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Gene: Erbb2 (erb-b2 receptor tyrosine kinase 2) Mus musculus
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Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
RGD ID: 10533
Description: Predicted to contribute to growth factor binding activity. Involved in several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and positive regulation of macromolecule metabolic process. Localizes to apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in malignant glioma; mammary Paget's disease; prostate cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: avian erythroblastosis oncogene B 2; c-erbB; c-erbB-2; c-erbB2; c-ne; c-neu; ErbB-; Erbb-2; HER; HER-; HER-2; HER2; l11Ju; l11Jus8; mKIAA3023; Ne; Neu; Neu oncogene; p185erbB2; proto-oncogene c-ErbB-2; proto-oncogene NEU; receptor tyrosine-protein kinase erbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Orthologs:
Homo sapiens (human) : ERBB2 (erb-b2 receptor tyrosine kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Erbb2 (erb-b2 receptor tyrosine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erbb2 (erb-b2 receptor tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
Canis lupus familiaris (dog) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Erbb2 (erb-b2 receptor tyrosine kinase 2)
Sus scrofa (pig) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
Chlorocebus sabaeus (African green monkey) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
Heterocephalus glaber (naked mole-rat) : Erbb2 (erb-b2 receptor tyrosine kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1198,412,470 - 98,437,716 (+)EnsemblGRCm38mm10GRCm38
GRCm381198,412,484 - 98,437,716 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371198,273,798 - 98,299,030 (+)NCBIGRCm37mm9NCBIm37
MGSCv361198,228,574 - 98,253,806 (+)NCBImm8
Celera11108,066,701 - 108,091,920 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Erbb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10533
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-15
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.