Fasn (fatty acid synthase) - Rat Genome Database

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Gene: Fasn (fatty acid synthase) Mus musculus
Analyze
Symbol: Fasn
Name: fatty acid synthase
RGD ID: 1615200
MGI Page MGI
Description: Enables fatty acid synthase activity. Involved in ether lipid biosynthetic process; mammary gland development; and myeloid leukocyte differentiation. Acts upstream of or within cellular response to interleukin-4; epithelial cell development; and fatty acid biosynthetic process. Located in glycogen granule. Is expressed in several structures, including adipose tissue; alimentary system; integumental system; nervous system; and sensory organ. Orthologous to human FASN (fatty acid synthase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A630082H08Rik; F; FAS; type I Fatty Acid Synthase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,696,784 - 120,715,992 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,696,672 - 120,715,373 (-)EnsemblGRCm39 Ensembl
GRCm3811120,805,958 - 120,825,166 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,805,846 - 120,824,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,667,272 - 120,685,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,623,167 - 120,640,332 (-)NCBIMGSCv36mm8
Celera11132,542,449 - 132,561,038 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-catechin  (EXP,ISO)
(+)-pinoresinol  (ISO)
(+/-)-Aegeline  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (ISO)
(R)-linalyl acetate  (ISO)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,8-cineole  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-benzylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2,5-hexanedione  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4'-Methoxychalcone  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-tert-Octylphenol  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7,12-dimethyltetraphene  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acarbose  (ISO)
acetamide  (ISO)
acetamiprid  (ISO)
Acetyl tributyl citrate  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alcohol  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alliin  (ISO)
allopurinol  (ISO)
alpha-linolenic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
amlexanox  (EXP)
amphotericin B  (EXP)
ampicillin  (EXP)
andrographolide  (EXP)
antimony(0)  (EXP)
antimycin A  (ISO)
apigenin  (EXP)
arachidonic acid  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azoxystrobin  (EXP,ISO)
baicalein  (EXP)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzyl parahydroxybenzoate  (EXP,ISO)
benzylpenicillin  (EXP)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (EXP,ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
bexarotene  (ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
boric acid  (EXP)
brexpiprazole  (ISO)
bromobenzene  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
camphor  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP,ISO)
carvedilol  (ISO)
celecoxib  (EXP)
cerulenin  (EXP,ISO)
chenodeoxycholic acid  (EXP)
chitosan  (ISO)
chloroethene  (EXP)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chlorothalonil  (EXP)
chlorpyrifos  (EXP,ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
ciguatoxin CTX1B  (EXP)
cis-caffeic acid  (EXP,ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corn oil  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumarin  (ISO)
crizotinib  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP,ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
deoxypodophyllotoxin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (EXP)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
dihydroartemisinin  (ISO)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
Diosbulbin B  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (EXP)
elemental selenium  (EXP,ISO)
Elemicin  (EXP)
endosulfan  (ISO)
endrin  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
erythromycin A  (EXP)
erythromycin estolate  (ISO)
esculetin  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (EXP)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
ferulic acid  (EXP)
fipronil  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fructooligosaccharide  (EXP)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
gadolinium trichloride  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (EXP,ISO)
Gastrodin  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
Geraniin  (EXP)
geraniol  (ISO)
gingerol  (EXP)
glafenine  (ISO)
glucagon  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycine betaine  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
