Erbb3 (erb-b2 receptor tyrosine kinase 3) - Rat Genome Database

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Gene: Erbb3 (erb-b2 receptor tyrosine kinase 3) Mus musculus
Analyze
Symbol: Erbb3
Name: erb-b2 receptor tyrosine kinase 3
RGD ID: 736142
MGI Page MGI
Description: Enables neuregulin receptor activity. Involved in ERBB2-ERBB3 signaling pathway; Schwann cell development; and myelination. Acts upstream of or within several processes, including negative regulation of motor neuron apoptotic process; nervous system development; and positive regulation of calcineurin-NFAT signaling cascade. Located in apical plasma membrane and lateral plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: avian erythroblastosis oncogene B 3 receptor; c-erbB-3; C76256; Erbb; Erbb-; Erbb-3; Erbb3r; glial growth factor receptor; HER; Her3; MGC117742; proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,403,392 - 128,425,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,403,392 - 128,425,521 (-)EnsemblGRCm39 Ensembl
GRCm3810128,567,523 - 128,589,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,567,523 - 128,589,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,006,424 - 128,026,557 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,972,317 - 127,992,450 (-)NCBIMGSCv36mm8
Celera10130,961,356 - 130,981,519 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP)
allethrin  (ISO)
amphetamine  (ISO)
androgen antagonist  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capecitabine  (ISO)
captan  (EXP)
carbamazepine  (ISO)
casticin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
DDD  (ISO)
DDE  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fenvalerate  (ISO)
fisetin  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glucose  (ISO)
glycidol  (ISO)
hydrogen sulfide  (EXP)
L-methionine  (EXP)
lapatinib  (ISO)
lead diacetate  (ISO)
linuron  (ISO)
lithium chloride  (ISO)
LY294002  (ISO)
menadione  (ISO)
metformin  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-acetylcysteamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP)
prochloraz  (ISO)
procymidone  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tephrosin  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (EXP)
tunicamycin  (EXP)
uranium atom  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axonogenesis  (ISO)
cellular response to insulin stimulus  (ISO)
circadian rhythm  (ISO)
cranial nerve development  (IMP)
endocardial cushion development  (IMP)
epidermal growth factor receptor signaling pathway  (ISO)
ERBB2-ERBB3 signaling pathway  (IDA,IMP)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
mammary gland involution  (ISO)
motor neuron apoptotic process  (IMP)
myelination  (IMP)
negative regulation of apoptotic process  (IBA)
negative regulation of cell adhesion  (ISO)
negative regulation of motor neuron apoptotic process  (IMP)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of secretion  (ISO)
negative regulation of signal transduction  (ISO)
neurogenesis  (IBA)
neuron apoptotic process  (IMP,ISO)
peripheral nervous system development  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phosphorylation  (IEA)
positive regulation of calcineurin-NFAT signaling cascade  (IGI)
positive regulation of cardiac muscle tissue development  (IMP)
positive regulation of cell population proliferation  (IBA)
positive regulation of gene expression  (IMP)
positive regulation of glucose import  (ISO)
regulation of cell population proliferation  (ISO)
response to xenobiotic stimulus  (ISO)
Schwann cell development  (IMP)
Schwann cell differentiation  (IMP)
signal transduction  (ISO)
skeletal muscle tissue development  (ISO)
tongue development  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal gland morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal axon fasciculation  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain ventricular system morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cerebellar plate morphology  (IAGP)
abnormal cerebral aqueduct morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal cranial flexure morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryonic neuroepithelial layer differentiation  (IAGP)
abnormal enteric ganglia morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal glial cell morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland duct morphology  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mandibular nerve morphology  (IEA)
