RGD Reference Report - ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. - Rat Genome Database

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ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.

Authors: Silva, S D  Cunha, I W  Younes, R N  Soares, F A  Kowalski, L P  Graner, E 
Citation: Silva SD, etal., Oral Dis. 2010 Nov;16(8):774-80. doi: 10.1111/j.1601-0825.2010.01687.x.
RGD ID: 126790467
Pubmed: PMID:20604875   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1601-0825.2010.01687.x   (Journal Full-text)


SUMMARY: Overexpression of ErbB receptors is frequent in head and neck squamous cell carcinomas (HNSCC) and seems to be correlated with tumor progression and metastasis. Fatty acid synthase (FASN), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, is regulated by ErbB2 and overexpressed in several human malignancies.
METHODS: This study was performed to examine the immunohistochemical expression patterns of ErbB1, ErbB2, ErbB3, ErbB4, and FASN in a tissue microarray, containing 33 representative areas from aggressive primary HNSCC (whose patients had distant metastasis), and 21 matched lung metastasis.
RESULTS: Strong correlation among the expression of ErbB family receptors was found (ErbB1-ErbB2 P = 0.008, ErbB1-ErbB4 P = 0.018, EbB2-ErbB3 P = 0.001, ErbB2-ErbB4 P = 0.006, ErbB3-ErbB4 P=0.012) in the HNSCC. FASN expression was significantly associated with ErbB2 (P = 0.024). Lymphatic permeation was correlated with ErbB3 (P = 0.033) and histological grade with ErbB4 staining (P = 0.050). ErbB1 and ErbB2 were found mainly in patients with smoking habit (P = 0.011 and P = 0.027), and ErbB2 was associated with alcohol consumption and clinical stage (P = 0.014 and P = 0.031). Finally, FASN was overexpressed in lung metastasis, in comparison with matched HNSCC samples (P = 0.006).
CONCLUSIONS:   The results showed that high FASN immunohistochemical expression is a feature of HNSCC lung metastasis, and ErbB1-ErbB2, ErbB1-ErbB4, ErbB2-ErbB3, ErbB2-ErbB4, and ErbB3-ErbB4 expression levels are correlated in the respective primary tumors, being ErbB2 the preferred coexpression partner of all the other ErbB receptors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
head and neck squamous cell carcinoma disease_progressionIEP 126790467 RGD 
head and neck squamous cell carcinoma severityIEP 126790467 RGD 
head and neck squamous cell carcinoma disease_progressionISOERBB2 (Homo sapiens)126790467; 126790467 RGD 
head and neck squamous cell carcinoma severityISOERBB4 (Homo sapiens)126790467; 126790467 RGD 
lung metastasis  IEP 126790467associated with head and neck squamous cell carcinomaRGD 
lung metastasis  ISOFASN (Homo sapiens)126790467; 126790467associated with head and neck squamous cell carcinomaRGD 
Lymphatic Metastasis  IEP 126790467associated with head and neck squamous cell carcinomaRGD 
Lymphatic Metastasis  ISOERBB3 (Homo sapiens)126790467; 126790467associated with head and neck squamous cell carcinomaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Erbb2  (erb-b2 receptor tyrosine kinase 2)
Erbb3  (erb-b2 receptor tyrosine kinase 3)
Erbb4  (erb-b2 receptor tyrosine kinase 4)
Fasn  (fatty acid synthase)

Genes (Mus musculus)
Erbb2  (erb-b2 receptor tyrosine kinase 2)
Erbb3  (erb-b2 receptor tyrosine kinase 3)
Erbb4  (erb-b2 receptor tyrosine kinase 4)
Fasn  (fatty acid synthase)

Genes (Homo sapiens)
ERBB2  (erb-b2 receptor tyrosine kinase 2)
ERBB3  (erb-b2 receptor tyrosine kinase 3)
ERBB4  (erb-b2 receptor tyrosine kinase 4)
FASN  (fatty acid synthase)


Additional Information