guggulsterone  (EXP)
GW 3965  (EXP,ISO)
GW 4064  (ISO)
GW 6471  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
herbacetin  (EXP)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrazines  (EXP)
ibuprofen  (ISO)
indinavir  (EXP)
indometacin  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
ivermectin  (EXP,ISO)
kahweol  (ISO)
L-methionine  (EXP,ISO)
lamivudine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
Lipstatin  (ISO)
lithocholic acid  (EXP)
loliolide  (ISO)
losartan  (ISO)
lovastatin  (ISO)
luteolin  (EXP)
LY294002  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
metronidazole  (EXP)
mevalonic acid  (ISO)
miconazole  (EXP)
microcystin-LR  (EXP)
mifepristone  (ISO)
Mitotane  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP,ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (EXP,ISO)
morin  (EXP)
motexafin gadolinium  (ISO)
myriocin  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Phenylmaleimide  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (ISO)
naringin  (EXP)
nefazodone  (ISO)
nelfinavir  (ISO)
neomycin  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
NMN zwitterion  (EXP)
nordihydroguaiaretic acid  (ISO)
norethisterone  (ISO)
Norethynodrel  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
Octicizer  (EXP)
olanzapine  (EXP)
olaparib  (EXP)
oleic acid  (EXP,ISO)
oleuropein  (ISO)
Olmesartan medoxomil  (ISO)
orlistat  (EXP,ISO)
orotic acid  (ISO)
oroxylin A  (EXP,ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paxilline  (ISO)
PD 0325901  (ISO)
penconazole  (EXP)
pendimethalin  (ISO)
perfluorobutanesulfonic acid  (EXP,ISO)
perfluorobutyric acid  (EXP,ISO)
perfluorodecanoic acid  (EXP,ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phosphatidylcholine  (ISO)
phosphocholine  (ISO)
phosphorylcholine chloride  (ISO)
pimecrolimus  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (EXP)
propamocarb  (EXP)
propiconazole  (ISO)
Propiverine  (ISO)
propylparaben  (EXP)
prostaglandin E2  (EXP)
protein kinase inhibitor  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (EXP)
PX-866  (EXP)
pyriproxyfen  (EXP)
pyrroloquinoline quinone  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raffinose  (EXP,ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
rimonabant  (EXP)
ritonavir  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
S-allylcysteine  (ISO)
sabinene  (ISO)
SB 431542  (ISO)
scopoletin  (ISO)
selenium atom  (EXP,ISO)
sildenafil citrate  (EXP)
silibinin  (EXP,ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Sodium oleate  (EXP)
spathulenol  (ISO)
stavudine  (EXP)
steviol  (EXP)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulconazole  (ISO)
sulfluramid  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
taurine  (EXP)
tebuconazole  (ISO)
tectorigenin  (EXP)
temozolomide  (ISO)
teriflunomide  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thiazolidinediones  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
trametinib  (ISO)
trans-caffeic acid  (EXP,ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triclocarban  (ISO)
triclosan  (EXP,ISO)
triolein  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tungsten  (EXP)
tunicamycin  (EXP,ISO)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
Valilactone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vanillic acid  (ISO)
vemurafenib  (ISO)
vitamin D  (ISO)
voriconazole  (ISO)
vorinostat  (ISO)
withaferin A  (EXP)
yohimbine  (EXP)
zearalenone  (EXP)
zidovudine  (EXP,ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
glycogen granule  (IDA)
Golgi apparatus  (IEA,ISO)
melanosome  (IEA)
mitochondrion  (HDA)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics. Gertz K, etal., Exp Neurol. 2018 Aug;306:34-44. doi: 10.1016/j.expneurol.2018.04.004. Epub 2018 Apr 21.
3. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
4. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Menendez JA and Lupu R, Nat Rev Cancer. 2007 Oct;7(10):763-77.
5. Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer. Menendez JA, etal., Clin Chem. 2009 Mar;55(3):425-38. Epub 2009 Jan 30.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates. Rendina AR and Cheng D, Biochem J. 2005 Jun 15;388(Pt 3):895-903.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. Silva SD, etal., Oral Dis. 2010 Nov;16(8):774-80. doi: 10.1111/j.1601-0825.2010.01687.x.
12. AZGP1 suppresses the process of colorectal cancer after upregulating FASN expression via mTOR signal pathway. Yu W, etal., Gen Physiol Biophys. 2020 May;39(3):239-248. doi: 10.4149/gpb_2019061.
13. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:2452820   PMID:2920037   PMID:7506544   PMID:7595075   PMID:7803821   PMID:8043949   PMID:8075499   PMID:8661038   PMID:8833906   PMID:9096121   PMID:9271675   PMID:9367675  
PMID:9798653   PMID:9890958   PMID:9922208   PMID:10341080   PMID:10349636   PMID:10409670   PMID:10464095   PMID:10725249   PMID:10922068   PMID:10982846   PMID:11029661   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11254743   PMID:11756683   PMID:12376313   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12588883   PMID:12738878   PMID:12897158   PMID:12904583  
PMID:14522948   PMID:14610273   PMID:14662765   PMID:14668353   PMID:14681479   PMID:15169678   PMID:15306695   PMID:15489334   PMID:15707987   PMID:15782199   PMID:16054078   PMID:16054098  
PMID:16141072   PMID:16141073   PMID:16203972   PMID:16498401   PMID:16894240   PMID:17369526   PMID:17694178   PMID:17786030   PMID:18079124   PMID:18307411   PMID:18591393   PMID:18614015  
PMID:18635971   PMID:18682402   PMID:18706411   PMID:18722179   PMID:18770866   PMID:19029118   PMID:20479009   PMID:20606731   PMID:20657840   PMID:20890301   PMID:21093383   PMID:21098489  
PMID:21180279   PMID:21267068   PMID:21281598   PMID:21387314   PMID:21389266   PMID:21677750   PMID:21757749   PMID:21873635   PMID:22055502   PMID:22096492   PMID:22331133   PMID:22341463  
PMID:22794259   PMID:22863804   PMID:22872236   PMID:22922362   PMID:23000407   PMID:23201681   PMID:23260145   PMID:23269672   PMID:23376793   PMID:23637738   PMID:23675653   PMID:23727646  
PMID:24154525   PMID:24223732   PMID:24275123   PMID:24457600   PMID:24668799   PMID:24717294   PMID:25249504   PMID:25340345   PMID:25565205   PMID:25655684   PMID:25955199   PMID:26220403  
PMID:26370502   PMID:26439735   PMID:26508642   PMID:26670611   PMID:26685326   PMID:26857837   PMID:26910791   PMID:27113764   PMID:27133129   PMID:27307439   PMID:27416896   PMID:27524625  
PMID:27545894   PMID:27746183   PMID:27754788   PMID:27806377   PMID:27858140   PMID:27974211   PMID:28118080   PMID:28281280   PMID:28378742   PMID:28752043   PMID:28848043   PMID:29385670  
PMID:29434029   PMID:29463677   PMID:29475397   PMID:30146486   PMID:30333137   PMID:30425250   PMID:30550785   PMID:30562941   PMID:30713523   PMID:30898933   PMID:30962418   PMID:31063129  
PMID:31287803   PMID:31358769   PMID:31405565   PMID:31545012   PMID:31676791   PMID:31693883   PMID:31811668   PMID:32035613   PMID:32325033   PMID:32386572   PMID:32554809   PMID:32694609  
PMID:32755590   PMID:32892421   PMID:32994417   PMID:33059001   PMID:33128541   PMID:33166087   PMID:33888555   PMID:34048454   PMID:34231239   PMID:34348145   PMID:34723832   PMID:34996870  
PMID:35076948   PMID:35733999   PMID:35742953   PMID:35863637   PMID:36114006   PMID:36421460   PMID:36469534   PMID:36640260   PMID:36651176   PMID:36914626   PMID:37142655   PMID:37163372  
PMID:37249651   PMID:37270622   PMID:37377173   PMID:37541847   PMID:37606038   PMID:37640697   PMID:37681411   PMID:37726733   PMID:38042368   PMID:38167725   PMID:38167727   PMID:38206764  
PMID:38732103   PMID:38878833   PMID:38972757  


Genomics

Comparative Map Data
Fasn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,696,784 - 120,715,992 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,696,672 - 120,715,373 (-)EnsemblGRCm39 Ensembl
GRCm3811120,805,958 - 120,825,166 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,805,846 - 120,824,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,667,272 - 120,685,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,623,167 - 120,640,332 (-)NCBIMGSCv36mm8
Celera11132,542,449 - 132,561,038 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.56NCBI
FASN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,078,338 - 82,098,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1782,078,338 - 82,098,294 (-)EnsemblGRCh38hg38GRCh38
GRCh371780,036,214 - 80,056,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,629,503 - 77,649,395 (-)NCBINCBI36Build 36hg18NCBI36
Build 341777,629,503 - 77,649,395NCBI
Celera1776,630,560 - 76,648,850 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,436,168 - 75,456,057 (-)NCBIHuRef
CHM1_11780,122,440 - 80,142,272 (-)NCBICHM1_1
T2T-CHM13v2.01782,945,493 - 82,965,389 (-)NCBIT2T-CHM13v2.0
Fasn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,570,415 - 106,588,581 (-)NCBIGRCr8
mRatBN7.210106,072,093 - 106,090,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,072,091 - 106,090,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10111,176,141 - 111,194,306 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,639,183 - 110,657,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,992,540 - 106,010,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,987,735 - 110,005,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,987,735 - 110,005,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,579,051 - 109,597,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10104,615,873 - 104,634,039 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Fasn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,063,002 - 1,079,939 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,063,002 - 1,079,939 (+)NCBIChiLan1.0ChiLan1.0
FASN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,613,649 - 98,633,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,514,379 - 103,534,420 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,483,108 - 76,503,148 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,187,516 - 82,205,647 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,187,516 - 82,205,647 (-)Ensemblpanpan1.1panPan2