abnormal midbrain morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neocortex morphology  (IAGP)
abnormal nerve conduction  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal ophthalmic nerve morphology  (IEA)
abnormal pancreas morphology  (IAGP)
abnormal paravertebral ganglion morphology  (IAGP)
abnormal PNS glial cell morphology  (IAGP)
abnormal pontine flexure morphology  (IAGP)
abnormal prevertebral ganglion morphology  (IAGP)
abnormal spinal nerve morphology  (IEA)
abnormal stomach epithelium morphology  (IAGP)
abnormal superior cervical ganglion morphology  (IAGP)
abnormal sympathetic ganglion morphology  (IAGP)
abnormal sympathetic system morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal trigeminal nerve morphology  (IEA)
abnormal ventral spinal root morphology  (IAGP)
absent adrenergic chromaffin cells  (IAGP)
absent cerebellum vermis  (IAGP)
absent Schwann cell precursors  (IAGP)
absent Schwann cells  (IAGP)
atrioventricular valve regurgitation  (IAGP)
cerebellum hypoplasia  (IAGP)
cyanosis  (IAGP)
decreased birth weight  (IAGP)
decreased body weight  (IAGP)
decreased metastatic potential  (IAGP)
decreased myelin sheath thickness  (IAGP)
decreased noradrenaline level  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased Schwann cell number  (IAGP)
decreased tumor incidence  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
hypermyelination  (IAGP)
hypolactation  (IAGP)
hypopigmentation  (IAGP)
increased mammary gland apoptosis  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased tumor latency  (IAGP)
intestine polyps  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
motor neuron degeneration  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
no spontaneous movement  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
poor circulation  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
prenatal lethality, complete penetrance  (IEA)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
respiratory failure  (IAGP)
small dorsal root ganglion  (IAGP)
small nodose ganglion  (IAGP)
small petrosal ganglion  (IAGP)
small superior cervical ganglion  (IAGP)
thin atrioventricular cushion  (IAGP)
unresponsive to tactile stimuli  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. Amsellem-Ouazana D, etal., J Urol. 2006 Mar;175(3 Pt 1):1127-32.
2. ErbB receptors modulation in different types of peripheral nerve regeneration. Audisio C, etal., Neuroreport. 2008 Oct 29;19(16):1605-9. doi: 10.1097/WNR.0b013e32831313ef.
3. Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome. Begnami MD, etal., J Clin Oncol. 2011 Aug 1;29(22):3030-6. doi: 10.1200/JCO.2010.33.6313. Epub 2011 Jun 27.
4. c-erbB-3 protein expression in ductal carcinoma in situ of the breast. Bobrow LG, etal., Eur J Cancer. 1997 Oct;33(11):1846-50.
5. Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas: antioncogenic significance of the HER4 protein in laryngeal squamous cell carcinoma. Bussu F, etal., Laryngoscope. 2012 Aug;122(8):1724-33. doi: 10.1002/lary.23311. Epub 2012 May 1.
6. Neuregulin signaling on glucose transport in muscle cells. Canto C, etal., J Biol Chem. 2004 Mar 26;279(13):12260-8. Epub 2004 Jan 6.
7. Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. Carroll SL, etal., J Neurosci 1997 Mar 1;17(5):1642-59.
8. EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma. Chen HY, etal., Oncotarget. 2016 Feb 23;7(8):9017-25. doi: 10.18632/oncotarget.7029.
9. Bone microenvironment and androgen status modulate subcellular localization of ErbB3 in prostate cancer cells. Cheng CJ, etal., Mol Cancer Res. 2007 Jul;5(7):675-84.
10. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
11. Protein levels and gene expressions of the epidermal growth factor receptors, HER1, HER2, HER3 and HER4 in benign and malignant ovarian tumors. Dahl Steffensen K, etal., Int J Oncol. 2008 Jul;33(1):195-204.
12. HER family receptors expression in squamous cell carcinoma of the tongue: study of the possible prognostic and biological significance. Del Sordo R, etal., J Oral Pathol Med. 2010 Jan;39(1):79-86. doi: 10.1111/j.1600-0714.2009.00815.x. Epub 2009 Aug 18.
13. Expression of the epidermal growth factor system in endometrioid endometrial cancer. Ejskjaer K, etal., Gynecol Oncol. 2007 Jan;104(1):158-67. Epub 2006 Sep 7.
14. The prognostic significance of human epidermal growth factor receptor correlations in squamous cell cervical carcinoma. Fuchs I, etal., Anticancer Res. 2007 Mar-Apr;27(2):959-63.
15. Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. Ito Y, etal., Br J Cancer. 2001 May 18;84(10):1377-83. doi: 10.1054/bjoc.2000.1580.
16. Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients. Junttila TT, etal., Clin Cancer Res. 2003 Nov 1;9(14):5346-57.
17. Expression of the HER family mRNA in breast cancer tissue and association with cell cycle inhibitors p21(waf1) and p27(kip1). Kalemi TG, etal., Anticancer Res. 2007 Mar-Apr;27(2):913-20.
18. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
19. Low nuclear ErbB3 predicts biochemical recurrence in patients with prostate cancer. Koumakpayi IH, etal., BJU Int. 2007 Aug;100(2):303-9. Epub 2007 May 26.
20. Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas. Kountourakis P, etal., BMC Cancer. 2006 Feb 28;6:46. doi: 10.1186/1471-2407-6-46.
21. Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer. Lai WW, etal., Ann Thorac Surg. 2001 Dec;72(6):1868-76. doi: 10.1016/s0003-4975(01)03207-6.
22. Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway. Li M, etal., Nat Genet. 2014 Aug;46(8):872-6. doi: 10.1038/ng.3030. Epub 2014 Jul 6.
23. Soluble ErbB3 Levels in Bone Marrow and Plasma of Men with Prostate Cancer. Lin SH, etal., Clin Cancer Res. 2008 Jun 15;14(12):3729-36.
24. Expression of neuregulin and ErbB3 and ErbB4 after a traumatic lesion in the ventral funiculus of the spinal cord and in the intact primary olfactory system. Lindholm T, etal., Exp Brain Res. 2002 Jan;142(1):81-90. Epub 2001 Nov 9.
25. Prognostic significance of serum ERBB3 and ERBB4 mRNA in lung adenocarcinoma patients. Masroor M, etal., Tumour Biol. 2016 Jan;37(1):857-63. doi: 10.1007/s13277-015-3859-3. Epub 2015 Aug 9.
26. Gene-specific inhibition of breast carcinoma in BALB-neuT mice by active immunization with rat Neu or human ErbB receptors. Masuelli L, etal., Int J Oncol. 2007 Feb;30(2):381-92.
27. The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients. Memon AA, etal., Br J Cancer. 2006 Jun 5;94(11):1703-9.
28. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
29. MGDs mouse GO annotations MGD data from the GO Consortium
30. MGD IEA MGD IEA
31. Neuregulins and cancer. Montero JC, etal., Clin Cancer Res. 2008 Jun 1;14(11):3237-41. doi: 10.1158/1078-0432.CCR-07-5133.
32. Denervation and reinnervation of adult skeletal muscle modulate mRNA expression of neuregulin-1 and ErbB receptors. Nicolino S, etal., Microsurgery. 2009;29(6):464-72. doi: 10.1002/micr.20636.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. Mouse MP Annotation Import Pipeline RGD automated import pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Rodrigues-Ferreira S and Nahmias C, Trends Endocrinol Metab. 2010 Nov;21(11):684-90.
40. Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. Sassen A, etal., Breast Cancer Res. 2008 Jan 8;10(1):R2.
41. ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. Silva SD, etal., Oral Dis. 2010 Nov;16(8):774-80. doi: 10.1111/j.1601-0825.2010.01687.x.
42. Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer. Srinivasan R, etal., Clin Cancer Res. 1999 Oct;5(10):2877-83.
43. Phyllodes tumor of the breast: EGFR family expression and relation to clinicopathological features. Suo Z and Nesland JM, Ultrastruct Pathol. 2000 Nov-Dec;24(6):371-81.
44. ErbB-3 predicts survival in ovarian cancer. Tanner B, etal., J Clin Oncol. 2006 Sep 10;24(26):4317-23. Epub 2006 Aug 8.
45. ERBB3 as an independent prognostic marker for nasopharyngeal carcinoma. Tulalamba W, etal., J Clin Pathol. 2014 Aug;67(8):667-72. doi: 10.1136/jclinpath-2013-202154. Epub 2014 May 13.
