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Gene: Erbb3 (erb-b2 receptor tyrosine kinase 3) Mus musculus
Symbol: Erbb3
Name: erb-b2 receptor tyrosine kinase 3
RGD ID: 736142
Description: Predicted to have several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and transmembrane signaling receptor activity. Involved in several processes, including nervous system development; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cardiac muscle tissue development. Localizes to apical plasma membrane and lateral plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; epidermal growth factor/neuregulin signaling pathway; endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: avian erythroblastosis oncogene B 3 receptor; c-erbB-3; C76256; Erbb; Erbb-; Erbb-3; Erbb3r; glial growth factor receptor; HER; Her3; MGC117742; proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
Homo sapiens (human) : ERBB3 (erb-b2 receptor tyrosine kinase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Erbb3 (erb-b2 receptor tyrosine kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erbb3 (erb-b2 receptor tyrosine kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ERBB3 (erb-b2 receptor tyrosine kinase 3)
Canis lupus familiaris (dog) : ERBB3 (erb-b2 receptor tyrosine kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Erbb3 (erb-b2 receptor tyrosine kinase 3)
Sus scrofa (pig) : ERBB3 (erb-b2 receptor tyrosine kinase 3)
Chlorocebus sabaeus (African green monkey) : ERBB3 (erb-b2 receptor tyrosine kinase 3)
Heterocephalus glaber (naked mole-rat) : Erbb3 (erb-b2 receptor tyrosine kinase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910128,403,392 - 128,425,504 (-)NCBI
GRCm3810128,567,523 - 128,589,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,567,523 - 128,589,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,006,424 - 128,026,557 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610127,972,317 - 127,992,450 (-)NCBImm8
Celera10130,961,356 - 130,981,519 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Erbb3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736142
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.