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Gene: Timp3 (tissue inhibitor of metalloproteinase 3) Mus musculus
Symbol: Timp3
Name: tissue inhibitor of metalloproteinase 3
Description: Predicted to have metalloendopeptidase inhibitor activity and protease binding activity. Involved in cellular response to organic substance and negative regulation of metalloendopeptidase activity. Localizes to basement membrane. Is expressed in several structures, including alimentary system; central nervous system; eye posterior segment; genitourinary system; and musculoskeletal system. Used to study Sorsby's fundus dystrophy and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; INTERACTS WITH (S)-nicotine; 1,1-dichloroethene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: metalloproteinase inhibitor 3; Timp-3; tissue inhibitor of metalloproteinases 3
Homo sapiens (human) : TIMP3 (TIMP metallopeptidase inhibitor 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Timp3 (TIMP metallopeptidase inhibitor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp3 (TIMP metallopeptidase inhibitor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP3 (TIMP metallopeptidase inhibitor 3)
Canis lupus familiaris (dog) : TIMP3 (TIMP metallopeptidase inhibitor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp3 (TIMP metallopeptidase inhibitor 3)
Sus scrofa (pig) : TIMP3 (TIMP metallopeptidase inhibitor 3)
Chlorocebus sabaeus (African green monkey) : TIMP3 (TIMP metallopeptidase inhibitor 3)
Heterocephalus glaber (naked mole-rat) : Timp3 (TIMP metallopeptidase inhibitor 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1086,300,372 - 86,349,506 (+)EnsemblGRCm38mm10GRCm38
GRCm381086,300,412 - 86,349,505 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371085,763,157 - 85,812,250 (+)NCBIGRCm37mm9NCBIm37
MGSCv361085,730,336 - 85,779,305 (+)NCBImm8
Celera1088,278,411 - 88,327,541 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1042.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Timp3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11419
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.