46. Enhancement of erbB2 and erbB3 expression during oral oncogenesis in diabetic rats. Vairaktaris E, etal., J Cancer Res Clin Oncol. 2008 Mar;134(3):337-44. Epub 2007 Aug 18.
47. Multiple mouse chromosomal loci for dynein-based motility. Vaughan KT, etal., Genomics 1996 Aug 15;36(1):29-38.
48. A peptide antagonist of the ErbB1 receptor inhibits receptor activation, tumor cell growth and migration in vitro and xenograft tumor growth in vivo. Xu R, etal., Cell Oncol. 2010 Jan 1;32(4):259-74. doi: 10.3233/CLO-2010-0515.
Additional References at PubMed
PMID:2687875   PMID:7477375   PMID:7589796   PMID:7731691   PMID:8530075   PMID:8643489   PMID:8653788   PMID:8702723   PMID:8814290   PMID:8838799   PMID:8884266   PMID:9000438  
PMID:9070650   PMID:9168115   PMID:9173868   PMID:9247128   PMID:9262482   PMID:9305636   PMID:9338783   PMID:9342050   PMID:9344654   PMID:9362461   PMID:9504046   PMID:9539122  
PMID:9585504   PMID:9637684   PMID:9742126   PMID:9771475   PMID:9778496   PMID:9851845   PMID:10205169   PMID:10349636   PMID:10360575   PMID:10419687   PMID:10545246   PMID:10655590  
PMID:10704452   PMID:10707974   PMID:10762692   PMID:10821760   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11114734   PMID:11156606   PMID:11163240   PMID:11173924   PMID:11217851  
PMID:11276227   PMID:11325528   PMID:11337386   PMID:11412999   PMID:11425901   PMID:11440971   PMID:11641219   PMID:11694877   PMID:12044478   PMID:12045181   PMID:12112465   PMID:12134143  
PMID:12417529   PMID:12466851   PMID:12477932   PMID:12483526   PMID:12495620   PMID:12575949   PMID:12642503   PMID:12904583   PMID:12951658   PMID:14610273   PMID:14648841   PMID:14697354  
PMID:14975714   PMID:15044753   PMID:15096597   PMID:15254894   PMID:15306553   PMID:15322547   PMID:15475267   PMID:15489334   PMID:15496447   PMID:15524405   PMID:15682390   PMID:15691760  
PMID:15731393   PMID:15733067   PMID:16141072   PMID:16141073   PMID:16168116   PMID:16203963   PMID:16275754   PMID:16401639   PMID:16488402   PMID:16602821   PMID:16825286   PMID:16991114  
PMID:17203234   PMID:17274974   PMID:17332320   PMID:17336907   PMID:17452457   PMID:17478475   PMID:17638862   PMID:17638894   PMID:17822758   PMID:17960183   PMID:18036209   PMID:18426980  
PMID:18490922   PMID:18632642   PMID:18752272   PMID:18760695   PMID:18773073   PMID:18799693   PMID:19019207   PMID:19179536   PMID:19295126   PMID:19298847   PMID:19493314   PMID:19561085  
PMID:19659570   PMID:19690388   PMID:19748502   PMID:19837037   PMID:19936227   PMID:20126551   PMID:20300111   PMID:20360002   PMID:20410128   PMID:20457761   PMID:20626560   PMID:20628057  
PMID:20639901   PMID:20661224   PMID:20672328   PMID:21267068   PMID:21297994   PMID:21451047   PMID:21466799   PMID:21482676   PMID:21512138   PMID:21554097   PMID:21677750   PMID:21741919  
PMID:21782525   PMID:21839733   PMID:21873635   PMID:22157714   PMID:22178756   PMID:22183742   PMID:22274864   PMID:22328506   PMID:22376253   PMID:22461506   PMID:22493501   PMID:22504067  
PMID:22665265   PMID:22815787   PMID:22922260   PMID:22984073   PMID:23293290   PMID:23382219   PMID:23469020   PMID:23633485   PMID:23858437   PMID:23897819   PMID:24142862   PMID:24278323  
PMID:24364879   PMID:24493648   PMID:24925909   PMID:24925912   PMID:24945252   PMID:24952961   PMID:25038043   PMID:25079316   PMID:25204498   PMID:25488665   PMID:25564653   PMID:25596284  
PMID:25805134   PMID:26085643   PMID:26187852   PMID:26194695   PMID:26261492   PMID:26492920   PMID:26633882   PMID:26745185   PMID:26745281   PMID:26774483   PMID:26930157   PMID:26942872  
PMID:27017927   PMID:27122033   PMID:27586651   PMID:27732090   PMID:27782124   PMID:28304405   PMID:28322798   PMID:28414273   PMID:28684471   PMID:28886748   PMID:28981898   PMID:29031500  
PMID:29078343   PMID:30040984   PMID:30061196   PMID:30237243   PMID:30550785   PMID:30637799   PMID:30870413   PMID:31724799   PMID:31924792   PMID:32274496   PMID:32325033   PMID:33127760  
PMID:33259856   PMID:33340715   PMID:33497358   PMID:33500353   PMID:33505018   PMID:34490995   PMID:34686326   PMID:34714866   PMID:34843459   PMID:36765071   PMID:36916303   PMID:37385754  


