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Gene: TIMP3 (TIMP metallopeptidase inhibitor 3) Homo sapiens
Symbol: TIMP3
Name: TIMP metallopeptidase inhibitor 3
Description: Predicted to have metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of TRAIL-activated apoptotic signaling pathway. Localizes to collagen-containing extracellular matrix and nucleus. Implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Biomarker of several diseases, including breast cancer (multiple); preretinal fibrosis; reproductive organ cancer (multiple); thoracic aortic aneurysm; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HSMRK222; K222; K222TA2; metalloproteinase inhibitor 3; MIG-5 protein; protein MIG-5; SFD; TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory); TIMP-3; tissue inhibitor of metalloproteinase 3; tissue inhibitor of metalloproteinases 3
Mus musculus (house mouse) : Timp3 (tissue inhibitor of metalloproteinase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Timp3 (TIMP metallopeptidase inhibitor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp3 (TIMP metallopeptidase inhibitor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP3 (TIMP metallopeptidase inhibitor 3)
Canis lupus familiaris (dog) : TIMP3 (TIMP metallopeptidase inhibitor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp3 (TIMP metallopeptidase inhibitor 3)
Sus scrofa (pig) : TIMP3 (TIMP metallopeptidase inhibitor 3)
Chlorocebus sabaeus (African green monkey) : TIMP3 (TIMP metallopeptidase inhibitor 3)
Heterocephalus glaber (naked mole-rat) : Timp3 (TIMP metallopeptidase inhibitor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2232,801,701 - 32,863,043 (+)EnsemblGRCh38hg38GRCh38
GRCh382232,801,705 - 32,863,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372233,196,802 - 33,259,028 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,526,802 - 31,589,028 (+)NCBINCBI36hg18NCBI36
Build 342231,521,361 - 31,583,581NCBI
Celera2216,999,013 - 17,061,296 (+)NCBI
Cytogenetic Map22q12.3ENTREZGENE
HuRef2216,154,700 - 16,216,984 (+)NCBIHuRef
CHM1_12233,156,307 - 33,218,500 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated


Comparative Map Data
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miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants