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Angiotensin II (AgtII), the product of Ace action in the renin-angiotensin pathway, is probably the most potent of the biologically active peptides the system generates. Overall AgtII elicits distinct responses through signaling via receptor type 1 and 2, Agtr1 and Agtr2, respectively. Signaling via receptor type 1 is by far the better understood system. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. The powerful but potentially

Pathway Diagram:

Ariadne Genomics Inc. natriuresis Gnai3 Gnai2 G protein mediated signaling pathway via Galphai family Agtr2 mediated effects anti-proliferative vasodilation anti-inflammatory AgtII independent effects Agtr2 --+> Agtr2 mediated effects G protein independent effects Dusp1 the extracellular signal-regulated Raf/Mek/Erk signaling pathway Agtr2 --+> AgtII independent effects Ptpn6 Agtr2 --+> Ptpn6 Agtr2 Agtr2 --+> Dusp1 Ptpn6 ---| the extracellular signal-regulated Raf/Mek/Erk signaling pathway Dusp1 ---| the extracellular signal-regulated Raf/Mek/Erk signaling pathway Agtr2 ---- Gnai2 Agtr2 ---- Mtus1 Mtus1 Agtr2 ---- other Agtr2 partners other Agtr2 partners renin-angiotensin cascade pathway AgtII Agt ---> AgtII Agt Agtr2 ---- Gnai3 AgtII ---- Agtr2

Genes in Pathway:

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angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582434
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581825
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:5133679
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:5133675
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:5133679
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:7401256
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:7401256
G Mtus1 microtubule associated scaffold protein 1 JBrowse link 16 54,240,892 54,386,131 RGD:5133679
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:5133675
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:5133679
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:5133679
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:5133679

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Groupother Agtr2 partnersadditional Agtr2 interacting proteins
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin pathway

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the angiotensin II signaling pathway via AT2 receptor
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyGnai2
acute myeloid leukemia pathwayZbtb16
angiotensin (1-7) signaling pathwayAgt
angiotensin II signaling pathwayAgt , Agtr2
angiotensin II signaling pathway via AT1 receptorAgt
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2 , Cnksr1 , Dusp1 , Erbb3 , Gnai2 , Gnai3 , Mtus1 , Ptpn6 , Slc9a6 , Timp3 , Zbtb16
angiotensin III signaling pathwayAgt , Agtr2
angiotensin III signaling pathway via AT1 receptorAgt
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
B cell receptor signaling pathwayPtpn6
benazepril pharmacodynamics pathwayAgt
c-Jun N-terminal kinases MAPK signaling pathwayDusp1
calcium/calcium-mediated signaling pathwayErbb3
candesartan pharmacodynamics pathwayAgt
captopril pharmacodynamics pathwayAgt
chemokine mediated signaling pathwayGnai2 , Gnai3
cilazapril pharmacodynamics pathwayAgt
dopamine signaling pathway via D2 family of receptorsGnai2
eicosanoid signaling pathwayGnai2
enalapril pharmacodynamics pathwayAgt
endocytosis pathwayErbb3
endothelin signaling pathwayGnai2 , Gnai3
epidermal growth factor/neuregulin signaling pathwayErbb3 , Gnai3 , Ptpn6
eprosartan pharmacodynamics pathwayAgt
erythropoietin signaling pathwayPtpn6
forasartsn pharmacodynamics pathwayAgt
fosinopril pharmacodynamics pathwayAgt
G protein mediated signaling pathway via Galphai familyAgtr2 , Gnai2 , Gnai3
glutamate signaling pathwayGnai2 , Gnai3
Hedgehog signaling pathwayGnai2 , Gnai3
interleukin-3 signaling pathwayCnksr1
interleukin-4 signaling pathwayPtpn6
irbesartan pharmacodynamics pathwayAgt
Jak-Stat signaling pathwayPtpn6
Leishmania infection pathwayPtpn6
lisinopril pharmacodynamics pathwayAgt
long term depressionGnai2 , Gnai3
long term potentiationAgt
losartan pharmacodynamics pathwayAgt
mitogen activated protein kinase signaling pathwayDusp1
moexipril pharmacodynamics pathwayAgt
myocardial infarction pathwayAgt
olmesartan pharmacodynamics pathwayAgt
p38 MAPK signaling pathwayDusp1
perindopril pharmacodynamics pathwayAgt
quinapril pharmacodynamics pathwayAgt
ramipril pharmacodynamics pathwayAgt
renin-angiotensin cascade pathwayAgt , Agtr2
sphingosine 1-phosphate signaling pathwayGnai2 , Gnai3
spirapril pharmacodynamics pathwayAgt
T cell receptor signaling pathwayPtpn6
telmisartan pharmacodynamics pathwayAgt
Toxoplasma gondii infection pathwayGnai2 , Gnai3
trandolapril pharmacodynamics pathwayAgt
Trypanosoma cruzi infection pathwayGnai2 , Gnai3
valsartan pharmacodynamics pathwayAgt
vascular endothelial growth factor signaling pathwayPtpn6
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway via AT2 receptor
Phenotype TermsGene Symbols
cardiac hypertrophyAgtr2

References Associated with the angiotensin II signaling pathway via AT2 receptor:

Ontology Path Diagram:

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