Genomics

Comparative Map Data
Erbb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,403,392 - 128,425,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,403,392 - 128,425,521 (-)EnsemblGRCm39 Ensembl
GRCm3810128,567,523 - 128,589,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,567,523 - 128,589,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,006,424 - 128,026,557 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,972,317 - 127,992,450 (-)NCBIMGSCv36mm8
Celera10130,961,356 - 130,981,519 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.1NCBI
ERBB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,080,108 - 56,103,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,076,799 - 56,103,505 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,473,892 - 56,497,289 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,760,159 - 54,783,395 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,760,158 - 54,783,395NCBI
Celera1256,125,560 - 56,149,315 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,512,788 - 53,536,430 (+)NCBIHuRef
CHM1_11256,441,254 - 56,464,656 (+)NCBICHM1_1
T2T-CHM13v2.01256,047,558 - 56,071,109 (+)NCBIT2T-CHM13v2.0
Erbb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27994,549 - 1,015,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,758,331 - 3,777,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,634,321 - 5,653,694 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,932,064 - 5,951,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,989,202 - 3,010,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,989,340 - 3,010,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,962,964 - 2,984,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,858,057 - 1,877,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,858,056 - 1,877,353 (-)NCBI
Celera7866,587 - 885,873 (-)NCBICelera
Cytogenetic Map7q11NCBI
Erbb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,683,126 - 3,702,978 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,683,126 - 3,701,752 (+)NCBIChiLan1.0ChiLan1.0
ERBB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11238,224,995 - 38,248,393 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,811,533 - 32,834,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,062,681 - 33,085,426 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,063,434 - 33,084,994 (-)Ensemblpanpan1.1panPan2
ERBB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110406,856 - 424,746 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10406,633 - 424,264 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10468,642 - 486,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010416,919 - 431,621 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10417,394 - 431,614 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110391,236 - 409,084 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010634,155 - 651,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010758,352 - 776,205 (+)NCBIUU_Cfam_GSD_1.0
Erbb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,354,988 - 58,370,728 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646498,749 - 513,297 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936646497,783 - 515,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERBB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,474,475 - 21,495,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,474,218 - 21,495,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,085,940 - 23,092,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERBB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,020,912 - 52,043,809 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,021,058 - 52,044,028 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,941,255 - 193,963,311 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erbb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,905,271 - 11,925,707 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,906,279 - 11,925,530 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Erbb3
