ANGIOTENSIN II SIGNALING PATHWAY VIA AT2 RECEPTOR (PW:0000528)

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Description

Angiotensin II (AgtII), the product of Ace action in the renin-angiotensin pathway, is probably the most potent of the biologically active peptides the system generates. Overall AgtII elicits distinct responses through signaling via receptor type 1 and 2, Agtr1 and Agtr2, respectively. Signaling via receptor type 1 is by far the better understood system. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. The powerful but potentially

Pathway Diagram:

Ariadne Genomics Inc. natriuresis Gnai3 Gnai2 G protein mediated signaling pathway via Galphai family Agtr2 mediated effects anti-proliferative vasodilation anti-inflammatory AgtII independent effects Agtr2 --+> Agtr2 mediated effects G protein independent effects Dusp1 the extracellular signal-regulated Raf/Mek/Erk signaling pathway Agtr2 --+> AgtII independent effects Ptpn6 Agtr2 --+> Ptpn6 Agtr2 Agtr2 --+> Dusp1 Ptpn6 ---| the extracellular signal-regulated Raf/Mek/Erk signaling pathway Dusp1 ---| the extracellular signal-regulated Raf/Mek/Erk signaling pathway Agtr2 ---- Gnai2 Agtr2 ---- Mtus1 Mtus1 Agtr2 ---- other Agtr2 partners other Agtr2 partners renin-angiotensin cascade pathway AgtII Agt ---> AgtII Agt Agtr2 ---- Gnai3 AgtII ---- Agtr2
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Genes in Pathway:

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angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582434
RGD:7401256
RGD:1582435
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581825
RGD:7401256
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:5133679
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:5133675
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:5133679
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:7401256
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:7401256
G Mtus1 microtubule associated scaffold protein 1 JBrowse link 16 54,240,892 54,386,131 RGD:5133679
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:5133675
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:5133679
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:5133679
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:5133679

