ERBB3 (erb-b2 receptor tyrosine kinase 3) - Rat Genome Database

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Gene: ERBB3 (erb-b2 receptor tyrosine kinase 3) Sus scrofa
Analyze
Symbol: ERBB3
Name: erb-b2 receptor tyrosine kinase 3
RGD ID: 14112474
Description: ENCODES a protein that exhibits growth factor binding (ortholog); neuregulin binding (ortholog); neuregulin receptor activity (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); circadian rhythm (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH bladder urothelial carcinoma (ortholog); Breast Neoplasms (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN apical part of cell (ortholog); cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: receptor tyrosine-protein kinase erbB-3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,431,656 - 21,496,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,474,218 - 21,495,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,085,940 - 23,092,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axonogenesis  (ISO)
cellular response to insulin stimulus  (ISO)
circadian rhythm  (ISO)
cranial nerve development  (IEA,ISO)
endocardial cushion development  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
mammary gland involution  (ISO)
negative regulation of cell adhesion  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of secretion  (IEA)
negative regulation of signal transduction  (IEA)
nervous system development  (IBA)
neuron apoptotic process  (IEA)
odontogenesis  (ISO)
peptidyl-tyrosine phosphorylation  (IEA)
peripheral nervous system development  (ISO)
phosphatidylinositol 3-kinase signaling  (IEA)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cardiac muscle tissue development  (IEA,ISO)
positive regulation of cell population proliferation  (IBA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glucose import  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of protein tyrosine kinase activity  (IEA)
protein phosphorylation  (IEA)
regulation of cell population proliferation  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
Schwann cell differentiation  (IEA,ISO)
signal transduction  (ISO)
skeletal muscle tissue development  (ISO)
tongue development  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
ERBB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,431,656 - 21,496,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,474,218 - 21,495,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,085,940 - 23,092,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERBB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1256,076,799 - 56,103,505 (+)EnsemblGRCh38hg38GRCh38
GRCh381256,080,108 - 56,103,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,473,892 - 56,497,289 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,760,159 - 54,783,395 (+)NCBINCBI36hg18NCBI36
Build 341254,760,158 - 54,783,395NCBI
Celera1256,125,560 - 56,149,315 (+)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1253,512,788 - 53,536,430 (+)NCBIHuRef
CHM1_11256,441,254 - 56,464,656 (+)NCBICHM1_1
Erbb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,403,392 - 128,425,504 (-)NCBIGRCm39mm39
GRCm39 Ensembl10128,403,392 - 128,425,521 (-)Ensembl
GRCm3810128,567,523 - 128,589,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,567,523 - 128,589,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,006,424 - 128,026,557 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610127,972,317 - 127,992,450 (-)NCBImm8
Celera10130,961,356 - 130,981,519 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.1NCBI
Erbb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27994,549 - 1,015,876 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)Ensembl
Rnor_6.072,989,202 - 3,010,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,989,340 - 3,010,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,962,964 - 2,984,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,858,057 - 1,877,353 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,858,056 - 1,877,353 (-)NCBI
Celera7866,587 - 885,873 (-)NCBICelera
Cytogenetic Map7q11NCBI
Erbb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,683,126 - 3,702,978 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,683,126 - 3,701,752 (+)NCBIChiLan1.0ChiLan1.0
ERBB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11233,062,681 - 33,085,426 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,063,434 - 33,084,994 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,811,533 - 32,834,958 (-)NCBIMhudiblu_PPA_v0panPan3
ERBB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110406,856 - 424,746 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10406,633 - 424,264 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10468,642 - 486,495 (+)NCBI
ROS_Cfam_1.010416,919 - 431,621 (+)NCBI
UMICH_Zoey_3.110391,236 - 409,084 (+)NCBI
UNSW_CanFamBas_1.010634,155 - 651,980 (+)NCBI
UU_Cfam_GSD_1.010758,352 - 776,205 (+)NCBI
Erbb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,354,988 - 58,370,728 (-)NCBI
SpeTri2.0NW_004936646497,783 - 515,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERBB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,020,912 - 52,043,809 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,021,058 - 52,044,028 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,941,255 - 193,963,311 (-)NCBIVero_WHO_p1.0
Erbb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480211,906,279 - 11,925,530 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 11 2 3 1
Low 2 4 3 4 2 12
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000027288   ⟹   ENSSSCP00000019799
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl521,474,476 - 21,496,279 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000037734   ⟹   ENSSSCP00000032875
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl521,431,656 - 21,495,038 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000053677   ⟹   ENSSSCP00000042037
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl521,491,665 - 21,495,037 (+)Ensembl
RefSeq Acc Id: XM_021091799   ⟹   XP_020947458
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1521,474,218 - 21,495,040 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020947458 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020947458   ⟸   XM_021091799
- Sequence:
RefSeq Acc Id: ENSSSCP00000019799   ⟸   ENSSSCT00000027288
RefSeq Acc Id: ENSSSCP00000042037   ⟸   ENSSSCT00000053677
RefSeq Acc Id: ENSSSCP00000032875   ⟸   ENSSSCT00000037734
Protein Domains
PK_Tyr_Ser-Thr   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000020725 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070029749 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000019799 UniProtKB/TrEMBL
  ENSSSCP00000032875 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000042037 UniProtKB/TrEMBL
  ENSSSCP00070050946 UniProtKB/TrEMBL
  ENSSSCP00070050948 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000027288 UniProtKB/TrEMBL
  ENSSSCT00000037734 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000053677 UniProtKB/TrEMBL
  ENSSSCT00070059798 UniProtKB/TrEMBL
  ENSSSCT00070059800 UniProtKB/TrEMBL
Gene3D-CATH 3.80.20.20 UniProtKB/TrEMBL
InterPro Furin-like_Cys-rich_dom UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_EGF/ERB/XmrK_rcpt UniProtKB/TrEMBL
NCBI Gene ERBB3 ENTREZGENE
Pfam Furin-like UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/TrEMBL
PIRSF TyrPK_EGF-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART SM00261 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A286ZMT1_PIG UniProtKB/TrEMBL
  A0A287ADX1_PIG UniProtKB/TrEMBL
  A0A4X1W9N6_PIG UniProtKB/TrEMBL
  A0A4X1WAT0_PIG UniProtKB/TrEMBL
  I3L6Z7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87760 ENTREZGENE