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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69323
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb3
Name: erb-b2 receptor tyrosine kinase 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb3affects expressionEXP 6480464CTDbisphenol A affects the expression of ERBB3 mRNAPMID:32145629
Erbb3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ERBB3 mRNAPMID:25181051 PMID:34947998
Erbb3increases expressionEXP 6480464CTDbisphenol A results in increased expression of ERBB3 proteinPMID:19590682
Erbb3multiple interactionsEXP 6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ERBB3 mRNA; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of ERBB3 mRNAPMID:25607892
Erbb3affects methylationISOERBB3 (Homo sapiens)6480464CTDbisphenol A affects the methylation of ERBB3 genePMID:31601247
Erbb3decreases expressionISOERBB3 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of ERBB3 mRNAPMID:16029874
Erbb3increases expressionISOERBB3 (Homo sapiens)6480464CTDbisphenol A results in increased expression of ERBB3 mRNAPMID:22576693
Erbb3increases expressionISOErbb3 (Mus musculus)6480464CTDbisphenol A results in increased expression of ERBB3 mRNA; bisphenol A results in increased expression of ERBB3 proteinPMID:30951980 PMID:32156529 PMID:32353937
Erbb3increases phosphorylationISOErbb3 (Mus musculus)6480464CTDbisphenol A results in increased phosphorylation of ERBB3 proteinPMID:21988766
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