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Groupother Agtr2 partnersadditional Agtr2 interacting proteins
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the angiotensin II signaling pathway via AT2 receptor
Disease TermsGene Symbols
abdominal aortic aneurysmAgt
Abortion, SpontaneousTimp3
ACTH-secreting pituitary adenomaGnai2
Acute ErythroleukemiaErbb3
acute promyelocytic leukemiaZbtb16
Adrenal Cortex NeoplasmsGnai2
AIDS-Associated NephropathyAgtr2
AlbuminuriaAgt
alcoholic cardiomyopathyAgt
alcoholic hepatitisAgt
AlkalosisAgt
Allanson Pantzar McLeod SyndromeAgt
allergic hypersensitivity diseaseAgt
Alzheimer's diseaseAgt
amnestic disorderGnai3
Amyloid NeuropathiesDusp1
AnaphylaxisAgt
anemiaAgt
anti-basement membrane glomerulonephritisAgt , Dusp1
anuriaAgt
aortic aneurysmAgt
Aortic CalcificationAgt
Aortic CoarctationAgt
arteriosclerosisDusp1
arteriovenous malformations of the brainTimp3
asthmaAgtr2 , Timp3
astigmatismSlc9a6
atherosclerosisAgt
atrial fibrillationAgt
atrioventricular blockGnai2
Auriculo-Condylar SyndromeGnai3
bipolar disorderAgt
bladder diseaseTimp3
bladder urothelial carcinomaErbb3
BradycardiaAgt , Gnai2
breast cancerErbb3
Breast NeoplasmsAgt , Dusp1 , Erbb3 , Gnai2 , Mtus1 , Timp3
calcinosisPtpn6
carcinomaGnai2
Cardiac ArrhythmiasAgt , Gnai2
CardiomegalyAgt
cardiomyopathyAgt
Cardiovascular AbnormalitiesAgt
cardiovascular system diseaseAgt
carotid artery diseaseAgt
Carotid Artery InjuriesDusp1
CatalepsyAgt
cerebrovascular diseaseAgt
cholestasisAgt
choriocarcinomaTimp3
Christianson syndromeSlc9a6
Chronic Intermittent HypoxiaAgt
chronic kidney diseaseAgtr2
chronic myeloid leukemiaAgt
chronic obstructive pulmonary diseaseErbb3
Cognition DisordersAgt
colitisDusp1 , Timp3
Colonic NeoplasmsErbb3 , Mtus1
Colorectal NeoplasmsErbb3
congenital diaphragmatic herniaAgt
congestive heart failureAgt , Agtr2
contact dermatitisDusp1
corneal neovascularizationAgt
coronary artery diseaseAgt
Crohn's diseaseAgt
Diabetic CardiomyopathiesAgtr2
diabetic encephalopathyDusp1
Diabetic NephropathiesAgt , Agtr2
diabetic retinopathyAgt
diffuse sclerodermaAgt
dilated cardiomyopathyAgt , Agtr2 , Timp3
disease of cellular proliferationErbb3
Disease ProgressionErbb3
Dissecting AneurysmAgt
Drug OverdoseAgt
ductal carcinoma in situErbb3
end stage renal failureAgt , Agtr2
Endometrial NeoplasmsErbb3 , Timp3
Endometrioid CarcinomasErbb3
endometriosisDusp1
endomyocardial fibrosisAgt
EndotoxemiaAgtr2 , Timp3
essential hypertensionAgt
Experimental Autoimmune EncephalomyelitisTimp3
Experimental Diabetes MellitusAgt , Agtr2 , Dusp1 , Timp3
Experimental Liver CirrhosisAgt , Gnai2
Fabry diseaseAgt
Familial ErythroleukemiaErbb3
Fetal Growth RetardationAgt , Agtr2 , Dusp1
FibrosisAgt , Agtr2
focal segmental glomerulosclerosisAgt , Agtr2
Gallbladder NeoplasmsErbb3
gastric adenocarcinomaErbb3
gastric ulcerAgt
glomerulonephritisAgt , Agtr2
glomerulosclerosisAgtr2
glucose intoleranceAgt , Dusp1
granulosa cell tumorGnai2
Granulosa Cell Tumor of the OvaryGnai2
heart diseaseAgt
heart valve diseasePtpn6
HemorrhageAgt
Henoch-Schoenlein purpuraAgt
Hereditary Eye DiseasesTimp3
Hernias, Diaphragmatic, CongenitalAgtr2
Huntington's diseaseDusp1
hydronephrosisAgt
HyperalgesiaAgt , Dusp1
HyperemiaAgt
hyperinsulinismAgt
hypertensionAgt , Agtr2 , Dusp1 , Gnai2 , Gnai3
