ERBB3 (erb-b2 receptor tyrosine kinase 3)

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Gene: ERBB3 (erb-b2 receptor tyrosine kinase 3) Pan paniscus

Analyze

Symbol:

ERBB3

Name:

erb-b2 receptor tyrosine kinase 3

RGD ID:

11724570

Description:

ENCODES a protein that exhibits ErbB-3 class receptor binding (ortholog); growth factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); circadian rhythm (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); bladder urothelial carcinoma (ortholog); breast cancer (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

receptor tyrosine-protein kinase erbB-3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	33,062,681 - 33,085,426 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,063,434 - 33,084,994 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	32,811,533 - 32,834,958 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Erythroleukemia (ISO)

bladder urothelial carcinoma (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

chronic obstructive pulmonary disease (ISO)

Colonic Neoplasms (ISO)

Colorectal Neoplasms (ISO)

disease of cellular proliferation (ISO)

Disease Progression (ISO)

ductal carcinoma in situ (ISO)

Endometrial Neoplasms (ISO)

Endometrioid Carcinomas (ISO)

Familial Erythroleukemia (ISO)

gallbladder carcinoma (ISO)

Gallbladder Neoplasms (ISO)

gastric adenocarcinoma (ISO)

lethal congenital contracture syndrome 2 (ISO)

Lung Neoplasms (ISO)

Lymphatic Metastasis (ISO)

Mammary Neoplasms, Experimental (ISO)

median neuropathy (ISO)

Mouth Neoplasms (ISO)

Neoplasm Metastasis (ISO)

Ovarian Neoplasms (ISO)

Phyllodes Tumor (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

Recurrence (ISO)

Spinal Cord Injuries (ISO)

Stomach Neoplasms (ISO)

transitional cell carcinoma (ISO)

urinary bladder cancer (ISO)

uterine cancer (ISO)

uterine carcinosarcoma (ISO)

Uterine Cervical Neoplasms (ISO)

Wallerian Degeneration (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonogenesis (ISO)

cellular response to insulin stimulus (ISO)

circadian rhythm (ISO)

cranial nerve development (ISO)

endocardial cushion development (ISO)

epidermal growth factor receptor signaling pathway (ISO)

extrinsic apoptotic signaling pathway in absence of ligand (ISO)

mammary gland involution (ISO)

negative regulation of cell adhesion (ISO)

negative regulation of neuron apoptotic process (ISO)

negative regulation of secretion (ISO)

negative regulation of signal transduction (ISO)

neuron apoptotic process (ISO)

odontogenesis (ISO)

peripheral nervous system development (ISO)

phosphatidylinositol 3-kinase signaling (ISO)

positive regulation of calcineurin-NFAT signaling cascade (ISO)

positive regulation of cardiac muscle tissue development (ISO)

positive regulation of gene expression (ISO)

positive regulation of glucose import (ISO)

positive regulation of protein tyrosine kinase activity (ISO)

regulation of cell population proliferation (ISO)

response to drug (ISO)

response to wounding (ISO)

Schwann cell differentiation (ISO)

signal transduction (ISO)

skeletal muscle tissue development (ISO)

tongue development (ISO)

Cellular Component

apical part of cell (ISO)

apical plasma membrane (ISO)

basolateral plasma membrane (ISO)

cytoplasm (ISO)

ERBB3:ERBB2 complex (ISO)

extracellular space (ISO)

lateral plasma membrane (ISO)

nucleus (ISO)

postsynaptic membrane (ISO)

receptor complex (ISO)

Molecular Function

ErbB-3 class receptor binding (ISO)

growth factor binding (ISO)

identical protein binding (ISO)

neuregulin binding (ISO)

neuregulin receptor activity (ISO)

protein binding (ISO)

protein heterodimerization activity (ISO)

protein tyrosine kinase activator activity (ISO)

protein tyrosine kinase activity (ISO)

ubiquitin protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

angiotensin II signaling pathway via AT2 receptor (ISO)

epidermal growth factor/neuregulin signaling pathway (ISO)

References

Genomics

Comparative Map Data

ERBB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	33,062,681 - 33,085,426 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,063,434 - 33,084,994 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	32,811,533 - 32,834,958 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

