID:20682778   PMID:21451047   PMID:21575594   PMID:22815787   PMID:22871113   PMID:23301073   PMID:23380500   PMID:23382219   PMID:23436906  
PMID:24364879   PMID:26116536   PMID:27113200   PMID:27353365   PMID:28162790   PMID:29190819   PMID:31669265   PMID:32200526   PMID:33640362  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27994,549 - 1,015,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,758,331 - 3,777,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,634,321 - 5,653,694 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,932,064 - 5,951,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,989,202 - 3,010,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,989,340 - 3,010,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,962,964 - 2,984,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,858,057 - 1,877,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,858,056 - 1,877,353 (-)NCBI
Celera7866,587 - 885,873 (-)NCBICelera
Cytogenetic Map7q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381256,080,108 - 56,103,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,076,799 - 56,103,505 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,473,892 - 56,497,289 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,760,159 - 54,783,395 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,760,158 - 54,783,395NCBI
Celera1256,125,560 - 56,149,315 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,512,788 - 53,536,430 (+)NCBIHuRef
CHM1_11256,441,254 - 56,464,656 (+)NCBICHM1_1
T2T-CHM13v2.01256,047,558 - 56,071,109 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910128,403,392 - 128,425,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,403,392 - 128,425,521 (-)EnsemblGRCm39 Ensembl
GRCm3810128,567,523 - 128,589,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,567,523 - 128,589,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,006,424 - 128,026,557 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,972,317 - 127,992,450 (-)NCBIMGSCv36mm8
Celera10130,961,356 - 130,981,519 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554583,683,126 - 3,702,978 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,683,126 - 3,701,752 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11238,224,995 - 38,248,393 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,811,533 - 32,834,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,062,681 - 33,085,426 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,063,434 - 33,084,994 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.110406,856 - 424,746 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10406,633 - 424,264 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10468,642 - 486,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010416,919 - 431,621 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10417,394 - 431,614 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110391,236 - 409,084 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010634,155 - 651,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010758,352 - 776,205 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494558,354,988 - 58,370,728 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646498,749 - 513,297 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936646497,783 - 515,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl521,474,475 - 21,495,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,474,218 - 21,495,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,085,940 - 23,092,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11152,020,912 - 52,043,809 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,021,058 - 52,044,028 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,941,255 - 193,963,311 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462480211,905,271 - 11,925,707 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,906,279 - 11,925,530 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Erbb3
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:76
Interacting mature miRNAs:80
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27997,013 - 997,186 (+)MAPPERmRatBN7.2
Rnor_6.072,991,805 - 2,991,977NCBIRnor6.0
Rnor_5.072,965,429 - 2,965,601UniSTSRnor5.0
RGSC_v3.471,858,846 - 1,859,018UniSTSRGSC3.4
Celera7867,376 - 867,548UniSTS
Cytogenetic Map7q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 29 29 29 11 33 12 11
Low 43 28 12 19 12 8 11 63 2 29 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000006796   ⟹   ENSRNOP00000006796
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)Ensembl
Rnor_6.0 Ensembl72,989,340 - 3,010,350 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097232   ⟹   ENSRNOP00000096071
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102209   ⟹   ENSRNOP00000084638
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115760   ⟹   ENSRNOP00000082134
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117138   ⟹   ENSRNOP00000088244
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7996,225 - 1,012,566 (-)Ensembl
RefSeq Acc Id: NM_017218   ⟹   NP_058914
Rat AssemblyChrPosition (strand)Source
mRatBN7.27996,225 - 1,015,525 (-)NCBI
Rnor_6.072,991,016 - 3,010,312 (-)NCBI
Rnor_5.072,962,964 - 2,984,938 (-)NCBI
RGSC_v3.471,858,057 - 1,877,353 (-)RGD
Celera7866,587 - 885,873 (-)RGD
RefSeq Acc Id: XM_017594700   ⟹   XP_017450189
Rat AssemblyChrPosition (strand)Source
mRatBN7.27994,549 - 1,015,876 (-)NCBI
Rnor_6.072,989,202 - 3,010,610 (-)NCBI
RefSeq Acc Id: XM_017594701   ⟹   XP_017450190
Rat AssemblyChrPosition (strand)Source
mRatBN7.27994,549 - 1,012,457 (-)NCBI
Rnor_6.072,989,202 - 3,007,917 (-)NCBI
RefSeq Acc Id: XM_017594702   ⟹   XP_017450191
Rat AssemblyChrPosition (strand)Source
mRatBN7.27994,549 - 1,012,413 (-)NCBI
Rnor_6.072,989,202 - 3,007,218 (-)NCBI
RefSeq Acc Id: NP_058914   ⟸   NM_017218
- Peptide Label: precursor
- UniProtKB: Q62955 (UniProtKB/Swiss-Prot),   Q62799 (UniProtKB/Swiss-Prot),   A0A8I6A5T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450189   ⟸   XM_017594700
- Peptide Label: isoform X1
- UniProtKB: G3V6N1 (UniProtKB/TrEMBL),   A6KSF8 (UniProtKB/TrEMBL),   A0A8I6A5T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450190   ⟸   XM_017594701
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A5T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450191   ⟸   XM_017594702
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A5T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006796   ⟸   ENSRNOT00000006796
RefSeq Acc Id: ENSRNOP00000096071   ⟸   ENSRNOT00000097232
RefSeq Acc Id: ENSRNOP00000088244   ⟸   ENSRNOT00000117138
RefSeq Acc Id: ENSRNOP00000082134   ⟸   ENSRNOT00000115760
RefSeq Acc Id: ENSRNOP00000084638   ⟸   ENSRNOT00000102209
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62799-F1-model_v2 AlphaFold Q62799 1-1339 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694945
Promoter ID:EPDNEW_R5470
Type:multiple initiation site
Description:erb-b2 receptor tyrosine kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,010,312 - 3,010,372EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69323 AgrOrtholog
BioCyc Gene G2FUF-35350 BioCyc
Ensembl Genes ENSRNOG00000004964 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006796 ENTREZGENE
  ENSRNOT00000006796.5 UniProtKB/TrEMBL
  ENSRNOT00000097232.1 UniProtKB/TrEMBL
  ENSRNOT00000102209.1 UniProtKB/TrEMBL
  ENSRNOT00000115760.1 UniProtKB/TrEMBL
  ENSRNOT00000117138.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor like domain UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Furin-like_Cys-rich_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_EGF/ERB/XmrK_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29496 UniProtKB/Swiss-Prot
Pfam Furin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Erbb3 PhenoGen
PIRSF TyrPK_EGF-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004964 RatGTEx
SMART SM00261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209519
  ERBB3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q62955 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-29 Erbb3  erb-b2 receptor tyrosine kinase 3  Erbb3  v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Erbb3  v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3  Erbb3  v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Erbb3  v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)    avian erythroblastosis oncogene B 3  Name updated 1299863 APPROVED
2002-06-10 Erbb3  avian erythroblastosis oncogene B 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the erB family of membrane tyrosine kinase receptors 68774