Hypertension, Pregnancy-InducedAgt
Hypertensive NephropathyAgt
hypertrophic cardiomyopathyAgt
HypertrophyAgt
Hypertrophy, Left VentricularAgt , Agtr2 , Dusp1
hypoglycemiaAgtr2
hypokalemiaAgt
HypotensionAgt
Hypoxia-Ischemia, BrainAgtr2
IgA glomerulonephritisAgt , Agtr2
impotenceAgt
InflammationAgt , Agtr2
inflammatory bowel diseaseAgt
inflammatory bowel disease 12Gnai2
Insulin ResistanceAgtr2
intellectual disabilityAgtr2 , Cnksr1 , Slc9a6
intermediate coronary syndromeAgt
Intestinal Reperfusion InjuryAgt
invasive lobular carcinomaAgtr2
juvenile rheumatoid arthritisDusp1
kidney diseaseAgt
kidney failureAgt
Kidney NeoplasmsTimp3
leishmaniasisDusp1
lethal congenital contracture syndrome 1Erbb3
lethal congenital contracture syndrome 2Erbb3
Leukemia, Erythroblastic, AcuteErbb3
liver cirrhosisAgt
liver diseaseTimp3
Lung NeoplasmsErbb3
Lymphatic MetastasisErbb3 , Timp3
macular degenerationTimp3
major depressive disorderDusp1
malignant hypertensionAgt
Mammary Neoplasms, AnimalGnai2
Mammary Neoplasms, ExperimentalAgt , Agtr2 , Dusp1 , Erbb3 , Gnai2
meconium aspiration syndromeAgt , Agtr2
median neuropathyErbb3
Mental Retardation, X-LinkedAgtr2
Mental Retardation, X-Linked 88Agtr2
Metabolic SyndromeAgt
middle cerebral artery infarctionAgt
mitral valve prolapseAgt
Mouth NeoplasmsErbb3
multiple sclerosisAgt
myocardial infarctionAgt
Myocardial IschemiaAgt , Dusp1
Myocardial Reperfusion InjuryAgt
nasopharynx carcinomaErbb3
NecrosisAgt
NeointimaAgt
Neoplasm InvasivenessTimp3 , Zbtb16
Neoplasm MetastasisAgtr2 , Erbb3
Neoplasm Recurrence, LocalGnai2
nephrosisAgt
Nephrosis, Puromycin AminonucleosideAgt
non-syndromic X-linked intellectual disabilityAgtr2
obesityAgt , Agtr2 , Dusp1
otitis mediaDusp1
otosclerosisAgt
ovarian cystAgtr2
Ovarian NeoplasmsDusp1 , Erbb3 , Mtus1 , Timp3
pancreatic cancerAgtr2
pancreatitisDusp1
Peptic Ulcer HemorrhageAgt
Phyllodes TumorErbb3
pituitary-dependent Cushing's diseaseGnai2
pneumoniaAgt
Polycystic Kidney DiseasesAgt
polydactylyZbtb16
portal hypertensionDusp1
pre-eclampsiaAgt
prediabetes syndromeAgt
preretinal fibrosisTimp3
primary biliary cirrhosisAgt
prostate cancerErbb3
Prostatic NeoplasmsDusp1 , Erbb3 , Timp3 , Zbtb16
proteinuriaAgt
Pseudoinflammatory Fundus Dystrophy, Finnish TypeTimp3
psoriasisDusp1
pulmonary edemaAgt
pulmonary fibrosisAgt , Agtr2
pulmonary hypertensionAgt
Radiation Injuries, ExperimentalAgtr2
RecurrenceErbb3
renal cell carcinomaAgtr2 , Timp3
renal hypertensionAgt
Renal Tubular DysgenesisAgt
renovascular hypertensionAgtr2
Reperfusion InjuryAgt , Agtr2 , Gnai2 , Gnai3 , Timp3
respiratory allergyPtpn6
Retina Reperfusion InjuryDusp1
retinal vasculitisAgt
retinopathy of prematurityAgt
schistosomiasisTimp3
sciatic neuropathyAgt
sick sinus syndromeAgt
Skeletal Defects, Genital Hypoplasia, And Mental RetardationZbtb16
skin melanomaAgt
Sorsby's fundus dystrophyTimp3
Spinal Cord InjuriesDusp1 , Erbb3
squamous cell carcinomaDusp1
Stomach NeoplasmsAgtr2 , Erbb3 , Timp3
StrokeAgt , Agtr2
Sudden DeathAgt
systemic lupus erythematosusAgtr2
systemic sclerodermaAgt
Tachycardia, VentricularGnai2
temporal lobe epilepsyAgt
ThecomaGnai2
thrombosisAgt
toxic encephalopathyTimp3
transient cerebral ischemiaAgt , Dusp1
transitional cell carcinomaErbb3
type 1 diabetes mellitusDusp1
type 2 diabetes mellitusAgt , Agtr2 , Timp3