ERBB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	56,076,799 - 56,103,505 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	56,080,108 - 56,103,505 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	56,473,892 - 56,497,289 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	54,760,159 - 54,783,395 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	12	54,760,158 - 54,783,395	NCBI
Celera	12	56,125,560 - 56,149,315 (+)	NCBI
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	53,512,788 - 53,536,430 (+)	NCBI		HuRef
CHM1_1	12	56,441,254 - 56,464,656 (+)	NCBI		CHM1_1

Erbb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,403,392 - 128,425,504 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	10	128,403,392 - 128,425,521 (-)	Ensembl
GRCm38	10	128,567,523 - 128,589,635 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,567,523 - 128,589,652 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	128,006,424 - 128,026,557 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	127,972,317 - 127,992,450 (-)	NCBI			mm8
Celera	10	130,961,356 - 130,981,519 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	77.1	NCBI

Erbb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	994,549 - 1,015,876 (-)	NCBI
Rnor_6.0 Ensembl	7	2,989,340 - 3,010,350 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	2,989,202 - 3,010,610 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	2,962,964 - 2,984,938 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,858,057 - 1,877,353 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	1,858,056 - 1,877,353 (-)	NCBI
Celera	7	866,587 - 885,873 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Erbb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,683,126 - 3,702,978 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,683,126 - 3,701,752 (+)	NCBI	ChiLan1.0	ChiLan1.0

ERBB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	10	406,633 - 424,264 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	10	406,856 - 424,746 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Erbb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936646	497,783 - 515,247 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ERBB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	21,431,656 - 21,496,279 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	21,474,218 - 21,495,040 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	23,085,940 - 23,092,633 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ERBB3
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	52,020,912 - 52,043,809 (+)	NCBI
ChlSab1.1 Ensembl	11	52,021,058 - 52,044,028 (+)	Ensembl

Erbb3
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624802	11,906,279 - 11,925,530 (-)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_034935667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034935669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034935670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000047421 ⟹ ENSPPAP00000024596

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	33,063,434 - 33,084,994 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000047429 ⟹ ENSPPAP00000024604

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	33,063,434 - 33,084,994 (-)	Ensembl

RefSeq Acc Id:

XM_034935667 ⟹ XP_034791558

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	12	32,811,533 - 32,834,958 (-)	NCBI

RefSeq Acc Id:

XM_034935669 ⟹ XP_034791560

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	12	32,811,533 - 32,831,698 (-)	NCBI

RefSeq Acc Id:

XM_034935670 ⟹ XP_034791561

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	12	32,811,533 - 32,829,369 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_034791558	(Get FASTA)	NCBI Sequence Viewer
	XP_034791560	(Get FASTA)	NCBI Sequence Viewer
	XP_034791561	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_034791558 ⟸ XM_034935667
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_034791560 ⟸ XM_034935669
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_034791561 ⟸ XM_034935670
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSPPAP00000024604 ⟸ ENSPPAT00000047429

RefSeq Acc Id:

ENSPPAP00000024596 ⟸ ENSPPAT00000047421

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000035409	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000024596	UniProtKB/TrEMBL
	ENSPPAP00000024604	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000047421	UniProtKB/TrEMBL
	ENSPPAT00000047429	UniProtKB/TrEMBL
Gene3D-CATH	3.80.20.20	UniProtKB/TrEMBL
InterPro	Furin-like_Cys-rich_dom	UniProtKB/TrEMBL
	Furin_repeat	UniProtKB/TrEMBL
	GF_recep_IV	UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Rcpt_L-dom	UniProtKB/TrEMBL
	Rcpt_L-dom_sf	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Tyr_kinase_EGF/ERB/XmrK_rcpt	UniProtKB/TrEMBL
NCBI Gene	ERBB3	ENTREZGENE
Pfam	Furin-like	UniProtKB/TrEMBL
	GF_recep_IV	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
	Recep_L_domain	UniProtKB/TrEMBL
PIRSF	TyrPK_EGF-R	UniProtKB/TrEMBL
PRINTS	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
SMART	SM00261	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
UniProt	A0A2R9B6A5_PANPA	UniProtKB/TrEMBL
	A0A2R9BBP6_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)