655 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:547
Count of miRNA genes:404
Interacting mature miRNAs:445
Transcripts:ENSMUST00000082059
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse
12911219Frct3b_mfear conditioning traits 3b (mouse)10127675574129466996Mouse
12911221Frct3d_mfear conditioning traits 3d (mouse)10127675574129466996Mouse
12904000Opfaq7_mopen field activity QTL 7 (mouse)10127746318129466375Mouse

Markers in Region
Erbb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,585,085 - 128,586,175UniSTSGRCm38
MGSCv3710128,022,141 - 128,023,231UniSTSGRCm37
Celera10130,977,103 - 130,978,193UniSTS
Cytogenetic Map10D3UniSTS
cM Map1070.0UniSTS
cM Map1070.0UniSTS
C76256  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,567,916 - 128,568,111UniSTSGRCm38
MGSCv3710128,004,972 - 128,005,167UniSTSGRCm37
Celera10130,959,904 - 130,960,099UniSTS
Cytogenetic Map10D3UniSTS
cM Map1070.0UniSTS
Whitehead/MRC_RH101374.83UniSTS
UniSTS:236490  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,567,910 - 128,568,173UniSTSGRCm38
MGSCv3710128,004,966 - 128,005,229UniSTSGRCm37
Celera10130,959,898 - 130,960,161UniSTS
Cytogenetic Map10D3UniSTS
cM Map1070.0UniSTS
Erbb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,570,097 - 128,570,269UniSTSGRCm38
MGSCv3710128,007,153 - 128,007,325UniSTSGRCm37
Celera10130,962,085 - 130,962,257UniSTS
Cytogenetic Map10D3UniSTS
cM Map1070.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000082059   ⟹   ENSMUSP00000080716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,403,392 - 128,425,521 (-)Ensembl
GRCm38.p6 Ensembl10128,567,523 - 128,589,652 (-)Ensembl
RefSeq Acc Id: NM_010153   ⟹   NP_034283
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,403,392 - 128,425,504 (-)NCBI
GRCm3810128,567,523 - 128,589,635 (-)NCBI
MGSCv3710128,006,424 - 128,026,557 (-)RGD
Celera10130,961,356 - 130,981,519 (-)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034283   ⟸   NM_010153
- Peptide Label: precursor
- UniProtKB: Q810U8 (UniProtKB/Swiss-Prot),   Q68J64 (UniProtKB/Swiss-Prot),   Q3KQR1 (UniProtKB/Swiss-Prot),   Q8K317 (UniProtKB/Swiss-Prot),   Q61526 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000080716   ⟸   ENSMUST00000082059
Protein Domains
Protein kinase   Receptor L-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61526-F1-model_v2 AlphaFold Q61526 1-1339 view protein structure

Promoters
RGD ID:6819266
Promoter ID:MM_KWN:6007
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:OTTMUST00000074150
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610128,026,356 - 128,026,957 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95411 AgrOrtholog
Ensembl Genes ENSMUSG00000018166 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000080716 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000082059 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.20.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Furin-like_Cys-rich_dom UniProtKB/Swiss-Prot
  Furin_repeat UniProtKB/Swiss-Prot
  GF_recep_IV UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Rcpt_L-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_EGF/ERB/XmrK_rcpt UniProtKB/Swiss-Prot
KEGG Report mmu:13867 UniProtKB/Swiss-Prot
MGD MGI:95411 ENTREZGENE
NCBI Gene 13867 ENTREZGENE
PANTHER RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
Pfam Furin-like UniProtKB/Swiss-Prot
  GF_recep_IV UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  Recep_L_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ERBB3 RGD
PhenoGen Erbb3 PhenoGen
PIRSF TyrPK_EGF-R UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
SMART SM00261 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt ERBB3_MOUSE UniProtKB/Swiss-Prot
  O88458_MOUSE UniProtKB/TrEMBL
  Q3KQR1 ENTREZGENE
  Q61526 ENTREZGENE
  Q68J64 ENTREZGENE
  Q810U8 ENTREZGENE
  Q8K317 ENTREZGENE
UniProt Secondary Q3KQR1 UniProtKB/Swiss-Prot
  Q68J64 UniProtKB/Swiss-Prot
  Q810U8 UniProtKB/Swiss-Prot
  Q8K317 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Erbb3  erb-b2 receptor tyrosine kinase 3    v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)  Symbol and/or name change 5135510 APPROVED