ureteral obstructionAgt
urinary bladder cancerDusp1 , Erbb3 , Timp3
Urogenital AbnormalitiesAgtr2
uterine carcinosarcomaErbb3
Uterine Cervical NeoplasmsErbb3 , Timp3
Uterine NeoplasmsErbb3
Vascular RemodelingAgt
Vascular System InjuriesAgtr2
Ventricular Dysfunction, LeftAgt
Ventricular Tachycardia, FamilialGnai2
vesicoureteral refluxAgtr2
visual epilepsyAgt , Dusp1
Wallerian DegenerationErbb3 , Timp3
Pathway Annotations Associated with Genes in the angiotensin II signaling pathway via AT2 receptor
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyGnai2
acute myeloid leukemia pathwayZbtb16
angiotensin (1-7) signaling pathwayAgt
angiotensin II signaling pathwayAgt , Agtr2
angiotensin II signaling pathway via AT1 receptorAgt
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2 , Cnksr1 , Dusp1 , Erbb3 , Gnai2 , Gnai3 , Mtus1 , Ptpn6 , Slc9a6 , Timp3 , Zbtb16
angiotensin III signaling pathwayAgt , Agtr2
angiotensin III signaling pathway via AT1 receptorAgt
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
B cell receptor signaling pathwayPtpn6
benazepril pharmacodynamics pathwayAgt
c-Jun N-terminal kinases MAPK signaling pathwayDusp1
calcium/calcium-mediated signaling pathwayErbb3
candesartan pharmacodynamics pathwayAgt
captopril pharmacodynamics pathwayAgt
Chagas disease pathwayGnai2 , Gnai3
chemokine mediated signaling pathwayGnai2 , Gnai3
cilazapril pharmacodynamics pathwayAgt
dopamine signaling pathway via D2 family of receptorsGnai2
eicosanoid signaling pathwayGnai2
enalapril pharmacodynamics pathwayAgt
endocytosis pathwayErbb3
endothelin signaling pathwayGnai2 , Gnai3
epidermal growth factor/neuregulin signaling pathwayErbb3 , Gnai3 , Ptpn6
eprosartan pharmacodynamics pathwayAgt
erythropoietin signaling pathwayPtpn6
forasartsn pharmacodynamics pathwayAgt
fosinopril pharmacodynamics pathwayAgt
G protein mediated signaling pathway via Galphai familyAgtr2 , Gnai2 , Gnai3
glutamate signaling pathwayGnai2 , Gnai3
Hedgehog signaling pathwayGnai2 , Gnai3
interleukin-3 signaling pathwayCnksr1
interleukin-4 signaling pathwayPtpn6
irbesartan pharmacodynamics pathwayAgt
Jak-Stat signaling pathwayPtpn6
Leishmaniasis pathwayPtpn6
lisinopril pharmacodynamics pathwayAgt
long term depressionGnai2 , Gnai3
long term potentiationAgt
losartan pharmacodynamics pathwayAgt
mitogen activated protein kinase signaling pathwayDusp1
moexipril pharmacodynamics pathwayAgt
myocardial infarction pathwayAgt
olmesartan pharmacodynamics pathwayAgt
p38 MAPK signaling pathwayDusp1
perindopril pharmacodynamics pathwayAgt
quinapril pharmacodynamics pathwayAgt
ramipril pharmacodynamics pathwayAgt
renin-angiotensin cascade pathwayAgt , Agtr2
sphingosine 1-phosphate signaling pathwayGnai2 , Gnai3
spirapril pharmacodynamics pathwayAgt
T cell receptor signaling pathwayPtpn6
telmisartan pharmacodynamics pathwayAgt
toxoplasmosis pathwayGnai2 , Gnai3
trandolapril pharmacodynamics pathwayAgt
valsartan pharmacodynamics pathwayAgt
vascular endothelial growth factor signaling pathwayPtpn6
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway via AT2 receptor
Phenotype TermsGene Symbols
cardiac hypertrophyAgtr2

References Associated with the angiotensin II signaling pathway via AT2 receptor:

Ontology Path Diagram:

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