RGD Reference Report - An ATIPical family of angiotensin II AT2 receptor-interacting proteins. - Rat Genome Database

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An ATIPical family of angiotensin II AT2 receptor-interacting proteins.

Authors: Rodrigues-Ferreira, S  Nahmias, C 
Citation: Rodrigues-Ferreira S and Nahmias C, Trends Endocrinol Metab. 2010 Nov;21(11):684-90.
RGD ID: 5133679
Pubmed: PMID:20889352   (View Abstract at PubMed)
DOI: DOI:10.1016/j.tem.2010.08.009   (Journal Full-text)

AT2, the second subtype of angiotensin II receptors, is a major component of the renin-angiotensin system involved in cardiovascular and neuronal functions. AT2 belongs to the superfamily of G protein-coupled receptors, but its intracellular signaling pathways have long remained elusive. Over the past few years, efforts to characterize this atypical receptor have led to the identification of novel molecular scaffolds that directly bind to its intracellular tail. The present review focuses on a family of AT2 receptor-interacting proteins (ATIPs) involved in neuronal differentiation, vascular remodeling and tumor suppression. Recent findings that ATIPs and ATIP-related proteins associate with microtubules suggest that they might constitute a novel family of multifunctional proteins regulating a wide range of physiopathological functions.



RGD Manual Annotations

1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
CNKSR1Humanangiotensin II signaling pathway via AT2 receptor   TAS  RGD 
Cnksr1Ratangiotensin II signaling pathway via AT2 receptor   ISOCNKSR1 (Homo sapiens) RGD 
Cnksr1Mouseangiotensin II signaling pathway via AT2 receptor   ISOCNKSR1 (Homo sapiens) RGD 
ERBB3Humanangiotensin II signaling pathway via AT2 receptor   TAS  RGD 
Erbb3Ratangiotensin II signaling pathway via AT2 receptor   ISOERBB3 (Homo sapiens) RGD 
Erbb3Mouseangiotensin II signaling pathway via AT2 receptor   ISOERBB3 (Homo sapiens) RGD 
MTUS1Humanangiotensin II signaling pathway via AT2 receptor   TAS  RGD 
Mtus1Ratangiotensin II signaling pathway via AT2 receptor   ISOMTUS1 (Homo sapiens) RGD 
Mtus1Mouseangiotensin II signaling pathway via AT2 receptor   ISOMTUS1 (Homo sapiens) RGD 
SLC9A6Humanangiotensin II signaling pathway via AT2 receptor   TAS  RGD 
Slc9a6Mouseangiotensin II signaling pathway via AT2 receptor   ISOSLC9A6 (Homo sapiens) RGD 
Slc9a6Ratangiotensin II signaling pathway via AT2 receptor   ISOSLC9A6 (Homo sapiens) RGD 
TIMP3Humanangiotensin II signaling pathway via AT2 receptor   TAS  RGD 
Timp3Ratangiotensin II signaling pathway via AT2 receptor   ISOTIMP3 (Homo sapiens) RGD 
Timp3Mouseangiotensin II signaling pathway via AT2 receptor   ISOTIMP3 (Homo sapiens) RGD 
ZBTB16Humanangiotensin II signaling pathway via AT2 receptor   TAS  RGD 
Zbtb16Ratangiotensin II signaling pathway via AT2 receptor   ISOZBTB16 (Homo sapiens) RGD 
Zbtb16Mouseangiotensin II signaling pathway via AT2 receptor   ISOZBTB16 (Homo sapiens) RGD 
1 to 18 of 18 rows

Genes (Rattus norvegicus)
Cnksr1  (connector enhancer of kinase suppressor of Ras 1) Erbb3  (erb-b2 receptor tyrosine kinase 3) Mtus1  (microtubule associated scaffold protein 1)
Slc9a6  (solute carrier family 9 member A6) Timp3  (TIMP metallopeptidase inhibitor 3) Zbtb16  (zinc finger and BTB domain containing 16)

Genes (Mus musculus)
Cnksr1  (connector enhancer of kinase suppressor of Ras 1) Erbb3  (erb-b2 receptor tyrosine kinase 3) Mtus1  (mitochondrial tumor suppressor 1)
Slc9a6  (solute carrier family 9 (sodium/hydrogen exchanger), member 6) Timp3  (tissue inhibitor of metalloproteinase 3) Zbtb16  (zinc finger and BTB domain containing 16)

Genes (Homo sapiens)
CNKSR1  (connector enhancer of kinase suppressor of Ras 1) ERBB3  (erb-b2 receptor tyrosine kinase 3) MTUS1  (microtubule associated scaffold protein 1)
SLC9A6  (solute carrier family 9 member A6) TIMP3  (TIMP metallopeptidase inhibitor 3) ZBTB16  (zinc finger and BTB domain containing 16)