RGD Reference Report - Phyllodes tumor of the breast: EGFR family expression and relation to clinicopathological features. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Phyllodes tumor of the breast: EGFR family expression and relation to clinicopathological features.

Authors: Suo, Z  Nesland, JM 
Citation: Suo Z and Nesland JM, Ultrastruct Pathol. 2000 Nov-Dec;24(6):371-81.
RGD ID: 2289951
Pubmed: PMID:11206334   (View Abstract at PubMed)

The expression of EGFR family members was examined by immunohistochemistry in 22 phyllodes tumors, and the results were evaluated together with immunohistochemical findings for proliferation markers Ki67 and BM28, and the tumor suppressor gene product p53. Light and electron microscopy were performed in all cases. Clinical information was obtained from the medial records. We did find that expression of EG FR, c-erbB-3 and c-erbB-4 proteins could be detected in the neoplastic mesenchymal cells, and that the expression increased with increasing malignancy. Increased expressions of Ki67, BM28, p53 and EGFR family members in neoplastic cells were associated with malignancy and unfavorable clinical course. Furthermore, the expression of ER-alpha and PR in the epithelial cells of phyllodes tumors was increased compared to that in normal breast epithelium. Finally, the application of electron microscopy helped to identify a group of malignant tumors, revealing neoplastic cells with characteristic nuclear indentations, as well as an increasing number of myofibroblasts.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Phyllodes Tumor disease_progressionIEP 2289951protein:increased expression:tumorRGD 
Phyllodes Tumor disease_progressionIEP 2289951; 2289951 RGD 
Phyllodes Tumor disease_progressionISOEGFR (Homo sapiens)2289951; 2289951protein:increased expression:tumorRGD 
Phyllodes Tumor disease_progressionISOERBB3 (Homo sapiens)2289951; 2289951 RGD 
Phyllodes Tumor disease_progressionISOERBB4 (Homo sapiens)2289951; 2289951 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Egfr  (epidermal growth factor receptor)
Erbb3  (erb-b2 receptor tyrosine kinase 3)
Erbb4  (erb-b2 receptor tyrosine kinase 4)

Genes (Mus musculus)
Egfr  (epidermal growth factor receptor)
Erbb3  (erb-b2 receptor tyrosine kinase 3)
Erbb4  (erb-b2 receptor tyrosine kinase 4)

Genes (Homo sapiens)
EGFR  (epidermal growth factor receptor)
ERBB3  (erb-b2 receptor tyrosine kinase 3)
ERBB4  (erb-b2 receptor tyrosine kinase 4)


Additional Information