FASN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19233,105 - 249,573 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9232,963 - 249,092 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha9835,096 - 852,365 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09826,552 - 843,813 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9825,448 - 843,670 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19851,506 - 868,761 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.09978,401 - 995,678 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,056,702 - 1,073,992 (+)NCBIUU_Cfam_GSD_1.0
Fasn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602802,978 - 820,174 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,592,609 - 5,608,972 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,591,785 - 5,609,886 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12920,509 - 937,561 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112922,405 - 937,560 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,023,512 - 1,032,662 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,988,410 - 74,008,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,982,899 - 74,006,551 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,523,735 - 45,543,679 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fasn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,909,647 - 10,927,547 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,910,022 - 10,926,505 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fasn
329 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1309
Count of miRNA genes:664
Interacting mature miRNAs:798
Transcripts:ENSMUST00000055655, ENSMUST00000146541, ENSMUST00000155276
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
Fasn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3711120,668,414 - 120,668,555UniSTSGRCm37
MGSCv3711120,670,530 - 120,670,786UniSTSGRCm37
Celera11132,545,707 - 132,545,963UniSTS
Celera11132,543,591 - 132,543,732UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
cM Map1172.0UniSTS
UniSTS:236790  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,806,175 - 120,806,436UniSTSGRCm38
MGSCv3711120,667,489 - 120,667,750UniSTSGRCm37
Celera11132,542,666 - 132,542,927UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
PMC156147P10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,809,451 - 120,809,561UniSTSGRCm38
MGSCv3711120,670,765 - 120,670,875UniSTSGRCm37
Celera11132,545,942 - 132,546,052UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
PMC164451P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,815,605 - 120,815,970UniSTSGRCm38
MGSCv3711120,676,919 - 120,677,284UniSTSGRCm37
Celera11132,552,096 - 132,552,461UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
UniSTS:225262  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,821,996 - 120,822,192UniSTSGRCm38
MGSCv3711120,683,310 - 120,683,506UniSTSGRCm37
Celera11132,558,487 - 132,558,683UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
PMC166350P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,823,952 - 120,824,218UniSTSGRCm38
MGSCv3711120,685,266 - 120,685,532UniSTSGRCm37
Celera11132,560,443 - 132,560,709UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
PMC166350P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,811,304 - 120,811,476UniSTSGRCm38
MGSCv3711120,672,618 - 120,672,790UniSTSGRCm37
Celera11132,547,795 - 132,547,967UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
PMC207565P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,818,048 - 120,818,130UniSTSGRCm38
MGSCv3711120,679,362 - 120,679,444UniSTSGRCm37
Celera11132,554,539 - 132,554,621UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
Fasn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,809,216 - 120,809,472UniSTSGRCm38
MGSCv3711120,670,530 - 120,670,786UniSTSGRCm37
Celera11132,545,707 - 132,545,963UniSTS
Cytogenetic Map11E2UniSTS
Fasn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,807,100 - 120,807,241UniSTSGRCm38
MGSCv3711120,668,414 - 120,668,555UniSTSGRCm37
Celera11132,543,591 - 132,543,732UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
Fasn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF127033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ125823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000055655   ⟹   ENSMUSP00000052872
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,696,672 - 120,715,373 (-)Ensembl
GRCm38.p6 Ensembl11120,805,846 - 120,824,547 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146541
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,699,390 - 120,700,527 (-)Ensembl
GRCm38.p6 Ensembl11120,808,564 - 120,809,701 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155276
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,698,373 - 120,699,431 (-)Ensembl
GRCm38.p6 Ensembl11120,807,547 - 120,808,605 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205905   ⟹   ENSMUSP00000146068
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,713,598 - 120,714,606 (-)Ensembl
GRCm38.p6 Ensembl11120,822,772 - 120,823,780 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206589   ⟹   ENSMUSP00000145585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,697,931 - 120,714,921 (-)Ensembl
GRCm38.p6 Ensembl11120,807,105 - 120,824,095 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206637
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,705,321 - 120,706,281 (-)Ensembl
GRCm38.p6 Ensembl11120,814,495 - 120,815,455 (-)Ensembl
RefSeq Acc Id: NM_007988   ⟹   NP_032014
RefSeq Status: VALIDATED
Type: CODING